 bcl-2 Homologous Antagonist-Killer Protein
"bcl-2 Homologous Antagonist-Killer Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.
| Descriptor ID |
D050998
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| MeSH Number(s) |
D12.644.360.075.718.750 D12.776.476.075.718.425
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| Concept/Terms |
bcl-2 Homologous Antagonist-Killer Protein- bcl-2 Homologous Antagonist-Killer Protein
- bcl 2 Homologous Antagonist Killer Protein
- bcl2 Homologous Antagonist-Killer Protein
- bcl2 Homologous Antagonist Killer Protein
- Bak Protein
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Below are MeSH descriptors whose meaning is more general than "bcl-2 Homologous Antagonist-Killer Protein".
Below are MeSH descriptors whose meaning is more specific than "bcl-2 Homologous Antagonist-Killer Protein".
This graph shows the total number of publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in UAMS Profiles by year, and whether "bcl-2 Homologous Antagonist-Killer Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2022 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2014 | 1 | 1 | 2 | | 2013 | 1 | 1 | 2 | | 2011 | 0 | 1 | 1 | | 2010 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "bcl-2 Homologous Antagonist-Killer Protein" by people in Profiles over the past ten years.
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Srivastava S, Sekar G, Ojoawo A, Aggarwal A, Ferreira E, Uchikawa E, Yang M, Grace CR, Dey R, Lin YL, Guibao CD, Jayaraman S, Mukherjee S, Kossiakoff AA, Dong B, Myasnikov A, Moldoveanu T. Structural basis of BAK sequestration by MCL-1 in apoptosis. Mol Cell. 2025 Apr 17; 85(8):1606-1623.e10.
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R?hl S, Li Z, Srivastava S, Mari L, Guy CS, Yang M, Moldoveanu T, Green DR. Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5. Cell Death Differ. 2025 Feb; 32(2):320-336.
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Sekar G, Ojoawo A, Moldoveanu T. Protein-protein and protein-lipid interactions of pore-forming BCL-2 family proteins in apoptosis initiation. Biochem Soc Trans. 2022 06 30; 50(3):1091-1103.
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Singh G, Guibao CD, Seetharaman J, Aggarwal A, Grace CR, McNamara DE, Vaithiyalingam S, Waddell MB, Moldoveanu T. Structural basis of BAK activation in mitochondrial apoptosis initiation. Nat Commun. 2022 01 11; 13(1):250.
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Ojoawo AM, Moldoveanu T. A killer metamorphosis: catching BAK in action at the membrane. EMBO J. 2021 10 18; 40(20):e109529.
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Schnetler R, Fanucchi S, Moldoveanu T, Koorsen G. Linker Histone H1.2 Directly Activates BAK through the K/RVVKP Motif on the C-Terminal Domain. Biochemistry. 2020 09 15; 59(36):3332-3346.
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Singh G, Moldoveanu T. Methods to Probe Conformational Activation and Mitochondrial Activity of Proapoptotic BAK. Methods Mol Biol. 2019; 1877:185-200.
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