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Alexei Basnakian

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
DivisionPharmacology DNases Res
Address4104 Outpatient Circle
Mail Slot # 638
Little Rock AR 72205
Phone501-526-6241
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    Other Positions
    TitleAssociate Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionNephrology


    Collapse Research Funds 
    Collapse research activities
    20186702127971     (BASNAKIAN, ALEXEI)Apr 1, 2018 - Mar 31, 2021
    US Department of Agriculture - Pass Through: University of Arkansas at Little Rock
    Environmental risk assessment of carbon nanomaterials used as plant growth regulators
    Role: Principal Investigator

    P20GM109005     (HAUER-JENSEN, MARTIN)Jun 24, 2015 - Mar 31, 2020
    NIH/NIGMS
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator

    I01BX002425     (BASNAKIAN, ALEXEI G)Oct 1, 2014 - Sep 30, 2023
    VA
    New mechanistic therapies for myoglobinuric acute kidney injury
    Role: Principal Investigator

    HHSF223201400079C     (ZHAROV, VLADIMIR)Sep 12, 2014 - Sep 10, 2017
    Food & Drug Administration - Pass Through: Arkansas Research Alliance
    Adapt novel methodology to the analysis of GBN pharmacokinetics, biodistribution
    Role: Principal Investigator

    R01DK096549     (KAUSHAL, GUR)Sep 1, 2012 - Feb 28, 2018
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Mount Sinai School of Medicine
    NOVEL SERUM AND URINARY BIOMARKERS OF DIABETIC KIDNEY DISEASE
    Role: Co-Investigator

    W81XWH-11-1-0795     (RADOMINSKA-PANDYA, ANNA)Sep 13, 2011 - Sep 12, 2014
    U.S. Army Medical Research & Materiel Command - Pass Through: University of Arkansas at Little Rock
    Using Advanced Functional Nanomaterials to Fight Cancer.
    Role: Principal Investigator

    R56AI093126     (SMELTZER, MARK S)Sep 1, 2011 - Aug 31, 2014
    NIH/NIAID
    A nanotherapeutic approach to combat staphylococcal biofilm-associated infection
    Role: Co-Investigator

    R01HL104071     (SHAH, SUDHIR V)Aug 15, 2010 - Jun 30, 2012
    NIH/NHLBI
    CRIC Ancillary Study: Carbamylated low-density lipoprotein and cardiovascular eve
    Role: Co-Investigator

    R21AR053967     (BASNAKIAN, ALEXEI)Apr 1, 2010 - Dec 9, 2011
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases - Pass Through: University of Kentucky Research Foundation
    The role of endonuclease G in nuclear apoptosis of atrophying skeletal muscle
    Role: Principal Investigator

    I01BX000690     (BASNAKIAN, ALEXEI G)Oct 1, 2009 - Sep 30, 2013
    VA
    Novel endonuclease-targeted approaches to nephroprotection
    Role: Principal Investigator

    P20RR016460     (CORNETT, LAWRENCE E)Aug 31, 2009 - Sep 29, 2004
    NIH/NCRR
    Partnerships for Biomedical Research in Arkansas
    Role: Co-Investigator

    0865046F     (APOSTOLOV, YEVGENIY)Jul 1, 2008 - Jun 30, 2011
    American Heart Association (South Central Affiliate)
    Role of chronic uremia and carbamylated LDL in atherosclerosis associated with chronic renal failure
    Role: Co-Investigator

    R21HL087405     (BASNAKIAN, ALEXEI G)May 1, 2008 - Apr 30, 2011
    NIH/NHLBI
    LDL isoforms in kidney-related atherosclerosisv
    Role: Principal Investigator

    R01DK078908     (BASNAKIAN, ALEXEI G)Apr 1, 2008 - Jan 31, 2014
    NIH/NIDDK
    Premortem enzymatic DNA damage in kidney injury
    Role: Principal Investigator

    R03CA114729     (BASNAKIAN, ALEXEI G)Sep 30, 2005 - Aug 31, 2008
    NIH/NCI
    Endonuclease dificiency in breast cancer progression
    Role: Principal Investigator

    U19AI67798     (HAUER-JENSEN, MARTIN)Aug 31, 2005 - Jul 31, 2010
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Duke University
    Somatostatin analogues as countermeasures against intestinal radiation toxicity
    Role: Principal Investigator

    P20GM103429     (CORNETT, LAWRENCE E)Sep 30, 2001 - Apr 30, 2020
    NIH/NIGMS
    Partnerships for Biomedical Research in Arkansas
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Sadhukhan R, Leung JWC, Garg S, Krager KJ, Savenka AV, Basnakian AG, Pathak R. Fractionated radiation suppresses Kruppel-like factor 2 pathway to a greater extent than by single exposure to the same total dose. Sci Rep. 2020 May 07; 10(1):7734. PMID: 32382091.
      View in: PubMed
    2. Whitt J, Duke C, Sumlin A, Chambers SA, Alnufaie R, Gilmore D, Fite T, Basnakian AG, Alam MA. Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii. Molecules. 2019 May 29; 24(11). PMID: 31146470.
      View in: PubMed
    3. Garg S, Sadhukhan R, Banerjee S, Savenka AV, Basnakian AG, McHargue V, Wang J, Pawar SA, Ghosh SP, Ware J, Hauer-Jensen M, Pathak R. Gamma-Tocotrienol Protects the Intestine from Radiation Potentially by Accelerating Mesenchymal Immune Cell Recovery. Antioxidants (Basel). 2019 Mar 06; 8(3). PMID: 30845647.
      View in: PubMed
    4. Fahmi T, Branch D, Nima ZA, Jang DS, Savenka AV, Biris AS, Basnakian AG. Mechanism of graphene-induced cytotoxicity: Role of endonucleases. J Appl Toxicol. 2017 Nov; 37(11):1325-1332. PMID: 28543094.
      View in: PubMed
    5. Nedosekin DA, Fahmi T, Nima ZA, Nolan J, Cai C, Sarimollaoglu M, Dervishi E, Basnakian A, Biris AS, Zharov VP. Photoacoustic in vitro flow cytometry for nanomaterial research. Photoacoustics. 2017 Jun; 6:16-25. PMID: 28417068.
      View in: PubMed
    6. Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH, Ling KKY, Rigo F, Ozdinler PH, Kiaei M. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Hum Mol Genet. 2017 02 15; 26(4):686-701. PMID: 28040732.
      View in: PubMed
    7. Rogers LJ, Basnakian AG, Orloff MS, Ning B, Yao-Borengasser A, Raj V, Kadlubar S. 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer. Nutr Metab (Lond). 2016; 13:54. PMID: 27547236.
      View in: PubMed
    8. Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG. Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol. 2015 May; 34(5):316-26. PMID: 25849439.
      View in: PubMed
    9. Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARa-cyclophilin D interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr 01; 308(7):H749-58. PMID: 25617357.
      View in: PubMed
    10. Shah SV, Shukla AM, Bose C, Basnakian AG, Rajapurkar M. Recent advances in understanding the pathogenesis of atherosclerosis in CKD patients. J Ren Nutr. 2015 Mar; 25(2):205-8. PMID: 25556310.
      View in: PubMed
    11. Jang DS, Penthala NR, Apostolov EO, Wang X, Crooks PA, Basnakian AG. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb; 34(2):92-100. PMID: 25401220.
      View in: PubMed
    12. Jang DS, Penthala NR, Apostolov EO, Wang X, Fahmi T, Crooks PA, Basnakian AG. Novel high-throughput deoxyribonuclease 1 assay. J Biomol Screen. 2015 Feb; 20(2):202-11. PMID: 25326282.
      View in: PubMed
    13. Nima ZA, Mahmood M, Xu Y, Mustafa T, Watanabe F, Nedosekin DA, Juratli MA, Fahmi T, Galanzha EI, Nolan JP, Basnakian AG, Zharov VP, Biris AS. Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances. Sci Rep. 2014 May 09; 4:4752. PMID: 24810323.
      View in: PubMed
    14. Mehta JL, Basnakian AG. Interaction of carbamylated LDL with LOX-1 in the induction of endothelial dysfunction and atherosclerosis. Eur Heart J. 2014 Nov 14; 35(43):2996-7. PMID: 24694664.
      View in: PubMed
    15. Miousse IR, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I. Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen. 2014 Jun; 55(5):428-35. PMID: 24535919.
      View in: PubMed
    16. Basnakian AG, Fite T, Fahmi T, Topiwala K, Apostolov EO. Direct measurement of DNase activity in vivo and in live cells during injury. The DNA damage response in cell physiology and disease. The DNA damage response in cell physiology and disease. 2014.
    17. Apostolov EO, Ok E, Burns S, Nawaz S, Savenka A, Shah S, Basnakian AG. Carbamylated-oxidized LDL: proatherosclerotic effects on endothelial cells and macrophages. J Atheroscler Thromb. 2013; 20(12):878-92. PMID: 24067603.
      View in: PubMed
    18. Singh M, Odeniyi DT, Apostolov EO, Savenka A, Fite T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F1022-30. PMID: 23825076.
      View in: PubMed
    19. Singh M, Odeniyi DT, Savenka A, Fite T, Apostolov EO, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-N-acetylcysteine on rat kidney during cold storage. Am J Physiol Renal Physiol. 2013; In Press [PMID: 23825076].
    20. Kharade SV, Basnakian AG. Development of cell-based high-throughput screening assay for DNase I inhibitors or activators. 2013.
    21. Jang D, Apostolov EO, Penthala N, Zheng G, Crooks P, Basnakian AG. Novel high-throughput DNase I assay. 2013.
    22. Eigenbrodt M, Apostolov EO, Ok E, Asci G, Orbek SS, Ray D, Shah SV, Basnakian AG. Relationship between carbamylated LDL and other modified LDLs with cardiovascular risk factors in patients on hemodialysis. Atherosclerosis. 2013; Submitted.
    23. Wang W, Rhee S, Chen C, Basnakian AG, Henning L, Mehta JL, Palade P. Vascular CaV1.2 expression in atherosclerotic mice. J Cardiovasc Pharmacol Therapeut. 2013; Submitted.
    24. Fahmi T, Wang X, Islam I, Apostolov EO, Basnakian AG. DNase I induced other endonucleases in kidney tubular epithelial cells by its DNA-degrading activity: Evidence of endonuclease network. J Biol Chem. 2013; Submitted.
    25. Zhdanov DD, Wang X, Fahmi T, Shah SV, Basnakian AG. Alternatively-spliced DNase I acts as dominant-negative inhibiting cisplatin toxicity to kidney cells. 2013.
    26. Fahmi T, Topiwala K, Stewart AG, Shah SV, Basnakian AG. DNases mediate pyknosis in kidney tubular epithelial cells. 2013.
    27. Penthala N, Jang DS, Basnakian AG, Crooks PA. Design and synthesis of novel indomethacin analogs as DNase EndoG inhibitors. 2013.
    28. Zhdanov DD, Fahmi T, Wang X, Fite T, Basnakian AG. EndoG regulates DNase I by inducing alternative splicing of its pre-mRNA. Cell Death Different. 2013; Submitted.
    29. Miousse IR, Chalbot MC, Aykin-Burns N, Singleton T, Wang X, Basnakian AG, Kavouras I, Koturbash I. Epigenetic alterations incuded by non-cytotoxic concentrations of ambient particulate matter in teh RAW264.7 macrophages. Toxicology Letters. 2013; Submitted.
    30. Zhdanov DD, Fahmi T, Savenka A, Basnakian AG. Truncated DNase I acts as dominant-negative inhibiting kidney cell death induced by cisplatin. 2013.
    31. Topiwala K, Fahmi T, Savenka A, Apostolov EO, Basnakian AG. DNase activity in kidney cell pyknosis induced by serum deprivation. 2013.
    32. Galanzha EI, Shashkov E, Sarimollaoglu M, Beenken KE, Basnakian AG, Shirtliff ME, Kim JW, Smeltzer MS, Zharov VP. In vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles. PLoS One. 2012; 7(9):e45557. PMID: 23049814.
      View in: PubMed
    33. Apostolov EO, Basnakian AG, Ok E, Shah SV. Carbamylated low-density lipoprotein: nontraditional risk factor for cardiovascular events in patients with chronic kidney disease. J Ren Nutr. 2012 Jan; 22(1):134-8. PMID: 22200430.
      View in: PubMed
    34. Zhdanov DD, Fahmi T, Wang X, Savenka A, Basnakian AG. October 30-November 4; San Diego, CA: Annual American Society of Nephrology Meeting; 2012. 2012.
    35. Basnakian AG, Wang X, Wangila GW, Walker RB, Shah SV, Apostolov EO. Protection of host tissues from chemotherapy- or radiation-induced injuries by inactivation of apoptotic endonucleases. Cancer-Science 2012. 2012.
    36. Holthoff JH, Pathak E, Basnakian AG, Wang Z, Mayeux PR. Sirtuin 1 enzyme activity and autophagy proteins are increased in the kidney during murine sepsis. 2012.
    37. Basnakian AG. Endonuclease delivery as a new anti-cancer therapy. 2012.
    38. Apostolov EO, Fite TW, Gaidar luA, Shah SV, Basnakian AG. Carbamylated LDL: novel potential mechanistic factor for progression of kidney disease. 2012.
    39. Jang D, Wang X, Fite T, Zhdanov DD, Basnakian AG. Degradation of plasmid DNA by DNase I and EndoG in blood plasma and relations between the endonucleases. 2012.
    40. Akrawinthawong K, Shaw M, Basnakian AG, Apostolov EO, Shah SV, McCullough P. Urine catalytic iron as an early marker of acute kidney injury after open heart surgery: A prospective pilot study. 2012; submitted.
    41. Zhdanov DD, Fahmi T, Wang X, Savenka A, Basnakian AG. Downregulation of DNase I expression by EndoG in kidney tubular epithelial cells. 2012.
    42. Singh M, Odeniyi DT, Apostolov EO, Savenka A, Basnakian AG. Zinc-N-acetylcysteine, a novel cytoprotecting agent for kidney cold storage. Positive and negative regulation of endonucleases by EndoG in kidney tubular epithelial cells. 2012.
    43. Basnakian AG, Apostolov EO, Eigenbrodt ML, Lensing SY, Ok E, Shah SV. Carbamylation versus oxidation of LDL: competition, mechanisms and role in cardiovascular disease. J Heart Dis 9. 2012.
    44. Basnakian AG, Fahmi T, Wang X, Savenka A, Fite T, Stewart AG, Apostolov EO, Shah SV. Induction of kidney endonucleases by DNase I: evidence of endonuclease network. 2012.
    45. Prantner D, Sikes JD, Hennings L, Savenka AV, Basnakian AG, Nagarajan UM. IRF3 protects from uterine horn pathology during Chlamydia muridarum genital infection in mice. Infect Immun. 2011; 79(10):3922-3933 [PMID: 21788382].
    46. Prantner D, Sikes JD, Hennings L, Savenka AV, Basnakian AG, Nagarajan UM. Interferon regulatory transcription factor 3 protects mice from uterine horn pathology during Chlamydia muridarum genital infection. Infect Immun. 2011 Oct; 79(10):3922-33. PMID: 21788382.
      View in: PubMed
    47. Apostolov EO, Ray D, Alobuia WM, Mikhailova MV, Wang X, Basnakian AG, Shah SV. Endonuclease G mediates endothelial cell death induced by carbamylated LDL. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H1997-2004. PMID: 21460199.
      View in: PubMed
    48. Basnakian AG, Eigenbrodt ML, Ok E, Apostolov EO, Asci G, Ozbek SS, Ray D, Shah SV. Associations of modified LDLs with atherosclerosis and cardiovascular disease in patients with end-stage kidney disease. 2011.
    49. Fahmi T, Wang X, Apostolov EO, Basnakian AG. DNase I induces other endonucleases, DNA damage and apoptosis pathways in kidney tubular epithelial cells by its DNA cleavage activity. 2011.
    50. Wang X, Mikhailova MV, Basnakian AG. In: Prostrate Cancer: From Bench to Bedside. Cytotoxic Endonucleases: New Targets for Prostate Cancer Chemotherapy. 2011.
    51. Ronis MJ, Hennings L, Stewart B, Basnakian AG, Apostolov EO, Albano E, Badger TM, Petersen DR. Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 300(1):G109-19. PMID: 21051528.
      View in: PubMed
    52. Apostolov EO, Ray D, Savenka AV, Shah SV, Basnakian AG. Chronic uermia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol. 2010; 21(11):1852-1857 [PMID: 20947625].
    53. Apostolov EO, Ray D, Savenka AV, Shah SV, Basnakian AG. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol. 2010 Nov; 21(11):1852-7. PMID: 20947625.
      View in: PubMed
    54. Mercer KE, Apostolov EO, Gamboa da Costa G, Yu X, Lang P, Roberts DW, Davis W, Basnakian AG, Kadlubar FF, Kadlubar SA. Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptosis. Int J Mol Epidemiol Genet. 2010 Jan 30; 1(2):92-103. PMID: 21537383.
      View in: PubMed
    55. Basnakian AG, Shah SV, Ok E, Altunel E, Apostolov EO. Carbamylated LDL. Adv Clin Chem. 2010; 51:25-52. PMID: 20857617.
      View in: PubMed
    56. Mercer KE, Apostolov EO, Da Costa GG, Yu X, Lang P, Roberts DW, Davis W, Basnakian AG, Kadlubar FF, Kadlubar SA. Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptostis. Int J Mol Epidemiol Genet. 2010; 30(1):92-103 [PMID: 21537383].
    57. Apostolov EO, Ray D, Savenka A, Shah SV, Basnakian AG. ICAM-1 is key molecule in carbamylated LDL-induced monocyte adhesion. 2010.
    58. Basnakian AG, Apostolov EO, Braman N, Cortez L, Hinson JA, Shah SV. Quantitative cytoplasmic TUNEL: the method to measure apoptosis and necrosis coexisting in a single liver or kidney cell. 2010; 32.
    59. Apostolov EO, Shah SV, Ok E, Basnakian AG. Modern Insights Into Disease From Molecules to Man. Adhesion Molecules. Carbamylated low-density lipoprotein and adhesion molecules. 2010.
    60. Apostolov EO, Ray D, Savenka A, Basnakian AG. Endonuclease G mediates endothelial toxicity induced by cisplatin. 2010.
    61. Walker RB, Everette JD, Durand KL, Bryant QM, Braman N, Savenka A, Basnakian AG, Waglia GW. Zn-RibCys and Zn-NAC: novel zinc complexes which show good promise as radioprotectors. 2010.
    62. Basnakian AG, Shah SV, Apostolov EO. Carbamylated LDL - missing link between uremia and atherosclerosis. 2010.
    63. Basnakian AG, Walker PB, Wanglia G, Braman N, Savenka A, Wang X, Shah SV. Endonuclease inhibitors: new agents for nephroprotection. 2010; 84.
    64. Basnakian AG, Apostolov EO, Shah SV. Carbamylated LDL: the missing link between uremia and atherosclerosis. 2010.
    65. Basnakian AG, Apostolov EO, Wang X, Shah SV. Hierarchy among executioners: cytotoxic endonucleases regulate one another in vitro and in mouse models of kidney injury. 2010.
    66. Singh M, Odeniyi DT, Savenka A, Fite T, Walker RB, Basnakian AG. Zinc-N-acetylcysteine protects kidney during cold storage. 2010.
    67. Braman N, Apostolov EO, Cortez L, Hinson J, Basnakian AG. Localization of endonuclease G and fragmented DNA during acetaminophen liver injury in mice. 2010.
    68. Apostolov EO, Soultanova I, Savenka A, Bagandov OO, Yin X, Stewart AG, Walker RB, Basnakian AG. Deoxyribonuclease I is essential for DNA fragmentation induced by gamma radiation in mice. Radiat Res. 2009 Oct; 172(4):481-92. PMID: 19772469.
      View in: PubMed
    69. Buzder T, Yin X, Wang X, Banfalvi G, Basnakian AG. Uptake of foreign nucleic acids in kidney tubular epithelial cells deficient in proapoptotic endonucleases. DNA Cell Biol. 2009 Sep; 28(9):435-42. PMID: 19558214.
      View in: PubMed
    70. Apostolov EO, Shah SV, Ray D, Basnakian AG. Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1622-30. PMID: 19696406.
      View in: PubMed
    71. Kang BY, You H, Bandyopadhyay S, Agrawal N, Melchert RB, Basnakian AG, Liu Y, Hermonat PL. Cervical cancer isolate PT3, super-permissive for adeno-associated virus replication, over-expresses DNA polymerase delta, PCNA, RFC and RPA. BMC Microbiol. 2009 Apr 23; 9:79. PMID: 19389243.
      View in: PubMed
    72. Apostolov EO, Alobuia WM, Ray D, Wang X, Shah SV, Basnakian AG. Human endothelial cell death induced by carbamylated LDL is mediated by apoptotic endonuclease G. 2009.
    73. Savenka AG, Wang X, Savenka AV, Basnakian AG, Apostolov EO. Apoptotic endonuclease G induces heat-shock proteins in renal proximal tubular epithelial cells. 2009; 41, abstract #14.
    74. Apostolov EO, Shah SV, Basnakian AG. LDL carbamylation in accelerated atherosclerosis caused by chronic renal failure in mice. 2009.
    75. Everett JD, Apostolov EO, Stewart AG, Walker RB, Basnakian AG. Delivery of zinc by Zn-chelates for radioprotection of human cells. 2009; 29.
    76. Apostolov EO, Ray D, Wang X, Shah SV, Basnakian AG. Endonuclease G mediates mitotic catastrophe induced by carbamylated LDL in human endothelial cells. 2009; F-PO1688.
    77. Marszalek JE, Swint M, Apostolov EO, Simon C, Basnakian AG, Karim A. Nanotopology of coated poly(?-caprolactone)/poly(D,L-lactide) blends scaffolds for ex vivo artificial organ modeling. 2009.
    78. Caro A, Joseph E, Lewis T, Tackett J, Evans K, Basnakian AG. CYP2E1 overexpression causes an elevation of mtDNA content in HepG2 cells. 2009.
    79. Basnakian AG, Soultanova I, Savenka A, Bagandov OO, Yin X, Stewart AG, Walker RB, Apostolov EO. Inactivation of cytotoxic endonuclease: a new approach for radioprotection. 2009; 27.
    80. Basnakian AG, Wang X, Apostolov EO. DNA damage assays in context of in vivo cytotoxicity screening. 2009; abstract #33, p 60.
    81. Wang X, Braman N, Apostolov EO, Shah SV, Basnakian AG. Endonuclease-mediated modulation of cytotoxoxic effects of chemotherapeutic drugs for prostate cancer therapy. 2009; 17.
    82. Wang X, Tryndyak V, Apostolov EO, Shah SV, Pogribny IP, Basnakian AG. Endonuclease G expression regulated by DNA methylation affects human prostate cancer cell sensitivity to chemoprevention and chemotherapeutic agents. 2009; abstract #46, p 73.
    83. Braman N, Apostolov EO, Shah SV, Basnakian AG. Compartmentalization of fragmented DNA during acetaminophen liver intoxication in mice. 2009; 28.
    84. Apostolov EO, Soultanova I, Savenka AV, Bagandov OO, Yin X, Stewart AG, Walker RB, Basnakian AG. Radioprotection by inactivation of deoxyribonuclease I. 2009.
    85. Apostolov EO, Soultanova I, Savenka A, Bagandov O, Yin X, Stewart AG, Walker R, Basnakian AG. Deoxyribonuclease I is essential for DNA fragmentation caused by gamma radiation in mice. Radiat Res. 2009; 4:481-492 [PMID: 19772469].
    86. Wang X, Apostolov EA, Stewart AG, Li P, Shah SV, Basnakian AG. Affinity to DNA contributes to nuclear import of DNase I in tubular epithelial cells. 2009.
    87. Apostolov EO, Shah SV, Ok E, Basnakian AG. Tobacco smoke-derived cyanate causes pro-atherogenic carbamylation of low density lipoprotein. Proceedings of the 26th Annual Meeting of the South-Central Chapter of the Society of Toxicology. 2009; abstract #32, p 59.
    88. Apostolov EO, Shah SV, Ok E, Basnakian AG. Carbamylation of the low density lipoprotein is promoted by tobacco smoke-derived cyanate. 2009.
    89. Wang X, Tryndyak V, Apostolov EO, Yin X, Shah SV, Pogribny IP, Basnakian AG. Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation. Cancer Lett. 2008 Oct 18; 270(1):132-43. PMID: 18565644.
      View in: PubMed
    90. Asci G, Basci A, Shah SV, Basnakian A, Toz H, Ozkahya M, Duman S, Ok E. Carbamylated low-density lipoprotein induces proliferation and increases adhesion molecule expression of human coronary artery smooth muscle cells. Nephrology (Carlton). 2008 Dec; 13(6):480-6. PMID: 18518940.
      View in: PubMed
    91. Basnakian AG. Netrin-1: a potential universal biomarker for acute kidney injury. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F729-30. PMID: 18305096.
      View in: PubMed
    92. Shah SV, Apostolov EO, Ok E, Basnakian AG. Novel mechanisms in accelerated atherosclerosis in kidney disease. J Ren Nutr. 2008 Jan; 18(1):65-9. PMID: 18089447.
      View in: PubMed
    93. Wang X, Tryndyak V, Apostolov E.O, Yin X, Shah S.V, Pogribny I.P, Basnakian A.G. Apoptotic/Recombinogenic Endonuclease G is Regulated by Promoter Methylation and Histone Acetylation. 2008.
    94. Basnakian AG, Soultanova I, Savenka A, Bagandov OO, Yin X, Stewart AG, Walker RB, Apostolov EO. Amelioration of gamma radiation-induced DNA damage and multi-organ injury by inactive of DNase I in mice. 2008.
    95. Apostolov EO, Shah SV, Wagner KD, Basnakian AG. Scavenger receptors participate in the effects of carbamylated LDL toward enthothelial cells. 2008; 41.
    96. Javadov S, Choi A, Rajapurohitam V, Zeidan A, Basnakian AG, Karmazyn M. NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition. Cardiovasc Res. 2008 Jan 15; 77(2):416-24. PMID: 18006455.
      View in: PubMed
    97. Yin X, Apostolov EO, Shah SV, Wang X, Bogdanov KV, Buzder T, Stewart AG, Basnakian AG. Induction of renal endonuclease G by cisplatin is reduced in DNase I-deficient mice. J Am Soc Nephrol. 2007 Sep; 18(9):2544-53. PMID: 17675668.
      View in: PubMed
    98. Banfalvi G, Ujvarosi K, Trencsenyi G, Somogyi C, Nagy G, Basnakian A. Cell culture density dependent toxicity and chromatin changes upon cadmium treatment in murine pre-B-cells. Apoptosis. 2007 Jul; 12(7):1219-28. PMID: 17260184.
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    99. Apostolov EO, Shah SV, Ok E, Basnakian AG. Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):826-32. PMID: 17255534.
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    100. Banfalvi G, Trencsenyi G, Ujvarosi K, Nagy G, Ombodi T, Bedei M, Somogyi C, Basnakian AG. Supranucleosomal organization of chromatin fibers in nuclei of Drosophila S2 cells. DNA Cell Biol. 2007 Jan; 26(1):55-62. PMID: 17263597.
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    101. Apostolov EO, Basnakian AG, Yin X, Ok E, Shah SV. Modified LDLs induce proliferation-mediated death of human vascular endothelial cells through MAPK pathway. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1836-46. PMID: 17158646.
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    102. Basnakian AG, Apostolov EO, Yin X, Abiri SO, Stewart AG, Singh AB, Shah SV. Endonuclease G promotes cell death of non-invasive human breast cancer cells. Exp Cell Res. 2006 Dec 10; 312(20):4139-49. PMID: 17046751.
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    103. Banfalvi G, Nagy G, Gacsi M, Roszer T, Basnakian AG. Common pathway of chromosome condensation in Mammalian cells. DNA Cell Biol. 2006 May; 25(5):295-301. PMID: 16716119.
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    104. Napirei M, Basnakian AG, Apostolov EO, Mannherz HG. Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. Hepatology. 2006 Feb; 43(2):297-305. PMID: 16440339.
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    105. Portilla D, Kaushal GP, Basnakian AG, Shah SV. In: Principles of Molecular Medicine. Recent Progress in the Pathophysiology of Acute Renal Failure. 2006.
    106. Ok E, Basnakian AG, Apostolov EO, Barri YM, Shah SV. Carbamylated low-density lipoprotein induces death of endothelial cells: a link to atherosclerosis in patients with kidney disease. Kidney Int. 2005 Jul; 68(1):173-8. PMID: 15954906.
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    107. Apostolov EO, Shah SV, Ok E, Basnakian AG. Quantification of carbamylated LDL in human sera by a new sandwich ELISA. Clin Chem. 2005 Apr; 51(4):719-28. PMID: 15684275.
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    108. Basnakian AG, Apostolov EO, Yin X, Napirei M, Mannherz HG, Shah SV. Cisplatin nephrotoxicity is mediated by deoxyribonuclease I. J Am Soc Nephrol. 2005 Mar; 16(3):697-702. PMID: 15647342.
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    109. Gacsi M, Nagy G, Pinter G, Basnakian AG, Banfalvi G. Condensation of interphase chromatin in nuclei of synchronized chinese hamster ovary (CHO-K1) cells. DNA Cell Biol. 2005 Jan; 24(1):43-53. PMID: 15684719.
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    110. Basnakian AG, Ueda N, Hong X, Galitovsky VE, Yin X, Shah SV. Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Am J Physiol Renal Physiol. 2005 Feb; 288(2):F308-14. PMID: 15479855.
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    111. Kaushal GP, Basnakian AG, Shah SV. Apoptotic pathways in ischemic acute renal failure. Kidney Int. 2004 Aug; 66(2):500-6. PMID: 15253697.
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    112. Basnakian AG, Kaushal GP, Shah SV. Apoptotic pathways of oxidative damage to renal tubular epithelial cells. Antioxid Redox Signal. 2002 Dec; 4(6):915-24. PMID: 12573140.
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    113. Basnakian AG, Singh AB, Shah SV. Identification and expression of deoxyribonuclease (DNase) I alternative transcripts in the rat. Gene. 2002 May 01; 289(1-2):87-96. PMID: 12036587.
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    114. Basnakian AG, Ueda N, Kaushal GP, Mikhailova MV, Shah SV. DNase I-like endonuclease in rat kidney cortex that is activated during ischemia/reperfusion injury. J Am Soc Nephrol. 2002 Apr; 13(4):1000-7. PMID: 11912259.
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    115. Basnak'ian AG, Baskov AV, Sokolov NN, Borshchenko IA. [Apoptosis during spinal cord trauma: prospects for pharmacological correction]. Vopr Med Khim. 2000; 46(5):431 - 443.
    116. Lebedeva LG, Aleksandrova SS, Kiselar' Z, Kirsanova ID, Dzhavadov SA, Basnak'ian AG, Votrin II. [Study of the spectrum of rabbit myocardium nuclear DNAases using models of ischemia and diabetes mellitus]. Vopr Med Khim. 1995; 41(4):2 - 4 [PMID: 8571579].
    117. Lebedeva LG, Aleksandrova SS, Kirsanova ID, Basnak'ian AG, Dzhavadov SA, Votrin II. [Nuclear endo-DNAse from rabbit myocardium in ischemia and diabetes mellitus]. Vopr Med Khim. 1995; 41(3):9 - 11 [PMID: 8585187].
    118. Lebedeva LG, Aleksandrova SS, Basnak'ian AG, Votrin II. [Characteristics of nuclear endo-DNAase from rat liver by molecular mass and cationic dependence]. Biokhimiia. 1995; 60(5):798 - 804 [PMID: 7662804].
    119. Smirnova NV, Novoderzhkina IS, Basnak'ian AG, Kozhura VL. [Detection of a steady increase in endonuclease activity in dog liver cell nuclei after long term arterial hypotension and in post-resuscitation period]. Vopr Med Khim. 1992; 38(2):50 - 51 [PMID: 1329346].
    120. Shcherbakov AB, Remenson EI, Kirsanova ID, Basnak'ian AG, Guseva NG. [The clinical significance of detecting the inhibition of topoisomerase I by the sera of patients with systemic scleroderma]. Ter Arkh. 1992; 64(5):73 - 75 [PMID: 1333647].
    121. Bubnov NV, Basnak'ian AG, Botrin II. [DNAses of the cell nuclei: Mn2+-dependent endonuclease]. Biull Eksp Biol Med. 1990; 110(10):370 - 372 [PMID: 2177666].
    122. Basnak'ian AG, Topol' LZ, Kirsanova ID, Votrin II, Kiselev FL. [Activity of topoisomerase I and endonucleases in cells transfected by a ras oncogene]. Mol Biol (Mosk). 1989; 23(3):750 - 757 [PMID: 2549400].
    123. Basnak'ian AG, Bubnov NV, Votrin II. [Cell nuclear DNases: multiplicity and heterogeneity]. Biokhimiia. 1989; 54(2):273 - 283 [PMID: 254581].
    124. Basnak'ian AG, Bubnov NV, Kirsanova ID, Votrin II. [The activity of nuclear endonucleases and topoisomerases in the liver of rats and in diethylnitrosamine-induced tumors]. Eksp Onkol. 1989; 11(2):15 - 19 [PMID: 2544392].
    125. Basnakyan AG, Antoni F, Bubnov NV, Votrin II, Banfalvi G. Bivalent cation and ATP requirements of endonucleases from rat liver nuclei. Acta Biochim Biophys Hung. 1987; 22(4):409 - 424.
    126. Bubnov NV, Basnak'ian AG, Votrin II. [Mn2+-dependent endonuclease activity of chromatin]. Biokhimiia. 1986; 51(7):1194 - 1202.
    127. Bubnov NV, Basnak'ian AG, Votrin II. [Cleavage of the repeats in the liver DNA of rats during initial chromatin endonucleolysis]. Mol Gen Mikrobiol Virusol. 1986; (6):25 - 30 [PMID: 3023988].
    128. Basnak'ian AG, Bubnov NV, Votrin II. [Dinucleosome as a product of initial chromatin cleavage by endogenous nucleases]. Biull Eksp Biol Med. 1986; 101(4):463 - 466 [PMID: 3008883].
    129. Bubnov NV, Basnak'ian AG, Votrin II. [Conditions for initial chromatin endonucleolysis and the characteristics of its products]. Biull Eksp Biol Med. 1985; 99(2):154 - 156 [PMID: 2982437].
    130. Basnak'ian AG, Votrin II. [Restrictases as a possible factor in the evolution of DNA nucleotide composition]. Zh Evol Biokhim Fiziol. 1983; 19(1):20 - 24 [PMID: 6301172].
    131. Votrin II, Khodarev NN, Basnak'ian AG. [Endonucleases as a tool for the analysis of the structural and functional organization of chromatin]. Vestn Akad Med Nauk SSSR. 1983; (3):88 - 95 [PMID: 6305052].
    132. Basnak'ian AG, Botrin II, Debov CC. [Specific effect of endonucleases from Brevibacterium ammoniagenes on DNA]. Biokhimiia. 1981; 46(7):1307 - 1314 [PMID: 6268197].
    133. Votrin II, Khodarev NN, Basnak'ian AG, Sokolov NN, Fitsner AB, Aleksandrova SS. [Controlled fragmentation of chromatin DNA by certain endonucleases, their isolation and properties]. Vestn Akad Med Nauk SSSR. 1981; (2):59 - 64 [PMID: 6264710].
    134. Basnak'ian AG, Votrin II, Debov SS. [Determination of the dinucleosome structure of chromatin by the action of exogenous endonuclease]. Dokl Akad Nauk SSSR. 1981; 256(5):1254 - 1257 [PMID: 6262034].
    135. Khodarev NN, Votrin II, Sokolov NN, Basnak'ian AG. [Methylation and degradation of chromatin DNA in isolated rat liver cell nuclei]. Biokhimiia. 1979; 44(6):1058 - 1067 [PMID: 465603].
    136. Khodarev NN, Votrin II, Basnak'ian AG, Debov SS. [Detection of endonuclease activity and several features of chromatin autolysis in brain cell nuclei]. Biokhimiia. 1979; 44(4):622 - 628 [PMID: 35248].
    137. Basnak'ian AG, Votrin II, Khodarev NN, Debov SS. [Nucleases from Brevibacterium ammoniagenes differing in their effects on chromatin]. Biokhimiia. 1979; 44(3):432 - 439 [PMID: 37928].
    138. Basnakian AG, Apostolov EO, Yin X, Wang X, Mikhailova MV, Buzder T, Shah SV. EndoG and DNase I cooperatively mediate kidney failure induced by rhabdomyolysis in mice.
    139. Apostolov EO, Ray D, Shah SV, Basnakian AG. Scavenger receptors of endothelial cells mediate the uptake and atherogenic effects of carbamylated LDL. Arteriosc Thromb Vasc Biol, 29, 10, 1622-1630. 10:1622-1630 [PMID: 1969406].
    140. Fahmi T, Wang X, Apostolov EO, Islam I, Yin Y, Savenka A, Shah SV, Basnakian AG. Role of beta-actin in DNase I-mediated death of tubular epithelial cells during kidney ischemia-reperfusion injury. The Annual American Society of Nephrology Meeting.
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