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Patricia Crew

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Biophysics, College of Medicine
DivisionPhysiology & Biophysics Myelin
AddressB212-B Biomedical Research I
325 S. Elm St.
Mail Slot # 750
Little Rock AR 72205
Phone501-686-5366
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    Collapse Research Funds 
    Collapse research activities
    R01NS106179     (CREW, PATRICIA)Apr 1, 2019 - Mar 31, 2024
    NIH/Nat. Inst. of Neurological Disorders & Stroke
    Elucidation of Mechanisms Controlling Human and Mouse Myelin PLP1 Gene Expression
    Role: Principal Investigator
    RG 2705E5/2     (CREW, PATRICIA)Oct 1, 2012 - Sep 30, 2014
    National Multiple Sclerosis Society
    Control of Human Myelin Proteolipid Protein Gene Expression during Development and Remyelination
    Role: Principal Investigator
    RG 2705D4/1     (CREW, PATRICIA)Oct 1, 2006 - Sep 30, 2010
    National Multiple Sclerosis Society
    Developmental Control of Myelin Proteolipid Protein Gene Regulation
    Role: Principal Investigator
    P30NS047546     (DREW, PAUL D)Aug 15, 2004 - Jul 31, 2010
    NIH/NINDS
    Neuroscience Research Center Core Facility at UAMS
    Role: Co-Investigator
    RG 2705C3/1     (CREW, PATRICIA)Oct 1, 2002 - Sep 30, 2006
    National Multiple Sclerosis Society
    Developmental Control of Myelin Proteolipid Protein Gene Regulation
    Role: Principal Investigator
    RG 2705-B-2     (CREW, PATRICIA)Sep 30, 1998 - Sep 30, 2002
    National Multiple Sclerosis Society
    Developmental Control of Myelin Proteolipid Protein Gene Regulation
    Role: Principal Investigator
    R01NS037821     (CREW, PATRICIA)Jul 15, 1998 - Aug 31, 2012
    NIH/Nat. Inst. of Neurological Disorders & Stroke
    Activation of PLP Gene Expression in Oligodendrocytes
    Role: Principal Investigator
    R01NS37821     (CREW, PATRICIA)Jul 15, 1998 - Jun 30, 2002
    NIH/Nat. Inst. of Neurological Disorders & Stroke
    Antisilencing of PLP Gene Expression in Oligodendrocytes
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Pereira GB, Meng F, Kockara NT, Yang B, Wight PA. Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination. J Neurochem. 2013; 124(4):454-65.
    2. Al-Dwairi A., Mercado C.P., Hamdan H., Pabona J.M., Simmen R.C.M. Augmented gastrointestinal expression of cytosolic malic enzyme (ME1) in mice pre-disposes to obesity. 94th Annual Endo Meeting. 2012.
    3. Zolova O.E. YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells. ASN Neuro. 2012; 3(4).
    4. Hamdan H., Haun S. Regulatory element(s) in human myelin proteolipid protein (PLP1) intron 1 are required for robust PLP1 gene activity in brain. 2012; 149.
    5. Pereira GB, Dobretsova A, Hamdan H, Wight PA. Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines. J Neurosci Res. 2011; 89(7):1070-8.
    6. Zolova OE, Wight PA. YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells. ASN Neuro. 2011; 3(4).
    7. Li S, Greuel BT, Meng F, Pereira GB, Pitts A, Dobretsova A, Wight PA. Leydig cells express the myelin proteolipid protein gene and incorporate a new alternatively spliced exon. Gene. 2009; 436(1-2):30 - 36.
    8. Li S, Greuel BT, Meng F, Pereira GB, Pitts A, Dobretsova A, Wight PA. Leydig cells express the myelin proteolipid protein gene and incorporate a new alternatively spliced exon. Gene. 2009; 436(1-2):30-6.
    9. Gimenez MA, Kokorina N, Wight PA, Russell JH. Targeted expression of cre recombinase to oligodendrocytes and Schwann cells by myelin proteolipid protein regulatory sequences in C57BL/6 transgenic mice (under revision). Genesis. 2008.
    10. Wight PA. Proteomic analysis of nuclear factors binding to the myelin proteolipid protein gene intronic enhancer. What Regulates Myelination?, Invited speaker. 2007.
    11. Wight PA. Understanding myelin gene regulation as a means to promote remyelination in MS patients. MS Awareness Day (Invited talk). 2007.
    12. Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007; 32(2):343-351.
    13. Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007; 32(2):343 - 351.
    14. Wight PA. PLP and PLP Mutants. Invited speaker in the session. 2006.
    15. Wight PA, Meng F, Yang B. Targeted deletion of the antisilencer/enhancer regulatory element from intron 1 of the mouse myelin Plp gene. 2006; 96 (suppl 1), 12.
    16. Meng F, Zolova O, Kokorina NA, Dobretsova A, Wight PA. Characterization of an intronic enhancer that regulates myelin proteolipid protein (Plp) gene expression in oligodendrocytes. J Neurosci Res. 2005; 82(3):346 - 356.
    17. Meng F, Zolova O, Kokorina NA, Dobretsova A, Wight PA. Characterization of an intronic enhancer that regulates myelin proteolipid protein (Plp) gene expression in oligodendrocytes. J Neurosci Res. 2005; 82(3):346-356.
    18. Dobretsova A, Lichti CF, Wight PA. Characterization of the enhanceosome formed on the myelin proteolipid protein gene by DNA affinity chromatography and mass spectrometry. 2005; 93 (suppl 1), 35.
    19. Meng F, Yang B, Wight PA. Targeted deletion of the antisilencer/enhancer (ASE) transcriptional regulatory element from intron 1 of the mouse myelin proteolipid protein (Plp) gene. Program No. 832.22. 2005.
    20. Greuel BT, Pereira B, Sample M, Wight PA. Regulation of myelin proteolipid protein gene expression: Molecular dissection of the antisilencer/enhancer region in intron 1. 2005; 93 (suppl 1), 34.
    21. Dobretsova A, Kokorina NA, Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. J Neurochem. 2004; 90(6):1500-1510.
    22. Dobretsova A, Kokorina NA, Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. J Neurochem. 2004; 90(6):1500 - 1510.
    23. Wight PA. Purification of a DNA-protein complex formed on the Plp intronic enhancer. 2004.
    24. Wight PA. Characterization of Components that Form an Enhanceosome on the Myelin Proteolipid Protein Gene by DNA Affinity Chromatography/Mass Spectrometry Analysis. 2004.
    25. Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. 2004.
    26. Wight PA, Dobretsova A. Where, when and how much: regulation of myelin proteolipid protein gene expression. Cell Mol Life Sci. 2004 Apr; 61(7-8):810-21. PMID: 15095005.
      View in: PubMed
    27. Wight PA. When, where and how much: regulation of myelin Plp gene expression. 2003.
    28. Li S, Moore CL, Dobretsova A, Wight PA. Myelin proteolipid protein (Plp) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. J Neurochem. 2002; 83(1):193 - 201.
    29. Li S, Moore CL, Dobretsova A, Wight PA. Myelin proteolipid protein (Plp) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. J Neurochem. 2002; 83(1):193-201.
    30. Li S, Dobretsova A, Kokorina NA, Wight PA. Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cells. J Neurochem. 2002; 82(1):159-171.
    31. Li S, Dobretsova A, Kokorina NA, Wight PA. Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cells. J Neurochem. 2002; 82(1):159 - 171.
    32. Wight PA, Li S, Moore CL, Dobretsova A. Myelin proteolipid protein (PLP) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. 2002; 81 (suppl 1), 6.
    33. Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 2001.
    34. Dobretsova A, Kokorina NA, Wight PA. AP-1 potentiates myelin proteolipid protein gene expression through protein-DNA interactions formed in the antisilencer region of intron 1. 2001; 78 (suppl), 167.
    35. Dobretsova A, Kokorina NA, Wight PA. Functional characterization of a cis-acting DNA antisilencer region that modulates myelin proteolipid protein gene expression. J Neurochem. 2000; 75(4):1368-1376.
    36. Dobretsova A, Kokorina NA, Wight PA. Functional characterization of a cis-acting DNA antisilencer region that modulates myelin proteolipid protein gene expression. J Neurochem. 2000; 75(4):1368 - 1376.
    37. Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 2000.
    38. Wight PA. Myelin proteolipid protein gene expression in oligodendrocytes is regulated by an antisilencer region located within intron 1 DNA. 2000.
    39. Li S, Wight PA. Sequences within myelin proteolipid protein intron 1 DNA are necessary for correct spatial regulation of PLP-lacZ fusion genes. 2000; 74 (suppl), S25C.
    40. Dobretsova A, Kokorina NA, Wight PA. Myelin proteolipid protein gene expression in oligodendrocytes is regulated by an antisilencer region located within intron 1 DNA. 2000; 74 (suppl), S25D.
    41. Wight PA. Surprising twists in the regulation of myelin proteolipid protein gene expression. 1999.
    42. Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 1999.
    43. Wight PA. Surprising twists in the regulation of myelin proteolipid protein gene expression. 1999.
    44. Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. J Neurochem. 1999; 72(6):2227-2237.
    45. Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. J Neurochem. 1999; 72(6):2227 - 2237.
    46. Wight PA. Antisilencing: Myelin proteolipid protein gene expression in oligodendrocytes is regulated via depression. 1999.
    47. Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1999.
    48. Li S, Dobretsova A, Wight P. The first intron of the myelin proteolipid protein gene contains multiple silencers that mediate repression in nonglial cells. 1999; 72 (suppl) S14D.
    49. Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. 1999; 72 (suppl) S14C.
    50. Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1998.
    51. Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1998.
    52. Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 1998.
    53. Wight PA. Antisilencing: Yet another way to regulate a gene. 1998.
    54. Wight PA. A cis-acting DNA antisilencer element located in the first intron of the myelin proteolipid protein (PLP) gene modulates expression of the POL in oligodendrocytes. 1998.
    55. Wight PA, Dobretsova A. Myelin proteolipid protein intron 1 sequences do not appear to enhance myelin proteolipid protein gene transcription. Dev Neurosci. 1998; 20(6):552-558.
    56. Dobretsova A, Wight PA. A cis-acting DNA antisilenacer element located in the first intron of the myelin proteolipid protein (PLP) gene modulates expression of PLP in oligodendrocytes. 1998; 70 (suppl), S55D.
    57. Wight PA, Dobretsova A. Myelin proteolipid protein intron 1 sequences do not appear to enhance myelin proteolipid protein gene transcription. Dev Neurosci. 1998; 20(6):552 - 558.
    58. Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997; 50(6):917-927.
    59. Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997; 50(6):917 - 927.
    60. Wight PA. Demyelinating diseases of the central nervous system. 1997.
    61. Wight PA. Demyelinating diseases of the central nervous system. 1997.
    62. Wight PA, Dobretsova A. The first intron of the myelin proteolipid protein gene confers cell type-specific expression by a transcriptional repression mechanism in non-expressing cell types. Gene. 1997; 201(1-2):111 - 117.
    63. Wight PA, Dobretsova A. The first intron of the myelin proteolipid protein gene confers cell type-specific expression by a transcriptional repression mechanism in non-expressing cell types. Gene. 1997; 201(1-2):111-117.
    64. Wight PA. Myelin proteolipid protein intron 1: A transcriptional antisilencer or an RNA splicing enhancer?. Oral presentation. 1997.
    65. Wight PA. Role of intron 1 sequences in myelin proteolipid protein gene expression; a posttranscriptional effect. Oral presentation. 1997.
    66. Dobretsova A, Wight PA. Role of intron 1 sequences in myelin proteolipid protein gene expression, a posttranscriptional effect. 1997; 69 (suppl), S100D.
    67. Wight PA, Dobretsova A. Myelin proteolipid protein intron 1: A transcriptional antisilencer or an RNA splicing enhancer?. Frontiers of Myelin Biology and Demyelinating Disease. 1997; 118.
    68. Martin CS, Wight PA, Dobretsova A, Bronstein I. Dual luminescence-based reporter gene assay for luciferase and beta-galactosidase. Biotechniques. 1996; 21(3):520 - 524.
    69. Wight PA. Blue Matter: Regulation of the myelin proteolipid protein gene. 1996.
    70. Dobretsova A, Wight PA. Sequences within the first intron of the myelin proteolipid protein gene restrict its expression to oligodendrocytes. 1996; 66 (suppl), S85B.
    71. Wight PA. Developmental control of myelin proteolipid protein gene expression. Keynote address. 1995.
    72. Wight PA, Dobretsova A. Transcriptional enhancement by elements(s) located in the first intron of the myelin proteolipid protein gene. 1995; 829, Vol 21, part 2.
    73. Duchala CS, Wight PA, Macklin WB. Expression of a myelin proteolipid protein-lacZ fusion protein in quaking mice. 1995; 64 (suppl), S20C.
    74. Wight PA. The use of transgenic mice to study the development and cellular specificity of the myelin PLP gene. 1994.
    75. Wight PA. Expression of a myelin proteolipid protein-lacZ fusion in myelin-deficient mice. 1994.
    76. Duchala CS, Wight PA, Macklin WB. Expression of a myelin proteolipid protein-lacZ fusion protein in myelin-deficient mice. 1994; 62 (suppl), S7C.
    77. Macklin WB, Wight PA, Duchala CS, Readhead C. Transgenic models for investigating oligodendrocyte differentiation and myelin formation. In: A Multidisciplinary Approach to Myelin Diseases. S. Salvati (Ed.). Plenum Press, New York. 1994; 11-22.
    78. Macklin WB, Wight PA, Duchala CS, Readhead C. A Multidisciplinary Approach to Myelin Diseases. Transgenic models for investigating oligodendrocyte differentiation and myelin formation. 1994.
    79. Wight PA, Duchala CS, Readhead C, Macklin WB. A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol. 1993; 123(2):443 - 454.
    80. Wight PA. Transcriptional regulation of myelin proteolipid protein gene expression. 1993.
    81. Duchala CS, Wight PA, Readhead C, Macklin WB. LacZ transgene expression in cultured oligodendrocytes. 1993; 138, Vol 24.
    82. Wight PA. Glial-specific expression of beta-galactosidase in transgenic mice. 1992.
    83. Wight PA. Beta-galactosidase expression in oligodendrocytes in transgenic mice. Oral presentation. 1992.
    84. Wight PA. Beta-galactosidase expression in oligodendrocytes in transgenic mice. Oral presentation. 1992.
    85. Wight PA. Blue oligodendrocytes: Expression of the lacZ gene in normal and mutant transgenic mice. Oral presentation. 1992.
    86. Wight PA. The use of transgenic mice to study the development and cellular specificity of the myelin proteolipid protein gene. 1992.
    87. Wight PA. Myelin proteolipid protein gene expression in transgenic mice. Oral presentation. 1992.
    88. Wight PA, Verity AN, Campagnoni AT, Macklin WB. Transcriptional regulatory elements of the myelin proteolipid protein gene. 1992; 210, Vol 23.
    89. Wight PA, Duchala CS, Readhead C, Macklin WB. Beta-galatosidase expression in oligodendrocytes in transgenic mice. 1992; 1089, Vol 18, Part 2.
    90. Wight PA, Readhead C, Duchala CS, Macklin WB. Myelin proteolipid protein gene expression in transgenic mice. 1992; 182, Vol 23.
    91. Macklin WB, Gardinier MV, Obeso ZO, King KD, Wight PA. Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice. J Neurochem. 1991; 56(1):163 - 171.
    92. Wight PA, Crew MD, Spindler SR. Sequences essential for activity of the thyroid hormone responsive transcription stimulatory element of the rat growth hormone gene. Mol Endocrinol. 1988; 2(6):536 - 542.
    93. Wight PA, Scougall RK, Shannon DW, Wells JW, Mawson R. Role of glucosinolates in the causation of liver haemorrhages in laying hens fed water-extracted or heat-treated rapeseed cakes. Res Vet Sci. 1987; 43(3):313 - 319.
    94. Wight PA, Crew MD, Spindler SR. Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene. J Biol Chem. 1987; 262(12):5659 - 5663.
    95. Williams RL, Cascio DA, Wight PA, Spindler SR. A computer method for scanning and analysis of dot-blots. DNA. 1985; 4::255-262.
    96. Hamdan H., Kockara N.T., Haun S. Human myelin proteolipid protein intron 1 DNA contains an enhancer that is essential for PLP1-lacZ expression in transgenic mice. J. Neurochem. 126.
    97. Hamdan H., Kockara N.T., Haun S. Human myelin proteolipid protein intron 1 DNA contains an enhancer that is essential for PLP1-lacZ expression in transgenic mice. MYELIN: from Basic to Translational Research. 64 .
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