 Vascular Endothelial Growth Factor A
"Vascular Endothelial Growth Factor A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
| Descriptor ID |
D042461
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| MeSH Number(s) |
D12.644.276.100.800.200 D12.776.467.100.800.200 D23.529.100.800.200
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| Concept/Terms |
Vascular Endothelial Growth Factor A- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor-A
- Vascular Permeability Factor
- Permeability Factor, Vascular
- VEGF
- VEGF-A
- Vascular Endothelial Growth Factor
- Vasculotropin
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Below are MeSH descriptors whose meaning is more general than "Vascular Endothelial Growth Factor A".
Below are MeSH descriptors whose meaning is more specific than "Vascular Endothelial Growth Factor A".
This graph shows the total number of publications written about "Vascular Endothelial Growth Factor A" by people in UAMS Profiles by year, and whether "Vascular Endothelial Growth Factor A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2022 | 0 | 2 | 2 | | 2021 | 0 | 6 | 6 | | 2020 | 1 | 1 | 2 | | 2019 | 1 | 3 | 4 | | 2018 | 2 | 2 | 4 | | 2017 | 2 | 3 | 5 | | 2016 | 3 | 5 | 8 | | 2015 | 1 | 6 | 7 | | 2014 | 1 | 5 | 6 | | 2013 | 2 | 7 | 9 | | 2012 | 2 | 6 | 8 | | 2011 | 2 | 5 | 7 | | 2010 | 4 | 6 | 10 | | 2009 | 6 | 7 | 13 | | 2008 | 3 | 1 | 4 | | 2007 | 1 | 9 | 10 | | 2006 | 5 | 3 | 8 | | 2005 | 1 | 5 | 6 | | 2004 | 4 | 3 | 7 | | 2003 | 0 | 3 | 3 | | 2002 | 0 | 2 | 2 | | 2001 | 0 | 3 | 3 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 3 | 3 |
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Below are the most recent publications written about "Vascular Endothelial Growth Factor A" by people in Profiles over the past ten years.
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Chauhan MZ, Rather PA, Samarah SM, Elhusseiny AM, Sallam AB. Current and Novel Therapeutic Approaches for Treatment of Diabetic Macular Edema. Cells. 2022 06 17; 11(12).
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Scott XO, Chen SH, Hadad R, Yavagal D, Peterson EC, Starke RM, Dietrich WD, Keane RW, de Rivero Vaccari JP. Cohort study on the differential expression of inflammatory and angiogenic factors in thrombi, cerebral and peripheral plasma following acute large vessel occlusion stroke. J Cereb Blood Flow Metab. 2022 10; 42(10):1827-1839.
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Lahiani MH, Gokulan K, Williams K, Khare S. Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells. Int J Mol Sci. 2021 Oct 23; 22(21).
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Chen Y, Shimoni O, Huang G, Wen S, Liao J, Duong HTT, Maddahfar M, Su QP, Ortega DG, Lu Y, Campbell DH, Walsh BJ, Jin D. Upconversion nanoparticle-assisted single-molecule assay for detecting circulating antigens of aggressive prostate cancer. Cytometry A. 2022 05; 101(5):400-410.
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Movahedan A, Barba H, Spedale M, Deng N, Arvans D, Nadeem U, Leone V, Chang EB, Theriault B, Skondra D. Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization. Transl Vis Sci Technol. 2021 08 02; 10(9):14.
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Gao XM, Yu YY, Zhao H, Cai H, Zhang L, Cao XX, Zhou DB, Li J. Bortezomib plus dexamethasone as first-line therapy for patients with POEMS syndrome. Ann Hematol. 2021 Nov; 100(11):2755-2761.
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Ohji M, Okada AA, Sasaki K, Moon SC, Machewitz T, Takahashi K. Relationship between retinal fluid and visual acuity in patients with exudative age-related macular degeneration treated with intravitreal aflibercept using a treat-and-extend regimen: subgroup and post-hoc analyses from the ALTAIR study. Graefes Arch Clin Exp Ophthalmol. 2021 Dec; 259(12):3637-3647.
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Song KM, Kim WJ, Choi MJ, Kwon KD, Limanjaya A, Ghatak K, Ock J, Yin GN, Sato Y, Hong SS, Ryu JK, Suh JK. Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice. Sci Rep. 2021 01 13; 11(1):1114.
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Kilgore DA, Behrens AW, Siddiqui MZ, Chancellor JR, Phillips PH, Uwaydat SH, Vonlanthen MG, Gonzalez-Krellwitz L, Sallam AB. Inflammatory choroiditis and papillitis from Crohn's disease in a child. J AAPOS. 2021 02; 25(1):37-40.
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Mulcrone PL, Edwards SKE, Petrusca DN, Haneline LS, Delgado-Calle J, Roodman GD. Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Sci Rep. 2020 10 14; 10(1):17319.
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Horta E, Bongiorno C, Ezzeddine M, Neil EC. Neurotoxicity of antibodies in cancer therapy: A review. Clin Neurol Neurosurg. 2020 01; 188:105566.
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Weinkopff T, Roys H, Bowlin A, Scott P. Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner. Infect Immun. 2019 11; 87(11).
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Singh SR, Fung AT, Fraser-Bell S, Lupidi M, Mohan S, Gabrielle PH, Zur D, Iglicki M, M López-Corell P, Gallego-Pinazo R, Farinha C, Lima LH, Mansour AM, Casella AM, Wu L, Silva R, Uwaydat SH, Govindahari V, Arevalo JF, Chhablani J. One-year outcomes of anti-vascular endothelial growth factor therapy in peripapillary choroidal neovascularisation. Br J Ophthalmol. 2020 05; 104(5):678-683.
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Skar GL, Synhorst D, Beaver M, Snowden JN. CSF inflammatory markers differ in gram-positive versus gram-negative shunt infections. J Neuroinflammation. 2019 Jan 09; 16(1):7.
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Li J, Huang XF, Cai QQ, Wang C, Cai H, Zhao H, Zhang L, Cao XX, Gale RP, Zhou DB. A prospective phase II study of low dose lenalidomide plus dexamethasone in patients with newly diagnosed polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. Am J Hematol. 2018 06; 93(6):803-809.
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Zhao H, Cai H, Wang C, Huang XF, Cao XX, Zhang L, Zhou DB, Li J. Prognostic value of serum vascular endothelial growth factor and hematological responses in patients with newly-diagnosed POEMS syndrome. Blood Cancer J. 2018 04 04; 8(4):37.
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Kim SR, Eirin A, Herrmann SMS, Saad A, Juncos LA, Lerman A, Textor SC, Lerman LO. Preserved endothelial progenitor cell angiogenic activity in African American essential hypertensive patients. Nephrol Dial Transplant. 2018 03 01; 33(3):392-401.
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Singh A, Bora P, Krishna A. Systemic adiponectin treatment reverses polycystic ovary syndrome-like features in an animal model. Reprod Fertil Dev. 2018 Mar; 30(4):571-584.
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Bais C, Mueller B, Brady MF, Mannel RS, Burger RA, Wei W, Marien KM, Kockx MM, Husain A, Birrer MJ. Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses. J Natl Cancer Inst. 2017 11 01; 109(11).
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Zhang X, Cai QQ, Huang XF, Cao XX, Cai H, Zhou DB, Dai RP, Li J. OCULAR MANIFESTATIONS AND TREATMENT OUTCOMES IN CHINESE PATIENTS WITH POEMS SYNDROME. Retina. 2017 Sep; 37(9):1784-1791.
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Rader JS, Sill MW, Beumer JH, Lankes HA, Benbrook DM, Garcia F, Trimble C, Tate Thigpen J, Lieberman R, Zuna RE, Leath CA, Spirtos NM, Byron J, Thaker PH, Lele S, Alberts D. A stratified randomized double-blind phase II trial of celecoxib for treating patients with cervical intraepithelial neoplasia: The potential predictive value of VEGF serum levels: An NRG Oncology/Gynecologic Oncology Group study. Gynecol Oncol. 2017 05; 145(2):291-297.
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Reina-Torres E, Wen JC, Liu KC, Li G, Sherwood JM, Chang JY, Challa P, Flügel-Koch CM, Stamer WD, Allingham RR, Overby DR. VEGF as a Paracrine Regulator of Conventional Outflow Facility. Invest Ophthalmol Vis Sci. 2017 03 01; 58(3):1899-1908.
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Makhoul I, Todorova VK, Siegel ER, Erickson SW, Dhakal I, Raj VR, Lee JY, Orloff MS, Griffin RJ, Henry-Tillman RS, Klimberg S, Hutchins LF, Kadlubar SA. Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients. PLoS One. 2017; 12(1):e0168550.
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Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P. Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease. J Immunol. 2016 09 01; 197(5):1823-31.
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Makhoul I, Griffin RJ, Siegel E, Lee J, Dhakal I, Raj V, Jamshidi-Parsian A, Klimberg S, Hutchins LF, Kadlubar S. High-circulating Tie2 Is Associated With Pathologic Complete Response to Chemotherapy and Antiangiogenic Therapy in Breast Cancer. Am J Clin Oncol. 2016 06; 39(3):248-54.
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Sinha S, Khan S, Shukla S, Lakra AD, Kumar S, Das G, Maurya R, Meeran SM. Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis. Int J Biochem Cell Biol. 2016 08; 77(Pt A):41-56.
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Divine LM, Kizer NT, Hagemann AR, Pittman ME, Chen L, Powell MA, Mutch DG, Rader JS, Thaker PH. Clinicopathologic characteristics and survival of patients with gynecologic malignancies metastatic to the brain. Gynecol Oncol. 2016 07; 142(1):76-82.
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Bender Ignacio RA, Lee JY, Rudek MA, Dittmer DP, Ambinder RF, Krown SE. Brief Report: A Phase 1b/Pharmacokinetic Trial of PTC299, a Novel PostTranscriptional VEGF Inhibitor, for AIDS-Related Kaposi's Sarcoma: AIDS Malignancy Consortium Trial 059. J Acquir Immune Defic Syndr. 2016 May 01; 72(1):52-7.
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Kwon MH, Park SH, Song KM, Ghatak K, Limanjaya A, Ryu DS, Ock J, Hong SS, Ryu JK, Suh JK. Penile erection induces angiogenic, survival, and antifibrotic signals: molecular events associated with penile erection induced by cavernous nerve stimulation in mice. Int J Urol. 2016 07; 23(7):614-22.
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Goyal S, Lyzogubov VV, Ali O, Bora PS, Bora NS, Uwaydat SH. Effect of aspirin on models of retinal pigment epithelium pathology. Clin Exp Ophthalmol. 2016 Sep; 44(7):610-617.
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Yeruva L, Spencer NE, Saraf MK, Hennings L, Bowlin AK, Cleves MA, Mercer K, Chintapalli SV, Shankar K, Rank RG, Badger TM, Ronis MJ. Formula diet alters small intestine morphology, microbial abundance and reduces VE-cadherin and IL-10 expression in neonatal porcine model. BMC Gastroenterol. 2016 Mar 22; 16:40.
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Morshedi RG, Ricca AM, Wirostko BM. Ocular Hypertension Following Intravitreal Antivascular Endothelial Growth Factor Therapy: Review of the Literature and Possible Role of Nitric Oxide. J Glaucoma. 2016 Mar; 25(3):291-300.
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Ulrich F, Carretero-Ortega J, Menéndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, Véliz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-Vázquez J. Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development. 2016 Jan 01; 143(1):147-59.
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Xie H, Li C, He Y, Griffin R, Ye Q, Li L. Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model. Oral Oncol. 2015 Nov; 51(11):991-997.
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Soliman S, Ishrat T, Fouda AY, Patel A, Pillai B, Fagan SC. Sequential Therapy with Minocycline and Candesartan Improves Long-Term Recovery After Experimental Stroke. Transl Stroke Res. 2015 Aug; 6(4):309-22.
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Ikhapoh IA, Pelham CJ, Agrawal DK. Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells. Differentiation. 2015 Mar-Apr; 89(3-4):87-96.
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Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. Food Chem Toxicol. 2015 Jul; 81:92-103.
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Elimova E, Wadhwa R, Shiozaki H, Sudo K, Estrella JS, Badgwell BD, Das P, Matamoros A, Song S, Ajani JA. Molecular biomarkers in gastric cancer. J Natl Compr Canc Netw. 2015 Apr; 13(4):e19-29.
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Ricca AM, Morshedi RG, Wirostko BM. High intraocular pressure following anti-vascular endothelial growth factor therapy: proposed pathophysiology due to altered nitric oxide metabolism. J Ocul Pharmacol Ther. 2015 Feb; 31(1):2-10.
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Buckle M, Lee A, Mohamed Q, Fletcher E, Sallam A, Healy R, Stratton I, Tufail A, Johnston RL. Prevalence and incidence of blindness and other degrees of sight impairment in patients treated for neovascular age-related macular degeneration in a well-defined region of the United Kingdom. Eye (Lond). 2015 Mar; 29(3):403-8.
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Ikhapoh IA, Pelham CJ, Agrawal DK. Synergistic effect of angiotensin II on vascular endothelial growth factor-A-mediated differentiation of bone marrow-derived mesenchymal stem cells into endothelial cells. Stem Cell Res Ther. 2015 Jan 06; 6:4.
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Davis SJ, Lauer AK, Flaxel CJ. Polypoidal choroidal vasculopathy in white patients. Retina. 2014 Nov; 34(11):2185-91.
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Wang X, Khaidakov M, Guo Z, Ding Z, He Q, Mehta JL. LOX-1 deletion limits cardiac angiogenesis in mice given angiotensin II. Cardiovasc Drugs Ther. 2014 Oct; 28(5):441-6.
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Giorgakis E, Mavroeidis V, Tsironis D, Davidson B. Vascular endothelial growth factor detection in serous pancreatic cysts: have we really reached a breakthrough? J Am Coll Surg. 2014 Sep; 219(3):591.
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Ishrat T, Pillai B, Soliman S, Fouda AY, Kozak A, Johnson MH, Ergul A, Fagan SC. Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats. Mol Neurobiol. 2015; 51(3):1542-53.
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Wei C, Wang HT, Jiang ZC, Zhang W, Cao XX, Li TJ, Wang X, Zhou DB. [Interaction between tumor-associated macrophages (TAMs) and HUT-78 lymphoma cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Aug; 22(4):988-94.
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Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis. 2014 Jun; 35(6):1341-51.
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Kang L, Mayes WH, James FD, Bracy DP, Wasserman DH. Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice. Diabetologia. 2014 Mar; 57(3):603-13.
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Keenan TD, Kelly SP, Sallam A, Mohamed Q, Tufail A, Johnston RL. Incidence and baseline clinical characteristics of treated neovascular age-related macular degeneration in a well-defined region of the UK. Br J Ophthalmol. 2013 Sep; 97(9):1168-72.
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Veldman MB, Zhao C, Gomez GA, Lindgren AG, Huang H, Yang H, Yao S, Martin BL, Kimelman D, Lin S. Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor Etv2. PLoS Biol. 2013; 11(6):e1001590.
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