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Reza Hakkak

TitleAssociate Dean for Research
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentDietetics and Nutrition, College of Health Profession
AddressG44 CHRP Building 5
300 Hooper
Mail Slot # 627
Little Rock AR 72205
Phone501-686-6166
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPediatrics, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentCollege of Public Health


    Collapse Research 
    Collapse research activities and funding
    GR034036     (HAKKAK, REZA)Apr 1, 2020 - Mar 31, 2024
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Li W, Hakkak R. Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats. Nutrients. 2024 Mar 28; 16(7). PMID: 38613016.
      View in: PubMed
    2. Li W, Hakkak R. Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation. Front Nutr. 2023; 10:1278158. PMID: 38075211.
      View in: PubMed
    3. Li W, Spray B, B?rsheim E, Korourian S, Hakkak R. Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels. J Med Food. 2023 Dec; 26(12):911-918. PMID: 37971778.
      View in: PubMed
    4. Melnyk S, Hakkak R. Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease. Biomolecules. 2023 08 10; 13(8). PMID: 37627299.
      View in: PubMed
    5. Li W, Twaddle NC, Spray B, Nounamo B, Monzavi-Karbassi B, Hakkak R. Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats. J Med Food. 2023 Feb; 26(2):120-127. PMID: 36720082.
      View in: PubMed
    6. Hakkak R, Spray B, B?rsheim E, Korourian S. Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats. Front Nutr. 2022; 9:913571. PMID: 35811988.
      View in: PubMed
    7. Robeson MS, Manna K, Randolph C, Byrum S, Hakkak R. Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model. Front Microbiol. 2022; 13:834776. PMID: 35432282.
      View in: PubMed
    8. Melnyk S, Hakkak R. Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum. Biomedicines. 2022 Jan 12; 10(1). PMID: 35052832.
      View in: PubMed
    9. Kozaczek M, Kong B, Bottje W, Hakkak R. Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding. J Med Food. 2022 Mar; 25(3):293-302. PMID: 34883038.
      View in: PubMed
    10. Kozaczek M, Bottje W, Albataineh D, Hakkak R. Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model. Front Nutr. 2021; 8:699620. PMID: 34262928.
      View in: PubMed
    11. Hakkak R, Rose S, Spray B, Kozaczek M, Korourian S. Effects of obesity and 10 weeks metformin treatment on liver steatosis. Biomed Rep. 2021 Jun; 14(6):49. PMID: 33859820.
      View in: PubMed
    12. Kozaczek M, Bottje W, Kong B, Albataineh D, Hakkak R. A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport. J Med Food. 2021 Sep; 24(9):1010-1016. PMID: 33751907.
      View in: PubMed
    13. Kozaczek M, Bottje W, Kong B, Dridi S, Albataineh D, Lassiter K, Hakkak R. Long-Term Soy Protein Isolate Consumption Reduces Liver Steatosis Through Changes in Global Transcriptomics in Obese Zucker Rats. Front Nutr. 2020; 7:607970. PMID: 33363197.
      View in: PubMed
    14. Zeng H, Larson KJ, Cheng WH, Bukowski MR, Safratowich BD, Liu Z, Hakkak R. Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet. J Nutr Biochem. 2020 04; 78:108336. PMID: 32004929.
      View in: PubMed
    15. Kozaczek M, Bottje W, Greene E, Lassiter K, Kong B, Dridi S, Korourian S, Hakkak R. Comparison of liver gene expression by RNAseq and PCR analysis after 8 weeks of feeding soy protein isolate- or casein-based diets in an obese liver steatosis rat model. Food Funct. 2019 Dec 11; 10(12):8218-8229. PMID: 31701992.
      View in: PubMed
    16. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. Correction: A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 12 11; 10(12):8309. PMID: 31691687.
      View in: PubMed
    17. Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857. PMID: 31580380.
      View in: PubMed
    18. Hakkak R, Gauss CH, Bell A, Korourian S. Short-Term Soy Protein Isolate Feeding Prevents Liver Steatosis and Reduces Serum ALT and AST Levels in Obese Female Zucker Rats. Biomedicines. 2018 May 14; 6(2). PMID: 29757972.
      View in: PubMed
    19. Hakkak R, Korourian S, Foley SL, Erickson BD. Assessment of gut microbiota populations in lean and obese Zucker rats. PLoS One. 2017; 12(7):e0181451. PMID: 28704522.
      View in: PubMed
    20. Melnyk S, Korourian S, Levy JW, Pavliv O, Evans T, Hakkak R. Effects of Obesity on Pro-Oxidative Conditions and DNA Damage in Liver of DMBA-Induced Mammary Carcinogenesis Models. Metabolites. 2017 Jun 08; 7(2). PMID: 28594380.
      View in: PubMed
    21. Bell A, Korourian S, Zeng H, Phelps J, Hakkak R. A diet containing a high- versus low-daidzein level does not protect against liver steatosis in the obese Zucker rat model. Food Funct. 2017 Mar 22; 8(3):1293-1298. PMID: 28244519.
      View in: PubMed
    22. Hakkak R, Bell A, Korourian S. Dehydroepiandrosterone (DHEA) Feeding Protects Liver Steatosis in Obese Breast Cancer Rat Model. Sci Pharm. 2017 Mar 20; 85(1). PMID: 28335515.
      View in: PubMed
    23. Zeng H, Taussig DP, Cheng WH, Johnson LK, Hakkak R. Butyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells. Nutrients. 2017 Jan 01; 9(1). PMID: 28045428.
      View in: PubMed
    24. Jousheghany F, Phelps J, Crook T, Hakkak R. Relationship between level of HbA1C and breast cancer. BBA Clin. 2016 Dec; 6:45-48. PMID: 27957429.
      View in: PubMed
    25. Hakkak R, Zeng H, Dhakal IB, Korourian S. Short- and Long-Term Soy Diet Versus Casein Protects Liver Steatosis Independent of the Arginine Content. J Med Food. 2015 Nov; 18(11):1274-80. PMID: 26186426.
      View in: PubMed
    26. Ronis MJ, Hakkak R, Korourian S, Badger TM. Whey Protein Hydrolysate but not Whole Whey Protein Protects Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats. Nutr Cancer. 2015; 67(6):949-53. PMID: 26168336.
      View in: PubMed
    27. Feresin RG, Johnson SA, Elam ML, Jo E, Arjmandi BH, Hakkak R. Effects of obesity on bone mass and quality in ovariectomized female Zucker rats. J Obes. 2014; 2014:690123. PMID: 25309751.
      View in: PubMed
    28. Melnyk S, Evans T, Korourian S and R Hakkak. Effects of Obesity on Serum Vitamin D Metabolites using Obese Zucker rat Model. 2014; (3):112.
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    29. Phelps J, Parker S R Hakkak. Obesity, Chronic Disease Risk Factors & Fighting Words – The Collateral Damage to Health. 2014.
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    30. Filla C, Hays N, Gonzales D and R Hakkak. Self-Reported Changes in Weight, Food Intake, and Physical Activity from High School to College. 2013.
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    31. Hakkak R, Macleod S and S Korourian. . Effects of Obesity and 7,12-Dimethylbenz(a)anthracene (DMBA) Treatment on Liver Cytochrome P4501A1 and 1B1 Expression in Ovariectomized Obese Zucker Rats. 2013; (3):S1:003.
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    32. Crook T and R Hakkak. Nutrition Screening and Assessment: A Critical Element of Care in Children with Developmental Disabilities and Special Health Care Needs. 2013; (3):e111.
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    33. Hakkak R, Al-Dwairi A, Fuchs GJ, Korourian S, Simmen FA. Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors. Genes Nutr. 2012 Oct; 7(4):549-58. PMID: 22528625.
      View in: PubMed
    34. Prins A, Gonzales D, Crook T and Hakkak R. Impact of Menu Labeling on Food Choices of Southern Undergraduate Students. 2012; S4-001.
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    35. Melnyk, S and Hakkak R. Effects of obesity on serum concentration of methylation and oxidative/nitrosative stress metabolites following DMBA treatment of female Zucker rats. 2012.
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    36. Monzavi-Karbassi BJ, Keiber-Emmons T and Hakkak R. Obesity, Diabetes and Breast Cancer: Defining Metabolic Oncogenesis. 2012.
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    37. Hakkak R, Shaaf S, Jo CH, Macleod S, Korourian S. Effects of high-isoflavone soy diet vs. casein protein diet and obesity on DMBA-induced mammary tumor development. Oncol Lett. 2011 Jan; 2(1):29-36. PMID: 22870124.
      View in: PubMed
    38. Hakkak R, Shaaf S, Jo CH, MacLeod S, Korourian S. Dehydroepiandrosterone intake protects against 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in the obese Zucker rat model. Oncol Rep. 2010 Aug; 24(2):357-62. PMID: 20596621.
      View in: PubMed
    39. Enderlin CA, Coleman EA, Stewart CB, Hakkak R. Dietary soy intake and breast cancer risk. Oncol Nurs Forum. 2009 Sep; 36(5):531-9. PMID: 19726393.
      View in: PubMed
    40. Whitehead TL, Holley AW, Korourian S, Shaaf S, Kieber-Emmons T, Hakkak R. (1)H nuclear magnetic resonance metabolomic analysis of mammary tumors from lean and obese Zucker rats exposed to 7,12-dimethylbenz[a]anthracene. Int J Mol Med. 2007 Oct; 20(4):573-80. PMID: 17786290.
      View in: PubMed
    41. Vargas PA, Perry TT, Robles E, Jo CH, Simpson PM, Magee JM, Feild CR, Hakkak R, Carroll PA, Jones SM. Relationship of body mass index with asthma indicators in head start children. Ann Allergy Asthma Immunol. 2007 Jul; 99(1):22-8. PMID: 17650825.
      View in: PubMed
    42. Hakkak R, MacLeod S, Shaaf S, Holley AW, Simpson P, Fuchs G, Jo CH, Kieber-Emmons T, Korourian S. Obesity increases the incidence of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in an ovariectomized Zucker rat model. Int J Oncol. 2007 Mar; 30(3):557-63. PMID: 17273756.
      View in: PubMed
    43. Hakkak R, Holley AW, Macleod SL, Simpson PM, Fuchs GJ, Jo CH, Kieber-Emmons T, Korourian S. Obesity promotes 7,12-dimethylbenz(a)anthracene-induced mammary tumor development in female zucker rats. Breast Cancer Res. 2005; 7(5):R627-33. PMID: 16168107.
      View in: PubMed
    44. Ronis MJ, Korourian S, Zipperman M, Hakkak R, Badger TM. Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition. J Nutr. 2004 Apr; 134(4):904-12. PMID: 15051845.
      View in: PubMed
    45. Ronis MJ, Hakkak R, Korourian S, Albano E, Yoon S, Ingelman-Sundberg M, Lindros KO, Badger TM. Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets. Exp Biol Med (Maywood). 2004 Apr; 229(4):351-60. PMID: 15044719.
      View in: PubMed
    46. Rowlands JC, Hakkak R, Ronis MJ, Badger TM. Altered mammary gland differentiation and progesterone receptor expression in rats fed soy and whey proteins. Toxicol Sci. 2002 Nov; 70(1):40-5. PMID: 12388833.
      View in: PubMed
    47. Brown EC, Perrien DS, Fletcher TW, Irby DJ, Aronson J, Gao GG, Hogue WJ, Skinner RA, Suva LJ, Ronis MJ, Hakkak R, Badger TM, Lumpkin CK. Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition. J Pharmacol Exp Ther. 2002 Jun; 301(3):1132-8. PMID: 12023547.
      View in: PubMed
    48. Badger TM, Ronis MJ, Hakkak R, Rowlands JC, Korourian S. The health consequences of early soy consumption. J Nutr. 2002 Mar; 132(3):559S-565S. PMID: 11880593.
      View in: PubMed
    49. Rowlands JC, He L, Hakkak R, Ronis MJ, Badger TM. Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J Nutr. 2001 Dec; 131(12):3281-7. PMID: 11739881.
      View in: PubMed
    50. Hakkak R, Korourian S, Ronis MJ, Johnston JM, Badger TM. Soy protein isolate consumption protects against azoxymethane-induced colon tumors in male rats. Cancer Lett. 2001 May 10; 166(1):27-32. PMID: 11295283.
      View in: PubMed
    51. Hakkak R, Korourian S, Ronis MJ, Johnston JM, Badger TM. Dietary whey protein protects against azoxymethane-induced colon tumors in male rats. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):555-8. PMID: 11352868.
      View in: PubMed
    52. Badger TM, Ronis MJ, Hakkak R. Developmental effects and health aspects of soy protein isolate, casein, and whey in male and female rats. Int J Toxicol. 2001 May-Jun; 20(3):165-74. PMID: 11488559.
      View in: PubMed
    53. Ronis MJ, Rowlands JC, Hakkak R, Badger TM. Inducibility of hepatic CYP1A enzymes by 3-methylcholanthrene and isosafrole differs in male rats fed diets containing casein, soy protein isolate or whey from conception to adulthood. J Nutr. 2001 Apr; 131(4):1180-8. PMID: 11285323.
      View in: PubMed
    54. Rowlands JC, Wang H, Hakkak R, Ronis MJ, Strobel HW, Badger TM. Chronic intragastric infusion of ethanol-containing diets induces CYP3A9 while decreasing CYP3A2 in male rats. J Pharmacol Exp Ther. 2000 Nov; 295(2):747-52. PMID: 11046114.
      View in: PubMed
    55. Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJ, Badger TM. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev. 2000 Jan; 9(1):113-7. PMID: 10667471.
      View in: PubMed
    56. Ronis MJ, Rowlands JC, Hakkak R, Badger TM. Altered expression and glucocorticoid-inducibility of hepatic CYP3A and CYP2B enzymes in male rats fed diets containing soy protein isolate. J Nutr. 1999 Nov; 129(11):1958-65. PMID: 10539769.
      View in: PubMed
    57. Korourian S, Hakkak R, Ronis MJ, Shelnutt SR, Waldron J, Ingelman-Sundberg M, Badger TM. Diet and risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats. Toxicol Sci. 1999 Jan; 47(1):110-7. PMID: 10048159.
      View in: PubMed
    58. Cimino C, King S, Ronis MJ, Hakkak R, Shelnutt SR, Torres A, Badger TM. Development of a liquid chromatography-mass spectrometry procedure for quantitation of free and conjugated phytoestrogens in human urine: application in pharmacokinetic studies after soy consumption. J Med Food. 1999; 2(3-4):203-5. PMID: 19281381.
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    59. Ronis MJ, Hakkak R, Irby D, Shelnutt SR, King S, Cimino C, Badger TM. Development of a rat total enteral nutrition model for delivery of high levels of dietary phytoestrogens using soy protein isolate. J Med Food. 1999; 2(3-4):223-5. PMID: 19281386.
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    60. Hakkak R, Korourian S, Ronis MJ, Badger TM. Effects of diet and ethanol treatment on azoxymethane-induced liver and gastrointestinal neoplasia of male rats. Cancer Lett. 1996 Oct 22; 107(2):257-64. PMID: 8947522.
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    61. Helm RM, Wheeler G, Burks AW, Hakkak R, Badger TM. Flow cytometric analysis of lymphocytes from rats following chronic ethanol treatment. Alcohol. 1996 Sep-Oct; 13(5):467-71. PMID: 8888943.
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    62. Hakkak R, Korourian S, Ronis MJ, Ingelman-Sundberg M, Badger TM. Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats. Biochem Pharmacol. 1996 Jan 12; 51(1):61-9. PMID: 8534269.
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    63. Badger TM, Ronis MJ, Ingelman-Sundberg M, Hakkak R. Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions. Eur J Biochem. 1995 Jun 15; 230(3):914-9. PMID: 7601153.
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    64. Badger TM, Ronis MJ, Ingelman-Sundberg M, Hakkak R. Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusions in rats. Alcohol. 1993 Nov-Dec; 10(6):453-7. PMID: 8123199.
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    65. Hendry WJ, Hakkak R, Harrison RW. An analysis of autologous glucocorticoid receptor protein regulation in AtT-20 cells also reveals differential specificity of the BuGR2 monoclonal antibody. Biochim Biophys Acta. 1993 Aug 18; 1178(2):176-88. PMID: 8347676.
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    66. Hakkak R, Ronis MJ, Badger TM. Effects of enteral nutrition and ethanol on cytochrome P450 distribution in small intestine of male rats. Gastroenterology. 1993 Jun; 104(6):1611-8. PMID: 8500717.
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    67. Badger TM, Crouch J, Irby D, Hakkak R, Shahare M. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: continuous vs. cyclic ethanol and nutrient infusions. J Pharmacol Exp Ther. 1993 Feb; 264(2):938-43. PMID: 8437133.
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    68. Hendry WJ, Hakkak R, Cornett LE. Selective loss of glucocorticoid-dependent responses in a variant of the DDT1MF-2 tumor cell line. Cancer Res. 1992 May 01; 52(9):2516-22. PMID: 1314696.
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    69. Labandter H, Kaplan I, Shavitt C. Burns of the dorsum of the hand: conservative treatment with intensive physiotherapy versus tangential excision and grafting. Br J Plast Surg. 1976 Oct; 29(4):352-4. PMID: 1000122.
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    70. Ballantine JA, Roberts JC, Morris RJ. Marine sterols. III--The sterol compositions of oceanic jellyfish. The use of gas chromatographic mass spectrometric techniques to identify unresolved components. Biomed Mass Spectrom. 1976 Feb; 3(1):14-20. PMID: 4172.
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    71. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. PMID: 10.
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    72. Hakkak RR. [Clinical and radiographic studies on gangrenous teeth, without and with periapical granuloma and cysts, before and after root treatment using N2]. ZWR. 1974 Jan 25; 83(2):57-61. PMID: 4522133.
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