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Karl Boehme

CredentialsPostdoctoral Training - Vanderbilt University Medical Center
Ph.D. University of Wisconsin-Madison
M.S. University of Texas-San Antonio
B.S. University of Texas-San Antonio
TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address506A Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-5189
ORCID ORCID Icon0000-0003-2691-9763 Additional info
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    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director of Graduate Studies, Department of Microbiology & Immunology

    Director, Microbiology & Immunology Track, Graduate Program in Interdisciplinary Biomedical Sciences

    Member, Institutional Biosafety Committee

    Collapse awards and honors
    2017Charles C. Randall Award for Oustanding Accomplishments in Microbiolgoy, American Society for Microbiology South Central Branch
    2019Top 25 Peer Reviewers, Journal of Virology
    2020Top 25 Peer Reviewers, Journal of Virology
    2022Top 25 Peer Reviewers, Journal of Virology
    2023Top 25 Peer Reviewers, Journal of Virology

    Collapse Teaching 

    Collapse Research 
    Collapse research activities and funding
    2R01AI110637-10     (BOEHME, KARL W)Jul 1, 2024 - Jan 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Indiana University
    Subaward to Indiana
    Role: Principal Investigator
    1R21AI178222-01     (BOEHME, KARL W)Jun 1, 2023 - May 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Reovirus induction of host inflammatory responses
    Role: Principal Investigator
    P30GM145393     (SMELTZER, MARK S)May 5, 2022 - Apr 30, 2027
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator
    U01CA260526     (NEMBHARD, WENDY N)Sep 30, 2020 - Feb 28, 2025
    NIH
    DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas
    Role: Co-Investigator
    GR039080     (QUANG, LAWRENCE)Aug 1, 2020 - Jul 31, 2021
    UAMS ACHRI Flow Through
    Quang ACRI GR039080 Epidemiologic and Clinical Features of COVID-19 in Pediatric Patients and Healthcare Workers in the Pediatric Emergency Department: A Prospective, Observational Analysis (COVID)
    Role: Principal Investigator
    R01AI110637     (BOEHME, KARL W)Feb 1, 2019 - Jan 31, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Indiana University
    Sub R01 Dr. Danthi - Continuation
    Role: Principal Investigator
    R01AI118801     (BOEHME, KARL W)Sep 21, 2016 - Aug 31, 2021
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator
    R56AI118801     (BOEHME, KARL W)Sep 5, 2015 - Sep 20, 2016
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator
    117-1009264     (BOEHME, KARL W)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    No FP attached
    Role: Principal Investigator
    K22AI094079     (BOEHME, KARL W)Jul 2, 2012 - Jun 30, 2015
    NIH
    Mechanisms of Reovirus Bloodstream Dissemination
    Role: Principal Investigator
    F32AI075776     (BOEHME, KARL W)Apr 1, 2008 - Mar 31, 2009
    NIH
    Characterization of the reovirus simga 1s protien.
    Role: Principal Investigator

    Collapse Outreach 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, Liu J, Harville TO. Correction: Development of ACE2 autoantibodies after SARS-CoV-2 infection. PLoS One. 2024; 19(11):e0314426. PMID: 39565738.
      View in: PubMed
    2. Viswanathan P, Bersonda JR, Gill J, Navarro A, Farrar AC, Dunham D, Boehme KW, Manzano M. The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines. bioRxiv. 2024 Sep 24. PMID: 39386614.
      View in: PubMed
    3. Roys H, Arykbayeva A, Friedman SK, Gifford G, Palmer ER, Rogers A, Tran ENH, Fry L, Weaver A, Bowlin A, Jones MD, Eledge MR, Boehme KW, Naumiec GR, Weinkopff T. Synthesis and in vitro evaluation shows disquaramide compounds are a promising class of anti-leishmanial drugs. bioRxiv. 2024 Aug 24. PMID: 39229173.
      View in: PubMed
    4. Boehme KW. Timely T cell recruitment protects against viral myocarditis. Nat Cardiovasc Res. 2024 01; 3(1):26-27. PMID: 39195891.
      View in: PubMed
    5. Allen JL, Amick BC, Williams ML, Kennedy JL, Boehme KW, Forrest JC, Primack B, Sides EA, Nembhard WN, Gardner SF, Snowden JN, James LP, Olgaard E, Gandy J. A longitudinal study of SARS-CoV-2 antibody seroprevalence and mitigation behaviors among college students at an Arkansas University. J Am Coll Health. 2023 Jun 08; 1-10. PMID: 37289962.
      View in: PubMed
    6. Boehme KW, Kennedy JL, Snowden J, Owens SM, Kouassi M, Mann RL, Paredes A, Putt C, James L, Jin J, Du R, Kirkpatrick C, Modi Z, Caid K, Young S, Zohoori N, Kothari A, Boyanton BL, Craig Forrest J. Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic. J Pediatric Infect Dis Soc. 2022 Jun 22; 11(6):248-256. PMID: 35294550.
      View in: PubMed
    7. Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization. mSphere. 2022 08 31; 7(4):e0019322. PMID: 35703544.
      View in: PubMed
    8. Wilkins H, Jastaniah E, Spray B, Forrest JC, Boehme KW, Kirkpatrick C, Boyanton BL, Spiro DM, Crawley L, Quang L, Kennedy JL. Seroprevalence of SARS-CoV-2 antibodies in front-line pediatric health care workers. J Am Coll Emerg Physicians Open. 2022 Jun; 3(3):e12743. PMID: 35601650.
      View in: PubMed
    9. Figueiredo JC, Hirsch FR, Kushi LH, Nembhard WN, Crawford JM, Mantis N, Finster L, Merin NM, Merchant A, Reckamp KL, Melmed GY, Braun J, McGovern D, Parekh S, Corley DA, Zohoori N, Amick BC, Du R, Gregersen PK, Diamond B, Taioli E, Sariol C, Espino A, Weiskopf D, Gifoni A, Brien J, Hanege W, Lipsitch M, Zidar DA, Scheck McAlearney A, Wajnberg A, LaBaer J, Yvonne Lewis E, Binder RA, Moormann AM, Forconi C, Forrester S, Batista J, Schieffelin J, Kim D, Biancon G, VanOudenhove J, Halene S, Fan R, Barouch DH, Alter G, Pinninti S, Boppana SB, Pati SK, Latting M, Karaba AH, Roback J, Sekaly R, Neish A, Brincks AM, Granger DA, Karger AB, Thyagarajan B, Thomas SN, Klein SL, Cox AL, Lucas T, Furr-Holden D, Key K, Jones N, Wrammerr J, Suthar M, Yu Wong S, Bowman NM, Simon V, Richardson LD, McBride R, Krammer F, Rana M, Kennedy J, Boehme K, Forrest C, Granger SW, Heaney CD, Knight Lapinski M, Wallet S, Baric RS, Schifanella L, Lopez M, Fern?ndez S, Kenah E, Panchal AR, Britt WJ, Sanz I, Dhodapkar M, Ahmed R, Bartelt LA, Markmann AJ, Lin JT, Hagan RS, Wolfgang MC, Skarbinski J. Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies. Open Forum Infect Dis. 2022 Jun; 9(6):ofac171. PMID: 35765315.
      View in: PubMed
    10. Cardenas VM, Kennedy JL, Williams M, Nembhard WN, Zohoori N, Du R, Jin J, Boothe D, Fischbach LA, Kirkpatrick C, Modi Z, Caid K, Owens S, Forrest JC, James L, Boehme KW, Olgaard E, Gardner SF, Amick BC. State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020. PLoS One. 2022; 17(4):e0267322. PMID: 35476717.
      View in: PubMed
    11. Kennedy JL, Forrest JC, Young SG, Amick B, Williams M, James L, Snowden J, Cardenas VM, Boothe D, Kirkpatrick C, Modi Z, Caid K, Owens S, Kouassi M, Mann R, Putt C, Irish-Clardy K, Macechko M, Brimberry RK, Nembhard WN, McElfish PA, Du R, Jin J, Zohoori N, Kothari A, Hagrass H, Olgaard E, Boehme KW. Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas. Open Forum Infect Dis. 2022 May; 9(5):ofac154. PMID: 35493126.
      View in: PubMed
    12. Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization. medRxiv. 2022 Mar 14. PMID: 35262095.
      View in: PubMed
    13. Dina Zita M, Phillips MB, Stuart JD, Kumarapeli AR, Snyder AJ, Paredes A, Sridharan V, Boerma M, Danthi P, Boehme KW. The M2 Gene Is a Determinant of Reovirus-Induced Myocarditis. J Virol. 2022 01 26; 96(2):e0187921. PMID: 34757847.
      View in: PubMed
    14. Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, Liu J, Harville TO. Development of ACE2 autoantibodies after SARS-CoV-2 infection. PLoS One. 2021; 16(9):e0257016. PMID: 34478478.
      View in: PubMed
    15. Phillips MB, Dina Zita M, Howells MA, Weinkopff T, Boehme KW. Lymphatic Type 1 Interferon Responses Are Critical for Control of Systemic Reovirus Dissemination. J Virol. 2021 01 28; 95(4). PMID: 33208448.
      View in: PubMed
    16. Moran JH, Kessler L, Moylan J, Forrest C, Boehme K, Kennedy J, Greninger A, Baird G, Olgaard E, James L. Modifying laboratory testing via home brew during the COVID-19 pandemic. J Clin Transl Sci. 2021 Jan 25; 5(1):e93. PMID: 34192050.
      View in: PubMed
    17. Eledge MR, Zita MD, Boehme KW. Reovirus: Friend and Foe. Curr Clin Microbiol Rep. 2019; 6(3):132-138. PMID: 33134034.
      View in: PubMed
    18. Phillips MB, Stuart JD, Rodr?guez Stewart RM, Berry JT, Mainou BA, Boehme KW. Current understanding of reovirus oncolysis mechanisms. Oncolytic Virother. 2018; 7:53-63. PMID: 29942799.
      View in: PubMed
    19. Stuart JD, Holm GH, Boehme KW. Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. J Virol. 2018 05 01; 92(9). PMID: 29437975.
      View in: PubMed
    20. Phillips MB, Stuart JD, Simon EJ, Boehme KW. Nonstructural Protein s1s Is Required for Optimal Reovirus Protein Expression. J Virol. 2018 04 01; 92(7). PMID: 29321319.
      View in: PubMed
    21. Simon EJ, Howells MA, Stuart JD, Boehme KW. Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. Viruses. 2017 06 06; 9(6). PMID: 28587298.
      View in: PubMed
    22. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 04 07; 356(6333):44-50. PMID: 28386004.
      View in: PubMed
    23. Stuart JD, Phillips MB, Boehme KW. Reverse Genetics for Mammalian Orthoreovirus. Methods Mol Biol. 2017; 1602:1-10. PMID: 28508210.
      View in: PubMed
    24. Boehme KW, Ikizler M, Iskarpatyoti JA, Wetzel JD, Willis J, Crowe JE, LaBranche CC, Montefiori DC, Wilson GJ, Dermody TS. Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1. mSphere. 2016 May-Jun; 1(3). PMID: 27303748.
      View in: PubMed
    25. Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J Infect Dis. 2015 Feb 01; 211(3):383-93. PMID: 25149763.
      View in: PubMed
    26. Stebbing RE, Irvin SC, Rivera-Serrano EE, Boehme KW, Ikizler M, Yoder JA, Dermody TS, Sherry B. An ITAM in a nonenveloped virus regulates activation of NF-?B, induction of beta interferon, and viral spread. J Virol. 2014 Mar; 88(5):2572-83. PMID: 24352448.
      View in: PubMed
    27. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS. Nonstructural protein s1s mediates reovirus-induced cell cycle arrest and apoptosis. J Virol. 2013 Dec; 87(23):12967-79. PMID: 24067959.
      View in: PubMed
    28. Nygaard RM, Lahti L, Boehme KW, Ikizler M, Doyle JD, Dermody TS, Schiff LA. Genetic determinants of reovirus pathogenesis in a murine model of respiratory infection. J Virol. 2013 Aug; 87(16):9279-89. PMID: 23760238.
      View in: PubMed
    29. Boehme KW, Lai CM, Dermody TS. Mechanisms of reovirus bloodstream dissemination. Adv Virus Res. 2013; 87:1-35. PMID: 23809919.
      View in: PubMed
    30. Trask SD, Boehme KW, Dermody TS, Patton JT. Comparative analysis of Reoviridae reverse genetics methods. Methods. 2013 Feb; 59(2):199-206. PMID: 22687622.
      View in: PubMed
    31. Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J Virol. 2011 Nov; 85(22):11781-90. PMID: 21917967.
      View in: PubMed
    32. Boehme KW, Ikizler M, Kobayashi T, Dermody TS. Reverse genetics for mammalian reovirus. Methods. 2011 Oct; 55(2):109-13. PMID: 21798351.
      View in: PubMed
    33. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18652-7. PMID: 20937889.
      View in: PubMed
    34. Boehme KW, Guglielmi KM, Dermody TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19986-91. PMID: 19897716.
      View in: PubMed
    35. Juckem LK, Boehme KW, Feire AL, Compton T. Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol. 2008 Apr 01; 180(7):4965-77. PMID: 18354222.
      View in: PubMed
    36. Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19; 1(2):147-57. PMID: 18005692.
      View in: PubMed
    37. Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006 Nov 15; 177(10):7094-102. PMID: 17082626.
      View in: PubMed
    38. Lam V, Boehme KW, Compton T, Yin J. Spatial patterns of protein expression in focal infections of human cytomegalovirus. Biotechnol Bioeng. 2006 Apr 20; 93(6):1029-39. PMID: 16506244.
      View in: PubMed
    39. Boehme KW, Compton T. Innate sensing of viruses by toll-like receptors. J Virol. 2004 Aug; 78(15):7867-73. PMID: 15254159.
      View in: PubMed
    40. Boehme KW, Singh J, Perry ST, Compton T. Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B. J Virol. 2004 Feb; 78(3):1202-11. PMID: 14722275.
      View in: PubMed
    41. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol. 2003 Apr; 77(8):4588-96. PMID: 12663765.
      View in: PubMed
    42. Boehme KW, Popov VL, Heidner HW. The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells. J Virol. 2000 Dec; 74(23):11398-406. PMID: 11070041.
      View in: PubMed
    43. Boehme KW, Williams JC, Johnston RE, Heidner HW. Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell. J Gen Virol. 2000 Jan; 81(Pt 1):161-70. PMID: 10640554.
      View in: PubMed
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