Roy Morello
Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Physiology & Cell Biology, College of Medicine |
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Division | Physiology & Cell Biology Novel Gen |
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Address | 211-2 Biomedical Research I 325 S. Elm St. Mail Slot # 505 Little Rock AR 72205
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Phone | 501-526-4090 |
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vCard | Download vCard |
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Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Genetics, College of Medicine |
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Division | Genetics Faculty |
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Title | Associate Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Orthopaedics, College of Medicine |
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Research Funds R03HD097559 (MORELLO, ROY)Jan 11, 2019 - Dec 31, 2020 NIH/Nat. Inst. of Child Health & Human Development Primary lung defects in mouse models of osteogenesis imperfecta Role: Principal Investigator |
| R03HD097559 (MORELLO, ROY)Jan 11, 2019 - Dec 31, 2020 NIH Primary lung defects in mouse models of osteogenesis imperfecta Role: Principal Investigator |
| P20GM125503 (O'BRIEN, CHARLES A)Feb 16, 2018 - Jan 31, 2023 NIH Center for Musculoskeletal Disease Research (CMDR) Role: Co-Investigator |
| R01AI119380 (SMELTZER, MARK S)Jun 15, 2015 - May 31, 2021 NIH Impact of Staphylococcus aureus in osteomyelitis and bone physiology Role: Co-Investigator |
| R43AR066388 (RADIN, DAVID)Jun 1, 2014 - May 31, 2016 NIH Targeted Enzyme Replacement Therapy for Rare Forms of Osteogenesis Imperfecta Role: Co-Principal Investigator |
| R01AR060823 (MORELLO, ROY)Sep 17, 2012 - Jul 31, 2018 NIH Role of the Leprecan Genes in Skeletal Formation Role: Principal Investigator |
| R03AR051459 (MORELLO, ROY)Sep 26, 2005 - Aug 31, 2009 NIH Crtap function during skeletal homeostasis Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Marom R, Rabenhorst BM, Morello R. Osteogenesis imperfecta: an update on clinical features and therapies. Eur J Endocrinol. 2020 Oct; 183(4):R95-R106. PMID: 32621590.
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Xu H, Lenhart SA, Chu EY, Chavez MB, Wimer HF, Dimori M, Somerman MJ, Morello R, Foster BL, Hatch NE. Dental and craniofacial defects in the Crtap-/- mouse model of osteogenesis imperfecta type VII. Dev Dyn. 2020 07; 249(7):884-897. PMID: 32133710.
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Dimori M, Heard-Lipsmeyer ME, Byrum SD, Mackintosh SG, Kurten RC, Carroll JL, Morello R. Respiratory defects in the CrtapKO mouse model of osteogenesis imperfecta. Am J Physiol Lung Cell Mol Physiol. 2020 04 01; 318(4):L592-L605. PMID: 32022592.
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Zimmerman SM, Dimori M, Heard-Lipsmeyer ME, Morello R. The Osteocyte Transcriptome Is Extensively Dysregulated in Mouse Models of Osteogenesis Imperfecta. JBMR Plus. 2019 Jul; 3(7):e10171. PMID: 31372585.
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O'Brien CA, Morello R. Modeling Rare Bone Diseases in Animals. Curr Osteoporos Rep. 2018 08; 16(4):458-465. PMID: 29802575.
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Zimmerman SM, Heard-Lipsmeyer ME, Dimori M, Thostenson JD, Mannen EM, O'Brien CA, Morello R. Loss of RANKL in osteocytes dramatically increases cancellous bone mass in the osteogenesis imperfecta mouse (oim). Bone Rep. 2018 Dec; 9:61-73. PMID: 30105276.
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Morello R. Osteogenesis imperfecta and therapeutics. Matrix Biol. 2018 10; 71-72:294-312. PMID: 29540309.
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Zimmerman SM, Besio R, Heard-Lipsmeyer ME, Dimori M, Castagnola P, Swain FL, Gaddy D, Diekman AB, Morello R. Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm. AIMS Genet. 2018; 5(1):24-40. PMID: 30417103.
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Mohan M, Samant RS, Yoon D, Buros AF, Branca A, Montgomery CO, Nicholas R, Suva LJ, Morello R, Thanendrarajan S, Schinke C, Yaccoby S, van Rhee F, Davies FE, Morgan GJ, Zangari M. Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma. J Bone Miner Res. 2017 Jun; 32(6):1261-1266. PMID: 28240368.
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Hudson DM, Weis M, Rai J, Joeng KS, Dimori M, Lee BH, Morello R, Eyre DR. P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA. J Biol Chem. 2017 03 03; 292(9):3877-3887. PMID: 28115524.
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Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus. Infect Immun. 2016 09; 84(9):2586-94. PMID: 27354444.
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Heard ME, Besio R, Weis M, Rai J, Hudson DM, Dimori M, Zimmerman SM, Kamykowski JA, Hogue WR, Swain FL, Burdine MS, Mackintosh SG, Tackett AJ, Suva LJ, Eyre DR, Morello R. Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PLoS Genet. 2016 Apr; 12(4):e1006002. PMID: 27119146.
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Gruenwald K, Castagnola P, Besio R, Dimori M, Chen Y, Akel NS, Swain FL, Skinner RA, Eyre DR, Gaddy D, Suva LJ, Morello R. Sc65 is a novel endoplasmic reticulum protein that regulates bone mass homeostasis. J Bone Miner Res. 2014 Mar; 29(3):666-75. PMID: 23959653.
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Homan EP, Lietman C, Grafe I, Lennington J, Morello R, Napierala D, Jiang MM, Munivez EM, Dawson B, Bertin TK, Chen Y, Lua R, Lichtarge O, Hicks J, Weis MA, Eyre D, Lee BH. Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues. PLoS Genet. 2014 Jan; 10(1):e1004121. PMID: 24465224.
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Morello R, Haddad R. Transitional Care in Osteogenesis Imperfecta: Advances in Biology, Technology, and Clinical Practice. Recessive Osteogenesis Imperfecta: eER Genes Take the Stage. 2013.
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Homan EP, Lee B, Morello R. Osteogenesis Imperfecta: a Translational Approach to Brittle Bone Disease. Recessive Osteogenesis Imperfecta Due to Mutations in CRTAP, LEPRE1 and PPIB. 2013; 14.
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Morello R, Esposito PW. Osteogenesis. Osteogenesis imperfecta. 2012; 9.
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Homan EP, Rauch F, Grafe I, Lietman C, Doll JA, Dawson B, Bertin T, Napierala D, Morello R, Gibbs R, White L, Miki R, Cohn DH, Crawford S, Travers R, Glorieux FH, Lee B. Mutations in SERPINF1 cause osteogenesis imperfecta type VI. J Bone Miner Res. 2011 Dec; 26(12):2798-803. PMID: 21826736.
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Ben Amor IM, Rauch F, Gruenwald K, Weis M, Eyre DR, Roughley P, Glorieux FH, Morello R. Severe Osteogenesis Imperfecta Caused by a Small In-Frame Deletion in CRTAP. Amer J Med Genet. 2011; 155A(11):2865-70.
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Monticone M, Panfoli I, Ravera S, Puglisi R, Jiang MM, Morello R, Candiani S, Tonachini L, Biticchi R, Fabiano A, Cancedda R, Boitani C, Castagnola P. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. J Cell Physiol. 2010 Nov; 225(3):767-76. PMID: 20568109.
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Morello R, Rauch F. Role of cartilage-associated protein in skeletal development. Curr Osteoporos Rep. 2010 Jun; 8(2):77-83. PMID: 20425614.
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Gabbay KH, Bohren KM, Morello R, Bertin TK, Liu J, Vogel P. Delineation of the ascorbate synthesis pathway and the role of mild ascorbate deficiency in osteoporosis. J. Biol. Chem. 2010.
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Baldridge D, Lennington J, Weis M, Homan EP, Jiang MM, Munivez E, Keene DR, Hogue WR, Pyott S, Byers PH, Krakow D, Cohn DH, Eyre DR, Lee B, Morello R. Generalized connective tissue disease in Crtap-/- mouse. PLoS One. 2010 May 11; 5(5):e10560. PMID: 20485499.
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Gabbay KH, Bohren KM, Morello R, Bertin T, Liu J, Vogel P. Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem. 2010 Jun 18; 285(25):19510-20. PMID: 20410296.
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Fratz-Zelman N, Morello R, Lee B, Rauch F, Glorieux FH, Misof BM, Klaushofer K, Roschger P. CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with Osteogenesis Imperfecta type VII. BONE. 2010; (46):820-826.
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Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Facciolli A, Morello R, Agoulnik AI, Foresta C. New roles for INSL3 in adults. Ann N Y Acad Sci. 2009; 1160:215-8.
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Baldridge D, Schwarze U, Morello R, Lennington J, Bertin TK, Pace JM, Pepin MG, Weis M, Eyre DR, Walsh J, Lambert D, Green A, Robinson H, Michelson M, Houge G, Lindman C, Martin J, Ward J, Lemyre E, Mitchell JJ, Krakow D, Rimoin DL, Cohn DH, Byers PH, Lee B. CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta. Hum Mutat. 2008 Dec; 29(12):1435-42. PMID: 18566967.
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Morello R, Bertin TK, Schlaubitz S, Shaw CA, Kakuru S, Munivez E, Hermanns P, Chen Y, Zabel B, Lee B. Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct; 217(1):127-37. PMID: 18446812.
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Ferlin A, Pepe A, Gianesello L, Garolla A, Feng S, Giannini S, Zaccolo M, Facciolli A, Morello R, Agoulnik AI, Foresta C. Mutations in the insulin-like factor 3 receptor are associated with osteoporosis. J Bone Miner Res. 2008 May; 23(5):683-93. PMID: 18433302.
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Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B. Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15; 17(14):2244-54. PMID: 18424451.
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Barnes AM, Chang W, Morello R, Cabral WA, Weis M, Eyre DR, Leikin S, Makareeva E, Kuznetsova N, Uveges TE, Ashok A, Flor AW, Mulvihill JJ, Wilson PL, Sundaram UT, Lee B, Marini JC. Deficiency of cartilage-associated protein in recessive lethal osteogenesis imperfecta. N Engl J Med. 2006 Dec 28; 355(26):2757-64. PMID: 17192541.
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Morello R, Bertin TK, Chen Y, Hicks J, Tonachini L, Monticone M, Castagnola P, Rauch F, Glorieux FH, Vranka J, Bächinger HP, Pace JM, Schwarze U, Byers PH, Weis M, Fernandes RJ, Eyre DR, Yao Z, Boyce BF, Lee B. CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20; 127(2):291-304. PMID: 17055431.
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Zheng Q, Zhou G, Morello R, Chen Y, Garcia-Rojas X, Lee B. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol. 2003 Sep 01; 162(5):833-42. PMID: 12952936.
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Hamano Y, Grunkemeyer JA, Sudhakar A, Zeisberg M, Cosgrove D, Morello R, Lee B, Sugimoto H, Kalluri R. Determinants of vascular permeability in the kidney glomerulus. J Biol Chem. 2002 Aug 23; 277(34):31154-62. PMID: 12039968.
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Morello R, Lee B. Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes. Pediatr Res. 2002 May; 51(5):551-8. PMID: 11978876.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 2 | 2003 | 1 | 2006 | 2 | 2008 | 4 | 2009 | 1 | 2010 | 6 | 2011 | 2 | 2012 | 1 | 2013 | 2 | 2014 | 2 | 2016 | 2 | 2017 | 2 | 2018 | 4 | 2019 | 1 | 2020 | 3 |
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