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Pereira GB, Meng F, Kockara NT, Yang B, Wight PA. Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination. J Neurochem. 2013; 124(4):454-65.
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Al-Dwairi A., Mercado C.P., Hamdan H., Pabona J.M., Simmen R.C.M. Augmented gastrointestinal expression of cytosolic malic enzyme (ME1) in mice pre-disposes to obesity. 94th Annual Endo Meeting. 2012.
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Zolova O.E. YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells. ASN Neuro. 2012; 3(4).
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Hamdan H., Haun S. Regulatory element(s) in human myelin proteolipid protein (PLP1) intron 1 are required for robust PLP1 gene activity in brain. 2012; 149.
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Pereira GB, Dobretsova A, Hamdan H, Wight PA. Expression of myelin genes: comparative analysis of Oli-neu and N20.1 oligodendroglial cell lines. J Neurosci Res. 2011; 89(7):1070-8.
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Zolova OE, Wight PA. YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cells. ASN Neuro. 2011; 3(4).
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Li S, Greuel BT, Meng F, Pereira GB, Pitts A, Dobretsova A, Wight PA. Leydig cells express the myelin proteolipid protein gene and incorporate a new alternatively spliced exon. Gene. 2009; 436(1-2):30 - 36.
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Li S, Greuel BT, Meng F, Pereira GB, Pitts A, Dobretsova A, Wight PA. Leydig cells express the myelin proteolipid protein gene and incorporate a new alternatively spliced exon. Gene. 2009; 436(1-2):30-6.
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Gimenez MA, Kokorina N, Wight PA, Russell JH. Targeted expression of cre recombinase to oligodendrocytes and Schwann cells by myelin proteolipid protein regulatory sequences in C57BL/6 transgenic mice (under revision). Genesis. 2008.
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Wight PA. Proteomic analysis of nuclear factors binding to the myelin proteolipid protein gene intronic enhancer. What Regulates Myelination?, Invited speaker. 2007.
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Wight PA. Understanding myelin gene regulation as a means to promote remyelination in MS patients. MS Awareness Day (Invited talk). 2007.
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Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007; 32(2):343-351.
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Wight PA, Duchala CS, Shick HE, Gudz TI, Macklin WB. Expression of a myelin proteolipid protein (Plp)-lacZ transgene is reduced in both the CNS and PNS of Plp(jp) mice. Neurochem Res. 2007; 32(2):343 - 351.
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Wight PA. PLP and PLP Mutants. Invited speaker in the session. 2006.
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Wight PA, Meng F, Yang B. Targeted deletion of the antisilencer/enhancer regulatory element from intron 1 of the mouse myelin Plp gene. 2006; 96 (suppl 1), 12.
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Meng F, Zolova O, Kokorina NA, Dobretsova A, Wight PA. Characterization of an intronic enhancer that regulates myelin proteolipid protein (Plp) gene expression in oligodendrocytes. J Neurosci Res. 2005; 82(3):346 - 356.
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Meng F, Zolova O, Kokorina NA, Dobretsova A, Wight PA. Characterization of an intronic enhancer that regulates myelin proteolipid protein (Plp) gene expression in oligodendrocytes. J Neurosci Res. 2005; 82(3):346-356.
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Dobretsova A, Lichti CF, Wight PA. Characterization of the enhanceosome formed on the myelin proteolipid protein gene by DNA affinity chromatography and mass spectrometry. 2005; 93 (suppl 1), 35.
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Meng F, Yang B, Wight PA. Targeted deletion of the antisilencer/enhancer (ASE) transcriptional regulatory element from intron 1 of the mouse myelin proteolipid protein (Plp) gene. Program No. 832.22. 2005.
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Greuel BT, Pereira B, Sample M, Wight PA. Regulation of myelin proteolipid protein gene expression: Molecular dissection of the antisilencer/enhancer region in intron 1. 2005; 93 (suppl 1), 34.
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Dobretsova A, Kokorina NA, Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. J Neurochem. 2004; 90(6):1500-1510.
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Dobretsova A, Kokorina NA, Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. J Neurochem. 2004; 90(6):1500 - 1510.
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Wight PA. Purification of a DNA-protein complex formed on the Plp intronic enhancer. 2004.
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Wight PA. Characterization of Components that Form an Enhanceosome on the Myelin Proteolipid Protein Gene by DNA Affinity Chromatography/Mass Spectrometry Analysis. 2004.
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Wight PA. Potentiation of myelin proteolipid protein (Plp) gene expression is mediated through AP-1-like binding sites. 2004.
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Wight PA, Dobretsova A. Where, when and how much: regulation of myelin proteolipid protein gene expression. Cell Mol Life Sci. 2004 Apr; 61(7-8):810-21. PMID: 15095005.
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Wight PA. When, where and how much: regulation of myelin Plp gene expression. 2003.
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Li S, Moore CL, Dobretsova A, Wight PA. Myelin proteolipid protein (Plp) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. J Neurochem. 2002; 83(1):193 - 201.
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Li S, Moore CL, Dobretsova A, Wight PA. Myelin proteolipid protein (Plp) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. J Neurochem. 2002; 83(1):193-201.
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Li S, Dobretsova A, Kokorina NA, Wight PA. Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cells. J Neurochem. 2002; 82(1):159-171.
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Li S, Dobretsova A, Kokorina NA, Wight PA. Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cells. J Neurochem. 2002; 82(1):159 - 171.
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Wight PA, Li S, Moore CL, Dobretsova A. Myelin proteolipid protein (PLP) intron 1 DNA is required to temporally regulate Plp gene expression in the brain. 2002; 81 (suppl 1), 6.
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Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 2001.
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Dobretsova A, Kokorina NA, Wight PA. AP-1 potentiates myelin proteolipid protein gene expression through protein-DNA interactions formed in the antisilencer region of intron 1. 2001; 78 (suppl), 167.
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Dobretsova A, Kokorina NA, Wight PA. Functional characterization of a cis-acting DNA antisilencer region that modulates myelin proteolipid protein gene expression. J Neurochem. 2000; 75(4):1368-1376.
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Dobretsova A, Kokorina NA, Wight PA. Functional characterization of a cis-acting DNA antisilencer region that modulates myelin proteolipid protein gene expression. J Neurochem. 2000; 75(4):1368 - 1376.
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Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 2000.
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Wight PA. Myelin proteolipid protein gene expression in oligodendrocytes is regulated by an antisilencer region located within intron 1 DNA. 2000.
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Li S, Wight PA. Sequences within myelin proteolipid protein intron 1 DNA are necessary for correct spatial regulation of PLP-lacZ fusion genes. 2000; 74 (suppl), S25C.
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Dobretsova A, Kokorina NA, Wight PA. Myelin proteolipid protein gene expression in oligodendrocytes is regulated by an antisilencer region located within intron 1 DNA. 2000; 74 (suppl), S25D.
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Wight PA. Surprising twists in the regulation of myelin proteolipid protein gene expression. 1999.
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Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 1999.
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Wight PA. Surprising twists in the regulation of myelin proteolipid protein gene expression. 1999.
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Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. J Neurochem. 1999; 72(6):2227-2237.
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Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. J Neurochem. 1999; 72(6):2227 - 2237.
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Wight PA. Antisilencing: Myelin proteolipid protein gene expression in oligodendrocytes is regulated via depression. 1999.
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Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1999.
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Li S, Dobretsova A, Wight P. The first intron of the myelin proteolipid protein gene contains multiple silencers that mediate repression in nonglial cells. 1999; 72 (suppl) S14D.
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Dobretsova A, Wight PA. Antisilencing: myelin proteolipid protein gene expression in oligodendrocytes is regulated via derepression. 1999; 72 (suppl) S14C.
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Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1998.
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Wight PA. Antisilencing: Yet another way to regulate myelin PLP gene expression. 1998.
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Wight PA. Antisilencing: Yet another way to regulate myelin proteolipid protein gene expression. 1998.
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Wight PA. Antisilencing: Yet another way to regulate a gene. 1998.
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Wight PA. A cis-acting DNA antisilencer element located in the first intron of the myelin proteolipid protein (PLP) gene modulates expression of the POL in oligodendrocytes. 1998.
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Wight PA, Dobretsova A. Myelin proteolipid protein intron 1 sequences do not appear to enhance myelin proteolipid protein gene transcription. Dev Neurosci. 1998; 20(6):552-558.
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Dobretsova A, Wight PA. A cis-acting DNA antisilenacer element located in the first intron of the myelin proteolipid protein (PLP) gene modulates expression of PLP in oligodendrocytes. 1998; 70 (suppl), S55D.
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Wight PA, Dobretsova A. Myelin proteolipid protein intron 1 sequences do not appear to enhance myelin proteolipid protein gene transcription. Dev Neurosci. 1998; 20(6):552 - 558.
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Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997; 50(6):917-927.
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Wight PA, Dobretsova A, Macklin WB. Regulation of murine myelin proteolipid protein gene expression. J Neurosci Res. 1997; 50(6):917 - 927.
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Wight PA. Demyelinating diseases of the central nervous system. 1997.
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Wight PA. Demyelinating diseases of the central nervous system. 1997.
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Wight PA, Dobretsova A. The first intron of the myelin proteolipid protein gene confers cell type-specific expression by a transcriptional repression mechanism in non-expressing cell types. Gene. 1997; 201(1-2):111 - 117.
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Wight PA, Dobretsova A. The first intron of the myelin proteolipid protein gene confers cell type-specific expression by a transcriptional repression mechanism in non-expressing cell types. Gene. 1997; 201(1-2):111-117.
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Wight PA. Myelin proteolipid protein intron 1: A transcriptional antisilencer or an RNA splicing enhancer?. Oral presentation. 1997.
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Wight PA. Role of intron 1 sequences in myelin proteolipid protein gene expression; a posttranscriptional effect. Oral presentation. 1997.
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Dobretsova A, Wight PA. Role of intron 1 sequences in myelin proteolipid protein gene expression, a posttranscriptional effect. 1997; 69 (suppl), S100D.
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Wight PA, Dobretsova A. Myelin proteolipid protein intron 1: A transcriptional antisilencer or an RNA splicing enhancer?. Frontiers of Myelin Biology and Demyelinating Disease. 1997; 118.
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Martin CS, Wight PA, Dobretsova A, Bronstein I. Dual luminescence-based reporter gene assay for luciferase and beta-galactosidase. Biotechniques. 1996; 21(3):520 - 524.
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Wight PA. Blue Matter: Regulation of the myelin proteolipid protein gene. 1996.
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Dobretsova A, Wight PA. Sequences within the first intron of the myelin proteolipid protein gene restrict its expression to oligodendrocytes. 1996; 66 (suppl), S85B.
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Wight PA. Developmental control of myelin proteolipid protein gene expression. Keynote address. 1995.
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Wight PA, Dobretsova A. Transcriptional enhancement by elements(s) located in the first intron of the myelin proteolipid protein gene. 1995; 829, Vol 21, part 2.
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Duchala CS, Wight PA, Macklin WB. Expression of a myelin proteolipid protein-lacZ fusion protein in quaking mice. 1995; 64 (suppl), S20C.
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Wight PA. The use of transgenic mice to study the development and cellular specificity of the myelin PLP gene. 1994.
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Wight PA. Expression of a myelin proteolipid protein-lacZ fusion in myelin-deficient mice. 1994.
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Duchala CS, Wight PA, Macklin WB. Expression of a myelin proteolipid protein-lacZ fusion protein in myelin-deficient mice. 1994; 62 (suppl), S7C.
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Macklin WB, Wight PA, Duchala CS, Readhead C. Transgenic models for investigating oligodendrocyte differentiation and myelin formation. In: A Multidisciplinary Approach to Myelin Diseases. S. Salvati (Ed.). Plenum Press, New York. 1994; 11-22.
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Macklin WB, Wight PA, Duchala CS, Readhead C. A Multidisciplinary Approach to Myelin Diseases. Transgenic models for investigating oligodendrocyte differentiation and myelin formation. 1994.
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Wight PA, Duchala CS, Readhead C, Macklin WB. A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol. 1993; 123(2):443 - 454.
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Wight PA. Transcriptional regulation of myelin proteolipid protein gene expression. 1993.
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Duchala CS, Wight PA, Readhead C, Macklin WB. LacZ transgene expression in cultured oligodendrocytes. 1993; 138, Vol 24.
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Wight PA. Glial-specific expression of beta-galactosidase in transgenic mice. 1992.
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Wight PA. Beta-galactosidase expression in oligodendrocytes in transgenic mice. Oral presentation. 1992.
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Wight PA. Beta-galactosidase expression in oligodendrocytes in transgenic mice. Oral presentation. 1992.
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Wight PA. Blue oligodendrocytes: Expression of the lacZ gene in normal and mutant transgenic mice. Oral presentation. 1992.
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Wight PA. The use of transgenic mice to study the development and cellular specificity of the myelin proteolipid protein gene. 1992.
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Wight PA. Myelin proteolipid protein gene expression in transgenic mice. Oral presentation. 1992.
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Wight PA, Verity AN, Campagnoni AT, Macklin WB. Transcriptional regulatory elements of the myelin proteolipid protein gene. 1992; 210, Vol 23.
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Wight PA, Duchala CS, Readhead C, Macklin WB. Beta-galatosidase expression in oligodendrocytes in transgenic mice. 1992; 1089, Vol 18, Part 2.
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Wight PA, Readhead C, Duchala CS, Macklin WB. Myelin proteolipid protein gene expression in transgenic mice. 1992; 182, Vol 23.
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Macklin WB, Gardinier MV, Obeso ZO, King KD, Wight PA. Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice. J Neurochem. 1991; 56(1):163 - 171.
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Wight PA, Crew MD, Spindler SR. Sequences essential for activity of the thyroid hormone responsive transcription stimulatory element of the rat growth hormone gene. Mol Endocrinol. 1988; 2(6):536 - 542.
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Wight PA, Scougall RK, Shannon DW, Wells JW, Mawson R. Role of glucosinolates in the causation of liver haemorrhages in laying hens fed water-extracted or heat-treated rapeseed cakes. Res Vet Sci. 1987; 43(3):313 - 319.
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Wight PA, Crew MD, Spindler SR. Discrete positive and negative thyroid hormone-responsive transcription regulatory elements of the rat growth hormone gene. J Biol Chem. 1987; 262(12):5659 - 5663.
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Williams RL, Cascio DA, Wight PA, Spindler SR. A computer method for scanning and analysis of dot-blots. DNA. 1985; 4::255-262.
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Hamdan H., Kockara N.T., Haun S. Human myelin proteolipid protein intron 1 DNA contains an enhancer that is essential for PLP1-lacZ expression in transgenic mice. J. Neurochem. 126.
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Hamdan H., Kockara N.T., Haun S. Human myelin proteolipid protein intron 1 DNA contains an enhancer that is essential for PLP1-lacZ expression in transgenic mice. MYELIN: from Basic to Translational Research. 64 .