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Eric Peterson

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
DivisionPharmacology Antibody-Based Meds
AddressB110A Biomedical Research I
325 S. Elm St.
Mail Slot # 611
Little Rock AR 72205
Phone501-686-7335
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiomedical Informatics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    R21DA041822     (TACKETT, ALAN)Jul 1, 2016 - Jun 30, 2019
    NIH
    Technology for Identification of Epiproteomes in Tissue Samples
    Role: Co-Investigator

    R01DA039195     (OWENS, SAMUEL)Apr 15, 2015 - Aug 31, 2019
    NIH/Nat. Inst. on Drug Abuse
    Pharmacology and Therapy for MDPV and alpha-PVP Like Drugs of Abuse
    Role: Co-Investigator

    R01DA036600     (PETERSON, ERIC C)Jul 1, 2014 - Jun 30, 2019
    NIH
    Antibody Gene Therapy for Methamphetamine Abuse
    Role: Principal Investigator

    R01DA026423     (PETERSON, ERIC C)Apr 1, 2009 - Mar 31, 2014
    NIH
    Antibody-nanoparticle conjugates for the treatment of methamphetamine abuse
    Role: Principal Investigator

    U01DA023900     (OWENS, SAMUEL)Sep 30, 2007 - Aug 31, 2013
    NIH/Nat. Inst. on Drug Abuse
    Active Immunization for Treating Methamphetamine Abuse
    Role: Co-Investigator

    F32DA018039     (PETERSON, ERIC)Sep 5, 2004 - Sep 4, 2007
    NIH/Nat. Inst. on Drug Abuse
    Single Chain Antibody Medications for (+) METH Abuse
    Role: Principal Investigator

    P20GM103429     (CORNETT, LAWRENCE E)Sep 30, 2001 - Apr 30, 2025
    NIH
    Partnerships for Biomedical Research in Arkansas
    Role: Co-Investigator

    R01DA011560     (OWENS, SAMUEL)Jan 5, 1998 - Mar 31, 2012
    NIH/Nat. Inst. on Drug Abuse
    Antibody-based Therapy for Methamphetamine Abuse
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon-McGill S, Spencer HJ, Dranoff JA. Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatol Commun. 2021 Aug 25. PMID: 34558847.
      View in: PubMed
    2. Chappell K, Graw S, Washam CL, Storey AJ, Bolden C, Peterson EC, Byrum SD. PTMViz: a tool for analyzing and visualizing histone post translational modification data. BMC Bioinformatics. 2021 May 26; 22(1):275. PMID: 34039258.
      View in: PubMed
    3. Li W, Chen C, Drelich A, Martinez DR, Gralinski LE, Sun Z, Schäfer A, Kulkarni SS, Liu X, Leist SR, Zhelev DV, Zhang L, Kim YJ, Peterson EC, Conard A, Mellors JW, Tseng CK, Falzarano D, Baric RS, Dimitrov DS. Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2020 11 24; 117(47):29832-29838. PMID: 33139569.
      View in: PubMed
    4. Graw S, Tang J, Zafar MK, Byrd AK, Bolden C, Peterson EC, Byrum SD. proteiNorm - A User-Friendly Tool for Normalization and Analysis of TMT and Label-Free Protein Quantification. ACS Omega. 2020 Oct 13; 5(40):25625-25633. PMID: 33073088.
      View in: PubMed
    5. Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS. High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models. Cell. 2020 10 15; 183(2):429-441.e16. PMID: 32941803.
      View in: PubMed
    6. Hay CE, Ewing LE, Hambuchen MD, Zintner SM, Small JC, Bolden CT, Fantegrossi WE, Margaritis P, Owens SM, Peterson EC. The Development and Characterization of an scFv-Fc Fusion-Based Gene Therapy to Reduce the Psychostimulant Effects of Methamphetamine Abuse. J Pharmacol Exp Ther. 2020 07; 374(1):16-23. PMID: 32245884.
      View in: PubMed
    7. McClenahan SJ, Kormos CM, Gunnell M, Hambuchen MD, Lamb P, Carroll FI, Lewin AH, Peterson EC, Owens SM. Design, synthesis and biological evaluation of a bi-specific vaccine against a-pyrrolidinovalerophenone (a-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats. Vaccine. 2020 01 10; 38(2):336-344. PMID: 31629568.
      View in: PubMed
    8. Hay CE, Gonzalez GA, Ewing LE, Reichard EE, Hambuchen MD, Nanaware-Kharade N, Alam S, Bolden CT, Owens SM, Margaritis P, Peterson EC. Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse. PLoS One. 2018; 13(6):e0200060. PMID: 29958300.
      View in: PubMed
    9. Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA. Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope. Cell Rep. 2017 Dec 12; 21(11):3243-3255. PMID: 29241550.
      View in: PubMed
    10. Mueller-Kronast NH, Zaidat OO, Froehler MT, Jahan R, Aziz-Sultan MA, Klucznik RP, Saver JL, Hellinger FR, Yavagal DR, Yao TL, Liebeskind DS, Jadhav AP, Gupta R, Hassan AE, Martin CO, Bozorgchami H, Kaushal R, Nogueira RG, Gandhi RH, Peterson EC, Dashti SR, Given CA, Mehta BP, Deshmukh V, Starkman S, Linfante I, McPherson SH, Kvamme P, Grobelny TJ, Hussain MS, Thacker I, Vora N, Chen PR, Monteith SJ, Ecker RD, Schirmer CM, Sauvageau E, Abou-Chebl A, Derdeyn CP, Maidan L, Badruddin A, Siddiqui AH, Dumont TM, Alhajeri A, Taqi MA, Asi K, Carpenter J, Boulos A, Jindal G, Puri AS, Chitale R, Deshaies EM, Robinson DH, Kallmes DF, Baxter BW, Jumaa MA, Sunenshine P, Majjhoo A, English JD, Suzuki S, Fessler RD, Delgado Almandoz JE, Martin JC, Haussen DC. Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke: Primary Results of the STRATIS Registry. Stroke. 2017 10; 48(10):2760-2768. PMID: 28830971.
      View in: PubMed
    11. Menaker SA, Shah SS, Snelling BM, Sur S, Starke RM, Peterson EC. Current applications and future perspectives of robotics in cerebrovascular and endovascular neurosurgery. J Neurointerv Surg. 2018 Jan; 10(1):78-82. PMID: 28821626.
      View in: PubMed
    12. Reichard EE, Nanaware-Kharade N, Gonzalez GA, Thakkar S, Owens SM, Peterson EC. PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance. Pharm Res. 2016 12; 33(12):2954-2966. PMID: 27620175.
      View in: PubMed
    13. Peterson EC, Ewing LE. Nanomedicine: Going small to beat the high. Nat Nanotechnol. 2016 07; 11(7):580-1. PMID: 26974956.
      View in: PubMed
    14. Nanaware-Kharade N, Thakkar S, Gonzalez GA, Peterson EC. A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments. Sci Rep. 2015 Jul 10; 5:12060. PMID: 26159352.
      View in: PubMed
    15. Peterson EC, Hambuchen MD, Tawney RL, Gunnell MG, Cowell JL, Lay JO, Blough BE, Carroll FI, Owens SM. Simple radiometric method for accurately quantitating epitope densities of hapten-protein conjugates with sulfhydryl linkages. Bioconjug Chem. 2014 Dec 17; 25(12):2112-5. PMID: 25426820.
      View in: PubMed
    16. Thakkar S, Nanaware-Kharade N, Celikel R, Peterson EC, Varughese KI. Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering. Sci Rep. 2014 Jan 14; 4:3673. PMID: 24419156.
      View in: PubMed
    17. Peterson EC, Gentry WB, Owens SM. Customizing monoclonal antibodies for the treatment of methamphetamine abuse: current and future applications. Adv Pharmacol. 2014; 69:107-27. PMID: 24484976.
      View in: PubMed
    18. Peterson EC, Celikel R, Gokulan K, Varughese KI. Structural characterization of a therapeutic anti-methamphetamine antibody fragment: oligomerization and binding of active metabolites. PLoS One. 2013; 8(12):e82690. PMID: 24349338.
      View in: PubMed
    19. Nanaware-Kharade N, Gonzalez GA, Lay JO, Hendrickson HP, Peterson EC. Therapeutic anti-methamphetamine antibody fragment-nanoparticle conjugates: synthesis and in vitro characterization. Bioconjug Chem. 2012 Sep 19; 23(9):1864-72. PMID: 22873701.
      View in: PubMed
    20. Nanware-Kharade N, Guilermo A. Gonzalez III, Jackson O. Lay Jr., Howard P. Hendrickson, Eric C. Peterson. Theraputic Anti-Methamphetamine Antibody Fragment-Nanoparticle Conjugates: Synthesis and In Vitro Characterization. Bioconjug Chem. 2012; 23(9):1864-72, PMID 22873701.
    21. EC Peterson, WB Gentry, SM Owens. Customizing Monoclonal Antibodies for the Treatment of Methamphetamine Abuse: Current and Future Apllications. Advances in Pharmacology. 2012.
    22. Owens SM, Atchley WT, Hambuchen MD, Peterson EC, Gentry WB. Monoclonal antibodies as pharmacokinetic antagonists for the treatment of (+)-methamphetamine addiction. CNS Neurol Disord Drug Targets. 2011 Dec; 10(8):892-8. PMID: 22229314.
      View in: PubMed
    23. Carroll FI, Blough BE, Pidaparthi RR, Abraham P, Gong PK, Deng L, Huang X, Gunnell M, Lay JO, Peterson EC, Owens SM. Synthesis of mercapto-(+)-methamphetamine haptens and their use for obtaining improved epitope density on (+)-methamphetamine conjugate vaccines. J Med Chem. 2011 Jul 28; 54(14):5221-8. PMID: 21682289.
      View in: PubMed
    24. DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ. Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci. 2011 Apr; 120(2):381-91. PMID: 21227907.
      View in: PubMed
    25. Owens SM, Atchley WT, Hambuchen MD, E. Peterson, Gentry WB. Monoclonal antibodies as pharmacokinetics antagonists for the treatment of (+)-methamphetamine addiction. CNS Neurol Disord Drug Targets. 2011; 10(8):892-898, PMID 22229314.
    26. Carroll FI, Abraham P, Gong PK, Pidaparthi RR, Blough BE, Che Y, Hampton A, Gunnell M, Lay JO, Peterson EC, Owens SM. The synthesis of haptens and their use for the development of monoclonal antibodies for treating methamphetamine abuse. J Med Chem. 2009 Nov 26; 52(22):7301-9. PMID: 19877685.
      View in: PubMed
    27. Celikel R, Peterson EC, Owens SM, Varughese KI. Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine. Protein Sci. 2009 Nov; 18(11):2336-45. PMID: 19760665.
      View in: PubMed
    28. Celikel R, EC Peterson, SM Owens, KI Varughese. High Resolution Crystal Structures of a Therapeutic Single Chain Antibody in Complex with two Drugs of Abuse – methamphetamine and 3,4 methylenedioxy-N-methamphetamine. Protein Sci. 2009; 18(11):2336-45, PMID 19760665.
    29. Laurenzana EM, HP Hendrickson, D Carpenter, EC Peterson, WB Gentry, CM West, FI Carroll, SM Owens. Functional and Biological Determinants of the Time Course of Action of Anti-(+)-Methamphetamine Monoclonal Antibodies in Rats. Vaccine. 2009; 27(50):7011-20, PMID 19800446.
    30. Laurenzana EM, Hendrickson HP, Carpenter D, Peterson EC, Gentry WB, West M, Che Y, Carroll FI, Owens SM. Functional and biological determinants affecting the duration of action and efficacy of anti-(+)-methamphetamine monoclonal antibodies in rats. Vaccine. 2009 Nov 23; 27(50):7011-20. PMID: 19800446.
      View in: PubMed
    31. Peterson EC, Owens SM. Designing immunotherapies to thwart drug abuse. Mol Interv. 2009 Jun; 9(3):119-24. PMID: 19592672.
      View in: PubMed
    32. Peterson EC, Laurenzana EM, Atchley WT, Hendrickson HP, Owens SM. Development and preclinical testing of a high-affinity single-chain antibody against (+)-methamphetamine. J Pharmacol Exp Ther. 2008 Apr; 325(1):124-33. PMID: 18192498.
      View in: PubMed
    33. Peterson EC, Henry RL, Owens SM. Drug Addiction: From Basic Research to Therapy. Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuse. 2008; 5.
    34. Peterson EC, Gunnell M, Che Y, Goforth RL, Carroll FI, Henry R, Liu H, Owens SM. Using hapten design to discover therapeutic monoclonal antibodies for treating methamphetamine abuse. J Pharmacol Exp Ther. 2007 Jul; 322(1):30-9. PMID: 17452421.
      View in: PubMed
    35. Goforth RL, Peterson EC, Yuan J, Moore MJ, Kight AD, Lohse MB, Sakon J, Henry RL. Regulation of the GTPase cycle in post-translational signal recognition particle-based protein targeting involves cpSRP43. J Biol Chem. 2004 Oct 08; 279(41):43077-84. PMID: 15292240.
      View in: PubMed
    36. Yuan J, Kight A, Goforth RL, Moore M, Peterson EC, Sakon J, Henry R. ATP stimulates signal recognition particle (SRP)/FtsY-supported protein integration in chloroplasts. J Biol Chem. 2002 Aug 30; 277(35):32400-4. PMID: 12105232.
      View in: PubMed
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