 In Situ Nick-End Labeling
"In Situ Nick-End Labeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
| Descriptor ID |
D020287
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| MeSH Number(s) |
E05.393.475
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| Concept/Terms |
In Situ Nick-End Labeling- In Situ Nick-End Labeling
- TUNEL
- Nick-End Labeling, In Situ
- In Situ Nick End Labelling
- In Situ Nick End Labeling
- In Situ Nick End-Labelling
- In Situ Nick-End Labelling
- Nick End-Labeling, In Situ
- Nick End Labeling, In Situ
- Nick End-Labelling, In Situ
- Nick End Labelling, In Situ
- Nick-End Labelling, In Situ
- In Situ Nick End-Labeling
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Below are MeSH descriptors whose meaning is more general than "In Situ Nick-End Labeling".
Below are MeSH descriptors whose meaning is more specific than "In Situ Nick-End Labeling".
This graph shows the total number of publications written about "In Situ Nick-End Labeling" by people in UAMS Profiles by year, and whether "In Situ Nick-End Labeling" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2014 | 0 | 4 | 4 | | 2013 | 0 | 3 | 3 | | 2012 | 0 | 4 | 4 | | 2011 | 0 | 3 | 3 | | 2010 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2008 | 0 | 3 | 3 | | 2007 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2005 | 0 | 5 | 5 | | 2004 | 0 | 7 | 7 | | 2003 | 0 | 6 | 6 | | 2002 | 0 | 2 | 2 | | 2001 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "In Situ Nick-End Labeling" by people in Profiles over the past ten years.
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Moore CL, Savenka AV, Basnakian AG. TUNEL Assay: A Powerful Tool for Kidney Injury Evaluation. Int J Mol Sci. 2021 Jan 02; 22(1).
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Zhdanov DD, Fahmi T, Wang X, Apostolov EO, Sokolov NN, Javadov S, Basnakian AG. Regulation of Apoptotic Endonucleases by EndoG. DNA Cell Biol. 2015 May; 34(5):316-26.
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Scindia Y, Dey P, Thirunagari A, Liping H, Rosin DL, Floris M, Okusa MD, Swaminathan S. Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis. J Am Soc Nephrol. 2015 Nov; 26(11):2800-14.
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Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH. Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Food Chem Toxicol. 2015 Feb; 76:19-26.
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Mazoch MJ, Cheema GA, Suva LJ, Thomas RL. Effects of alcohol injection in rat sciatic nerve as a model for Morton's neuroma treatment. Foot Ankle Int. 2014 Nov; 35(11):1187-91.
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Lyzogubov VV, Bora NS, Tytarenko RG, Bora PS. Polyethylene glycol induced mouse model of retinal degeneration. Exp Eye Res. 2014 Oct; 127:143-52.
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Miousse IR, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I. Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen. 2014 Jun; 55(5):428-35.
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Apostolov EO, Ok E, Burns S, Nawaz S, Savenka A, Shah S, Basnakian AG. Carbamylated-oxidized LDL: proatherosclerotic effects on endothelial cells and macrophages. J Atheroscler Thromb. 2013; 20(12):878-92.
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Suman S, Datta K, Chakraborty K, Kulkarni SS, Doiron K, Fornace AJ, Sree Kumar K, Hauer-Jensen M, Ghosh SP. Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival. Food Chem Toxicol. 2013 Oct; 60:488-96.
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Singh M, Odeniyi DT, Apostolov EO, Savenka A, Fite T, Wangila GW, Walker RB, Basnakian AG. Protective effect of zinc-N-acetylcysteine on the rat kidney during cold storage. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F1022-30.
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