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Karl Boehme

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address506A Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-5189
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    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Director of Graduate Studies, Department of Microbiology & Immunology

    Director, Microbiology & Immunology Track, Graduate Program in Interdisciplinary Biomedical Sciences

    Member, Institutional Biosafety Committee


    Collapse Educational Activities 

    Collapse Research Funds 
    Collapse principal investigator
    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 1 R01 AI118801-01A1 - Start Date: 2016-09-21

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 5 R01 AI118801-02 - Start Date: 2016-09-21

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 5 R01 AI118801-03 - Start Date: 2016-09-21

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 5 R01 AI118801-04 - Start Date: 2016-09-21

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 5 R01 AI118801-05 - Start Date: 2016-09-21

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 1 R56 AI118801-01 - Start Date: 2015-09-05

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 1 R56 AI118801-01 - Total direct costs: $1,250,000 - Start Date: 2015-09-05

    Funding Agency: UAMS Foundation/Medical Research Endowment - Title: UAMS Foundation / Medical Research Foundation MRE 2013 - Award Number: MRE 2013 - Total direct costs: $11,265 - Start Date: 2013-01-01

    Funding Agency: NIH/Nat. Inst. of Allergy & Infectious Diseases - Title: Mechanisms of Reovirus Bloodstream Dissemination - Award Number: 1 K22 AI094079-01A1 - Total direct costs: $250,000 - Start Date: 2012-07-02


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Simon EJ, Howells MA, Stuart JD, Boehme KW. Serotype-Specific Killing of Large Cell Carcinoma Cells by Reovirus. Viruses. 2017 Jun 06; 9(6). PMID: 28587298.
      View in: PubMed
    2. Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 Apr 07; 356(6333):44-50. PMID: 28386004.
      View in: PubMed
    3. Stuart JD, Phillips MB, Boehme KW. Reverse Genetics for Mammalian Orthoreovirus. Methods Mol Biol. 2017; 1602:1-10. PMID: 28508210.
      View in: PubMed
    4. Boehme KW, Ikizler M, Iskarpatyoti JA, Wetzel JD, Willis J, Crowe JE, LaBranche CC, Montefiori DC, Wilson GJ, Dermody TS. Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1. mSphere. 2016 May-Jun; 1(3). PMID: 27303748; PMCID: PMC4888892.
    5. Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J Infect Dis. 2015 Feb 01; 211(3):383-93. PMID: 25149763; PMCID: PMC4351375.
    6. Stebbing RE, Irvin SC, Rivera-Serrano EE, Boehme KW, Ikizler M, Yoder JA, Dermody TS, Sherry B. An ITAM in a nonenveloped virus regulates activation of NF-?B, induction of beta interferon, and viral spread. J Virol. 2014 Mar; 88(5):2572-83. PMID: 24352448; PMCID: PMC3958081.
    7. Boehme KW, Hammer K, Tollefson WC, Konopka-Anstadt JL, Kobayashi T, Dermody TS. Nonstructural protein s1s mediates reovirus-induced cell cycle arrest and apoptosis. J Virol. 2013 Dec; 87(23):12967-79. PMID: 24067959; PMCID: PMC3838159.
    8. Nygaard RM, Lahti L, Boehme KW, Ikizler M, Doyle JD, Dermody TS, Schiff LA. Genetic determinants of reovirus pathogenesis in a murine model of respiratory infection. J Virol. 2013 Aug; 87(16):9279-89. PMID: 23760238; PMCID: PMC3754055.
    9. Boehme KW, Lai CM, Dermody TS. Mechanisms of reovirus bloodstream dissemination. Adv Virus Res. 2013; 87:1-35. PMID: 23809919; PMCID: PMC4603565.
    10. Trask SD, Boehme KW, Dermody TS, Patton JT. Comparative analysis of Reoviridae reverse genetics methods. Methods. 2013 Feb; 59(2):199-206. PMID: 22687622; PMCID: PMC3449048.
    11. Boehme KW, Frierson JM, Konopka JL, Kobayashi T, Dermody TS. The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice. J Virol. 2011 Nov; 85(22):11781-90. PMID: 21917967; PMCID: PMC3209282.
    12. Boehme KW, Ikizler M, Kobayashi T, Dermody TS. Reverse genetics for mammalian reovirus. Methods. 2011 Oct; 55(2):109-13. PMID: 21798351; PMCID: PMC3208765.
    13. Trask SD, Taraporewala ZF, Boehme KW, Dermody TS, Patton JT. Dual selection mechanisms drive efficient single-gene reverse genetics for rotavirus. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18652-7. PMID: 20937889; PMCID: PMC2972929.
    14. Boehme KW, Guglielmi KM, Dermody TS. Reovirus nonstructural protein sigma1s is required for establishment of viremia and systemic dissemination. Proc Natl Acad Sci U S A. 2009 Nov 24; 106(47):19986-91. PMID: 19897716; PMCID: PMC2774258.
    15. Juckem LK, Boehme KW, Feire AL, Compton T. Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol. 2008 Apr 01; 180(7):4965-77. PMID: 18354222.
      View in: PubMed
    16. Kobayashi T, Antar AA, Boehme KW, Danthi P, Eby EA, Guglielmi KM, Holm GH, Johnson EM, Maginnis MS, Naik S, Skelton WB, Wetzel JD, Wilson GJ, Chappell JD, Dermody TS. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 2007 Apr 19; 1(2):147-57. PMID: 18005692; PMCID: PMC2034303.
    17. Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006 Nov 15; 177(10):7094-102. PMID: 17082626.
      View in: PubMed
    18. Lam V, Boehme KW, Compton T, Yin J. Spatial patterns of protein expression in focal infections of human cytomegalovirus. Biotechnol Bioeng. 2006 Apr 20; 93(6):1029-39. PMID: 16506244.
      View in: PubMed
    19. Boehme KW, Compton T. Innate sensing of viruses by toll-like receptors. J Virol. 2004 Aug; 78(15):7867-73. PMID: 15254159; PMCID: PMC446107.
    20. Boehme KW, Singh J, Perry ST, Compton T. Human cytomegalovirus elicits a coordinated cellular antiviral response via envelope glycoprotein B. J Virol. 2004 Feb; 78(3):1202-11. PMID: 14722275; PMCID: PMC321386.
    21. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol. 2003 Apr; 77(8):4588-96. PMID: 12663765; PMCID: PMC152130.
    22. Boehme KW, Popov VL, Heidner HW. The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells. J Virol. 2000 Dec; 74(23):11398-406. PMID: 11070041; PMCID: PMC113246.
    23. Boehme KW, Williams JC, Johnston RE, Heidner HW. Linkage of an alphavirus host-range restriction to the carbohydrate-processing phenotypes of the host cell. J Gen Virol. 2000 Jan; 81(Pt 1):161-70. PMID: 10640554.
      View in: PubMed
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