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Kevin Phelan

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentNeurobiology & Developmental Science, College of Medicine
DivisionNeuro & Devl SFaculty
Address564-2 Biomedical Research II
200 South Cedar
Mail Slot # 846
Little Rock AR 72202
Phone501-686-8192
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    Collapse Research Funds 
    Collapse research activities
    R25GM129817     (PHELAN, KEVIN D)Aug 10, 2018 - May 31, 2023
    NIH/NIGMS
    ArkanSONO: A Technology Based Outreach Exposure Program for High School Students
    Role: Principal Investigator

    R01AA024695     (DREW, PAUL D)Aug 1, 2016 - Jul 31, 2021
    NIH/NIAAA
    Regulation of Neuroimmune Responses in FASD Models
    Role: Co-Investigator

    R01DK102206     (BALDINI, GIULIA)Sep 15, 2014 - Aug 31, 2019
    NIH/NIDDK
    Lipid Stress and MC4R
    Role: Co-Investigator

    R01AA018834     (KANE, CYNTHIA J.M.)Sep 30, 2009 - Aug 31, 2014
    NIH/NIAAA
    Microglia modulate ethanol impact on CNS development.
    Role: Co-Investigator

    R01NS058503     (ZHENG, FANG)Jul 16, 2009 - Jun 30, 2013
    NIH/NINDS
    Canonical Transient Receptor Potential Channels and Excitotoxicity
    Role: Co-Investigator

    R03NS050381     (ZHENG, FANG)Jan 1, 2006 - Dec 31, 2008
    NIH/NINDS
    METABOTROPIC GLUTAMATE RECEPTORS AND EXCITOTOXICITY
    Role: Co-Investigator

    R03HD042199     (PHELAN, KEVIN D)Jan 1, 2003 - Dec 31, 2005
    NIH/NICHD
    MHC CLASS I EXPRESSION AND FUNCTION IN MURINE CEREBELLUM
    Role: Principal Investigator

    R01HD042199     (PHELAN, KEVIN)Jan 1, 2002 - Dec 31, 2005
    NIH/Nat. Inst. of Child Health & Human Development
    MHC CLASS I Expression and Function in Murine Cerebellum
    Role: Principal Investigator

    R01NS039418     (ZHENG, FANG)Dec 1, 1999 - Apr 30, 2013
    NIH/NINDS
    ZINC-DEPENDENT APPARENT DESENSITIZATION OF NMDA RECEPTOR
    Role: Co-Investigator

    R01NS033959     (PHELAN, KEVIN D)Apr 1, 1995 - Feb 28, 2000
    NIH/NINDS
    MECHANISMS OF GABA-B INHIBITION AND EPILEPSY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Cozart MA, Phelan KD, Wu H, Mu S, Birnbaumer L, Rusch NJ, Zheng F. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Sci Rep. 2020 Jan 21; 10(1):812. PMID: 31964991.
      View in: PubMed
    2. Whited TM, DeClerk L, Berber A, Phelan KD. An innovative technique to promote understanding of anatomy for nurse practitioner students. J Am Assoc Nurse Pract. 2019 Nov 21. PMID: 31764402.
      View in: PubMed
    3. Baldini G, Phelan KD. The melanocortin pathway and control of appetite-progress and therapeutic implications. J Endocrinol. 2019 04 01; 241(1):R1-R33. PMID: 30812013.
      View in: PubMed
    4. Nyamugenda E, Trentzsch M, Russell S, Miles T, Boysen G, Phelan KD, Baldini G. Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice. J Neurochem. 2019 04; 149(1):73-97. PMID: 30615192.
      View in: PubMed
    5. Meek MEM, Meek JC, Hollowoa B, Li R, Deloney LA, Phelan KD. Lightly Embalmed Cadavers as a Training Tool for Ultrasound-Guided Procedures Commonly Used in Interventional Radiology. Acad Radiol. 2018 11; 25(11):1503-1509. PMID: 30017501.
      View in: PubMed
    6. Sharma SG, Arthur JM, Bonsib SM, Phelan KD, Singh M, Karakala N, Bulloch KW, Niyyar VD, Velez JCQ. An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy?. Clin Nephrol. 2018 03; 89(3):214-221. PMID: 29249232.
      View in: PubMed
    7. Phelan KD, Shwe UT, Cozart MA, Wu H, Mock MM, Abramowitz J, Birnbaumer L, Zheng F. TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice. Epilepsia. 2017 02; 58(2):247-254. PMID: 28012173.
      View in: PubMed
    8. Phelan KD, Shwe UT, Williams DK, Greenfield LJ, Zheng F. Pilocarpine-induced status epilepticus in mice: A comparison of spectral analysis of electroencephalogram and behavioral grading using the Racine scale. Epilepsy Res. 2015 Nov; 117:90-6. PMID: 26432759.
      View in: PubMed
    9. Drew PD, Johnson JW, Douglas JC, Phelan KD, Kane CJ. Pioglitazone blocks ethanol induction of microglial activation and immune responses in the hippocampus, cerebellum, and cerebral cortex in a mouse model of fetal alcohol spectrum disorders. Alcohol Clin Exp Res. 2015 Mar; 39(3):445-54. PMID: 25703036.
      View in: PubMed
    10. Phelan KD, Shwe UT, Abramowitz J, Birnbaumer L, Zheng F. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11533-8. PMID: 25049394.
      View in: PubMed
    11. Zheng F, Phelan KD. The role of canonical transient receptor potential channels in seizure and excitotoxicity. Cells. 2014 Apr 09; 3(2):288-303. PMID: 24722470.
      View in: PubMed
    12. Kane CJ, Phelan KD, Douglas JC, Wagoner G, Johnson JW, Xu J, Phelan PS, Drew PD. Effects of ethanol on immune response in the brain: region-specific changes in adolescent versus adult mice. Alcohol Clin Exp Res. 2014 Feb; 38(2):384-91. PMID: 24033454.
      View in: PubMed
    13. Kane CJ, Phelan KD, Douglas JC, Wagoner G, Johnson JW, Xu J, Drew PD. Effects of ethanol on immune response in the brain: region-specific changes in aged mice. J Neuroinflammation. 2013 May 23; 10:66. PMID: 23701841.
      View in: PubMed
    14. Kane CJM, Drew PD, Phelan KD. Encyclopedia of Addictive Behaviors. Molecular Targets of Ethanol in the Developing Brain. 2013; 147.
    15. Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F. Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Mol Pharmacol. 2013 Feb; 83(2):429-38. PMID: 23188715.
      View in: PubMed
    16. Kane CJ, Phelan KD, Drew PD. Neuroimmune mechanisms in fetal alcohol spectrum disorder. Dev Neurobiol. 2012 Oct; 72(10):1302-16. PMID: 22623427.
      View in: PubMed
    17. Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Mol Pharmacol. 2012 Mar; 81(3):384-92. PMID: 22144671.
      View in: PubMed
    18. Kane CJM, Phelan KD, Douglas JC, Wagoner G, Johnson J, Xu J. Alchohol Exposure Activates the Neuroimmune System in Rodent Models. 2011.
    19. Phelan KD, Thrush CR, Newton BW. Critical Thinking Increases Among Initially Low Critical Thinkers After One Year of Medical School. IAMSE 15th Annual Meeting. 2011.
    20. C.J.M. Kane, Phelan KD, P.D. Drew. Neuroimmune Targets of Alcohol Across the Lifespan: The Role of Microglia. Alcholism and Stress: A Frameworkd for Future Treatment Strategies. 2011.
    21. Drew PD, Han L, Smith RR, Douglas JC, Phelan KD, Kane CJM. Role of Neuroimmune Signalling Molecules in the Neuropathology of Fetal Alcohol Spectrum Disorders. Society on Neuroimmune Pharmacology (SNIP) Meeting. 2011; 6 (1): S13.
    22. Kane CJ, Phelan KD, Han L, Smith RR, Xie J, Douglas JC, Drew PD. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-? agonists. Brain Behav Immun. 2011 Jun; 25 Suppl 1:S137-45. PMID: 21376806.
      View in: PubMed
    23. Phelan KD, K.D. Lockart, P.S. Phelan, J. Abromowitz, L. Birnbaumer, F. Zheng. Functional Role of Canonical Transient Receptor Potential Channels in Astrocytic Activation. 2011.
    24. F. Zheng, Phelan KD, MM Mock, UT Shwe, E. Valenzuela, Jr. Exploring the role of the hight affinity zinc site of the NMDA receptor using an NR2AH128A knockin mouse model. 2011.
    25. Phelan KD, MM Mock, UT Shwe, E. Valenzuela, Jr, H. Wu, S. Rhee, J. Abramowitz, L. Birnbaumer, F. Zheng. The role of TRPC3 in excitotoxicity in the mouse hippocampus. 2011.
    26. Kane CJM, Phelan KD, Han L, Smith RR, Xie J, Douglas JC, Drew PD. Protection of Neurons and Microglia Against Ethanol in a Mouse Model of Fetal Alcohol Spectrum Disorders by Peroxisome Proliferator Activated Receptor-gamma Agonists. Brain Behavior and Immunity. 2011; 25:S137-S145.
    27. Phelan KD, Desjardin, C.L, Thrush, C.R, Newton, B.W. Do low critical thinking medical students really exhibit poor academic performance?. 2011.
    28. C.J.M. Kane, J.C. Douglas, J. Xu, J. Johnson, G. Waggoner, D. Rose, Phelan KD. Brain Region- and Age-Specific Impact of Ethanol on Glial Derived Neuroinflammatory Molecules. 2011.
    29. Phelan KD, Carol R. Thrush, Bruce W. Newton. Correlations Between Critical Thinking Skills and MCAT Performance Revisited. 2010.
    30. Zheng F, Phelan KD. Pharmacological properties of metabotropic glutamate receptors that mediate epileptic firing in rat lateral septum. Society for Neuroscience Annual Meeting. 2008; Program #577.7/L8.
    31. Phelan KD, Mahler HR, Deere T, Cross C.B., Good C, Garcia-Rill E. Postnatal Maturational Properties of Rat Parafascicular Thalamic Neurons Recorded In Vitro. 2006; (3):889 - 1113.
    32. Shen PJ, Fu P, Phelan KD, Scott DJ, Layfield S, Tregear GW, Bathgate RA, Gundlach AL. Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems. Ann N Y Acad Sci. 2005 May; 1041:510-5. PMID: 15956753.
      View in: PubMed
    33. Chang JY, Phelan KD. The effects of oxysterols on cells of the nervous system. Sterols and Oxyserols: Chemistry, Biology and Pathobiology S J Fiesler (Ed ), Research Signpost publ. 2002; 175 - 200.
    34. Phelan KD, Falls WM. An analysis of the cyto- and myeloarchitectonic organization of trigeminal nucleus interpolaris in the rat. Somatosens Mot Res. 1989; 6(4):333 - 366.
    35. Phelan KD. The Intrinsic Organization and Connectivity of Trigeminal Nucleus Interpolaris and the Interstitial System of the Spinal Trigeminal Tract in the Rat. Ph.D. 1988.
    36. Gallagher, PJ, Lewis, MR, Phelan KD, Shinnick-Gallagher, P. Space Life Sciences Symposium: Three Decades of Life Science Research in Space. 1987; 3.
    37. Mehler WR, Pretorius JK, Phelan KD, Mantyh PW. Diencephalic afferent connections of the amygdala in the squirrel monkey with observations in the cat and rat. INSERM Symposium No 20. 1981; 105-120.
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