 Analgesics, Non-Narcotic
"Analgesics, Non-Narcotic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.
| Descriptor ID |
D018712
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| MeSH Number(s) |
D27.505.696.663.850.014.040 D27.505.954.427.040.100
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| Concept/Terms |
Analgesics, Non-Narcotic- Analgesics, Non-Narcotic
- Analgesics, Non Narcotic
- Non-Narcotic Analgesics
- Analgesics, Nonopioid
- Nonopioid Analgesics
- Analgesics, Nonnarcotic
- Nonnarcotic Analgesics
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Below are MeSH descriptors whose meaning is more general than "Analgesics, Non-Narcotic".
Below are MeSH descriptors whose meaning is more specific than "Analgesics, Non-Narcotic".
This graph shows the total number of publications written about "Analgesics, Non-Narcotic" by people in UAMS Profiles by year, and whether "Analgesics, Non-Narcotic" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 3 | 0 | 3 | | 2018 | 0 | 1 | 1 | | 2017 | 2 | 0 | 2 | | 2016 | 2 | 0 | 2 | | 2015 | 2 | 4 | 6 | | 2014 | 2 | 1 | 3 | | 2013 | 3 | 0 | 3 | | 2012 | 6 | 2 | 8 | | 2011 | 7 | 2 | 9 | | 2010 | 2 | 0 | 2 | | 2009 | 2 | 1 | 3 | | 2008 | 2 | 0 | 2 | | 2006 | 0 | 2 | 2 | | 2004 | 1 | 1 | 2 | | 2003 | 5 | 0 | 5 | | 2002 | 3 | 2 | 5 | | 2001 | 4 | 1 | 5 | | 2000 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "Analgesics, Non-Narcotic" by people in Profiles over the past ten years.
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Derefinko KJ, Salgado García FI, Johnson KC, Hand S, Murphy JG, McDevitt-Murphy M, Suda KJ, Andrasik F, Bursac Z, Chiu CY, Talley K, Brooks JH. A randomized pilot program to reduce opioid use following dental surgery and increase safe medication return. Addict Behav. 2020 03; 102:106190.
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Jiang S, Vozmediano V, Abdel-Rahman SM, Schmidt S, James LP. Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen. J Clin Pharmacol. 2019 10; 59(10):1291-1299.
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Kennedy RC, Smith AK, Ropella GEP, McGill MR, Jaeschke H, Hunt CA. Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange. Toxicol Sci. 2019 05 01; 169(1):151-166.
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Arthur J, Duran-Gehring P, Kumetz C, Chadwick S, McIntosh M. Cerebral Venous Thrombosis: An Uncommon Cause of Papilledema on Bedside Ocular Ultrasound. J Emerg Med. 2019 Mar; 56(3):288-293.
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Du K, Ramachandran A, McGill MR, Mansouri A, Asselah T, Farhood A, Woolbright BL, Ding WX, Jaeschke H. Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity. Food Chem Toxicol. 2017 Oct; 108(Pt A):339-350.
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Court MH, Zhu Z, Masse G, Duan SX, James LP, Harmatz JS, Greenblatt DJ. Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers. J Pharmacol Exp Ther. 2017 09; 362(3):431-440.
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Bhushan B, Chavan H, Borude P, Xie Y, Du K, McGill MR, Lebofsky M, Jaeschke H, Krishnamurthy P, Apte U. Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. Toxicol Sci. 2017 02; 155(2):363-378.
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Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Maria Monteiro de Araújo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M. Involvement of connexin43 in acetaminophen-induced liver injury. Biochim Biophys Acta. 2016 06; 1862(6):1111-21.
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Du K, McGill MR, Xie Y, Jaeschke H. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. Food Chem Toxicol. 2015 Dec; 86:253-61.
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Banerjee S, Melnyk SB, Krager KJ, Aykin-Burns N, Letzig LG, James LP, Hinson JA. The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes. Free Radic Biol Med. 2015 Dec; 89:750-7.
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Miyakawa K, Joshi N, Sullivan BP, Albee R, Brandenberger C, Jaeschke H, McGill MR, Scott MA, Ganey PE, Luyendyk JP, Roth RA. Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice. Blood. 2015 Oct 08; 126(15):1835-43.
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Miyakawa K, Albee R, Letzig LG, Lehner AF, Scott MA, Buchweitz JP, James LP, Ganey PE, Roth RA. A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes. J Pharmacol Exp Ther. 2015 Aug; 354(2):230-7.
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Beger RD, Bhattacharyya S, Yang X, Gill PS, Schnackenberg LK, Sun J, James LP. Translational biomarkers of acetaminophen-induced acute liver injury. Arch Toxicol. 2015 Sep; 89(9):1497-522.
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Xie Y, McGill MR, Cook SF, Sharpe MR, Winefield RD, Wilkins DG, Rollins DE, Jaeschke H. Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica. 2015; 45(10):921-9.
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Du K, Williams CD, McGill MR, Jaeschke H. Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase. Toxicol Appl Pharmacol. 2014 11 15; 281(1):58-66.
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Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H. Mechanisms of acetaminophen-induced cell death in primary human hepatocytes. Toxicol Appl Pharmacol. 2014 Sep 15; 279(3):266-274.
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Lim KB, Tan SS, Abdullah SN, Ong LL, Wong ML, Allen JC. Percutaneous pin removal in the outpatient clinic--do children require analgesia?: a randomized controlled trial. J Bone Joint Surg Am. 2014 Apr 02; 96(7):597-602.
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McGill MR, Jaeschke H. Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*. Crit Care Med. 2013 Nov; 41(11):2653-4.
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McGill MR, Lebofsky M, Norris HR, Slawson MH, Bajt ML, Xie Y, Williams CD, Wilkins DG, Rollins DE, Jaeschke H. Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications. Toxicol Appl Pharmacol. 2013 Jun 15; 269(3):240-9.
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McGill MR, Jaeschke H. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res. 2013 Sep; 30(9):2174-87.
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Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol. 2013 Jan 15; 266(2):224-32.
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Kelkar M, Cleves MA, Foster HR, Hogan WR, James LP, Martin BC. Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study. Ann Pharmacother. 2012 Dec; 46(12):1598-608.
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Yang X, Greenhaw J, Shi Q, Roberts DW, Hinson JA, Muskhelishvili L, Davis K, Salminen WF. Mouse liver protein sulfhydryl depletion after acetaminophen exposure. J Pharmacol Exp Ther. 2013 Jan; 344(1):286-94.
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James LP, Chiew A, Abdel-Rahman SM, Letzig L, Graudins A, Day P, Roberts D. Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol. 2013 Apr; 69(4):851-7.
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McGill MR, Williams CD, Xie Y, Ramachandran A, Jaeschke H. Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol. 2012 Nov 01; 264(3):387-94.
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Chaudhuri S, McCullough SS, Hennings L, Brown AT, Li SH, Simpson PM, Hinson JA, James LP. Effect of trifluoperazine on toxicity, HIF-1a induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol. 2012 Oct 15; 264(2):192-201.
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Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL. AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology. 2012 Oct; 63(5):905-15.
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Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev. 2012 Feb; 44(1):88-106.
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Brown AT, Ou X, James LP, Jambhekar K, Pandey T, McCullough S, Chaudhuri S, Borrelli MJ. Correlation of MRI findings to histology of acetaminophen toxicity in the mouse. Magn Reson Imaging. 2012 Feb; 30(2):283-9.
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Agarwal R, Hennings L, Rafferty TM, Letzig LG, McCullough S, James LP, MacMillan-Crow LA, Hinson JA. Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice. J Pharmacol Exp Ther. 2012 Jan; 340(1):134-42.
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McQueen-Shadfar LA, Megalla SA, White WD, Olufolabi AJ, Jones CA, Habib AS. Impact of intraoperative dexmedetomidine on postoperative analgesia following gynecologic surgery. Curr Med Res Opin. 2011 Nov; 27(11):2091-7.
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Gokhale M, Martin BC. Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008. Pharmacoepidemiol Drug Saf. 2012 Feb; 21(2):226-30.
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Singh K, Sharma R, Rai J. Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee. Int J Rheum Dis. 2012 Feb; 15(1):69-77.
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Ceelie I, James LP, Gijsen V, Mathot RA, Ito S, Tesselaar CD, Tibboel D, Koren G, de Wildt SN. Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med. 2011 Apr; 39(4):678-82.
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