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Rupak Pathak

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentCollege of Pharmacy, College of Provost
DivisionPharmaceutical Science
Address333 Cancer Institute
325 S. Elm St.
Mail Slot # 522-3
Little Rock AR 72205
Phone501-603-1472
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    Collapse Research Funds 
    Collapse research activities
    80NSSC19K0437     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Co-Investigator

    80NSSC19K0437 P00001     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Co-Investigator

    80NSSC19K0437 P00002     (BOERMA, MARJAN)Jan 31, 2019 - Mar 31, 2022
    National Aeronautics & Space Administration
    Tocotrienol as a countermeasure against high-energy charged particle-induced carcinogenesis, cardiovascular disease, and central nervous system effects- Resubmission
    Role: Co-Investigator

    R01 CA211963     (PATHAK, RUPAK)Sep 1, 2018 - Mar 31, 2022
    NIH/Nat. Cancer Institute - Pass Through: University of Florida
    Ionizing radiation induced hematological malignancies
    Role: Principal Investigator

    R01CA211963     (PATHAK, RUPAK)Sep 1, 2018 - Mar 31, 2022
    NIH/Nat. Cancer Institute - Pass Through: University of Florida
    Ionizing radiation induced hematological malignancies
    Role: Principal Investigator

    NNX15AR71H     (PATHAK, RUPAK)Jul 1, 2018 - Aug 3, 2019
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Studies of Endothelial Dysfunction under Simulated Space Environment
    Role: Principal Investigator

    242029-16-UAMS-02     (PATHAK, RUPAK)Jan 1, 2016 - Jan 31, 2017
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Effect of microgravity and GT3 on proton-induced genomic instability in endothelial cells
    Role: Principal Investigator

    W81XWH-15-C-0117     (HAUER-JENSEN, MARTIN)Oct 1, 2015 - Sep 20, 2021
    US Department of Defense - Pass Through: Armed Forces Radiobiology Research Institute
    Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure
    Role: Co-Investigator

    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - Mar 31, 2020
    NIH/NIGMS
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    NCC 9-58 95     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Co-Investigator

    NCC9-58     (BOERMA, MARJAN)Jun 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute
    Center for Research on Cardiac and Vascular Effects of Space Radiation
    Role: Co-Investigator

    NNX13AB29A     (PATHAK, RUPAK)Jul 1, 2013 - Nov 30, 2015
    Arkansas Space Grant Consortium - Pass Through: University of Arkansas at Little Rock
    Effect of microgravity and GT3 on radiation-induced genomic instability in endothelial cells
    Role: Principal Investigator

    HHSO100201100045C     (HAUER-JENSEN, MARTIN)Sep 26, 2011 - Jun 30, 2017
    DHHS - Biomedical Advanced Research and Development Authority
    Advanced Development of SOM230 as a Radiation Mitigator
    Role: Co-Investigator

    HU0001-10-1-0004     (HAUER-JENSEN, MARTIN)Aug 6, 2010 - Feb 13, 2012
    Defense Threat Reduction Agency - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Advanced Drug Development of Gamma-Tocotrienol as a Radiation Countermeasure in Rhesus Macaque Non-Human Primates
    Role: Co-Investigator

    U54MD002329     (RACZYNSKI, JAMES M)Sep 30, 2007 - Apr 30, 2022
    NIH/NIMHD
    Arkansas Center for Health Disparities (ARCHD): An NIMHD COE
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Ewing LE, Skinner CM, Pathak R, Yee EU, Krager K, Gurley PC, Melnyk S, Boerma M, Hauer-Jensen M, Koturbash I. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. Int J Radiat Oncol Biol Phys. 2020 Sep 28. PMID: 33002540.
      View in: PubMed
    2. Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 05 07; 10(1):7734. PMID: 32382091.
      View in: PubMed
    3. Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G439-G450. PMID: 31961718.
      View in: PubMed
    4. Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R. Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation. Sci Rep. 2019 07 22; 9(1):10554. PMID: 31332273.
      View in: PubMed
    5. Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel). 2019 Mar 06; 8(3). PMID: 30845647.
      View in: PubMed
    6. Pathak R, Kumar VP, Hauer-Jensen M, Ghosh SP. Enhanced Survival in Mice Exposed to Ionizing Radiation by Combination of Gamma-Tocotrienol and Simvastatin. Mil Med. 2019 03 01; 184(Suppl 1):644-651. PMID: 30901461.
      View in: PubMed
    7. Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol. 2020 01; 96(1):93-99. PMID: 30561233.
      View in: PubMed
    8. Pathak R, Shah SK, Hauer-Jensen M. Therapeutic potential of natural plant products and their metabolites in preventing radiation enteropathy resulting from abdominal or pelvic irradiation. Int J Radiat Biol. 2019 04; 95(4):493-505. PMID: 30526224.
      View in: PubMed
    9. Aykin-Burns N, Pathak R, Boerma M, Kim T, Hauer-Jensen M. Utilization of Vitamin E Analogs to Protect Normal Tissues While Enhancing Antitumor Effects. Semin Radiat Oncol. 2019 01; 29(1):55-61. PMID: 30573184.
      View in: PubMed
    10. Banerjee S, Shah SK, Melnyk SB, Pathak R, Hauer-Jensen M, Pawar SA. Cebpd Is Essential for Gamma-Tocotrienol Mediated Protection against Radiation-Induced Hematopoietic and Intestinal Injury. Antioxidants (Basel). 2018 Apr 06; 7(4). PMID: 29642403.
      View in: PubMed
    11. Wang Y, Chang J, Li X, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice. PLoS One. 2017; 12(12):e0189466. PMID: 29232383.
      View in: PubMed
    12. Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017; 12:22. PMID: 28904640.
      View in: PubMed
    13. Chang J, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice. Int J Radiat Biol. 2017 12; 93(12):1312-1320. PMID: 28782442.
      View in: PubMed
    14. Wang J, Pathak R, Garg S, Hauer-Jensen M. Fibrinogen deficiency suppresses the development of early and delayed radiation enteropathy. World J Gastroenterol. 2017 Jul 14; 23(26):4701-4711. PMID: 28765691.
      View in: PubMed
    15. Miousse IR, Chang J, Shao L, Pathak R, Nzabarushimana É, Kutanzi KR, Landes RD, Tackett AJ, Hauer-Jensen M, Zhou D, Koturbash I. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. Int J Mol Sci. 2017 Jul 04; 18(7). PMID: 28677663.
      View in: PubMed
    16. Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. J Vis Exp. 2017 01 11; (119). PMID: 28117817.
      View in: PubMed
    17. Miousse IR, Koturbash I, Chalbot MC, Hauer-Jensen M, Kavouras I, Pathak R. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. J Vis Exp. 2016 12 21; (118). PMID: 28060322.
      View in: PubMed
    18. Pathak R, Ghosh SP, Zhou D, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM). Int J Mol Sci. 2016 Nov 18; 17(11). PMID: 27869747.
      View in: PubMed
    19. Pathak R, Wang J, Garg S, Aykin-Burns N, Petersen KU, Hauer-Jensen M. Recombinant Thrombomodulin (Solulin) Ameliorates Early Intestinal Radiation Toxicity in a Preclinical Rat Model. Radiat Res. 2016 08; 186(2):112-20. PMID: 27459702.
      View in: PubMed
    20. Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner C, Kutanzi KR, Allen AR, Raber J, Tackett AJ, Hauer-Jensen M, Nelson GA, Koturbash I. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environ Res. 2016 10; 150:470-481. PMID: 27419368.
      View in: PubMed
    21. Chang J, Luo Y, Wang Y, Pathak R, Sridharan V, Jones T, Mao XW, Nelson G, Boerma M, Hauer-Jensen M, Zhou D, Shao L. Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice. PLoS One. 2016; 11(7):e0158097. PMID: 27367604.
      View in: PubMed
    22. Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 09; 33(9):2117-25. PMID: 27216753.
      View in: PubMed
    23. Ghosh SP, Pathak R, Kumar P, Biswas S, Bhattacharyya S, Kumar VP, Hauer-Jensen M, Biswas R. Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen. Radiat Res. 2016 05; 185(5):485-95. PMID: 27128741.
      View in: PubMed
    24. Liu YL, Yan Y, Webster C, Shao L, Lensing SY, Ni H, Feng W, Colorado N, Pathak R, Xiang Z, Hauer-Jensen M, Li S, Zhou D, Emanuel PD. Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy. Blood. 2016 Apr 14; 127(15):1912-22. PMID: 26764354.
      View in: PubMed
    25. Wu Y, Lee SH, Williamson EA, Reinert BL, Cho JH, Xia F, Jaiswal AS, Srinivasan G, Patel B, Brantley A, Zhou D, Shao L, Pathak R, Hauer-Jensen M, Singh S, Kong K, Wu X, Kim HS, Beissbarth T, Gaedcke J, Burma S, Nickoloff JA, Hromas RA. EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair. PLoS Genet. 2015 Dec; 11(12):e1005675. PMID: 26684013.
      View in: PubMed
    26. Miousse IR, Chalbot MC, Pathak R, Lu X, Nzabarushimana E, Krager K, Aykin-Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash I. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicol Sci. 2015 Dec; 148(2):473-87. PMID: 26342214.
      View in: PubMed
    27. Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I. Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life Sci Space Res (Amst). 2015 Nov; 7:1-8. PMID: 26553631.
      View in: PubMed
    28. Pathak R, Hauer-Jensen M. Particle Beam may have Higher Effectiveness in Treating Chemo-resistant Cancers than Low-LET Photon Beam Therapy. Res Rev J Pharm Pharm Sci. 2015 Apr-Jun; 4(2):1-2. PMID: 26779544.
      View in: PubMed
    29. Pathak R, Shao L, Ghosh SP, Zhou D, Boerma M, Weiler H, Hauer-Jensen M. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice. PLoS One. 2015; 10(4):e0122511. PMID: 25860286.
      View in: PubMed
    30. Pathak R, Cheema AK, Boca SM, Krager KJ, Hauer-Jensen M, Aykin-Burns N. Modulation of Radiation Response by the Tetrahydrobiopterin Pathway. Antioxidants (Basel). 2015 Jan 22; 4(1):68-81. PMID: 26785338.
      View in: PubMed
    31. Cheema AK, Pathak R, Zandkarimi F, Kaur P, Alkhalil L, Singh R, Zhong X, Ghosh S, Aykin-Burns N, Hauer-Jensen M. Liver metabolomics reveals increased oxidative stress and fibrogenic potential in gfrp transgenic mice in response to ionizing radiation. J Proteome Res. 2014 Jun 06; 13(6):3065-74. PMID: 24824572.
      View in: PubMed
    32. Pawar SA, Shao L, Chang J, Wang W, Pathak R, Zhu X, Wang J, Hendrickson H, Boerma M, Sterneck E, Zhou D, Hauer-Jensen M. C/EBPd deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury. PLoS One. 2014; 9(4):e94967. PMID: 24747529.
      View in: PubMed
    33. Pathak R, Prasanna PG. Premature chromosome condensation in human resting peripheral blood lymphocytes without mitogen stimulation for chromosome aberration analysis using specific whole chromosome DNA hybridization probes. Methods Mol Biol. 2014; 1105:171-81. PMID: 24623228.
      View in: PubMed
    34. Pathak R, Pawar SA, Fu Q, Gupta PK, Berbée M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20; 20(9):1436-46. PMID: 23521531.
      View in: PubMed
    35. Wray J, Williamson EA, Singh SB, Wu Y, Cogle CR, Weinstock DM, Zhang Y, Lee SH, Zhou D, Shao L, Hauer-Jensen M, Pathak R, Klimek V, Nickoloff JA, Hromas R. PARP1 is required for chromosomal translocations. Blood. 2013 May 23; 121(21):4359-65. PMID: 23568489.
      View in: PubMed
    36. Ghosh SP, Singh R, Chakraborty K, Kulkarni S, Uppal A, Luo Y, Kaur P, Pathak R, Kumar KS, Hauer-Jensen M, Cheema AK. Metabolomic changes in gastrointestinal tissues after whole body radiation in a murine model. Mol Biosyst. 2013 Apr 05; 9(4):723-31. PMID: 23403731.
      View in: PubMed
    37. Berbee M, Fu Q, Boerma M, Pathak R, Zhou D, Kumar KS, Hauer-Jensen M. Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog ?-tocotrienol: evidence of a role for tetrahydrobiopterin. Int J Radiat Oncol Biol Phys. 2011 Mar 01; 79(3):884-91. PMID: 20950957.
      View in: PubMed
    38. Pathak R, Dey SK, Sarma A, Khuda-Bukhsh AR. Cell killing, nuclear damage and apoptosis in Chinese hamster V79 cells after irradiation with heavy-ion beams of (16)O, (12)C and (7)Li. Mutat Res. 2007 Aug 15; 632(1-2):58-68. PMID: 17532254.
      View in: PubMed
    39. Pathak R, Dey SK, Sarma A, Khuda-Bukhsh AR. Genotoxic effects in M5 cells and Chinese hamster V79 cells after exposure to 7Li-beam (LET=60 keV/microm) and correlation of their survival dynamics to nuclear damages and cell death. Mutat Res. 2007 Mar 30; 628(1):56-66. PMID: 17258499.
      View in: PubMed
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