 Analgesics, Non-Narcotic
"Analgesics, Non-Narcotic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
| Descriptor ID |
D018712
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| MeSH Number(s) |
D27.505.696.663.850.014.040 D27.505.954.427.040.100
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| Concept/Terms |
Analgesics, Non-Narcotic- Analgesics, Non-Narcotic
- Analgesics, Non Narcotic
- Non-Narcotic Analgesics
- Analgesics, Nonopioid
- Nonopioid Analgesics
- Analgesics, Nonnarcotic
- Nonnarcotic Analgesics
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Below are MeSH descriptors whose meaning is more general than "Analgesics, Non-Narcotic".
Below are MeSH descriptors whose meaning is more specific than "Analgesics, Non-Narcotic".
This graph shows the total number of publications written about "Analgesics, Non-Narcotic" by people in UAMS Profiles by year, and whether "Analgesics, Non-Narcotic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 | | 2024 | 1 | 2 | 3 | | 2022 | 2 | 0 | 2 | | 2021 | 1 | 1 | 2 | | 2020 | 3 | 0 | 3 | | 2019 | 5 | 0 | 5 | | 2018 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2016 | 2 | 0 | 2 | | 2015 | 2 | 4 | 6 | | 2014 | 1 | 1 | 2 | | 2013 | 3 | 0 | 3 | | 2012 | 6 | 2 | 8 | | 2011 | 7 | 1 | 8 | | 2010 | 2 | 0 | 2 | | 2009 | 2 | 1 | 3 | | 2008 | 2 | 0 | 2 | | 2006 | 1 | 2 | 3 | | 2004 | 0 | 1 | 1 | | 2003 | 4 | 0 | 4 | | 2002 | 2 | 1 | 3 | | 2001 | 1 | 1 | 2 | | 2000 | 2 | 0 | 2 |
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Below are the most recent publications written about "Analgesics, Non-Narcotic" by people in Profiles over the past ten years.
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Ali NA, Kennon-McGill S, Parker LD, James LP, Fantegrossi WE, McGill MR. NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen. Toxicol Sci. 2025 Jun 01; 205(2):274-278.
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Rule JA, Ajayi F, James LP, Tujios SR, Sussman NL, Rakela JL, Ganger D, Bass NL, Reuben A, Stravitz RT, Lee WM. Differentiating Ischemic Hepatitis from Acetaminophen Overdose in Acute Liver Failure: Role of Acetaminophen Adducts-Ischemic Hepatitis vs Acetaminophen Overdose. Dig Dis Sci. 2024 Oct; 69(10):3952-3961.
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McGill MR. The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans. Drug Metab Dispos. 2024 Jul 16; 52(8):729-739.
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Lee WM, Barnard C, Rule JA, Orandi BJ, James LP, Stravitz RT, Durkalski V, Fontana RJ. Association of Acetaminophen (Paracetamol) Use With Severity and Outcomes in Patients With Viral Hepatitis-Associated Acute Liver Failure. Am J Gastroenterol. 2025 Mar 01; 120(3):584-592.
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Filip AB, Mullins ME. Fomepizole should be used more liberally in paracetamol overdose. Br J Clin Pharmacol. 2023 02; 89(2):594-598.
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Alwan S, Conover EA, Harris-Sagaribay L, Lamm SH, Lavigne SV, Lusskin SI, Obican SG, Romeo AN, Scialli AR, Wisner KL. Paracetamol use in pregnancy - caution over causal inference from available data. Nat Rev Endocrinol. 2022 03; 18(3):190.
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McGill MR, James LP, McCullough SS, Moran JH, Mathews SE, Peterson EC, Fleming DP, Tripod ME, Vazquez JH, Kennon-McGill S, Spencer HJ, Dranoff JA. Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis. Hepatol Commun. 2022 02; 6(2):361-373.
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Stoner K, Preston MA, Mustain WC, Mizell JS, Mehaffey G, Laryea JA. The Impact of Transversus Abdominis Plane Block Within an Enhanced Recovery After Surgery Protocol on Length of Stay. Dis Colon Rectum. 2021 03 01; 64(3):313-318.
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Baumgartner K, Filip A, Liss D, Devgun J, Schwarz E, Mullins M. N-acetylcysteine for acetaminophen toxicity: The one-bag regimen. Br J Clin Pharmacol. 2021 05; 87(5):2399-2400.
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Theroux LM, Cappa R, Mendoza A, Mallawaarachchi I, Samanta D, Goodkin HP. Implementation of an Intravenous Dihydroergotamine Protocol for Refractory Migraine in Children. Headache. 2020 Sep; 60(8):1653-1663.
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McCullough S, Dweep H, McGill MR, Bhattacharyya S, James L, Frankowski S, Woodall A, Kearns G, Gill P. Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. Microrna. 2020; 9(2):121-132.
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Chiew AL, James LP, Isbister GK, Pickering JW, McArdle K, Chan BSH, Buckley NA. Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5). J Hepatol. 2020 03; 72(3):450-462.
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Derefinko KJ, Salgado Garc?a FI, Johnson KC, Hand S, Murphy JG, McDevitt-Murphy M, Suda KJ, Andrasik F, Bursac Z, Chiu CY, Talley K, Brooks JH. A randomized pilot program to reduce opioid use following dental surgery and increase safe medication return. Addict Behav. 2020 03; 102:106190.
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Bansal P, Garg S. Effect of Adding Dexmedetomidine to Local Anesthetic Agents for Transversus Abdominis Plane Block: A Meta-analysis. Clin J Pain. 2019 10; 35(10):844-854.
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Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 10; 59(10):1291-1299.
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Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA. Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. Toxicol Sci. 2019 05 01; 169(1):151-166.
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Arthur J, Duran-Gehring P, Kumetz C, Chadwick S, McIntosh M. Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. J Emerg Med. 2019 Mar; 56(3):288-293.
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Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H. Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol. 2017 Oct; 108(Pt A):339-350.
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Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440.
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Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017 02; 155(2):363-378.
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Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Maria Monteiro de Ara?jo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M. Involvement of connexin43 in acetaminophen-induced liver injury. Biochim Biophys Acta. 2016 06; 1862(6):1111-21.
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Du K, McGill MR, Xie Y, Jaeschke H. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol. 2015 Dec; 86:253-61.
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Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec; 89:750-7.
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Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA. Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. 2015 Oct 08; 126(15):1835-43.
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