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Gohar Azhar

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentGeriatrics, College of Medicine
DivisionGeriatrics Faculty
Address3155 Institute on Aging
629 Jack Stephens Drive
Mail Slot # 807
Little Rock AR 72205
Phone501-526-5821
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    Other Roles
    IRB committee member

    Collapse Overview 
    Collapse overview
    Dr. Gohar Azhar is a Professor of Geriatrics at the Reynolds Institute on Aging, College of Medicine, at UAMS. She is also the Director of Clinical Research, Director of the Pat Walker Memory Clinic and Research Center and Co-Director of the Cardiovascular Aging Program. Dr. Azhar graduated from Dow Medical College in Karachi, Pakistan. She completed her internship and residency in internal medicine at the Western Pennsylvania Hospital in Pittsburgh where she was recognized for her “Excellence in Ambulatory Care” and as an “Outstanding Resident ”. Subsequently, she trained as a geriatrician and physician-scientist at the Beth Israel Deaconess Medical Center and the Division on Aging, at Harvard Medical School, in Boston. Prior to her appointment at UAMS, she was an Instructor at Harvard and worked in the laboratory of Dr. Jeanne Wei. She received pilot funding from the Nathan Shock Program to study the effects of oxidative damage on the heart and the brain and was the first to report on the age-associated changes in the heart and brain in response to hypoxia-reoxygenation in terms of altered bcl2/bax ratios. She also conducted some of the first experiments on cardiac ischemia-reperfusion in the aging mouse model and determined that the window of opportunity for intervention and salvaging of cardiac tissue was significantly shorter for the old heart versus the young adult heart. Her basic research focused on elucidating the role of serum response factor (SRF) in the aging heart. Dr. Azhar was responsible for the physiological and functional characterization of a number of transgenic mouse models of SRF under-expression and over-expression. She co-authored a salient paper describing the cardiac changes in these mice titled “Model of functional cardiac aging” in in which a modest increase in a single transcription factor, SRF, led to accelerated aging of the heart. In brief, this was a model with premature diastolic dysfunction, represented an “old heart in a young adult body.” Diastolic dysfunction is a condition that is very commonly observed in older adults and is now also termed “heart failure” with preserved ejection fraction or HFPEF. Dr. Azhar also practiced as a geriatrician at community care centers in inner city, Boston before moving to UAMS in 2002.
    Dr. Azhar also held the position of Director of the Research Career and Development Core of the Arkansas Older American Independence Center and has helped establish a program to train numerous students and junior faculty members in aging research. Her basic research interests continue include investigating transcriptional control of the aging heart and physiological evaluation of stress responses of the aging cardiovascular system. She has recently been awarded an NIH, R41 STTR grant titled, “Nutritional Therapy in Elderly with Heart Failure” which builds on her clinical interests in cardiovascular aging. The clinical research projects involve the study of heart failure in the elderly, memory disorders, frailty and functional outcomes in response to nutritional interventions or new drug therapies. She is interested in investigating memory disorders and dementias and discovering new genes and proteins that could help turn the older hearts and brains into younger hearts and brains. She enjoys being a geriatrician and integrating all aspects of science and technology to maintain functional independence of older individuals and their caregivers in her practice.


    Collapse Research 
    Collapse research activities and funding
    R24AG065175     (WILLIAMS, BRIE A)Sep 30, 2019 - Jun 30, 2024
    NIH
    Advancing Health Disparities Research in Aging: The Aging Research in Criminal Justice & Health (ARCH) Network
    Role: Co-Investigator

    R01MD013852     (MCELFISH, PEARL ANNA)Jul 29, 2019 - Feb 29, 2024
    NIH/National Center on Minority Health and Health Disparities
    Addressing Marshallese Immigrant Barriers to Diabetes Self-Management through Family DSMES
    Role: Co-Investigator

    UL1TR003107     (JAMES, LAURA P)Jul 1, 2019 - Jun 30, 2024
    NIH
    Expanding Translational Research in Arkansas
    Role: Co-Investigator

    4600044610     (WEI, JEANNE)Jul 1, 2019 - Apr 30, 2020
    AR Dept of Human Services/Division of Aging and Adult Services
    State Targeted Response (STR) No-Cost Extension
    Role: Co-Investigator

    H79TI081700     (Jeanne Wei)Jun 1, 2019 - Sep 29, 2022
    SAMHSA
    Arkansas DHS State Opioid Response Grant Supplement
    Role Description: The major aim of this proposal is to implement programs to increase opioid use disorder awareness in elderly persons in Arkansas
    Role: Co-Investigator

    43959     (WOLFE, ROBERT)Jan 1, 2018 - Jun 30, 2019
    MYOS RENS - Pass Through: University of California, Berkeley
    Wolfe-FORTE: Effects of Fortetropin on Skeletal Muscle Protein Fractional Synthetic Rate in Older Men and Women
    Role: Co-Investigator

    3000289848     (WOLFE, ROBERT)Dec 11, 2017 - Jun 30, 2019
    Zespri Group Limited - Pass Through: Massey University
    Wolfe-KIWI Sub w/Massey: Speeding Up a Slow Protein for Muscle Mass with Hayward Kiwi fruit
    Role: Co-Investigator

    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator

    R42AG050375     (AZHAR, GOHAR)Sep 15, 2017 - May 31, 2019
    NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC
    Subcontract w/Essential Blends, LLC: UpBeat Phase 2
    Role: Principal Investigator

    R41AG050375     (AZHAR, GOHAR)Aug 15, 2015 - Jan 31, 2017
    NIH/Nat. Inst. on Aging - Pass Through: Essential Blends, LLC
    Consortium w/Essential: Nutritional Therapy in the Elderly with Heart Failure- Resubmission
    Role: Principal Investigator

    R01HD084124     (FERRANDO, ARNY)Apr 15, 2015 - Feb 28, 2020
    NIH/National Institutes of Health - Pass Through: University of Alabama at Birmingham
    Overcoming TWEAK Signaling to Restore Muscle and Mobility Function after Joint Replacement
    Role: Co-Investigator

    1211     (FERRANDO, ARNY)Jun 1, 2013 - May 31, 2015
    National Dairy Council
    Ferrando - D.E.B. Dairy - Effect of Dietary Protein Intake Distribution on Protein Metabolism and Skeletal Muscle
    Role: Co-Investigator

    1165     (FERRANDO, ARNY)Oct 1, 2012 - Dec 31, 2014
    The Dairy Research Institute
    Ferrando - Dairy Macronutrient Effects on the Metabolic System
    Role: Co-Investigator

    P30AG028718     (WEI, JEANNE Y)Sep 1, 2011 - Aug 31, 2018
    NIH
    Arkansas Claude Pepper Older Americans Independence Center at UAMS
    Role: Co-Investigator

    R01AG026091     (WEI, JEANNE Y)Jul 1, 2006 - Jun 30, 2012
    NIH
    Transcription Regulation in the Aging Heart
    Role: Co-Investigator

    R43AG038210     (AZHAR, GOHAR)Jan 1, 2001 - Aug 31, 2012
    NIH/Nat. Inst. on Aging - Pass Through: Environment and Health Group, Inc.
    Care Coordination and Home Telehealth Program for Older Adults with Cardiovascular Disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Dayer SR, Mears SC, Pangle AK, Mendiratta P, Wei JY, Azhar G. Does Superior Bone Health Promote a Longer Lifespan? Geriatr Orthop Surg Rehabil. 2021; 12:21514593211036231. PMID: 34395047.
      View in: PubMed
    2. Azhar G, Wei JY, Schutzler SE, Coker K, Gibson RV, Kirby MF, Ferrando AA, Wolfe RR. Daily Consumption of a Specially Formulated Essential Amino Acid-Based Dietary Supplement Improves Physical Performance in Older Adults With Low Physical Functioning. J Gerontol A Biol Sci Med Sci. 2021 06 14; 76(7):1184-1191. PMID: 33475727.
      View in: PubMed
    3. Mize BM, Duke B, Pangle AK, Wei JY, Azhar G. Cardiovascular Health in Individuals with Exceptional Longevity Residing in Arkansas. Gerontol Geriatr Med. 2021 Jan-Dec; 7:23337214211018933. PMID: 34104686.
      View in: PubMed
    4. McAtee RE, Spradley L, Tobey L, Thomasson W, Azhar G, Mercado C. Caregiver Burden: Caregiving Workshops Have a Positive Impact on Those Caring for Individuals With Dementia in Arkansas. J Patient Exp. 2021; 8:23743735211018085. PMID: 34179446.
      View in: PubMed
    5. Park S, Church DD, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Wolfe RR. Metabolic Evaluation of the Dietary Guidelines' Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial. J Nutr. 2021 05 11; 151(5):1190-1196. PMID: 33693735.
      View in: PubMed
    6. Park S, Church DD, Starck C, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Moughan PJ, Wolfe RR. Correction to: The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism. Eur J Nutr. 2021 Mar; 60(2):1149-1151. PMID: 33306152.
      View in: PubMed
    7. Zhang X, Ameer FS, Azhar G, Wei JY. Alternative Splicing Increases Sirtuin Gene Family Diversity and Modulates Their Subcellular Localization and Function. Int J Mol Sci. 2021 Jan 06; 22(2). PMID: 33418837.
      View in: PubMed
    8. Azhar G, Raza S, Pangle A, Coleman K, Dawson A, Schrader A, Wolfe RR, Wei JY. Potential Beneficial Effects of Dietary Protein Supplementation and Exercise on Functional Capacity in a Pilot Study of Individuals with Heart Failure with Preserved Ejection Fraction. Gerontol Geriatr Med. 2020 Jan-Dec; 6:2333721420982808. PMID: 33426179.
      View in: PubMed
    9. Park S, Jang J, Choi MD, Shin YA, Schutzler S, Azhar G, Ferrando AA, Wolfe RR, Kim IY. The Anabolic Response to Dietary Protein Is Not Limited by the Maximal Stimulation of Protein Synthesis in Healthy Older Adults: A Randomized Crossover Trial. Nutrients. 2020 Oct 26; 12(11). PMID: 33114585.
      View in: PubMed
    10. Park S, Church DD, Starck C, Schutzler SE, Azhar G, Kim IY, Ferrando AA, Moughan PJ, Wolfe RR. The impact of Hayward green kiwifruit on dietary protein digestion and protein metabolism. Eur J Nutr. 2021 Mar; 60(2):1141-1148. PMID: 32970234.
      View in: PubMed
    11. Park S, Church DD, Azhar G, Schutzler SE, Ferrando AA, Wolfe RR. Anabolic response to essential amino acid plus whey protein composition is greater than whey protein alone in young healthy adults. J Int Soc Sports Nutr. 2020 Feb 10; 17(1):9. PMID: 32041644.
      View in: PubMed
    12. Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab. 2019 09 01; 317(3):E503-E512. PMID: 31211617.
      View in: PubMed
    13. Kim IY, Park S, Smeets ETHC, Schutzler S, Azhar G, Wei JY, Ferrando AA, Wolfe RR. Consumption of a Specially-Formulated Mixture of Essential Amino Acids Promotes Gain in Whole-Body Protein to a Greater Extent than a Complete Meal Replacement in Older Women with Heart Failure. Nutrients. 2019 Jun 17; 11(6). PMID: 31212940.
      View in: PubMed
    14. Mendiratta P, Dayama N, Azhar G, Prodhan P, Wei JY. Bariatric Procedures in Older Adults in the United States: Analysis of a Multicenter Database. Geriatrics (Basel). 2019 Apr 21; 4(2). PMID: 31010088.
      View in: PubMed
    15. Zhang X, Azhar G, Wei JY. SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. PLoS One. 2017; 12(12):e0190011. PMID: 29267359.
      View in: PubMed
    16. Picetti D, Foster S, Pangle AK, Schrader A, George M, Wei JY, Azhar G. Hydration health literacy in the elderly. Nutr Healthy Aging. 2017 Dec 07; 4(3):227-237. PMID: 29276792.
      View in: PubMed
    17. Marquis BJ, Hurren NM, Carvalho E, Kim IY, Schutzler S, Azhar G, Wolfe RR, Børsheim E. Skeletal Muscle Acute and Chronic Metabolic Response to Essential Amino Acid Supplementation in Hypertriglyceridemic Older Adults. Curr Dev Nutr. 2017 Nov; 1(11):e002071. PMID: 29955688.
      View in: PubMed
    18. Kim IY, Shin YA, Schutzler SE, Azhar G, Wolfe RR, Ferrando AA. Quality of meal protein determines anabolic response in older adults. Clin Nutr. 2018 12; 37(6 Pt A):2076-2083. PMID: 29066101.
      View in: PubMed
    19. Smeets ETHC, Schutzler SE, Wei JY, Azhar G, Wolfe RR. Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure? Physiol Rep. 2017 Aug; 5(15). PMID: 28778993.
      View in: PubMed
    20. George M, Azhar G, Pangle A, Peeler E, Dawson A, Coker R, Coleman KS, Schrader A, Wei J. Feasibility of Conducting a 6-month long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure. J Physiother Phys Rehabil. 2017; 2(2). PMID: 29226282.
      View in: PubMed
    21. Kim IY, Schutzler SE, Azhar G, Wolfe RR, Ferrando AA, Coker RH. Short term elevation in dietary protein intake does not worsen insulin resistance or lipids in older adults with metabolic syndrome: a randomized-controlled trial. BMC Nutr. 2017; 3. PMID: 28713581.
      View in: PubMed
    22. Kim IY, Schutzler S, Schrader AM, Spencer HJ, Azhar G, Wolfe RR, Ferrando AA. Protein intake distribution pattern does not affect anabolic response, lean body mass, muscle strength or function over 8 weeks in older adults: A randomized-controlled trial. Clin Nutr. 2018 04; 37(2):488-493. PMID: 28318687.
      View in: PubMed
    23. Zhang X, Williams ED, Azhar G, Rogers SC, Wei JY. Does p49/STRAP, a SRF-binding protein (SRFBP1), modulate cardiac mitochondrial function in aging? Exp Gerontol. 2016 09; 82:150-9. PMID: 27337995.
      View in: PubMed
    24. Kim IY, Schutzler S, Schrader A, Spencer HJ, Azhar G, Ferrando AA, Wolfe RR. The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthy young adults. Am J Physiol Endocrinol Metab. 2016 Jan 01; 310(1):E73-80. PMID: 26530155.
      View in: PubMed
    25. Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015 Dec 01; 309(11):E915-24. PMID: 26442881.
      View in: PubMed
    26. Williams ED, Rogers SC, Zhang X, Azhar G, Wei JY. Elevated oxygen consumption rate in response to acute low-glucose stress: Metformin restores rate to normal level. Exp Gerontol. 2015 Oct; 70:157-62. PMID: 26256471.
      View in: PubMed
    27. Zhang X, Azhar G, Williams ED, Rogers SC, Wei JY. MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes. Biomed Res Int. 2015; 2015:732397. PMID: 26221604.
      View in: PubMed
    28. George M, Azhar G, Kilmer G, Miller S, Bynum L, Balamurugan A. Falls and comorbid conditions among community dwelling Arkansas older adults from a population-based survey. J Ark Med Soc. 2014 Dec; 111(7):136-9. PMID: 25668921.
      View in: PubMed
    29. Zhang X, Azhar G, Rogers SC, Foster SR, Luo S, Wei JY. Overexpression of p49/STRAP alters cellular cytoskeletal structure and gross anatomy in mice. BMC Cell Biol. 2014 Sep 02; 15:32. PMID: 25183317.
      View in: PubMed
    30. Abraham RR, Girotra M, Wei JY, Azhar G. Is short-term percutaneous endoscopic gastrostomy tube placement beneficial in acutely ill cognitively intact elderly patients? A proposed decision-making algorithm. Geriatr Gerontol Int. 2015 May; 15(5):572-8. PMID: 25109444.
      View in: PubMed
    31. Azhar G, Wei JY. New Approaches to Treating Cardiac Cachexia in the Older Patient. Curr Cardiovasc Risk Rep. 2013 Dec 01; 7(6):480-484. PMID: 24489977.
      View in: PubMed
    32. Rogers SC, Zhang X, Azhar G, Luo S, Wei JY. Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase. J Gerontol A Biol Sci Med Sci. 2013 Dec; 68(12):1469-81. PMID: 23585419.
      View in: PubMed
    33. Zhang X, Azhar G, Wei JY. The expression of microRNA and microRNA clusters in the aging heart. PLoS One. 2012; 7(4):e34688. PMID: 22529925.
      View in: PubMed
    34. Zhang X, Azhar G, Helms S, Burton B, Huang C, Zhong Y, Gu X, Fang H, Tong W, Wei JY. Identification of New SRF Binding Sites in Genes Modulated by SRF Over-Expression in Mouse Hearts. Gene Regul Syst Bio. 2011; 5:41-59. PMID: 21792293.
      View in: PubMed
    35. Zhang X, Azhar G, Helms SA, Wei JY. Regulation of cardiac microRNAs by serum response factor. J Biomed Sci. 2011 Feb 08; 18:15. PMID: 21303526.
      View in: PubMed
    36. Helms SA, Azhar G, Zuo C, Theus SA, Bartke A, Wei JY. Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice. Int J Biol Sci. 2010 Sep 01; 6(5):475-90. PMID: 20827400.
      View in: PubMed
    37. Zhang X, Azhar G, Helms S, Zhong Y, Wei JY. Identification of a subunit of NADH-dehydrogenase as a p49/STRAP-binding protein. BMC Cell Biol. 2008 Jan 29; 9:8. PMID: 18230186.
      View in: PubMed
    38. Zhang X, Azhar G, Huang C, Cui C, Zhong Y, Huck S, Wei JY. Alternative splicing and nonsense-mediated mRNA decay regulate gene expression of serum response factor. Gene. 2007 Oct 01; 400(1-2):131-9. PMID: 17629633.
      View in: PubMed
    39. Azhar G, Zhang X, Wang S, Zhong Y, Quick CM, Wei JY. Maintaining serum response factor activity in the older heart equal to that of the young adult is associated with better cardiac response to isoproterenol stress. Basic Res Cardiol. 2007 May; 102(3):233-44. PMID: 17122890.
      View in: PubMed
    40. Zhang X, Azhar G, Zhong Y, Wei JY. Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):794-801. PMID: 16782067.
      View in: PubMed
    41. Azhar G, Wei JY. Nutrition and cardiac cachexia. Curr Opin Clin Nutr Metab Care. 2006 Jan; 9(1):18-23. PMID: 16340656.
      View in: PubMed
    42. Zhang X, Azhar G, Zhong Y, Wei JY. Identification of a novel serum response factor cofactor in cardiac gene regulation. J Biol Chem. 2004 Dec 31; 279(53):55626-32. PMID: 15492011.
      View in: PubMed
    43. Zhang X, Azhar G, Furr MC, Zhong Y, Wei JY. Model of functional cardiac aging: young adult mice with mild overexpression of serum response factor. . 2003 Sep; 285(3):R552-60. PMID: 12909581.
      View in: PubMed
    44. Azhar G and Lewis L. Lipsitz. Chapter 15, in Syncope: Mechanisms and Management. Armonk, NY: Futura Publishing Co., Inc.; 1998. . Armonk, NY: Futura Publishing Co., Inc. Syncope in the Elderly: Mechanisms and Management. 1998.
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