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Nancy Rusch

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
Address306B Biomedical Research I
325 S. Elm St.
Mail Slot # 611
Little Rock AR 72205
Phone501-686-8038
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    Collapse Research Funds 
    Collapse research activities
    TL1TR003109     (RUSCH, NANCY J)Jul 1, 2019 - Jun 30, 2024
    NIH/NCATS
    J. NRSA Training
    Role: Principal Investigator

    UL1TR003107     (JAMES, LAURA P)Jul 1, 2019 - Jun 30, 2024
    NIH/NCATS
    Expanding Translational Research in Arkansas
    Role: Co-Investigator

    U54TR001629     (JAMES, LAURA P)Sep 26, 2017 - Aug 31, 2018
    NIH/NCATS
    Expanding Translational Research in Arkansas
    Role: Co-Investigator

    R21CA187325     (RUSCH, NANCY J)Mar 9, 2015 - Feb 28, 2017
    NIH/NCI
    Doxorubicin suppression of lymphatic function and therapeutic reversal
    Role: Principal Investigator

    13GRNT14590001     (RUSCH, NANCY)Jan 1, 2013 - Dec 31, 2014
    American Heart Association (SouthWest Affiliate)
    AHA-Vascular TRPC3 Channels as Antihypertensive Targets
    Role: Principal Investigator

    R01HL097107     (RHEE, SUNG W)Mar 15, 2010 - Feb 28, 2015
    NIH/NHLBI
    PSD95 scaffolding of vascular K+ channels in hypertension
    Role: Co-Investigator

    R01HL095846     (PALADE, PHILIP T.)Jan 22, 2010 - Nov 30, 2014
    NIH/NHLBI
    MicroRNA to decrease vascular CaV1.2 in hypertension
    Role: Co-Investigator

    R01HL093526     (RUSCH, NANCY J)May 5, 2009 - Apr 30, 2014
    NIH/NHLBI
    Long-term Antihypertensive Therapy by Delivery of the BK Channel Gene to VSMCs
    Role: Principal Investigator

    R01HL083013     (RUSCH, NANCY J)Aug 1, 2005 - Jul 31, 2010
    NIH/NHLBI
    Calcium Channels in Neonatal Pulmonary Hypertension
    Role: Principal Investigator

    R01HL064806     (RUSCH, NANCY J)May 1, 2000 - Dec 31, 2013
    NIH/NHLBI
    Vascular Calcium Channel Expression in Hypertension
    Role: Principal Investigator

    R01HL059238     (RUSCH, NANCY J)Mar 1, 1998 - Nov 30, 2006
    NIH/NHLBI
    Role of Cerebrovascular K+ Channels in Hypertension
    Role: Principal Investigator

    R03TW000350     (RUSCH, NANCY J)Sep 30, 1993 - Sep 29, 1995
    NIH/FIC
    REGULATION OF VENOUS MUSCLE K+ CHANNELS
    Role: Principal Investigator

    R29HL040474     (RUSCH, NANCY J)Aug 1, 1988 - Jul 31, 1993
    NIH/NHLBI
    VASCULAR MUSCLE CALCIUM CURRENTS IN HYPERTENSION
    Role: Principal Investigator

    F32HL006907     (RUSCH, NANCY J)Jan 1, 1985
    NIH/NHLBI
    TROPHIC EFFECT OF SYMPATHETIC NERVES ON ARTERIAL MUSCLE
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Cozart MA, Phelan KD, Wu H, Mu S, Birnbaumer L, Rusch NJ, Zheng F. Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus. Sci Rep. 2020 Jan 21; 10(1):812. PMID: 31964991.
      View in: PubMed
    2. Shrum S, Rusch NJ, MacMillan-Crow LA. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro. Biomolecules. 2019 Dec 04; 9(12). PMID: 31817165.
      View in: PubMed
    3. Boulanger CM, Baretella O, Blaise G, Bond RA, Cai Y, Chan CKY, Chataigneau T, Chen MJ, Chen H, Cheng Y, Clement DL, Cohen RA, Collis M, Danser AHJ, de Mey J, Detremmerie CMS, Duprez D, Feletou M, Flavahan N, Gao Y, Guo Y, Hoeffner U, Houston DS, Huang IB, Huang Y, Iliano S, Junquero D, Katusic ZS, Komori K, Lee MYK, Leung SWS, Li Z, Liang SC, Liu JTC, Luscher TF, Michel F, Miller VM, Mombouli JV, Morrison K, Muldoon SM, O'Rourke S, Perrault L, Quignard JF, Rusch NJ, Sanchez-Ferrer CF, Schini-Kerth V, Shen K, Shi Y, Song E, Sun KWY, Taddei S, Tang EHC, Tuncer M, van den Ende R, Vedernikov Y, Verbeuren TJ, Webb C, Weigert A, Wong KHK, Xu C, Yang K, Ying F, Zellers T, Zhao Y, Zou Q, Shimokawa H. Tribute to Paul M. Vanhoutte, MD, PhD (1940-2019). Arterioscler Thromb Vasc Biol. 2019 Dec; 39(12):2445-2447. PMID: 31770032.
      View in: PubMed
    4. Zheng F, Mu S, Rusch NJ. Leptin Activates Trpm7 Channels in the Carotid Body As a Mechanism of Obesity-Related Hypertension. Circ Res. 2019 Nov 08; 125(11):1003-1005. PMID: 31697634.
      View in: PubMed
    5. Stolarz AJ, Sarimollaoglu M, Marecki JC, Fletcher TW, Galanzha EI, Rhee SW, Zharov VP, Klimberg VS, Rusch NJ. Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow. J Pharmacol Exp Ther. 2019 Nov; 371(2):278-289. PMID: 31439806.
      View in: PubMed
    6. Mu S, Fantegrossi WE, Rusch NJ. Cocaine-Responsive miRNA and Blood Pressure Elevation. Hypertension. 2018 04; 71(4):561-562. PMID: 29483229.
      View in: PubMed
    7. Sarimollaoglu M, Stolarz AJ, Nedosekin DA, Garner BR, Fletcher TW, Galanzha EI, Rusch NJ, Zharov VP. High-speed microscopy for in vivo monitoring of lymph dynamics. J Biophotonics. 2018 08; 11(8):e201700126. PMID: 29232054.
      View in: PubMed
    8. Rhee SW, Rusch NJ. Molecular determinants of beta-adrenergic signaling to voltage-gated K+ channels in the cerebral circulation. Microcirculation. 2018 01; 25(1). PMID: 29072364.
      View in: PubMed
    9. Hill BJF, Dalton RJ, Joseph BK, Thakali KM, Rusch NJ. 17ß-estradiol reduces Cav 1.2 channel abundance and attenuates Ca2+ -dependent contractions in coronary arteries. Pharmacol Res Perspect. 2017 10; 5(5). PMID: 28971605.
      View in: PubMed
    10. Hilgers RH, Kundumani-Sridharan V, Subramani J, Chen LC, Cuello LG, Rusch NJ, Das KC. Thioredoxin reverses age-related hypertension by chronically improving vascular redox and restoring eNOS function. Sci Transl Med. 2017 02 08; 9(376). PMID: 28179506.
      View in: PubMed
    11. Detweiler ND, Song L, McClenahan SJ, Versluis RJ, Kharade SV, Kurten RC, Rhee SW, Rusch NJ. BK channels in rat and human pulmonary smooth muscle cells are BKa-ß1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert. Pulm Circ. 2016 Dec; 6(4):563-575. PMID: 28090300.
      View in: PubMed
    12. Stolarz AJ, Rusch NJ. Gender Differences in Cardiovascular Drugs. Cardiovasc Drugs Ther. 2015 Aug; 29(4):403-10. PMID: 26227895.
      View in: PubMed
    13. Stimers JR, Song L, Rusch NJ, Rhee SW. Overexpression of the Large-Conductance, Ca2+-Activated K+ (BK) Channel Shortens Action Potential Duration in HL-1 Cardiomyocytes. PLoS One. 2015; 10(6):e0130588. PMID: 26091273.
      View in: PubMed
    14. Schleifenbaum J, Kassmann M, Szijártó IA, Hercule HC, Tano JY, Weinert S, Heidenreich M, Pathan AR, Anistan YM, Alenina N, Rusch NJ, Bader M, Jentsch TJ, Gollasch M. Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries. Circ Res. 2014 Jul 07; 115(2):263-72. PMID: 24838176.
      View in: PubMed
    15. Moore CL, Nelson PL, Parelkar NK, Rusch NJ, Rhee SW. Protein kinase A-phosphorylated KV1 channels in PSD95 signaling complex contribute to the resting membrane potential and diameter of cerebral arteries. Circ Res. 2014 Apr 11; 114(8):1258-67. PMID: 24585759.
      View in: PubMed
    16. Patton AL, Seely KA, Pulla S, Rusch NJ, Moran CL, Fantegrossi WE, Knight LD, Marraffa JM, Kennedy PD, James LP, Endres GW, Moran JH. Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS. Anal Chem. 2014 Feb 04; 86(3):1760-6. PMID: 24354295.
      View in: PubMed
    17. Abou-Saleh H, Pathan AR, Daalis A, Hubrack S, Abou-Jassoum H, Al-Naeimi H, Rusch NJ, Machaca K. Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility. J Biol Chem. 2013 Nov 15; 288(46):32941-51. PMID: 24097979.
      View in: PubMed
    18. Mercado CP, Quintero MV, Li Y, Singh P, Byrd AK, Talabnin K, Ishihara M, Azadi P, Rusch NJ, Kuberan B, Maroteaux L, Kilic F. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30; 3:2795. PMID: 24077408.
      View in: PubMed
    19. Nedosekin DA, Juralti MA, Sarimollaoglu M, Moore CL, Rusch NJ, Smeltzer MS, Zharov VP, Galazha EI. Photoacustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo. J Biophotonics. 2013; 6(6-7):523-33 (PMID: 23681943).
    20. Nedosekin DA, Juratli MA, Sarimollaoglu M, Moore CL, Rusch NJ, Smeltzer MS, Zharov VP, Galanzha EI. Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo. J Biophotonics. 2013 Jun; 6(6-7):523-33. PMID: 23681943.
      View in: PubMed
    21. Singh P, Fletcher TW, Li Y, Rusch NJ, Kilic F. Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice. Health (Irvine Calif). 2013 Mar 01; 5(4A):31-39. PMID: 24163726.
      View in: PubMed
    22. Kharade SV, Sonkusare SK, Srivastava AK, Thakali KM, Fletcher TW, Rhee SW, Rusch NJ. The Beta 3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice. Hypertension. 2013; 61(1):137-42 (PMID: 23129698).
    23. Kharade SV, Sonkusare SK, Srivastava AK, Thakali KM, Fletcher TW, Rhee SW, Rusch NJ. The ß3 subunit contributes to vascular calcium channel upregulation and hypertension in angiotensin II-infused C57BL/6 mice. Hypertension. 2013 Jan; 61(1):137-42. PMID: 23129698.
      View in: PubMed
    24. Nguyen AT, Gomez D, Bell RD, Campbell JH, Clowes AW, Gabbiani G, Giachelli CM, Parmacek MS, Raines EW, Rusch NJ, Speer MY, Sturek M, Thyberg J, Towler DA, Weiser-Evans MC, Yan C, Miano JM, Owens GK. Smooth muscle cell plasticity: fact or fiction? Circ Res. 2013 Jan 04; 112(1):17-22. PMID: 23093573.
      View in: PubMed
    25. Hirenallur-S DK, Detweiler ND, Haworth ST, Leming JT, Gordon JB, Rusch NJ. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun; 2(2):193-200. PMID: 22837860.
      View in: PubMed
    26. Detweiler ND, Srivastava AK, Pathan AR, Kharade SV, Rusch NJ. Cell Physiology Source Book. Smooth muscle excitability. 2012.
    27. Hirenallur-S DK, Detweiler ND, Haworth ST, Leming JT, Gordon JB, Rusch NJ. Furegulate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012; 2(2):193-200 (PMID: 22837860).
    28. Joseph BK, Thakali KM, Pathan AR, Kang E, Rusch NJ, Rhee SW. Postsynaptic density-95 scaffolding of Shaker-type K? channels in smooth muscle cells regulates the diameter of cerebral arteries. J Physiol. 2011 Nov 01; 589(Pt 21):5143-52. PMID: 21911612.
      View in: PubMed
    29. Pathan AR, Rusch NJ. Two-pore domain K? channels: evidence for TWIK-2 in blood pressure regulation. Hypertension. 2011 Oct; 58(4):539-41. PMID: 21876073.
      View in: PubMed
    30. Thakali KM, Kharade SV, Sonkusare SK, Rhee SW, Stimers JR, Rusch NJ. Intracellular Ca2+ silences L-type Ca2+ channels in mesenteric veins: mechanism of venous smooth muscle resistance to calcium channel blockers. Circ Res. 2010 Mar 05; 106(4):739-47. PMID: 20044515.
      View in: PubMed
    31. Pang L, Rusch NJ. High-conductance, Ca(2+) -activated K+ channels: altered expression profiles in aging and cardiovascular disease. Mol Interv. 2009 Oct; 9(5):230-3. PMID: 19828830.
      View in: PubMed
    32. Rusch NJ. BK channels in cardiovascular disease: a complex story of channel dysregulation. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1580-2. PMID: 19749161.
      View in: PubMed
    33. Tobin AA, Joseph BK, Al-Kindi HN, Albarwani S, Madden JA, Nemetz LT, Rusch NJ, Rhee SW. Loss of cerebrovascular Shaker-type K(+) channels: a shared vasodilator defect of genetic and renal hypertensive rats. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H293-303. PMID: 19411284.
      View in: PubMed
    34. Ahmed BA, Bukhari IA, Jeffus BC, Harney JT, Thyparambil S, Ziu E, Fraer M, Rusch NJ, Zimniak P, Lupashin V, Tang D, Kilic F. The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS One. 2009; 4(3):e4730. PMID: 19270731.
      View in: PubMed
    35. Tobin AA, Joseph BK, Albarwani S, Al-Kindi HN, Madden JA, Nemetz LT, Rusch NJ, Rhee SW. Loss of Shaker-type, voltage-gated K channels contributes to enhanced crebrovascular tome in hypertensive rats. 2009.
    36. Hirenallur-S DK, Haworth ST, Leming JT, Chang J, Hernandez G, Gordon JB, Rusch NJ. Upregulation of vascular calcium channels in neonatal piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Nov; 295(5):L915-24. PMID: 18776054.
      View in: PubMed
    37. Telemaque S, Sonkusare S, Grain T, Rhee S, Stimers JR, Rusch NJ, Marsh JD. Design of mutant beta subunits as decoy molecules to reduce the expression of function calcium channels in cardiac cells. J Pharm Experim Therap. 2008; 325(1):37-46 (PMID: 18184831).
    38. Télémaque S, Sonkusare S, Grain T, Rhee SW, Stimers JR, Rusch NJ, Marsh JD. Design of mutant beta2 subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells. J Pharmacol Exp Ther. 2008 Apr; 325(1):37-46. PMID: 18184831.
      View in: PubMed
    39. Marsh JD, Telemaque S, Rhee SW, Stimers JR, Rusch NJ. Delivery of ion channel genes to treat cardiovascular diseases. Trans Am Clin Climatol Assoc. 2008; 119:171-82; discussion 182-3. PMID: 18596857.
      View in: PubMed
    40. Bryan RM, Joseph BK, Lloyd E, Rusch NJ. Starring TREK-1: the next generation of vascular K+ channels. Circ Res. 2007 Jul 20; 101(2):119-21. PMID: 17641234.
      View in: PubMed
    41. Joseph BK, Rhee SW, Hirenallur DK, Rusch NJ. New Frontiers in Smooth Muscle Biology and Physiology. Potassium channels in vascular smooth muscle: Structure, function and experimental interventions. 2007.
    42. Sonkusare S, Fraer M, Marsh JD, Rusch NJ. Disrupting calcium channel expression to lower blood pressure: new targeting of a well-known channel. Mol Interv. 2006 Dec; 6(6):304-10. PMID: 17200457.
      View in: PubMed
    43. Sonkusare S, Palade PT, Marsh JD, Telemaque S, Pesic A, Rusch NJ. Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. Vascul Pharmacol. 2006 Mar; 44(3):131-42. PMID: 16427812.
      View in: PubMed
    44. Beech DJ, Cheong A, Rusch NJ. Regulation of arterial tone by KV1 potassium channels. Circ Res. 2005 Apr 01; 96(6):e58. PMID: 15802615.
      View in: PubMed
    45. Rademacher DJ, Patel S, Ho WS, Savoie AM, Rusch NJ, Gauthier KM, Hillard CJ. U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2694-701. PMID: 15695564.
      View in: PubMed
    46. Archer SL, Rusch NJ. Lung Biology in Health and Disease: Ion Channels in the Pulmonary Vasculature. Ion channel heterogeneity in the pulmonary vascular bed. 2005.
    47. Rusch NJ. Regulation of arterial tone by Kv1 potassium channels. 2005.
    48. Li H, Gutterman DD, Rusch NJ, Bubolz A, Liu Y. Nitration and functional loss of voltage-gated K+ channels in rat coronary microvessels exposed to high glucose. Diabetes. 2004 Sep; 53(9):2436-42. PMID: 15331556.
      View in: PubMed
    49. Pesic A, Madden JA, Pesic M, Rusch NJ. High blood pressure upregulates arterial L-type Ca2+ channels: is membrane depolarization the signal? Circ Res. 2004 May 28; 94(10):e97-104. PMID: 15131006.
      View in: PubMed
    50. Albarwani S, Nemetz LT, Madden JA, Tobin AA, England SK, Pratt PF, Rusch NJ. Voltage-gated K+ channels in rat small cerebral arteries: molecular identity of the functional channels. J Physiol. 2003 Sep 15; 551(Pt 3):751-63. PMID: 12815189.
      View in: PubMed
    51. Gauthier KG, Rusch NJ. EDHF 2002. Potassium channels and membrane potential in vascular smooth endothelial and smooth muscle cells. 2003.
    52. Gauthier KM, Liu C, Popovic A, Albarwani S, Rusch NJ. Freshly isolated bovine coronary endothelial cells do not express the BK Ca channel gene. J Physiol. 2002 12 15; 545(3):829-36. PMID: 12482889.
      View in: PubMed
    53. Molero MM, Giulumian AD, Reddy VB, Ludwig LM, Pollock JS, Pollock DM, Rusch NJ, Fuchs LC. Decreased endothelin binding and [Ca2+]i signaling in microvessels of DOCA-salt hypertensive rats. J Hypertens. 2002 Sep; 20(9):1799-805. PMID: 12195122.
      View in: PubMed
    54. Pratt PF, Bonnet S, Ludwig LM, Bonnet P, Rusch NJ. Upregulation of L-type Ca2+ channels in mesenteric and skeletal arteries of SHR. Hypertension. 2002 Aug; 40(2):214-9. PMID: 12154116.
      View in: PubMed
    55. Cox RH, Rusch NJ. New expression profiles of voltage-gated ion channels in arteries exposed to high blood pressure. Microcirculation. 2002; 9(4):243-57. PMID: 12152102.
      View in: PubMed
    56. Rusch NJ, Lombard JH. Physiology Secrets. Cell transport, nerves and muscle. 2002.
    57. Cox RH, Rusch NJ. Microcirculation. New expression profiles of voltage-gated ion channels in vasculat smooth muscle cells exposed to high blood pressure. 2002.
    58. Liu Y, Terata K, Rusch NJ, Gutterman DD. High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. Circ Res. 2001 Jul 20; 89(2):146-52. PMID: 11463721.
      View in: PubMed
    59. Liu X, Rusch NJ, Striessnig J, Sarna SK. Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon. Gastroenterology. 2001 Feb; 120(2):480-9. PMID: 11159888.
      View in: PubMed
    60. Madden J, Rusch NJ. Heart Physiology and Pathophysiology. Electrical properties of vascular smooth muscle. 2001.
    61. Hermsmeyer KH, Rusch NJ. Cell Physiology Source Book. Smooth muscle action potentials and electrical profiles. 2001.
    62. Koch RO, Trieb M, Koschak A, Wanner SG, Gauthier KM, Rusch NJ, Knaus H-G. Potassium Channels in Cardiovascular Biology. Design and use of antibodies for mapping K+ channel expression in the cardiovascular system. 2001.
    63. Gauthier KM, Rusch NJ. Rat Coronary Endothelial Cell Membrane Potential Responses During Hypertension. Hypertension. 2001; 37(1):66 - 71 (PMID: 11208758).
    64. Berger MG, Rusch NJ. Potassium Channels in Cardiovascular Biology. Overexpression of Ca2+-sensitive K+ channels in arterial muscle membranes during systemic hypertension. 2001.
    65. Gauthier-Rein KM, Rusch NJ. Impaired endothelial signaling and dilator mechanisms in small coronary arteries from renal hypertensive rats. 2001; 37:66-71.
    66. Gauthier KM, Rusch NJ. Rat Coronary Endothelial Cell Membrane Potential Responses During Hypertension. Hypertension. 2001 Jan; 37(1):66-71. PMID: 11208758.
      View in: PubMed
    67. Berger MG, Rusch NJ. Perspectives in Drug Discovery. Voltage and calcium-gated potassium channels: functional expression and therapeutic potential in the vasculature. 2000.
    68. Liu Y, Rusch NJ, Lombard JH. Loss of endothelium and receptor-mediated dilation in pial arterioles of rats fed a short-term high salt diet. Hypertension. 1999 Feb; 33(2):686-8. PMID: 10024328.
      View in: PubMed
    69. Lombard JH, Liu Y, Fredricks KT, Bizub DM, Roman RJ, Rusch NJ. Electrical and mechanical responses of rat middle cerebral arteries to reduced PO2 and prostacyclin. Am J Physiol. 1999 02; 276(2):H509-16. PMID: 9950852.
      View in: PubMed
    70. Berger MG, Vandier C, Bonnet P, Jackson WF, Rusch NJ. Intracellular acidosis differentially regulates KV channels in coronary and pulmonary vascular muscle. Am J Physiol. 1998 10; 275(4):H1351-9. PMID: 9746485.
      View in: PubMed
    71. Liu Y, Hudetz AG, Knaus HG, Rusch NJ. Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm. Circ Res. 1998 Apr 06; 82(6):729-37. PMID: 9546382.
      View in: PubMed
    72. Gauthier-Rein KM, Rusch NJ. Distinct endothelial impairment in coronary microvessels from hypertensive Dahl rats. Hypertension. 1998 Jan; 31(1 Pt 2):328-34. PMID: 9453324.
      View in: PubMed
    73. Rusch NJ, Lombard JH. Physiology Secrets. Cell transport, nerves and muscle. 1998; 1.
    74. Berger M, Vandier C, Jackson WF, Bonnet P, Rusch NJ. Differential regulation by intracellular acidosis of K+ current in coronary and pulmonary vascular smooth muscle cells. 1998; 44:H1351-H1359.
    75. Liu Y, Pleyte K, Knaus HG, Rusch NJ. Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats. Hypertension. 1997 Dec; 30(6):1403-9. PMID: 9403560.
      View in: PubMed
    76. Rusch NJ, Liu Y. Potassium channels in hypertension: homeostatic pathways to buffer arterial contraction. J Lab Clin Med. 1997 Sep; 130(3):245-51. PMID: 9341983.
      View in: PubMed
    77. Gauthier-Rein KM, Bizub DM, Lombard JH, Rusch NJ. Hypoxia-induced hyperpolarization is not associated with vasodilation of bovine coronary resistance arteries. Am J Physiol. 1997 Mar; 272(3 Pt 2):H1462-9. PMID: 9087625.
      View in: PubMed
    78. Jackson WF, Huebner JM, Rusch NJ. Enzymatic isolation and characterization of single vascular smooth muscle cells from cremasteric arterioles. Microcirculation. 1997 Mar; 4(1):35-50. PMID: 9110282.
      View in: PubMed
    79. Rusch NJ, Liu Y. Invited Review: K+ channels in hypertension: homeostatic pathways to buffer arterial contraction. Journal of Laboratory and Clinical Medicine. 1997; 130:245-251.
    80. Rusch NJ, Liu Y, Pleyte KA. Mechanisms for regulation of arterial tone by Ca2+-dependent K+ channels in hypertension. Clin Exp Pharmacol Physiol. 1996 Dec; 23(12):1077-81. PMID: 8977163.
      View in: PubMed
    81. Zhang H, Li P, Almassi GH, Nicolosi A, Olinger GN, Rusch NJ. Single-channel and functional characteristics of a KCa channel in vascular muscle membranes of human saphenous veins. J Cardiovasc Pharmacol. 1996 Nov; 28(5):611-7. PMID: 8945673.
      View in: PubMed
    82. Rusch NJ. Potassium channels: new targets for drug treatment. Wis Med J. 1996 Oct; 95(10):713-6. PMID: 8909191.
      View in: PubMed
    83. Jackson WF, Huebner JM, Rusch NJ. Enzymatic isolation and characterization of single vascular smooth muscle cells from cremasteric arterioles. Microcirculation. 1996 Sep; 3(3):313-28. PMID: 8930888.
      View in: PubMed
    84. Almassi GH, Farahbakhsh B, Wooldridge T, Rusch NJ, Olinger GN. Endothelium and vascular smooth muscle function in internal mammary artery after cryopreservation. J Surg Res. 1996 Feb 01; 60(2):355-60. PMID: 8598668.
      View in: PubMed
    85. Jackson WF, Rusch NJ. Voltage-activated and ATP-sensitive K+ channels regulate resting membrane potential in cremasteric arteriolar muscle cells. 1996; 909-913.
    86. Rusch NJ, Wooldridge TA, Kulig CC, Almassi GH, Nicolosi AC, Olinger GN, Boerboom LE. Reactivity of human saphenous veins at arterial perfusion pressures. J Thorac Cardiovasc Surg. 1995 Oct; 110(4 Pt 1):1005-12. PMID: 7475128.
      View in: PubMed
    87. Eskinder H, Gebremedhin D, Lee JG, Rusch NJ, Supan FD, Kampine JP, Bosnjak ZJ. Halothane and isoflurane decrease the open state probability of K+ channels in dog cerebral arterial muscle cells. Anesthesiology. 1995 Feb; 82(2):479-90. PMID: 7856906.
      View in: PubMed
    88. Rusch NJ, Wooldridge TA, Kulig C, Almassi GH, Olinger GN, Boerboom LE. Activation of human saphenous veins at arterial distending pressures. 1995; 110:1005-1012.
    89. Gebremedhin D, Bonnet P, Greene AS, England SK, Rusch NJ, Lombard JH, Harder DR. Hypoxia increases the activity of Ca(2+)-sensitive K+ channels in cat cerebral arterial muscle cell membranes. Pflugers Arch. 1994 Oct; 428(5-6):621-30. PMID: 7838685.
      View in: PubMed
    90. Fredricks KT, Liu Y, Rusch NJ, Lombard JH. Role of endothelium and arterial K+ channels in mediating hypoxic dilation of middle cerebral arteries. Am J Physiol. 1994 Aug; 267(2 Pt 2):H580-6. PMID: 8067414.
      View in: PubMed
    91. Rusch NJ, Runnells AM. Remission of high blood pressure reverses arterial potassium channel alterations. Hypertension. 1994 Jun; 23(6 Pt 2):941-5. PMID: 8206632.
      View in: PubMed
    92. Li P, Zou AP, al-Kayed NJ, Rusch NJ, Harder DR. Guanine nucleotide-binding proteins in aortic smooth muscle from hypertensive rats. Hypertension. 1994 Jun; 23(6 Pt 2):914-8. PMID: 8206627.
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    93. Sanchez AM, Wooldridge TA, Boerboom LE, Olinger GN, Almassi GH, Rusch NJ. Comparison of saphenous vein graft relaxation between Plasma-Lyte solution and normal saline solution. J Thorac Cardiovasc Surg. 1994 Jun; 107(6):1445-53. PMID: 8196386.
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    94. Rusch NJ, Runnels AM. Correlation of blood pressure and K+ channel current density in aortic muscle membranes of hypertensive rats. 1994; 23:941-945.
    95. Sanchez AM, Woolridge TA, Boerboom LE, Almassi GH, Olinger GN, Rusch NJ. Relaxation of canine saphenous veins during storage in Plasma-Lyte and normal saline solution. 1994; 107:1445-1453.
    96. Rusch NJ, England SK, Hermsmeyer K. Physiology and Pathophysiology of the Heart. Properties of vascular smooth muscle in hypertension. 1994; 53.
    97. Li P, Zou A, Al-Kayed NJ, Rusch NJ, Harder DR. GTP-binding proteins in aortic smooth muscle from experimentally-induced hypertensive rats. 1994; 23:914-918.
    98. Rusch NJ, Hermsmeyer K. Handbook on Ionic Transport in Hypertension: New Perspectives. Calcium channels in hypertension. 1994.
    99. Rusch NJ, Kotchen TA. Handbook of Hypertension. Vascular muscle regulation by calcium, potassium and magnesium in hypertension. 1994.
    100. Stekiel WJ, Contney SJ, Rusch NJ. Altered beta-receptor control of in situ membrane potential in hypertensive rats. Hypertension. 1993 Jun; 21(6 Pt 2):1005-9. PMID: 8099344.
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    101. England SK, Wooldridge TA, Stekiel WJ, Rusch NJ. Enhanced single-channel K+ current in arterial membranes from genetically hypertensive rats. Am J Physiol. 1993 May; 264(5 Pt 2):H1337-45. PMID: 8498547.
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    102. Rusch NJ, Wooldridge TA, Olinger GN, Boerboom LE. The effect of ambient temperature on papaverine-induced relaxations in canine saphenous veins. J Thorac Cardiovasc Surg. 1992 Nov; 104(5):1289-93. PMID: 1434708.
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    103. Buljubasic N, Flynn NM, Marijic J, Rusch NJ, Kampine JP, Bosnjak ZJ. Effects of isoflurane on K+ and Ca2+ conductance in isolated smooth muscle cells of canine cerebral arteries. Anesth Analg. 1992 Oct; 75(4):590-6. PMID: 1326907.
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    104. Berczi V, Stekiel WJ, Contney SJ, Rusch NJ. Pressure-induced activation of membrane K+ current in rat saphenous artery. Hypertension. 1992 Jun; 19(6 Pt 2):725-9. PMID: 1592474.
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    105. Buljubasic N, Rusch NJ, Marijic J, Kampine JP, Bosnjak ZJ. Effects of halothane and isoflurane on calcium and potassium channel currents in canine coronary arterial cells. Anesthesiology. 1992 Jun; 76(6):990-8. PMID: 1318010.
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    106. Rusch NJ, De Lucena RG, Wooldridge TA, England SK, Cowley AW. A Ca(2+)-dependent K+ current is enhanced in arterial membranes of hypertensive rats. Hypertension. 1992 Apr; 19(4):301-7. PMID: 1555863.
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    107. Boerboom LE, Wooldridge TA, Olinger GN, Rusch NJ. Effects of storage solutions on contraction and relaxation of isolated saphenous veins. J Cardiovasc Pharmacol. 1992; 20 Suppl 12:S80-4. PMID: 1282995.
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    108. Eskinder H, Rusch NJ, Supan FD, Kampine JP, Bosnjak ZJ. The effects of volatile anesthetics on L- and T-type calcium channel currents in canine cardiac Purkinje cells. Anesthesiology. 1991 May; 74(5):919-26. PMID: 1850580.
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    109. Bonnet P, Rusch NJ, Harder DR. Characterization of an outward K+ current in freshly dispersed cerebral arterial muscle cells. Pflugers Arch. 1991 Apr; 418(3):292-6. PMID: 1857636.
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    110. Bosnjak ZJ, Supan FD, Rusch NJ. The effects of halothane, enflurane, and isoflurane on calcium current in isolated canine ventricular cells. Anesthesiology. 1991 Feb; 74(2):340-5. PMID: 1846726.
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    111. Rusch NJ, Stekiel WJ. Ionic channels of vascular smooth muscle in hypertension. Adv Exp Med Biol. 1991; 308:1-7. PMID: 1724870.
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    112. Eskinder H, Rusch NJ, Bosnjak ZJ. Theeffects of halothane, enflurane and isoflurane on T-type and L-type calcium currents in single canine Purkinje cells. 1991; 74:919-926.
    113. Rusch NJ, Stekiel WJ. Cellular and Molecular Mechanisms in Hypertension: Implications for Pathogenesis and Treatments. Ionic channels of vascular muscle in hypertension. 1991.
    114. Wahler GM, Rusch NJ, Sperelakis N. 8-Bromo-cyclic GMP inhibits the calcium channel current in embryonic chick ventricular myocytes. Can J Physiol Pharmacol. 1990 Apr; 68(4):531-4. PMID: 2328456.
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    115. Hermsmeyer K, Rusch NJ. Calcium channel alterations in genetic hypertension. Hypertension. 1989 Oct; 14(4):453-6. PMID: 2551823.
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    116. Matherne GP, Nakamura KT, Alden BM, Rusch NJ, Robillard JE. Regional variation of postjunctional alpha-adrenoceptor responses in the developing renal vascular bed of sheep. Pediatr Res. 1989 May; 25(5):461-5. PMID: 2541395.
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    117. Hermsmeyer K, Rusch NJ. Essential Hypertension. Membrane potential and calcium influx in vascular muscle from spontaneously hypertensive rats. 1989.
    118. Rusch NJ, Hermsmeyer K. Calcium currents are altered in the vascular muscle cell membrane of spontaneously hypertensive rats. Circ Res. 1988 Dec; 63(6):997-1002. PMID: 3197275.
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    119. Rusch NJ, Aarhus LL, Shepherd JT, Vanhoutte PM. The effect of cold on adrenergic neurotransmission in canine saphenous arteries and veins. Proc Soc Exp Biol Med. 1988 Apr; 187(4):506-12. PMID: 3353400.
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    120. Rusch NJ, Hermsmeyer K. Measurement of whole-cell calcium current in voltage-clamped vascular muscle cells. Mol Cell Biochem. 1988 Mar-Apr; 80(1-2):87-93. PMID: 2459602.
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    121. Hermsmeyer K, Sturek M, Rusch NJ. Calcium channel modulation by dihydropyridines in vascular smooth muscle. Ann N Y Acad Sci. 1988; 522:25-31. PMID: 2454055.
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    122. Hermsmeyer K, Sturek M, Rusch NJ. Nitrendipine inhibition of calcium current in rat vascular muscle cells. J Cardiovasc Pharmacol. 1988; 12 Suppl 5:S100-3. PMID: 2469865.
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    123. Rusch NJ, Hermsmeyer K. Whole-cell calcium current in isolated vascular smooth muscle cells. 1988; 80:87-93.
    124. Hermsmeyer K, Rusch NJ. Felodipine actions on vascular muscle Ca2+ channels. J Cardiovasc Pharmacol. 1987; 10 Suppl 1:S40-3. PMID: 2442516.
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    125. Gutterman DD, Rusch NJ, Hermsmeyer K, Dole WP. Differential reactivity to 5-hydroxytryptamine in canine coronary arteries. Blood Vessels. 1986; 23(4-5):165-72. PMID: 3779106.
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    126. Rusch NJ, Chyatte D, Sundt TM, Vanhoutte PM. 5-hydroxytryptamine: source of activator calcium in human basilar arteries. Stroke. 1985 Jul-Aug; 16(4):718-20. PMID: 4024184.
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    127. Rusch NJ, Hermsmeyer K. Vasopressin induced rhythmic activity in rat basilar artery. Ann Biomed Eng. 1985; 13(3-4):295-302. PMID: 4037459.
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    128. Hermsmeyer K, Rusch NJ. Difference in vasopressin-induced contraction of basilar arteries from stroke-prone spontaneously-hypertensive rats (SP-SHR) and control Wistar-Kyoto rats (WKY). J Hypertens Suppl. 1984 Dec; 2(3):S423-5. PMID: 6443711.
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    129. Chyatte D, Rusch N, Sundt TM. Prevention of chronic experimental cerebral vasospasm with ibuprofen and high-dose methylprednisolone. J Neurosurg. 1983 Dec; 59(6):925-32. PMID: 6631514.
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    130. Chyatte D, Rusch NJ, Sundt TM. Prevention of chronic vasospasm using ibuprofen and high dose methylprednisolone. 1983; 59:925-932.
    131. Shepherd JT, Rusch NJ, Vanhoutte PM. Effect of cold on the blood vessel wall. Gen Pharmacol. 1983; 14(1):61-4. PMID: 6131011.
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    132. Rorie DK, Rusch NJ, Shepherd JT, Vanhoutte PM, Tyce GM. Prejunctional inhibition of norepinephrine release caused by acetylcholine in the human saphenous vein. Circ Res. 1981 Aug; 49(2):337-41. PMID: 7249270.
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    133. Rusch NJ, Shepherd JT, Webb RC, Vanhoutte PM. Different behavior of the resistance vessels of the human calf and forearm during contralateral isometric exercise, mental stress, and abnormal respiratory movements. Circ Res. 1981 Jun; 48(6 Pt 2):I118-30. PMID: 7226455.
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    134. Rusch NJ, Shepherd JT, Vanhoutte PM. The effect of profound cooling on adrenergic neurotransmission in canine cutaneous veins. J Physiol. 1981 Feb; 311:57-65. PMID: 6267258.
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    135. Webb RC, Rusch NJ, Vanhoutte PM. Influence of sex difference and oral contraceptives on forearm reactive hyperemia. Blood Vessels. 1981; 18(4-5):161-70. PMID: 6794679.
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    136. Rusch NJ, De Mey JG, Vanhoutte PM. Effect of BL-5111-A, prazosin and phentolamine on responses of canine cutaneous veins to adrenergic activation. Arch Int Pharmacodyn Ther. 1980 Apr; 244(2):341-3. PMID: 7406593.
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    137. Rusch NJ, Shepherd JT, Vanhoutte PM. Alternation of contraction and relaxation during profound cooling in canine cutaneous veins [proceedings]. J Physiol. 1979 Oct; 295:74P-75P. PMID: 521989.
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    138. Rusch NJ, Shepherd JT, Vanhoutte PM. Effect of profound cooling on adrenergic neuroeffector interaction in the blood vessel wall [proceedings]. Br J Pharmacol. 1979 May; 66(1):149P-150P. PMID: 454942.
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    139. Thakali KM, Pathan AR, Kharade SV, Rusch NJ. Muscle. Potassium, sodium and chloride channel in arterial smooth muscle cells.
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