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Mathias Brochhausen

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiomedical Informatics, College of Medicine
Address474 Stephens Spine Center
4301 W Markham St.
Mail Slot # 782
Little Rock AR 72205
Phone501-603-1765
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    Collapse Research 
    Collapse research activities and funding
    UL1TR003107     (JAMES, LAURA P)Jul 1, 2019 - Jun 30, 2024
    NIH
    Expanding Translational Research in Arkansas
    Role: Co-Investigator
    U54TR001629     (JAMES, LAURA P)Sep 26, 2017 - Aug 31, 2019
    NIH
    Expanding Translational Research in Arkansas
    Role: Co-Investigator
    U24CA215109     (PRIOR, FRED WILLIAM)Sep 22, 2017 - Jul 31, 2022
    NIH
    TCIA Sustainment and Scalability - Platforms for Quantitative Imaging Informatics in Precision Medicine
    Role: Co-Investigator
    U24OD024957     (LEE, JEANNETTE Y.)Sep 23, 2016 - Aug 31, 2025
    NIH
    Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network
    Role: Co-Investigator
    U24HD090912     (HOBBS, CHARLOTTE A)Sep 21, 2016 - Sep 22, 2016
    NIH
    Data Coordinating and Operations Center (DCOC) for the IDeA States Pediatric Clinical Trials Network
    Role: Co-Investigator
    R01GM111324     (BROCHHAUSEN, MATHIAS)Mar 5, 2015 - Feb 28, 2021
    NIH
    CAFE: Comparative Assessment Framework for Environments of Trauma Care
    Role: Principal Investigator
    0040478 (124095-2)     (BROCHHAUSEN, MATHIAS)Feb 15, 2014 - Jan 31, 2018
    DHHS - Biomedical Advanced Research and Development Authority - Pass Through: University of Pittsburgh
    Addressing gaps in clinically useful evidence on drug-drug interactions
    Role: Principal Investigator
    R01LM011838     (BROCHHAUSEN, MATHIAS)Feb 15, 2014 - Jan 31, 2018
    DHHS - Biomedical Advanced Research and Development Authority - Pass Through: University of Pittsburgh
    Addressing gaps in clinically useful evidence on drug-drug interactions
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Singh N, Braun N, Hogan W, Brochhausen M. Integration of Biobanking Architecture with Genomics Data: Genomics Integrated Biobanking Ontology (GIBO). Stud Health Technol Inform. 2022 Jun 29; 295:302-303. PMID: 35773868.
      View in: PubMed
    2. Brochhausen M, Whorton JM, Zayas CE, Kimbrell MP, Bost SJ, Singh N, Brochhausen C, Sexton KW, Blobel B. Assessing the Need for Semantic Data Integration for Surgical Biobanks-A Knowledge Representation Perspective. J Pers Med. 2022 May 07; 12(5). PMID: 35629179.
      View in: PubMed
    3. Du X, Aristizabal-Henao JJ, Garrett TJ, Brochhausen M, Hogan WR, Lemas DJ. A Checklist for Reproducible Computational Analysis in Clinical Metabolomics Research. Metabolites. 2022 Jan 17; 12(1). PMID: 35050209.
      View in: PubMed
    4. Brochhausen M, Hester DM. Data Properties or Analytical Methodologies: Too Much Attention to the Former Ignores Concerns About the Latter. Am J Bioeth. 2021 12; 21(12):70-72. PMID: 34806969.
      View in: PubMed
    5. Brochhausen M, Bost SJ, Singh N, Brochhausen C, Blobel B. Understanding the Gap Between Information Models and Realism-Based Ontologies Using the Generic Component Model. Stud Health Technol Inform. 2021 Oct 27; 285:159-164. PMID: 34734868.
      View in: PubMed
    6. Blobel B, Ruotsalainen P, Brochhausen M. Autonomous Systems and Artificial Intelligence - Hype or Prerequisite for P5 Medicine? Stud Health Technol Inform. 2021 Oct 27; 285:3-14. PMID: 34734847.
      View in: PubMed
    7. Vita R, Zheng J, Jackson R, Dooley D, Overton JA, Miller MA, Berrios DC, Scheuermann RH, He Y, McGinty HK, Brochhausen M, Lin AY, Jain SB, Chibucos MC, Judkins J, Giglio MG, Feng IY, Burns G, Brush MH, Peters B, Stoeckert CJ. Standardization of assay representation in the Ontology for Biomedical Investigations. Database (Oxford). 2021 07 09; 2021. PMID: 34244718.
      View in: PubMed
    8. Hochheiser H, Jing X, Garcia EA, Ayvaz S, Sahay R, Dumontier M, Banda JM, Beyan O, Brochhausen M, Draper E, Habiel S, Hassanzadeh O, Herrero-Zazo M, Hocum B, Horn J, LeBaron B, Malone DC, Nytrø Ø, Reese T, Romagnoli K, Schneider J, Zhang LY, Boyce RD. A Minimal Information Model for Potential Drug-Drug Interactions. Front Pharmacol. 2020; 11:608068. PMID: 33762928.
      View in: PubMed
    9. Hoang L, Boyce RD, Bosch N, Stottlemyer B, Brochhausen M, Schneider J. Automatically classifying the evidence type of drug-drug interaction research papers as a step toward computer supported evidence curation. AMIA Annu Symp Proc. 2020; 2020:554-563. PMID: 33936429.
      View in: PubMed
    10. Fedorov A, Hancock M, Clunie D, Brochhausen M, Bona J, Kirby J, Freymann J, Pieper S, J W L Aerts H, Kikinis R, Prior F. DICOM re-encoding of volumetrically annotated Lung Imaging Database Consortium (LIDC) nodules. Med Phys. 2020 Nov; 47(11):5953-5965. PMID: 32772385.
      View in: PubMed
    11. Brochhausen M, Ball JW, Sanddal ND, Dodd J, Braun N, Bost S, Utecht J, Winchell RJ, Sexton KW. Collecting data on organizational structures of trauma centers: the CAFE web service. Trauma Surg Acute Care Open. 2020; 5(1):e000473. PMID: 32789188.
      View in: PubMed
    12. Blobel B, Ruotsalainen P, Brochhausen M, Oemig F, Uribe GA. Autonomous Systems and Artificial Intelligence in Healthcare Transformation to 5P Medicine - Ethical Challenges. Stud Health Technol Inform. 2020 Jun 16; 270:1089-1093. PMID: 32570549.
      View in: PubMed
    13. Bost S, Ball JN, Sanddal ND, Dodd J, Utecht J, Winchell RJ, Brochhausen M. ACS COT participates in study to develop comparative data on trauma care organization. Bull Am Coll Surg. 2020 Apr; 105(4):43-48. PMID: 34531607.
      View in: PubMed
    14. Bona JP, Brochhausen M, Hogan WR. Enhancing the drug ontology with semantically-rich representations of National Drug Codes and RxNorm unique concept identifiers. BMC Bioinformatics. 2019 Dec 23; 20(Suppl 21):708. PMID: 31865907.
      View in: PubMed
    15. Utecht J, Ball J, Bowman SM, Dodd J, Judkins J, Maxson RT, Nabaweesi R, Pradhan R, Sanddal ND, Winchell RJ, Brochhausen M. Development and Validation of a Controlled Vocabulary: An OWL Representation of Organizational Structures of Trauma Centers and Trauma Systems. Stud Health Technol Inform. 2019 Aug 21; 264:403-407. PMID: 31437954.
      View in: PubMed
    16. Bona JP, Prior FW, Zozus MN, Brochhausen M. Enhancing Clinical Data and Clinical Research Data with Biomedical Ontologies - Insights from the Knowledge Representation Perspective. Yearb Med Inform. 2019 Aug; 28(1):140-151. PMID: 31419826.
      View in: PubMed
    17. Boyce RD, Ragueneau-Majlessi I, Yu J, Tay-Sontheimer J, Kinsella C, Chou E, Brochhausen M, Judkins J, Gufford BT, Pinkleton BE, Cooney R, Paine MF, McCune JS. Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers. AMIA Annu Symp Proc. 2018; 2018:279-287. PMID: 30815066.
      View in: PubMed
    18. Judkins J, Tay-Sontheimer J, Boyce RD, Brochhausen M. Extending the DIDEO ontology to include entities from the natural product drug interaction domain of discourse. J Biomed Semantics. 2018 05 09; 9(1):15. PMID: 29743102.
      View in: PubMed
    19. Blobel B, Brochhausen M, Ruotsalainen P. Modeling the Personal Health Ecosystem. Stud Health Technol Inform. 2018; 249:3-16. PMID: 29866950.
      View in: PubMed
    20. Brochhausen M, Bona J, Blobel B. The Role of Axiomatically-Rich Ontologies in Transforming Medical Data to Knowledge. Stud Health Technol Inform. 2018; 249:38-49. PMID: 29866954.
      View in: PubMed
    21. Utecht J, Brochhausen M, Judkins J, Schneider J, Boyce RD. Formalizing Evidence Type Definitions for Drug-Drug Interaction Studies to Improve Evidence Base Curation. Stud Health Technol Inform. 2017; 245:960-964. PMID: 29295242.
      View in: PubMed
    22. Hogan WR, Wagner MM, Brochhausen M, Levander J, Brown ST, Millett N, DePasse J, Hanna J. The Apollo Structured Vocabulary: an OWL2 ontology of phenomena in infectious disease epidemiology and population biology for use in epidemic simulation. J Biomed Semantics. 2016 Aug 18; 7:50. PMID: 27538448.
      View in: PubMed
    23. Judkins J, Utecht J, Brochhausen M. Easy Extraction of Terms and Definitions with OWL2TL. CEUR Workshop Proc. 2016 Aug; 1747. PMID: 28035214.
      View in: PubMed
    24. Utecht J, Judkins J, Otte JN, Colvin T, Rogers N, Rose R, Alvi M, Hicks A, Ball J, Bowman SM, Maxson RT, Nabaweesi R, Pradhan R, Sanddal ND, Tudoreanu ME, Winchell RJ, Brochhausen M. OOSTT: a Resource for Analyzing the Organizational Structures of Trauma Centers and Trauma Systems. CEUR Workshop Proc. 2016 Aug; 1747. PMID: 28217041.
      View in: PubMed
    25. Brochhausen M, Empey PE, Schneider J, Hogan WR, Boyce RD. Adding evidence type representation to DIDEO. CEUR Workshop Proc. 2016 Aug; 1747. PMID: 33139971.
      View in: PubMed
    26. Hicks A, Hanna J, Welch D, Brochhausen M, Hogan WR. The ontology of medically related social entities: recent developments. J Biomed Semantics. 2016 Jul 12; 7:47. PMID: 27406187.
      View in: PubMed
    27. Brochhausen M, Zheng J, Birtwell D, Williams H, Masci AM, Ellis HJ, Stoeckert CJ. OBIB-a novel ontology for biobanking. J Biomed Semantics. 2016; 7:23. PMID: 27148435.
      View in: PubMed
    28. Bandrowski A, Brinkman R, Brochhausen M, Brush MH, Bug B, Chibucos MC, Clancy K, Courtot M, Derom D, Dumontier M, Fan L, Fostel J, Fragoso G, Gibson F, Gonzalez-Beltran A, Haendel MA, He Y, Heiskanen M, Hernandez-Boussard T, Jensen M, Lin Y, Lister AL, Lord P, Malone J, Manduchi E, McGee M, Morrison N, Overton JA, Parkinson H, Peters B, Rocca-Serra P, Ruttenberg A, Sansone SA, Scheuermann RH, Schober D, Smith B, Soldatova LN, Stoeckert CJ, Taylor CF, Torniai C, Turner JA, Vita R, Whetzel PL, Zheng J. The Ontology for Biomedical Investigations. PLoS One. 2016; 11(4):e0154556. PMID: 27128319.
      View in: PubMed
    29. Utecht J, Brochhausen M. Measuring the Usability of Triple Stores for Knowledge Management on Trauma Care Organizations. CEUR Workshop Proc. 2015 Dec; 1546:241-242. PMID: 27013932.
      View in: PubMed
    30. Smith B, Arabandi S, Brochhausen M, Calhoun M, Ciccarese P, Doyle S, Gibaud B, Goldberg I, Kahn CE, Overton J, Tomaszewski J, Gurcan M. Biomedical imaging ontologies: A survey and proposal for future work. J Pathol Inform. 2015; 6:37. PMID: 26167381.
      View in: PubMed
    31. Ayvaz S, Horn J, Hassanzadeh O, Zhu Q, Stan J, Tatonetti NP, Vilar S, Brochhausen M, Samwald M, Rastegar-Mojarad M, Dumontier M, Boyce RD. Toward a complete dataset of drug-drug interaction information from publicly available sources. J Biomed Inform. 2015 Jun; 55:206-17. PMID: 25917055.
      View in: PubMed
    32. Bian J, Xie M, Hudson TJ, Eswaran H, Brochhausen M, Hanna J, Hogan WR. CollaborationViz: interactive visual exploration of biomedical research collaboration networks. PLoS One. 2014; 9(11):e111928. PMID: 25405477.
      View in: PubMed
    33. Brochhausen M, Schneider J, Malone D, Empey PE, Hogan WR, Boyce RD. Towards a foundational representation of potential drug-drug interaction knowledge. CEUR Workshop Proc. 2014 Oct; 1309:16-31. PMID: 33139970.
      View in: PubMed
    34. Fransson MN, Rial-Sebbag E, Brochhausen M, Litton JE. Toward a common language for biobanking. Eur J Hum Genet. 2015 Jan; 23(1):22-8. PMID: 24713663.
      View in: PubMed
    35. Ayvaz S, Zhu Q, Hochheiser H, Brochhausen M, Horn J, Dumontier M, Samwald M, Boyce RD. Drug-drug interaction data source survey and linking. AMIA Jt Summits Transl Sci Proc. 2014; 2014:16. PMID: 25717393.
      View in: PubMed
    36. Hanna J, Joseph E, Brochhausen M, Hogan WR. Building a drug ontology based on RxNorm and other sources. J Biomed Semantics. 2013 Dec 18; 4(1):44. PMID: 24345026.
      View in: PubMed
    37. Brochhausen M, Fransson MN, Kanaskar NV, Eriksson M, Merino-Martinez R, Hall RA, Norlin L, Kjellqvist S, Hortlund M, Topaloglu U, Hogan WR, Litton JE. Developing a semantically rich ontology for the biobank-administration domain. J Biomed Semantics. 2013 Oct 08; 4(1):23. PMID: 24103726.
      View in: PubMed
    38. Blobel B, Goossen W, Brochhausen M. Clinical modeling--a critical analysis. Int J Med Inform. 2014 Jan; 83(1):57-69. PMID: 24161541.
      View in: PubMed
    39. Slaughter L, Brochhausen M, Hogan W, Nytrø Ø. The core clinical protocol ontology (C2PO): A realist ontology for representing the recommendations within clinical guidelines. Stud Health Technol Inform. 2013; 192:997. PMID: 23920771.
      View in: PubMed
    40. Brochhausen M, Almeida MA, Slaughter M. Towards a formal representation of document acts and the resulting legal entities. 2013; 120-139.
    41. Hogan WR, Brochhausen M, Smith B. A Call to Urgent Action On Standard Ontologies for Translational Science. Clinical and Translation Science 6(2). 2013; 157.
    42. Hogan WR, Hanna J, Joseph E, Brochhausen M. Towards a Consistent and Scientifically Accurate Drug Ontology. CEUR Workshop Proc. 2013; 1060:68-73. PMID: 27867326.
      View in: PubMed
    43. Brochhausen M, Fransson MN, Eriksson M, Merino-Martinez R, Norlin L, Kjellqvist S, Anderberg M, Hogan WR, Litton JE. Developing an ontology for sharing biobank data based on the BBMRI minimum data set MIABIS. Ontologies in Biomedicine and Life Sciences (OBML) 2012. 2012.
    44. Blobel B, Brochhausen M, González C, Lopez DM, Oemig F. A system-theoretical, architecture-based approach to ontology management. Stud Health Technol Inform. 2012; 180:1087-9. PMID: 22874362.
      View in: PubMed
    45. Martin L, Anguita A, Graf N, Tsiknakis M, Brochhausen M, Rüping S, Bucur A, Sfakianakis S, Sengstag T, Buffa F, Stenzhorn H. ACGT: advancing clinico-genomic trials on cancer - four years of experience. Stud Health Technol Inform. 2011; 169:734-8. PMID: 21893844.
      View in: PubMed
    46. Brochhausen M, Blobel B. Architectural approach for providing relations in biomedical terminologies and ontologies. Stud Health Technol Inform. 2011; 169:739-43. PMID: 21893845.
      View in: PubMed
    47. EpSOS contributers. epSOS learnings: sematnics a matter of patient safety and the ultimate health care delivery system. Swiss Medical Informatics. 2011; (73):23-26.
    48. Brochhausen M, Spear AD, Cocos C, Weiler G, Martín L, Anguita A, Stenzhorn H, Daskalaki E, Schera F, Schwarz U, Sfakianakis S, Kiefer S, Dörr M, Graf N, Tsiknakis M. The ACGT Master Ontology and its applications--towards an ontology-driven cancer research and management system. J Biomed Inform. 2011 Feb; 44(1):8-25. PMID: 20438862.
      View in: PubMed
    49. Smith B, Brochhausen M. Putting biomedical ontologies to work. Methods Inf Med. 2010; 49(2):135-40. PMID: 20135080.
      View in: PubMed
    50. Brochhausen M, Slaughter L, Stenzhorn H, Graf N. User-specific perspectives on ontologies. Stud Health Technol Inform. 2010; 156:114-21. PMID: 20543346.
      View in: PubMed
    51. Stenzhorn H, Weiler G, Brochhausen M, Schera F, Kritsotakis V, Tsiknakis M, Kiefer S, Graf N. The ObTiMA system - ontology-based managing of clinical trials. Stud Health Technol Inform. 2010; 160(Pt 2):1090-4. PMID: 20841852.
      View in: PubMed
    52. Grigonyte G, Brochhausen M, Martin L, Tsiknakis M, Haller J. Evaluating Ontologies with NLP-Based Terminologies – A Case Study on ACGT and Its Master Ontology. Formal Ontology in Information Systems - Proceedings of the Sixth International Conference (FOIS 2010). 2010.
    53. Brochhausen M, Slaughter L. Patient Empowerment by Ontology-Based Multi-lingual Systems. IFMBE Proceedings 25/XII. 2009.
    54. Wagner M, Breiner T, Betz T, Bernhardt I, Pütz N, Weichert F, Shamaa A, Brochhausen M, Awad S, Richards T, Groh A, Linder R, Landes CA. [Virtual tissue. Quaoaring]. Pathologe. 2008 Nov; 29 Suppl 2:123-8. PMID: 19039616.
      View in: PubMed
    55. Tsiknakis M, Brochhausen M, Nabrzyski J, Pucacki J, Sfakianakis SG, Potamias G, Desmedt C, Kafetzopoulos D. A semantic grid infrastructure enabling integrated access and analysis of multilevel biomedical data in support of postgenomic clinical trials on cancer. IEEE Trans Inf Technol Biomed. 2008 Mar; 12(2):205-17. PMID: 18348950.
      View in: PubMed
    56. Martin L, Anguita A, Maojo V, Bonsma E, Bucur AID, Vrijnsen J, Brochhausen M, Cocos C, Stenzhorn H, Tsiknakis M, Doerr M, Kondylakis H. Ontology Based Integration of Distributed and Heterogeneous Data Sources in ACGT. Proceedings of the First International Conference on Health Informatics, HEALTHINF 2008. 2008.
    57. Brochhausen M. How Upper Level Ontologies Deal With Functions and Other Realizable Entities. Biomedical Computation Review. 2008; 25.
    58. Brochhausen M, Weiler G, Cocos C, Stenzhorn H, Graf N, Doerr M, Tsinakis M. The ACGT Master Ontology on Cancer - a New Terminology Source for Oncological Practice. Proceedings of the 21st IEEE International Symposium on Computer-Based Medical Systems. 2008.
    59. Smith B, Brochhausen M. Establishing and harmonizing ontologies in an interdisciplinary health care clinical research environment. Stud Health Technol Inform. 2008; 134:219-33. PMID: 18376049.
      View in: PubMed
    60. Brochhausen M, Weiler G, Martin L, Cocos C, Stenzhorn H, Graf N, Doerr M, Tsinakis M, Smith B. Applications of the ACGT Master Ontology on Cancer. Proceedings of 4th International IFIP Workshop On Semantic Web & Web Semantics (OTM 2008: Workshops), LNCS 5333. 2008.
    61. Tsiknakis M, Rueping S, Martin L, Sfakianakis S, Bucur A, Sengstag T, Brochhausen M, Pucaski J, Graf N. Developing a European grid infrastructure for cancer research: vision, architecture and services. Ecancermedicalscience. 2007; 1:56. PMID: 22275955.
      View in: PubMed
    62. Weiler G, Brochhausen M, Graf N, Schera F, Hoppe A, Kiefer S. Ontology based data management systems for post-genomic clinical trials within a European Grid Infrastructure for Cancer Research. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:6435-8. PMID: 18003495.
      View in: PubMed
    63. Hainaut JL, Rundensteiner EA, Kirchberg M, Bertolotto M, Brochhausen M, Chen P, Sisaid Cherfi S, Doerr M, Han H, Hartmann S, Parsons J, Poels G, Rolland C, Trujillo J, Yu E, Zimlanyi E. Advances in Conceptual Modeling - Foundations and Applications · ER 2007 Workshops CMLSA, FP-UML, ONISW, QoIS, RIGiM, SeCoGIS, Auckland, New Zealand, November 5-9, 2007, Proceedings. 2007.
    64. Brochhausen M. The derives_from relation in biomedical ontologies. Stud Health Technol Inform. 2006; 124:769-74. PMID: 17108607.
      View in: PubMed
    65. Brochhausen M. Wissenschaftsphilosophische Aspekte der Evolutionären Anthropologie. Studie zum Ursprung des anatomisch modernen Menschen. Gardez! Verlag. 2005.
    66. Brochhausen M. Evolution und Gesellschaft von einem naturalistischen Standpunkt aus. Erwägen Wissen Ethik. 2005; 16(3):378-380.
    67. Brochhausen C, Brochhausen M, Seyberth HW. In wessen bestem Interesse? Mögliche finanzielle Interessenkonflikte in der klinischen Forschung und ihre Relevanz für die Pädiatrie. 2003; 251-263.
    68. Brochhausen C, Brochhausen M, Seyberth HW. Pädiatrie zwischen Patientenschutz und Therapiesicherheit – eine interdisziplinäre Herausforderung. 2002; 458-471.
    69. Brochhausen M. Krankheit als subjektives Ereignis. 2001; 13-20.
    70. Brochhausen C, Brochhausen M. Relativistische Wissenschaftskritik als epistemologischer Ansatz in der Historischen Epidemiologie. 2001; 59-72.
    71. Kerstjens DP, Brochhausen M. Krankheiten als natürliche Arten. Schnittstelle Mensch – Umwelt in Vergangenheit, Gegenwart und Zukunft. 2000.
    72. Brochhausen M. Understanding Recent Apes As Parallel Models in Paleoanthropology. Anthropologie. (2):115-118.
    73. Schneider L, Brochhausen M, Koepsell D. On Some Best Practices in Large-Scale Ontology Development: The Chronious Ontology Suite as a Case Study. Formal Ontology Meets Industry 5th International Workshop Proceedings.
    74. Schneider L, Brochhausen M. The CHRONIUS Ontology Suite: Methodology and Design Principles. International Conference on Biomedical Ontologies (ICBO) 2011, University at Buffalo, Buffalo NY, 2011.
    75. Elmasri R, Doerr M, Brochhausen M, Han H. Proceedings of the 2nd International Workshop on Ontologies and Information Systems for the Semantic Web, ONISW 2008.
    76. Schulz S, Brochhausen M, Hoehndorf R. Higgs Bosons, Mars Missions, and Unicorn Delusions: How to Deal with Terms of Dubious Reference in Scientific Ontologies. International Conference on Biomedical Ontologies (ICBO) 2011, University at Buffalo, Buffalo NY, 2011.
    77. Almeida MB, Slaughter L, Brochhausen M. Towards an ontology of document acts: Introducing a document act template for healthcare. OTM 2012 Workshop, LNCS 7567.
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