Protein Kinase C-alpha
"Protein Kinase C-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.
| Descriptor ID |
D051571
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.100
|
| Concept/Terms |
Protein Kinase C-alpha- Protein Kinase C-alpha
- Protein Kinase C(alpha)
- PKC-alpha Serine-Threonine Kinase
- PKC alpha Serine Threonine Kinase
- Serine-Threonine Kinase, PKC-alpha
- Protein Kinase C alpha
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-alpha".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-alpha".
This graph shows the total number of publications written about "Protein Kinase C-alpha" by people in UAMS Profiles by year, and whether "Protein Kinase C-alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2013 | 2 | 1 | 3 |
| 2012 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C-alpha" by people in Profiles over the past ten years.
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Nowak G, Megyesi J. Protein kinase Ca mediates recovery of renal and mitochondrial functions following acute injury. FEBS J. 2020 05; 287(9):1830-1849.
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Nowak G, Bakajsova D. Protein kinase C-a interaction with F0F1-ATPase promotes F0F1-ATPase activity and reduces energy deficits in injured renal cells. J Biol Chem. 2015 Mar 13; 290(11):7054-66.
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Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hauer-Jensen M, Boerma M. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One. 2013; 8(7):e68762.
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Nowak G, Soundararajan S, Mestril R. Protein kinase C-a interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F764-76.