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Steven Barger

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Research B
Address3154 Institute on Aging
629 Jack Stephens Drive
Mail Slot # 807
Little Rock AR 72205
Phone501-526-5811
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentNeurobiology & Developmental Science, College of Medicine


    Collapse Overview 
    Collapse overview
    A native of Searcy, Arkansas, Steve graduated from Hendrix College and then obtained a Ph.D. in Cell Biology at Vanderbilt University. After a postdoctoral fellowship at the University of Kentucky, he became the first recipient of the Inglewood Fellowship for Alzheimer's research at UAMS, where he is currently Professor in the Departments of Geriatrics, Neurobiology & Developmental Sciences, and Internal Medicine. Since 1996, he has been jointly appointed at the Department of Veterans Affairs. He is also a member of the Arkansas General Assembly’s Alzheimer’s Disease Advisory Board.

    Steve has published over 100 articles in the field of neuroscience and neurological disease and has been nearly continuously funded by one or more grants from the National Institutes of Health since 1994. He is Deputy Chief Editor for the Journal of Neurochemistry and is active on the editorial boards of three other scientific journals. Steve has been a member of the Committee for Animals in Research at the Society for Neuroscience and president of that Society’s Arkansas Chapter. He received the Odyssey Medal for Research from Hendrix College in 2010. Steve is also an instructor and a research advisor for graduate students, including serving as course director for a course named “The Basic Biology of Aging.”

    Steve is an outdoors enthusiast and enjoys competition in a variety of endurance events, including triathlons and adventure racing.


    Collapse Biography 
    Collapse awards and honors
    1983 - 1987Alcorn Endowed Scholarship, Hendrix College, Hendrix College
    1987Spessard Biology Award, Hendrix College , Hendrix College
    1994 - 1995Postdoctoral National Research Service Award, NIH, National Institutes of Health
    1994 - 1996Research Fellowship, French Foundation for Alzheimer’s Research, French Foundation for Alzheimer’s Research
    1995 - 1998Alzheimer’s Disease Research Scholar, Inglewood Foundation, Inglewood Foundation
    1999National Research Prize, Neurosciences Education and Research Foundation, Neurosciences Education and Research Foundation
    2004Alumni Leadership Council, Hendrix College, Hendrix College
    2010Odyssey Medal for Research, Hendrix College, Hendrix College
    2013 - presMember of the Dana Alliance for Brain Initiatives, Dana Foundation
    2014 - presAlzheimer’s Disease Advisory Board, Arkansas General Assembly, Arkansas General Assembly

    Collapse Research Funds 
    Collapse research activities
    R01AG062254     (REIS, ROBERT)Sep 30, 2018 - May 31, 2023
    NIH/Nat. Inst. on Aging
    Inference of Common Pathways Underlying Neurodegeneration & Other Age-Progressive Diseases
    Role: Co-Investigator

    2P01AG012411-17A1 7946     (BARGER, STEVEN W)Jun 1, 2018 - May 31, 2019
    NIH/NIA
    Molecular aspects of endocrine and metabolic dysregulation in neurodegeneration
    Role: Principal Investigator

    5P01AG012411-19 7943     (BARGER, STEVEN W)Jun 1, 2018 - May 31, 2019
    NIH/NIA
    PPG Core C: Molecular Analysis
    Role: Principal Investigator

    R03AG043784     (BARGER, STEVEN W)Sep 30, 2013 - Jun 30, 2015
    NIH/NIA
    Destablization of LRP family receptors by Alzheimer-related presenilin mutations
    Role: Principal Investigator

    R21AG033215     (BARGER, STEVEN W)Jun 1, 2010 - May 31, 2013
    NIH/NIA
    Secreted Alzheimer amyloid precursor protein (sAPP) antagonizes Reelin receptors
    Role: Principal Investigator

    P30NS047546     (DREW, PAUL D)Aug 15, 2004 - Jul 31, 2010
    NIH/NINDS
    Neuroscience Research Center Core Facility at UAMS
    Role: Co-Investigator

    R01NS046439     (BARGER, STEVEN W)Jan 20, 2004 - Dec 31, 2009
    NIH/NINDS
    Sp1, kappa-B enhancers and transcriptions in neurons
    Role: Principal Investigator

    R01AG17498     (BARGER, STEVEN)Jul 23, 2002 - Jul 31, 2010
    University of Arkansas Foundation
    TO ESTABLISH UAMS ACCOUNT FOR SALARY SUPPORT OF XIANRONG MAO. INVOICE U OF A FOUNDATION OFFICE
    Role: Principal Investigator

    R01AG017498     (BARGER, STEVEN W)Apr 1, 2001 - Mar 31, 2007
    NIH/NIA
    BALANCED BIOACTIVITY OF ALZHEIMER BETA AMYLOID PRECURSOR
    Role: Principal Investigator

    R29NS035872     (BARGER, STEVEN W)Apr 1, 1996 - Mar 31, 2001
    NIH/NINDS
    CYCLIC GMP AND KB-DEPENDENT TRANSCRIPTION IN NEURONS
    Role: Principal Investigator

    P01AG012411     (GRIFFIN, SUE TILTON)Jun 1, 1995 - May 31, 2021
    NIH/NIA
    Early Events in Alzheimer Pathogenesis
    Role: Co-Principal Investigator

    F32NS009630     (BARGER, STEVEN W)Sep 1, 1994
    NIH/NINDS
    CYCLIC GMP--MEDIATOR OF BETA-AMYLOID PRECURSOR FUNCTION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Balasubramaniam M, Parcon PA, Bose C, Liu L, Jones RA, Farlow MR, Mrak RE, Barger SW, Griffin WST. Interleukin-1ß drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site. J Neuroinflammation. 2019 Dec 27; 16(1):275. PMID: 31882005.
      View in: PubMed
    2. Kakraba S, Ayyadevara S, Penthala NR, Balasubramaniam M, Ganne A, Liu L, Alla R, Bommagani SB, Barger SW, Griffin WST, Crooks PA, Shmookler Reis RJ. A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease. Front Mol Neurosci. 2019; 12:310. PMID: 31920540.
      View in: PubMed
    3. Kulas JA, Franklin WF, Smith NA, Manocha GD, Puig KL, Nagamoto-Combs K, Hendrix RD, Taglialatela G, Barger SW, Combs CK. Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues. Am J Physiol Endocrinol Metab. 2019 01 01; 316(1):E106-E120. PMID: 30422705.
      View in: PubMed
    4. Ayyadevara S, Ganne A, Hendrix RD, Balasubramaniam M, Shmookler Reis RJ, Barger SW. Functional assessments through novel proteomics approaches: Application to insulin/IGF signaling in neurodegenerative disease'. J Neurosci Methods. 2019 May 01; 319:40-46. PMID: 30412730.
      View in: PubMed
    5. Plucinska K, Barger SW. Maternal obesity reprograms offspring's executive brain centers in a sex-specific manner?: An Editorial for 'Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain' on page 362. J Neurochem. 2018 06; 145(5):358-361. PMID: 29663393.
      View in: PubMed
    6. Parcon PA, Balasubramaniam M, Ayyadevara S, Jones RA, Liu L, Shmookler Reis RJ, Barger SW, Mrak RE, Griffin WST. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. Alzheimers Dement. 2018 02; 14(2):230-242. PMID: 28945989.
      View in: PubMed
    7. Barger SW. Gene regulation and genetics in neurochemistry, past to future. J Neurochem. 2016 10; 139 Suppl 2:24-57. PMID: 27747882.
      View in: PubMed
    8. Wang W, Moerman-Herzog AM, Slaton A, Barger SW. Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. Neurobiol Aging. 2017 01; 49:145-153. PMID: 27810638.
      View in: PubMed
    9. Mehdi SJ, Rosas-Hernandez H, Cuevas E, Lantz SM, Barger SW, Sarkar S, Paule MG, Ali SF, Imam SZ. Protein Kinases and Parkinson's Disease. Int J Mol Sci. 2016 Sep 20; 17(9). PMID: 27657053.
      View in: PubMed
    10. Wu S, Barger SW. Disrupted-in-schizophrenia-1 as a broader link of glutamatergic transmission to schizophrenia impacts cerebral neurochemistry via the production of the 'gliotransmitter' d-serine, a NMDA receptor coagonist. J Neurochem. 2016 Aug; 138(4):503-5. PMID: 27501180.
      View in: PubMed
    11. Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell. 2016 10; 15(5):924-39. PMID: 27448508.
      View in: PubMed
    12. Mao X, Phanavanh B, Hamdan H, Moerman-Herzog AM, Barger SW. NF?B-inducing kinase inhibits NF?B activity specifically in neurons of the CNS. J Neurochem. 2016 Apr; 137(2):154-63. PMID: 26778773.
      View in: PubMed
    13. Wang W, Bodles-Brakhop AM, Barger SW. A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid ß -Peptide from the Brain. Curr Alzheimer Res. 2016; 13(6):615-20. PMID: 26971931.
      View in: PubMed
    14. Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3ß signaling pathway. J Neurochem. 2015 Nov; 135(3):630-7. PMID: 26342176.
      View in: PubMed
    15. Kuang XL, Liu F, Chen H, Li Y, Liu Y, Xiao J, Shan G, Li M, Snider BJ, Qu J, Barger SW, Wu S. Reductions of the components of the calreticulin/calnexin quality-control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease. J Neurosci Res. 2014 Oct; 92(10):1319-29. PMID: 24860980.
      View in: PubMed
    16. Barger SW. TMEM106B and frontotemporal lobar degeneration: can over-expression tell us how reductions are beneficial? J Neurochem. 2013 Sep; 126(6):696-8. PMID: 23875562.
      View in: PubMed
    17. Bailey AR, Hou H, Song M, Obregon DF, Portis S, Barger S, Shytle D, Stock S, Mori T, Sanberg PG, Murphy T, Tan J. GFAP expression and social deficits in transgenic mice overexpressing human sAPPa. Glia. 2013 Sep; 61(9):1556-69. PMID: 23840007.
      View in: PubMed
    18. Topchiy E, Panzhinskiy E, Griffin WS, Barger SW, Das M, Zawada WM. Nox4-generated superoxide drives angiotensin II-induced neural stem cell proliferation. Dev Neurosci. 2013; 35(4):293-305. PMID: 23751520.
      View in: PubMed
    19. Barger SW. Apolipoprotein E acts at pre-synaptic sites...among others. J Neurochem. 2013 Jan; 124(1):1-3. PMID: 23020739.
      View in: PubMed
    20. McMullan SM, Phanavanh B, Li GG, Barger SW. Metabotropic glutamate receptors inhibit microglial glutamate release. ASN Neuro. 2012 Aug 07; 4(5). PMID: 22770428.
      View in: PubMed
    21. Moerman-Herzog AM, Barger SW. A polymorphism in the upstream regulatory region of the interleukin-1a gene confers differential binding by transcription factors of the AP-1 family. Life Sci. 2012 Jun 27; 90(25-26):975-9. PMID: 22634325.
      View in: PubMed
    22. Wang W, Barger SW. Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species. J Neurosci Res. 2012 Jun; 90(6):1218-29. PMID: 22354542.
      View in: PubMed
    23. Thompson M, Marecki JC, Marinesco S, Labrie V, Roder JC, Barger SW, Crow JP. Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Feb; 120(4):598-610. PMID: 22117694.
      View in: PubMed
    24. Liu L, Aboud O, Jones RA, Mrak RE, Griffin WS, Barger SW. Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors. J Neuroinflammation. 2011 Dec 15; 8:175. PMID: 22171672.
      View in: PubMed
    25. Wang W, Barger SW. Roles of quaternary structure and cysteine residues in the activity of human serine racemase. BMC Biochem. 2011 Dec 08; 12:63. PMID: 22151352.
      View in: PubMed
    26. Jiang H, Fang J, Wu B, Yin G, Sun L, Qu J, Barger SW, Wu S. Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy. J Neuroinflammation. 2011 Sep 22; 8:119. PMID: 21939517.
      View in: PubMed
    27. Barger, S.W., Mao, X. Transcription Factor Regulation of Synapatic Plasticity and Memory Encoding. NFxB in Neurons-Mechanisms and Myths. 2010.
    28. Griffin WS, Barger SW. Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis. US Neurol. 2010; 6(2):19-27. PMID: 22408651.
      View in: PubMed
    29. Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009 Sep 01; 18(17):3227-43. PMID: 19483194.
      View in: PubMed
    30. Mao XR, Moerman-Herzog AM, Chen Y, Barger SW. Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors. J Neuroinflammation. 2009 May 18; 6:16. PMID: 19450264.
      View in: PubMed
    31. Aghdam, S.Y., Barger SW. Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: Lesson from Lithium. Curr. Alzheimer Res. 2009; 21-31.
    32. Mao, X, Moerman, A.M., Chen, Y, Barger, S.W. Unique aspects of transcriptional regulation in neurons - nuances in NFkB and Sp1 related factors. 2009; 16-28.
    33. Labrie V, Duffy S, Wang W, Barger SW, Baker GB, Roder JC. Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. Learn Mem. 2009 Jan; 16(1):28-37. PMID: 19117914.
      View in: PubMed
    34. Barger SW, DeWall KM, Liu L, Mrak RE, Griffin WS. Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies. J Neuropathol Exp Neurol. 2008 Aug; 67(8):773-83. PMID: 18648325.
      View in: PubMed
    35. Xu J, Barger SW, Drew PD. The PPAR-gamma Agonist 15-Deoxy-Delta-Prostaglandin J(2) Attenuates Microglial Production of IL-12 Family Cytokines: Potential Relevance to Alzheimer's Disease. PPAR Res. 2008; 2008:349185. PMID: 18615183.
      View in: PubMed
    36. Xianrong Mao, Andrea M. Moerman- Herzog, Wei Wang, Steven W. Barger. Differential Transcriptional Control of the SOD2 kB Element in Neurons and Astrocytes. J Biol Chem. 2007; 281(47):35863-25872.
    37. Xianrong Mao, Shao-Hua Yang, James W. Simpkins, Steven W. Barger. Glutamate receptor activation evokes calpain medicated degraduation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons. J Neurochem. 2007; 101(5):1300-1314.
    38. Wu S, Basile AS, Barger SW. Induction of serine racemase expression and D-serine release from microglia by secreted amyloid precursor protein (sAPP). Curr Alzheimer Res. 2007 Jul; 4(3):243-51. PMID: 17627481.
      View in: PubMed
    39. Barger SW, Goodwin ME, Porter MM, Beggs ML. Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation. J Neurochem. 2007 Jun; 101(5):1205-13. PMID: 17403030.
      View in: PubMed
    40. Mao X, Yang SH, Simpkins JW, Barger SW. Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons. J Neurochem. 2007 Mar; 100(5):1300-14. PMID: 17316402.
      View in: PubMed
    41. Aghdam SY, Barger SW. Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium. Curr Alzheimer Res. 2007 Feb; 4(1):21-31. PMID: 17316163.
      View in: PubMed
    42. Wu S-Z, Barger SW. Activation of microglia by secreted Alzheimer amyloid precursor protein induces serine racemase and D-serine release. Curr. Alzheimer Res. 2007; (4):243-251.
    43. Mao X, Moerman-Herzog AM, Wang W, Barger SW. Differential transcriptional control of the superoxide dismutase-2 kappaB element in neurons and astrocytes. J Biol Chem. 2006 Nov 24; 281(47):35863-72. PMID: 17023425.
      View in: PubMed
    44. Massa PT, Aleyasin H, Park DS, Mao X, Barger SW. NFkappaB in neurons? The uncertainty principle in neurobiology. J Neurochem. 2006 May; 97(3):607-18. PMID: 16573643.
      View in: PubMed
    45. Griffin WS, Liu L, Li Y, Mrak RE, Barger SW. Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation. 2006 Mar 16; 3:5. PMID: 16542445.
      View in: PubMed
    46. Chen CW, Boiteau RM, Lai WF, Barger SW, Cataldo AM. sAPPalpha enhances the transdifferentiation of adult bone marrow progenitor cells to neuronal phenotypes. Curr Alzheimer Res. 2006 Feb; 3(1):63-70. PMID: 16472205.
      View in: PubMed
    47. Wu SZ, Jiang S, Sims TJ, Barger SW. Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists. J Neurosci Res. 2005 Mar 01; 79(5):638-43. PMID: 15672444.
      View in: PubMed
    48. Liu L, Li Y, Van Eldik LJ, Griffin WS, Barger SW. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. J Neurochem. 2005 Feb; 92(3):546-53. PMID: 15659225.
      View in: PubMed
    49. Barger SW. Vascular consequences of passive Abeta immunization for Alzheimer's disease. Is avoidance of "malactivation" of microglia enough? J Neuroinflammation. 2005 Jan 11; 2(1):2. PMID: 15644140.
      View in: PubMed
    50. Barger SW, Moerman AM, Mao X. Molecular mechanisms of cytokine-induced neuroprotection: NFkappaB and neuroplasticity. Curr Pharm Des. 2005; 11(8):985-98. PMID: 15777249.
      View in: PubMed
    51. Bodles AM, Barger SW. Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK. Neurobiol Aging. 2005 Jan; 26(1):9-16. PMID: 15585341.
      View in: PubMed
    52. Wu S, Barger SW. Induction of serine racemase by inflammatory stimuli is dependent on AP-1. Ann N Y Acad Sci. 2004 Dec; 1035:133-46. PMID: 15681805.
      View in: PubMed
    53. Barger SW. Cooperative ideas about cooperative strategies. Ann N Y Acad Sci. 2004 Dec; 1035:350-3. PMID: 15681817.
      View in: PubMed
    54. Bodles AM, Barger SW. Cytokines and the aging brain - what we don't know might help us. Trends Neurosci. 2004 Oct; 27(10):621-6. PMID: 15374674.
      View in: PubMed
    55. Wu S, Barger SW, Sims TJ. Schwann cell and epineural fibroblast expression of serine racemase. Brain Res. 2004 Sep 10; 1020(1-2):161-6. PMID: 15312798.
      View in: PubMed
    56. Barger SW. An unconventional hypothesis of oxidation in Alzheimer's disease: intersections with excitotoxicity. Front Biosci. 2004 Sep 01; 9:3286-95. PMID: 15353358.
      View in: PubMed
    57. Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, Barger SW. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. J Neuroinflammation. 2004 Apr 20; 1(1):2. PMID: 15285800.
      View in: PubMed
    58. Li Y, Liu L, Liu D, Woodward S, Barger SW, Mrak RE, Griffin WS. Microglial activation by uptake of fDNA via a scavenger receptor. J Neuroimmunol. 2004 Feb; 147(1-2):50-5. PMID: 14741427.
      View in: PubMed
    59. Li Y, Liu L, Barger SW, Griffin WS. Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. J Neurosci. 2003 Mar 01; 23(5):1605-11. PMID: 12629164.
      View in: PubMed
    60. Mao X, Moerman AM, Barger SW. Neuronal kappa B-binding factors consist of Sp1-related proteins. Functional implications for autoregulation of N-methyl-D-aspartate receptor-1 expression. J Biol Chem. 2002 Nov 22; 277(47):44911-9. PMID: 12244044.
      View in: PubMed
    61. Ranganathan G, Song W, Dean N, Monia B, Barger SW, Kern PA. Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes. J Biol Chem. 2002 Oct 11; 277(41):38669-75. PMID: 12149272.
      View in: PubMed
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