 11-beta-Hydroxysteroid Dehydrogenase Type 2
"11-beta-Hydroxysteroid Dehydrogenase Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
| Descriptor ID |
D043209
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| MeSH Number(s) |
D08.811.682.047.436.174.600
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| Concept/Terms |
11-beta-Hydroxysteroid Dehydrogenase Type 2- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- 11 beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-Hydroxysteroid Dehydrogenase Type 2
- 11beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-HSD2
- 11beta-HSD2 Reductase
- 11 beta-HSD2
- 11 beta-Hydroxysteroid Dehydrogenase Type 2
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Below are MeSH descriptors whose meaning is more general than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
Below are MeSH descriptors whose meaning is more specific than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
This graph shows the total number of publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 2" by people in UAMS Profiles by year, and whether "11-beta-Hydroxysteroid Dehydrogenase Type 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2009 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2003 | 0 | 3 | 3 |
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Below are the most recent publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 2" by people in Profiles over the past ten years.
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Tao Y, Gao L, Wu X, Wang H, Yang G, Zhan F, Shi J. Down-regulation of 11ß-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis. PLoS One. 2013; 8(6):e67067.
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Iqbal J, Andrew R, Cruden NL, Kenyon CJ, Hughes KA, Newby DE, Hadoke PW, Walker BR. Displacement of cortisol from human heart by acute administration of a mineralocorticoid receptor antagonist. J Clin Endocrinol Metab. 2014 Mar; 99(3):915-22.
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Iqbal J, Macdonald LJ, Low L, Seckl JR, Yau CW, Walker BR, Hadoke PW. Contribution of endogenous glucocorticoids and their intravascular metabolism by 11ß-HSDs to postangioplasty neointimal proliferation in mice. Endocrinology. 2012 Dec; 153(12):5896-905.
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