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Karl Boehme

CredentialsPostdoctoral Training - Vanderbilt University Medical Center
Ph.D. University of Wisconsin-Madison
M.S. University of Texas-San Antonio
B.S. University of Texas-San Antonio
TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address506A Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-5189
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    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director of Graduate Studies, Department of Microbiology & Immunology

    Director, Microbiology & Immunology Track, Graduate Program in Interdisciplinary Biomedical Sciences

    Member, Institutional Biosafety Committee


    Collapse Teaching 

    Collapse Research 
    Collapse research activities and funding
    U01CA260526     (NEMBHARD, WENDY N)Sep 30, 2020 - Aug 31, 2022
    NIH
    DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas
    Role: Co-Investigator

    R01AI110637     (BOEHME, KARL)Feb 1, 2019 - Jan 31, 2024
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Indiana University
    Sub R01 Dr. Danthi
    Role: Principal Investigator

    R01AI118801     (BOEHME, KARL W)Sep 21, 2016 - Aug 31, 2021
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator

    R56AI118801     (BOEHME, KARL W)Sep 5, 2015 - Sep 20, 2016
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator

    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator

    K22AI094079     (BOEHME, KARL W)Jul 2, 2012 - Jun 30, 2015
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator

    F32AI075776     (BOEHME, KARL W)Apr 1, 2008 - Mar 31, 2009
    NIH
    Characterization of the reovirus simga 1s protien.
    Role: Principal Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, Liu J, Harville TO. Development of ACE2 autoantibodies after SARS-CoV-2 infection. PLoS One. 2021; 16(9):e0257016. PMID: 34478478.
      View in: PubMed
    2. Phillips MB, Dina Zita M, Howells MA, Weinkopff T, Boehme KW. Lymphatic Type 1 Interferon Responses Are Critical for Control of Systemic Reovirus Dissemination. J Virol. 2021 01 28; 95(4). PMID: 33208448.
      View in: PubMed
    3. Moran JH, Kessler L, Moylan J, Forrest C, Boehme K, Kennedy J, Greninger A, Baird G, Olgaard E, James L. Modifying laboratory testing via home brew during the COVID-19 pandemic. J Clin Transl Sci. 2021 Jan 25; 5(1):e93. PMID: 34192050.
      View in: PubMed
    4. Eledge MR, Zita MD, Boehme KW. Reovirus: Friend and Foe. Curr Clin Microbiol Rep. 2019; 6(3):132-138. PMID: 33134034.
      View in: PubMed
    5. Phillips MB, Stuart JD, Rodríguez Stewart RM, Berry JT, Mainou BA, Boehme KW. Current understanding of reovirus oncolysis mechanisms. Oncolytic Virother. 2018; 7:53-63. PMID: 29942799.
      View in: PubMed
    6. Stuart JD, Holm GH, Boehme KW. Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. J Virol. 2018 05 01; 92(9). PMID: 29437975.
      View in: PubMed
    7. Phillips MB, Stuart JD, Simon EJ, Boehme KW. Nonstructural Protein s1s Is Required for Optimal Reovirus Protein Expression. J Virol. 2018 04 01; 92(7). PMID: 29321319.
      View in: PubMed
    8. Simon EJ, Howells MA, Stuart JD, Boehme KW. Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. Viruses. 2017 06 06; 9(6). PMID: 28587298.
      View in: PubMed
    9. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50. PMID: 28386004.
      View in: PubMed
    10. Stuart JD, Phillips MB, Boehme KW. Reverse Genetics for Mammalian Orthoreovirus. Methods Mol Biol. 2017; 1602:1-10. PMID: 28508210.
      View in: PubMed
    11. Boehme KW, Ikizler M, Iskarpatyoti JA, Wetzel JD, Willis J, Crowe JE, LaBranche CC, Montefiori DC, Wilson GJ, Dermody TS. Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1. mSphere. 2016 May-Jun; 1(3). PMID: 27303748.
      View in: PubMed
    12. Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J Infect Dis. 2015 Feb 01; 211(3):383-93. PMID: 25149763.
      View in: PubMed
    13. Stebbing RE, Irvin SC, Rivera-Serrano EE, Boehme KW, Ikizler M, Yoder JA, Dermody TS, Sherry B. An ITAM in a nonenveloped virus regulates activation of NF-?B, induction of beta interferon, and viral spread. J Virol. 2014 Mar; 88(5):2572-83. PMID: 24352448.
      View in: PubMed
    14. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS. Nonstructural protein s1s mediates reovirus-induced cell cycle arrest and apoptosis. J Virol. 2013 Dec; 87(23):12967-79. PMID: 24067959.
      View in: PubMed
    15. Nygaard RM, Lahti L, Boehme KW, Ikizler M, Doyle JD, Dermody TS, Schiff LA. Genetic determinants of reovirus pathogenesis in a murine model of respiratory infection. J Virol. 2013 Aug; 87(16):9279-89. PMID: 23760238.
      View in: PubMed
    16. Boehme KW, Lai CM, Dermody TS. Mechanisms of reovirus bloodstream dissemination. Adv Virus Res. 2013; 87:1-35. PMID: 23809919.
      View in: PubMed
    17. Trask SD, Boehme KW, Dermody TS, Patton JT. Comparative analysis of Reoviridae reverse genetics methods. Methods. 2013 Feb; 59(2):199-206. PMID: 22687622.
      View in: PubMed
    18. Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J Virol. 2011 Nov; 85(22):11781-90. PMID: 21917967.
      View in: PubMed
    19. Boehme KW, Ikizler M, Kobayashi T, Dermody TS. Reverse genetics for mammalian reovirus. Methods. 2011 Oct; 55(2):109-13. PMID: 21798351.
      View in: PubMed
    20. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18652-7. PMID: 20937889.
      View in: PubMed
    21. Boehme KW, Guglielmi KM, Dermody TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19986-91. PMID: 19897716.
      View in: PubMed
    22. Juckem LK, Boehme KW, Feire AL, Compton T. Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol. 2008 Apr 01; 180(7):4965-77. PMID: 18354222.
      View in: PubMed
    23. Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19; 1(2):147-57. PMID: 18005692.
      View in: PubMed
    24. Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006 Nov 15; 177(10):7094-102. PMID: 17082626.
      View in: PubMed
    25. Lam V, Boehme KW, Compton T, Yin J. Spatial patterns of protein expression in focal infections of human cytomegalovirus. Biotechnol Bioeng. 2006 Apr 20; 93(6):1029-39. PMID: 16506244.
      View in: PubMed
    26. Boehme KW, Compton T. Innate sensing of viruses by toll-like receptors. J Virol. 2004 Aug; 78(15):7867-73. PMID: 15254159.
      View in: PubMed
    27. Boehme KW, Singh J, Perry ST, Compton T. Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B. J Virol. 2004 Feb; 78(3):1202-11. PMID: 14722275.
      View in: PubMed
    28. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol. 2003 Apr; 77(8):4588-96. PMID: 12663765.
      View in: PubMed
    29. Boehme KW, Popov VL, Heidner HW. The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells. J Virol. 2000 Dec; 74(23):11398-406. PMID: 11070041.
      View in: PubMed
    30. Boehme KW, Williams JC, Johnston RE, Heidner HW. Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell. J Gen Virol. 2000 Jan; 81(Pt 1):161-70. PMID: 10640554.
      View in: PubMed
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