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Alan Diekman

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
AddressB421E Biomedical Research I
325 S. Elm St.
Mail Slot # 516
Little Rock AR 72205
Phone501-686-5812
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentUrology, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    Summer Research Fellowship     (Townsley)May 1, 2022 - Jul 30, 2022
    Urology Care Foundation of the American Urologic Association
    Impact of genetic polymorphism on galectin-3 oligomerization: Implications for prostate cancer
    Role: Other
    Sturgis Foundation Award     (Diekman)Jan 1, 2022 - Dec 31, 2023
    Sturgis Foundation
    Galectin-3 single nucleotide polymorphisms as etiological factors in type 1 diabetes
    Role: Principal Investigator
    Supplement to HRSA Medical Student Education Progr     (Turnage)Jul 1, 2021 - Jun 30, 2022
    Health Resources and Services Administration
    Value-Based Medical Student Education Training Program
    Role: Other
    Summer Research Fellowship     (Kuykendall)Jun 1, 2021 - Aug 15, 2021
    Urology Care Foundation of the American Urologic Association
    Galectin-3 as a biomarker for prostate cancer screening
    Role: Other
    Summer Research Fellowship     (Ebijoyeldhas)May 1, 2020 - Jul 30, 2020
    Urology Care Foundation of the American Urologic Association
    Impact of genetic polymorphism on galectin-3 function: Implications for prostate cancer
    Role: Other
    T99HP33556     (TURNAGE, RICHARD H)Sep 1, 2019 - Jun 30, 2024
    Health Resources & Services Administration
    Medical Student Ed grant for Arkansas - Continuation - Revision
    Role: Principal Investigator
    Summer Research Fellowship     (Cranford)Jun 1, 2019 - Aug 15, 2019
    Urology Care Foundation of the American Urologic Association
    Impact of galectin-3 genetic polymorphism on zinc-binding and implications for prostate cancer
    Role: Other
    Summer Research Fellowship     (Gongola)May 29, 2018 - Aug 4, 2018
    Urology Care Foundation of the American Urologic Association
    Investigation of galectin-3 as a zinc-binding protein and implications for prostate cancer
    Role: Other
    Summer Research Fellowship     (Fiedling)May 29, 2017 - Aug 4, 2017
    Urology Care Foundation of the American Urologic Association
    Investigation of serum galectin-3 as a biomarker for prostate cancer screening
    Role: Other
    ABCRP FY17     (DIEKMAN, ALAN)Sep 1, 2016 - Sep 14, 2020
    UAMS Executive Breast Committee
    No FP attached
    Role: Principal Investigator
    ABCRP Pilot Award     (Diekman)Sep 1, 2016 - Mar 30, 2017
    Arkansas Breast Cancer Research Program
    Galectin-3 genetic and phenotypic polymorphism in breast cancer
    Role: Principal Investigator
    Foundation award     (DIEKMAN, ALAN)Jul 1, 2016 - Jun 30, 2017
    UAMS
    Seeds of Science
    Role: Principal Investigator
    Foundationaward     (DIEKMAN, ALAN)Jul 1, 2016 - Jun 30, 2017
    UAMS
    Seeds of Science
    Role: Principal Investigator
    Summer Research Fellowship     (Ubeda)May 30, 2016 - Aug 5, 2016
    Urology Care Foundation of the American Urologic Association
    Impact of genetic polymorphism and zinc on proteolytic cleavage of galectin-3 by prostate specific antigen (PSA)
    Role: Other
    Summer Research Fellowship     (Mansfield)May 30, 2016 - Aug 5, 2016
    Urology Care Foundation of the American Urologic Association
    Evaluation of galectin-3 as a biomarker for prostate cancer screening
    Role: Other
    Summer Research Fellowship     (Ubeda)May 30, 2016 - Aug 5, 2016
    Urology Care Foundation of the American Urologic Association
    Impact of genetic polymorphism and zinc on proteolytic cleavage of galectin-3 by prostate specific antigen (PSA)
    Role: Other
    Barton Award     (DIEKMAN, ALAN)Dec 1, 2015 - Nov 30, 2016
    UAMS College of Medicine
    Impact of genetic polymorphism on the ability of galectin-3 to function as a zinc-binding protein
    Role: Principal Investigator
    BartonAward     (DIEKMAN, ALAN)Dec 1, 2015 - Nov 30, 2016
    UAMS College of Medicine
    Impact of genetic polymorphism on the ability of galectin-3 to function as a zinc-binding protein
    Role: Principal Investigator
    117-1002727     (DIEKMAN, ALAN)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    Diekman Start-up
    Role: Principal Investigator
    Summer Research Fellowship     (Barrett)May 15, 2015 - Jul 15, 2015
    Urology Care Foundation of the American Urologic Association
    Impact of divalent cations on proteolytic cleavage of galectin-3 by prostate specific antigen (PSA
    Role: Other
    Summer Research Fellowship     (Lavender)May 15, 2015 - Jul 15, 2015
    Urology Care Foundation of the American Urologic Association
    Identification and characterization of galectin-3 binding ligands in the outer dense fibers of the human sperm tail
    Role: Other
    Summer Research Fellowship     (Kamath)May 15, 2015 - Jul 15, 2015
    Urology Care Foundation of the American Urologic Association
    Molecular interactions between prostate specific antigen and galectin-3
    Role: Other
    Summer Research Fellowship     (Houston)May 1, 2014 - Jul 30, 2014
    Urology Care Foundation of the American Urologic Association
    Purification of prostate specific antigen (PSA) from seminal plasma for prostate cancer (PCa) research
    Role: Other
    Summer Research Fellowship     (Ward)May 1, 2014 - Jul 20, 2014
    Urology Care Foundation of the American Urologic Association
    Identification and characterization of galectin-3 binding ligands in the cytoskeleton of the human sperm flagellum
    Role: Other
    Medical Research Endowment Award     (Diekman)Jan 1, 2014 - Mar 30, 2014
    UAMS Medical Research Foundation
    The galectin-3 SNP genotype as a marker of genetic predisposition for colorectal cancer
    Role: Principal Investigator
    Pilot Award     (Diekman)Jul 1, 2013 - Jun 30, 2014
    UAMS College of Medicine
    Prostasome interactions with female cervicovaginal epithelial cells: A Novel Paradigm for Women’s Reproductive Health
    Role: Principal Investigator
    Summer Research Fellowship     (Xu)Jun 18, 2013 - Aug 15, 2013
    Urology Care Foundation of the American Urologic Association
    Galectin-3 genetic polymorphism and proteolytic cleavage by prostate specific antigen (PSA) in prostate cancer progression
    Role: Other
    Summer Research Fellowship     (Schurhamer)Jun 15, 2013 - Aug 15, 2013
    Urology Care Foundation of the American Urologic Association
    Validation of a strategy to purify Prostate specific antigen (PSA) for prostate cancer (PCa) studies
    Role: Other
    Summer Research Fellowship     (Wardlaw)Jun 15, 2013 - Aug 15, 2013
    Urology Care Foundation of the American Urologic Association
    Evaluation of lectin binding to prostate specific antigen (PSA) for biomarker development
    Role: Other
    Sturgis Pilot Award     (Diekman)Feb 1, 2013 - Sep 30, 2013
    Sturgis Foundation
    Galectin-3 genetic polymorphism as an etiological factor in diabetes and diabetic complications
    Role: Principal Investigator
    Summer Research Fellowship     (Jacks)Jun 15, 2012 - Aug 15, 2012
    Urology Care Foundation of the American Urologic Association
    Purification of prostate specific antigen (PSA) for prostate cancer studies
    Role: Other
    Summer Research Fellowship     (Webb)Jun 15, 2012 - Aug 15, 2012
    Urology Care Foundation of the American Urologic Association
    Molecular mechanism for modified citrus pectin in prostate cancer prevention
    Role: Other
    W81XWH-11-1-0369     (DIEKMAN, ALAN)May 1, 2011 - Sep 30, 2012
    US Department of the Army
    Prostate cancer biomarker development based on galectin-3/prostate specific antigen (PSA) interactions
    Role: Principal Investigator
    R01GM089001     (RANEY, KEVIN D)Sep 1, 2009 - Aug 31, 2014
    NIH
    Mechanisms of RNA binding and remodeling proteins
    Role: Co-Investigator
    W81XWH     (WARE, JERRY)Sep 1, 2008 - Aug 31, 2011
    US Department of the Army
    Platelet glycoprotein Ib-IX and malignancy
    Role: Principal Investigator
    R01HD050540     (DIEKMAN, ALAN B)Aug 5, 2005 - May 31, 2010
    NIH
    Role of galectin-3 in genital tract immunosuppression
    Role: Principal Investigator
    Medical Research Endowment Award     (Diekman)Jan 31, 2003 - Jun 30, 2003
    UAMS Medical Research Foundation
    Peptide mimic for a human sperm-specific carbohydrate epitope
    Role: Principal Investigator
    Pilot Award     (Diekman)Jan 1, 2003 - Jun 30, 2003
    UAMS College of Medicine
    Beta-galactoside-binding proteins in human spermatozoa
    Role: Principal Investigator
    R03HD041524     (DIEKMAN, ALAN B)Sep 1, 2002 - Aug 31, 2005
    NIH
    Role of GPI-Anchored CD52 Glycoprotein in Sperm Function
    Role: Principal Investigator
    NIH HD35523     (DIEKMAN, ALAN)Aug 1, 2002 - Jul 31, 2003
    University of Virginia
    Immunologic Mechanisms in Human Female Infertility Sub Contract of NIH HD35523
    Role: Principal Investigator
    NIHHD35523     (DIEKMAN, ALAN)Aug 1, 2002 - Jul 31, 2003
    University of Virginia
    Immunologic Mechanisms in Human Female Infertility Sub Contract of NIH HD35523
    Role: Principal Investigator
    Career Development Award     (Diekman)May 1, 1999 - Apr 30, 2022
    Mellon Foundation
    Carbohydrate immunocontraceptive epitopes identified in a neoglycolipid library derived from the human sperm glycocalyx
    Role: Principal Investigator
    CIG-97-15     (Herr)Oct 1, 1997 - Dec 31, 1999
    Contraceptive Research and Development Program (CONRAD)
    Formulation and testing of a native S19 monoclonal antibody/Novasome® spermicidal cream
    Role: Co-Investigator
    R43HD035771     (DIEKMAN, ALAN B)Sep 29, 1997 - Sep 30, 1999
    NIH
    RECOMBINANT ANTIBODIES AS INTRA VAGINAL SPERMICIDES
    Role: Principal Investigator
    NIH R01 HD35523     (Herr)Aug 1, 1997 - Jul 30, 2003
    NIH
    Immunologic mechanisms in human female infertility
    Role: Co-Investigator
    F32HD008002     (DIEKMAN, ALAN B)Aug 6, 1996
    NIH
    HUMAN SPERM ZONA BINDING PROTEIN
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Lin HY, Steck SE, Sarkar I, Fontham ETH, Diekman A, Rogers LJ, Ratliff CT, Bensen JT, Mohler JL, Su LJ. Interactions of SNPs in Folate Metabolism Related Genes on Prostate Cancer Aggressiveness in European Americans and African Americans. Cancers (Basel). 2023 Mar 10; 15(6). PMID: 36980585.
      View in: PubMed
    2. Zimmerman SM, Besio R, Heard-Lipsmeyer ME, Dimori M, Castagnola P, Swain FL, Gaddy D, Diekman AB, Morello R. Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm. AIMS Genet. 2018; 5(1):24-40. PMID: 30417103.
      View in: PubMed
    3. Niederhoffer EC, Cline SD, Osheroff N, Simmons JM, Diekman AB, Franklin DS, Abali EE, Bateman RC, Fontes JD, Lindsley JE, Pearson D, Rubenstein PA, Slaughter CA, Bernstein JA, Hyland KM, Park VM, Sobering AK, Weiler TA, Dasgupta S. Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. Med Sci Educ. 2017 Dec; 27(4):855-859. PMID: 29291139.
      View in: PubMed
    4. Osheroff N, Niederhoffer EC, Sabina RL, Cline SD, Wimmer MJ, Franklin DS, Diekman AB, Hogg T, Kearney KR, King SC, Pearson D, Slaughter CA, Thompson K. Teaching Biochemistry to Students of Medicine, Pharmacy & Dentistry: 5th International Conference of the Association of Biochemistry Course Directors (ABCD) Santa Fe, NM, USA, May 3-7, 2015. Med Sci Educ. 2015 Dec; 25(4):473-477. PMID: 26693393.
      View in: PubMed
    5. Kovak MR, Saraswati S, Schoen DJ, Diekman AB. Investigation of galectin-3 function in the reproductive tract by identification of binding ligands in human seminal plasma. Am J Reprod Immunol. 2014 Oct; 72(4):403-12. PMID: 24863808.
      View in: PubMed
    6. Kovak MR, Saraswati S, Diekman AB. Investigation of Galectin-3 Binding Ligands in Human Seminal Plasma Using a Proteomic Approach. Andrology 1 Suppl. 2. 2013; 97.
    7. Diekman A, Kovak M, Goddard S, Gilbride R, Block A, Saraswati S. Molecular Interactions of Galectin-3 and PSA in Human Semen, Prostate, and Prostate Tumors. Journal of Andrology 33 Suppl. 2012; 49.
    8. Saraswati S, Block AS, Davidson MK, Rank RG, Mahadevan M, Diekman AB. Galectin-3 is a substrate for prostate specific antigen (PSA) in human seminal plasma. Prostate. 2011 Feb 01; 71(2):197-208. PMID: 20672323.
      View in: PubMed
    9. Saraswati S, Block AS, Davidson MK, Rank RG, Mahadevan M, Diekman AB. Galectin-3 is a substrate of prostate specific antigen (PSA) in human seminal plasma. The Prostate. 2011; 71:197-208.
    10. Block AS, Saraswati S, Lichti CF, Mahadevan M, Diekman AB. Co-purification of Mac-2 binding protein with galectin-3 and association with prostasomes in human semen. Prostate. 2011 May 15; 71(7):711-21. PMID: 21031433.
      View in: PubMed
    11. Naaby-Hansen S, Diekman A, Shetty J, Flickinger CJ, Westbrook A, Herr JC. Identification of calcium-binding proteins associated with the human sperm plasma membrane. Reprod Biol Endocrinol. 2010 Jan 15; 8:6. PMID: 20078857.
      View in: PubMed
    12. Jones JL, Saraswati S, Block AS, Lichti CF, Mahadevan M, Diekman AB. Galectin-3 is associated with prostasomes in human semen. Glycoconj J. 2010 Feb; 27(2):227-36. PMID: 19830550.
      View in: PubMed
    13. Gilbride, RJ, Block, AS, Saraswati, S, Diekman AB. Molecular Interactions between Galectin-3 and Prostate Specific Antigen (PSA) Secreted by Prostate Cancer Cell Lines. Journal of Andrology March/April Suppl. 2009.
    14. Tyler CD, Lichti CF, Diekman AB, Foley SL. Evaluation of differentially expressed proteins following serum exposure in avian pathogenic Escherichia coli. Avian Dis. 2008 Mar; 52(1):23-7. PMID: 18459291.
      View in: PubMed
    15. Tyler C, Lichti C, Diekman AB, Foley S. Evaluation of differentially expressed proteins following complement exposure in avian pathogenic Escherichia coli. Avian Diseases. 2008; 52:23-27.
    16. Saraswati S, Block AS, Diekman AB. Galectin-3 is a substrate for prostate specific antigen (PSA). Journal of Andrology March/April Suppl. 2008.
    17. Parry S, Wong NK, Easton RL, Panico M, Haslam SM, Morris HR, Anderson P, Klotz KL, Herr JC, Diekman AB, Dell A. The sperm agglutination antigen-1 (SAGA-1) glycoforms of CD52 are O-glycosylated. Glycobiology. 2007 Oct; 17(10):1120-6. PMID: 17640971.
      View in: PubMed
    18. Westbrook VA, Schoppee PD, Diekman AB, Klotz KL, Allietta M, Hogan KT, Slingluff CL, Patterson JW, Frierson HF, Irvin WP, Flickinger CJ, Coppola MA, Herr JC. Genomic organization, incidence, and localization of the SPAN-x family of cancer-testis antigens in melanoma tumors and cell lines. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 1):101-12. PMID: 14734458.
      View in: PubMed
    19. Diekman AB, Herr, JC. The Third International Conference on the Epididymis. Human sperm surface antigens acquired during epididymal maturation. 2004.
    20. Shetty J, Wolkowicz MJ, Digilio LC, Klotz KL, Jayes FL, Diekman AB, Westbrook VA, Farris EM, Hao Z, Coonrod SA, Flickinger CJ, Herr JC. SAMP14, a novel, acrosomal membrane-associated, glycosylphosphatidylinositol-anchored member of the Ly-6/urokinase-type plasminogen activator receptor superfamily with a role in sperm-egg interaction. J Biol Chem. 2003 Aug 15; 278(33):30506-15. PMID: 12788941.
      View in: PubMed
    21. Diekman AB. Glycoconjugates in sperm function and gamete interactions: how much sugar does it take to sweet-talk the egg? Cell Mol Life Sci. 2003 Feb; 60(2):298-308. PMID: 12678495.
      View in: PubMed
    22. Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC. SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa. Biol Reprod. 2003 May; 68(5):1525-37. PMID: 12606493.
      View in: PubMed
    23. McCauley TC, Kurth BE, Norton EJ, Klotz KL, Westbrook VA, Rao AJ, Herr JC, Diekman AB. Analysis of a human sperm CD52 glycoform in primates: identification of an animal model for immunocontraceptive vaccine development. Biol Reprod. 2002 Jun; 66(6):1681-8. PMID: 12021047.
      View in: PubMed
    24. Diekman AB, Herr, JC, Freemerman, AJ, Coonrod, SA. Proceedings of the Fifth World Congress on Fertility and Sterility. Recent advances in the path to a contraceptive vaccine. 1995.
    25. Cronkite DL, Diekman AB, Lewallen B, Phillips L. Aminotransferase and the production of alanine during hyperosmotic stress in Paramecium calkinsi. J Eukaryot Microbiol. 1993; 40(6):796 - 800.
    26. Saraswati S, Block AS, Diekman AB. Carbohydrate Recognition: Biological Problems, Methods, and Applications. Galectins and their role in various biological processes. 7.
    27. Diekman AB, Goldberg E. Immunology of Reproduction. What are their private specificities.
    28. Westbrock VA, Diekman AB, Herr JC. Introduction to Mammalian Reproduction. Novel signaling pathways involved in sperm acquisition of fertilizing capacity.
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