 Protease Inhibitors
"Protease Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).
| Descriptor ID |
D011480
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| MeSH Number(s) |
D27.505.519.389.745
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| Concept/Terms |
Protease Inhibitors- Protease Inhibitors
- Inhibitors, Protease
- Endopeptidase Inhibitors
- Inhibitors, Endopeptidase
- Protease Inhibitor
- Inhibitor, Protease
- Peptide Hydrolase Inhibitors
- Hydrolase Inhibitors, Peptide
- Inhibitors, Peptide Hydrolase
- Peptide Peptidohydrolase Inhibitors
- Inhibitors, Peptide Peptidohydrolase
- Peptidohydrolase Inhibitors, Peptide
- Protease Antagonists
- Antagonists, Protease
- Antiproteases
- Peptidase Inhibitors
- Inhibitors, Peptidase
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Below are MeSH descriptors whose meaning is more general than "Protease Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Protease Inhibitors".
This graph shows the total number of publications written about "Protease Inhibitors" by people in UAMS Profiles by year, and whether "Protease Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 2 | 0 | 2 | | 2014 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 0 | 2 | 2 | | 2010 | 1 | 2 | 3 | | 2009 | 2 | 2 | 4 | | 2008 | 3 | 3 | 6 | | 2007 | 1 | 2 | 3 | | 2006 | 2 | 0 | 2 | | 2005 | 2 | 2 | 4 | | 2004 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 1998 | 0 | 1 | 1 | | 1997 | 1 | 1 | 2 | | 1995 | 0 | 1 | 1 | | 1994 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protease Inhibitors" by people in Profiles over the past ten years.
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Ferrarezi AA, de Souza JVP, Maigret B, Kioshima ?S, Moura S, de Oliveira AJB, Rosa FA, Gon?alves RAC. Rational design and synthesis of pyrazole derivatives as potential SARS-CoV-2 Mpro inhibitors: An integrated approach merging combinatorial chemistry, molecular docking, and deep learning. Bioorg Med Chem. 2025 Apr 01; 120:118095.
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Shady NH, Hayallah AM, Mohamed MFA, Ghoneim MM, Chilingaryan G, Al-Sanea MM, Fouad MA, Kamel MS, Abdelmohsen UR. Targeting 3CLpro and SARS-CoV-2 RdRp by Amphimedon sp. Metabolites: A Computational Study. Molecules. 2021 Jun 21; 26(12).
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Bishnoi R, Xie Z, Shah C, Bian J, Murthy HS, Wingard JR, Farhadfar N. Real-world experience of carfilzomib-associated cardiovascular adverse events: SEER-Medicare data set analysis. Cancer Med. 2021 01; 10(1):70-78.
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Shady NH, Khattab AR, Ahmed S, Liu M, Quinn RJ, Fouad MA, Kamel MS, Muhsinah AB, Krischke M, Mueller MJ, Abdelmohsen UR. Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (Amphimedon) ?Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling. Int J Nanomedicine. 2020; 15:3377-3389.
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Yandrapalli S, Khan MH, Rochlani Y, Aronow WS. Sacubitril/valsartan in cardiovascular disease: evidence to date and place in therapy. Ther Adv Cardiovasc Dis. 2018 Aug; 12(8):217-231.
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Balasubramanian A, Manzano M, Teramoto T, Pilankatta R, Padmanabhan R. High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res. 2016 10; 134:6-16.
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Duarte-Rojo A, Fischer SE, Adeyi O, Zita D, Deneke MG, Selzner N, Chen L, Malespin M, Cotler SJ, McGilvray ID, Feld JJ. Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C. J Viral Hepat. 2016 May; 23(5):340-7.
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