 Biofilms
"Biofilms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
| Descriptor ID |
D018441
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| MeSH Number(s) |
G06.120
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Biofilms".
Below are MeSH descriptors whose meaning is more specific than "Biofilms".
This graph shows the total number of publications written about "Biofilms" by people in UAMS Profiles by year, and whether "Biofilms" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 0 | 3 | 3 | | 2019 | 4 | 1 | 5 | | 2018 | 0 | 4 | 4 | | 2017 | 4 | 2 | 6 | | 2016 | 3 | 3 | 6 | | 2015 | 4 | 1 | 5 | | 2014 | 8 | 1 | 9 | | 2013 | 6 | 1 | 7 | | 2012 | 8 | 2 | 10 | | 2011 | 12 | 1 | 13 | | 2010 | 1 | 0 | 1 | | 2009 | 6 | 1 | 7 | | 2008 | 5 | 0 | 5 | | 2007 | 6 | 2 | 8 | | 2006 | 0 | 1 | 1 | | 2005 | 3 | 0 | 3 | | 2004 | 2 | 0 | 2 | | 2003 | 2 | 1 | 3 | | 2002 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Biofilms" by people in Profiles over the past ten years.
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Dettweiler M, Marquez L, Lin M, Sweeney-Jones AM, Chhetri BK, Zurawski DV, Kubanek J, Quave CL. Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii. Sci Rep. 2020 09 18; 10(1):15340.
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Tang H, Porras G, Brown MM, Chassagne F, Lyles JT, Bacsa J, Horswill AR, Quave CL. Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis. Sci Rep. 2020 05 15; 10(1):8046.
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Rom JS, Ramirez AM, Beenken KE, Sahukhal GS, Elasri MO, Smeltzer MS. The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus. Infect Immun. 2020 01 22; 88(2).
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Ramirez AM, Byrum SD, Beenken KE, Washam C, Edmondson RD, Mackintosh SG, Spencer HJ, Tackett AJ, Smeltzer MS. Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis. ACS Infect Dis. 2020 02 14; 6(2):237-249.
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Krantz GP, Lucas K, Wunderlich EL, Hoang LT, Avci R, Siuzdak G, Fields MW. Bulk phase resource ratio alters carbon steel corrosion rates and endogenously produced extracellular electron transfer mediators in a sulfate-reducing biofilm. Biofouling. 2019 07; 35(6):669-683.
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Hong W, Khampang P, Kerschner AR, Mackinnon AC, Yan K, Simpson PM, Kerschner JE. Antibiotic modulation of mucins in otitis media; should this change our approach to watchful waiting? Int J Pediatr Otorhinolaryngol. 2019 Oct; 125:134-140.
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Dettweiler M, Lyles JT, Nelson K, Dale B, Reddinger RM, Zurawski DV, Quave CL. American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria. Sci Rep. 2019 05 22; 9(1):7692.
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Saeed K, McLaren AC, Schwarz EM, Antoci V, Arnold WV, Chen AF, Clauss M, Esteban J, Gant V, Hendershot E, Hickok N, Higuera CA, Coraça-Huber DC, Choe H, Jennings JA, Joshi M, Li WT, Noble PC, Phillips KS, Pottinger PS, Restrepo C, Rohde H, Schaer TP, Shen H, Smeltzer M, Stoodley P, Webb JCJ, Witsø E. 2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections. J Orthop Res. 2019 05; 37(5):1007-1017.
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Byrum SD, Loughran AJ, Beenken KE, Orr LM, Storey AJ, Mackintosh SG, Edmondson RD, Tackett AJ, Smeltzer MS. Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. J Proteome Res. 2018 10 05; 17(10):3384-3395.
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Hutchins DA. Adapt to warming and catch your breath. Nat Microbiol. 2018 09; 3(9):973-974.
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Meeker DG, Wang T, Harrington WN, Zharov VP, Johnson SA, Jenkins SV, Oyibo SE, Walker CM, Mills WB, Shirtliff ME, Beenken KE, Chen J, Smeltzer MS. Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections. Int J Hyperthermia. 2018 03; 34(2):209-219.
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Boles LR, Awais R, Beenken KE, Smeltzer MS, Haggard WO, Jessica AJ. Local Delivery of Amikacin and Vancomycin from Chitosan Sponges Prevent Polymicrobial Implant-Associated Biofilm. Mil Med. 2018 03 01; 183(suppl_1):459-465.
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Moon SH, Zhang X, Zheng G, Meeker DG, Smeltzer MS, Huang E. Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin. J Med Chem. 2017 12 14; 60(23):9630-9640.
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Lei MG, Gupta RK, Lee CY. Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection. PLoS One. 2017; 12(11):e0187981.
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Rom JS, Atwood DN, Beenken KE, Meeker DG, Loughran AJ, Spencer HJ, Lantz TL, Smeltzer MS. Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model. Virulence. 2017 11 17; 8(8):1776-1790.
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Harris MA, Beenken KE, Smeltzer MS, Haggard WO, Jennings JA. Phosphatidylcholine Coatings Deliver Local Antimicrobials and Reduce Infection in a Murine Model: A Preliminary Study. Clin Orthop Relat Res. 2017 Jul; 475(7):1847-1853.
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Dawn LE, Henry GD, Tan GK, Wilson SK. Biofilm and Infectious Agents Present at the Time of Penile Prosthesis Revision Surgery: Times Are a Changing. Sex Med Rev. 2017 04; 5(2):236-243.
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Muhs A, Lyles JT, Parlet CP, Nelson K, Kavanaugh JS, Horswill AR, Quave CL. Virulence Inhibitors from Brazilian Peppertree Block Quorum Sensing and Abate Dermonecrosis in Skin Infection Models. Sci Rep. 2017 02 10; 7:42275.
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Gutierrez-Murgas YM, Skar G, Ramirez D, Beaver M, Snowden JN. IL-10 plays an important role in the control of inflammation but not in the bacterial burden in S. epidermidis CNS catheter infection. J Neuroinflammation. 2016 10 13; 13(1):271.
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Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of Antibiotics Active against Methicillin-Resistant Staphylococcus aureus Based on Activity in an Established Biofilm. Antimicrob Agents Chemother. 2016 10; 60(10):5688-94.
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Smeltzer MS. Staphylococcus aureus Pathogenesis: The Importance of Reduced Cytotoxicity. Trends Microbiol. 2016 09; 24(9):681-682.
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Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC Contributes to Diverse Forms of Staphylococcus aureus Infection via agr-Dependent and agr-Independent Pathways. Infect Immun. 2016 Apr; 84(4):1214-1225.
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Jennings JA, Beenken KE, Parker AC, Smith JK, Courtney HS, Smeltzer MS, Haggard WO. Polymicrobial Biofilm Inhibition Effects of Acetate-Buffered Chitosan Sponge Delivery Device. Macromol Biosci. 2016 Apr; 16(4):591-8.
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Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory Mutations Impacting Antibiotic Susceptibility in an Established Staphylococcus aureus Biofilm. Antimicrob Agents Chemother. 2016 Jan 11; 60(3):1826-9.
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Gopalani M, Dhiman A, Rahi A, Bhatnagar R. Overexpression of the pleiotropic regulator CodY decreases sporulation, attachment and pellicle formation in Bacillus anthracis. Biochem Biophys Res Commun. 2016 Jan 15; 469(3):672-8.
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Earl CS, Keong TW, An SQ, Murdoch S, McCarthy Y, Garmendia J, Ward J, Dow JM, Yang L, O'Toole GA, Ryan RP. Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance. EMBO Mol Med. 2015 Aug; 7(8):1018-33.
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Jennings JA, Carpenter DP, Troxel KS, Beenken KE, Smeltzer MS, Courtney HS, Haggard WO. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res. 2015 Jul; 473(7):2270-82.
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Cue D, Junecko JM, Lei MG, Blevins JS, Smeltzer MS, Lee CY. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One. 2015; 10(4):e0123027.
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Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015 Jun; 4(3):436-51.
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Caly DL, Bellini D, Walsh MA, Dow JM, Ryan RP. Targeting cyclic di-GMP signalling: a strategy to control biofilm formation? Curr Pharm Des. 2015; 21(1):12-24.
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Yaryura PM, Conforte VP, Malamud F, Roeschlin R, de Pino V, Castagnaro AP, McCarthy Y, Dow JM, Marano MR, Vojnov AA. XbmR, a new transcription factor involved in the regulation of chemotaxis, biofilm formation and virulence in Xanthomonas citri subsp. citri. Environ Microbiol. 2015 Nov; 17(11):4164-76.
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Parker AC, Beenken KE, Jennings JA, Hittle L, Shirtliff ME, Bumgardner JD, Smeltzer MS, Haggard WO. Characterization of local delivery with amphotericin B and vancomycin from modified chitosan sponges and functional biofilm prevention evaluation. J Orthop Res. 2015 Mar; 33(3):439-47.
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Loughran AJ, Atwood DN, Anthony AC, Harik NS, Spencer HJ, Beenken KE, Smeltzer MS. Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants. Microbiologyopen. 2014 Dec; 3(6):897-909.
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Gutierrez-Murgas Y, Snowden JN. Ventricular shunt infections: immunopathogenesis and clinical management. J Neuroimmunol. 2014 Nov 15; 276(1-2):1-8.
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Talekar SJ, Chochua S, Nelson K, Klugman KP, Quave CL, Vidal JE. 220D-F2 from Rubus ulmifolius kills Streptococcus pneumoniae planktonic cells and pneumococcal biofilms. PLoS One. 2014; 9(5):e97314.
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Drilling A, Morales S, Boase S, Jervis-Bardy J, James C, Jardeleza C, Tan NC, Cleland E, Speck P, Vreugde S, Wormald PJ. Safety and efficacy of topical bacteriophage and ethylenediaminetetraacetic acid treatment of Staphylococcus aureus infection in a sheep model of sinusitis. Int Forum Allergy Rhinol. 2014 Mar; 4(3):176-86.
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Paramasivan S, Drilling AJ, Jardeleza C, Jervis-Bardy J, Vreugde S, Wormald PJ. Methylglyoxal-augmented manuka honey as a topical anti-Staphylococcus aureus biofilm agent: safety and efficacy in an in vivo model. Int Forum Allergy Rhinol. 2014 Mar; 4(3):187-95.
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Cassat JE, Smeltzer MS, Lee CY. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol Biol. 2014; 1085:195-211.
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Snowden JN. Generation of a central nervous system catheter-associated infection in mice with Staphylococcus epidermidis. Methods Mol Biol. 2014; 1106:193-8.
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Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. PLoS One. 2013; 8(12):e84089.
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Kennedy JL, Borish L. Chronic rhinosinusitis and antibiotics: the good, the bad, and the ugly. Am J Rhinol Allergy. 2013 Nov-Dec; 27(6):467-72.
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Kim W, Tengra FK, Young Z, Shong J, Marchand N, Chan HK, Pangule RC, Parra M, Dordick JS, Plawsky JL, Collins CH. Spaceflight promotes biofilm formation by Pseudomonas aeruginosa. PLoS One. 2013; 8(4):e62437.
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Zhang Y, Wei C, Jiang W, Wang L, Li C, Wang Y, Dow JM, Sun W. The HD-GYP domain protein RpfG of Xanthomonas oryzae pv. oryzicola regulates synthesis of extracellular polysaccharides that contribute to biofilm formation and virulence on rice. PLoS One. 2013; 8(3):e59428.
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Hart ME, Tsang LH, Deck J, Daily ST, Jones RC, Liu H, Hu H, Hart MJ, Smeltzer MS. Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants. Microbiology (Reading). 2013 Apr; 159(Pt 4):782-791.
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Cue D, Lei MG, Lee CY. Activation of sarX by Rbf is required for biofilm formation and icaADBC expression in Staphylococcus aureus. J Bacteriol. 2013 Apr; 195(7):1515-24.
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Boase S, Jervis-Bardy J, Cleland E, Pant H, Tan L, Wormald PJ. Bacterial-induced epithelial damage promotes fungal biofilm formation in a sheep model of sinusitis. Int Forum Allergy Rhinol. 2013 May; 3(5):341-8.
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Lu XH, An SQ, Tang DJ, McCarthy Y, Tang JL, Dow JM, Ryan RP. RsmA regulates biofilm formation in Xanthomonas campestris through a regulatory network involving cyclic di-GMP and the Clp transcription factor. PLoS One. 2012; 7(12):e52646.
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Foreman A, Jervis-Bardy J, Boase SJ, Tan L, Wormald PJ. Noninvasive Staphylococcus aureus biofilm determination in chronic rhinosinusitis by detecting the exopolysaccharide matrix component poly-N-acetylglucosamine. Int Forum Allergy Rhinol. 2013 Feb; 3(2):83-8.
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Hobby GH, Quave CL, Nelson K, Compadre CM, Beenken KE, Smeltzer MS. Quercus cerris extracts limit Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2012 Dec 18; 144(3):812-5.
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Zielinska AK, Beenken KE, Mrak LN, Spencer HJ, Post GR, Skinner RA, Tackett AJ, Horswill AR, Smeltzer MS. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol. 2012 Dec; 86(5):1183-96.
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Snowden JN, Beaver M, Smeltzer MS, Kielian T. Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system. Infect Immun. 2012 Sep; 80(9):3206-14.
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Dai L, Yang L, Parsons C, Findlay VJ, Molin S, Qin Z. Staphylococcus epidermidis recovered from indwelling catheters exhibit enhanced biofilm dispersal and "self-renewal" through downregulation of agr. BMC Microbiol. 2012 Jun 08; 12:102.
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Mrak LN, Zielinska AK, Beenken KE, Mrak IN, Atwood DN, Griffin LM, Lee CY, Smeltzer MS. saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus. PLoS One. 2012; 7(6):e38453.
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Cue D, Lei MG, Lee CY. Genetic regulation of the intercellular adhesion locus in staphylococci. Front Cell Infect Microbiol. 2012; 2:38.
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Beenken KE, Spencer H, Griffin LM, Smeltzer MS. Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions. Infect Immun. 2012 May; 80(5):1634-8.
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Quave CL, Estévez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 2012; 7(1):e28737.
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Twomey KB, O'Connell OJ, McCarthy Y, Dow JM, O'Toole GA, Plant BJ, Ryan RP. Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa. ISME J. 2012 May; 6(5):939-50.
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Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One. 2011; 6(11):e26714.
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Wilson SK, Costerton JW. Biofilm and penile prosthesis infections in the era of coated implants: a review. J Sex Med. 2012 Jan; 9(1):44-53.
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Fazli M, O'Connell A, Nilsson M, Niehaus K, Dow JM, Givskov M, Ryan RP, Tolker-Nielsen T. The CRP/FNR family protein Bcam1349 is a c-di-GMP effector that regulates biofilm formation in the respiratory pathogen Burkholderia cenocepacia. Mol Microbiol. 2011 Oct; 82(2):327-41.
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Valentine R, Jervis-Bardy J, Psaltis A, Tan LW, Wormald PJ. Efficacy of using a hydrodebrider and of citric acid/zwitterionic surfactant on a Staphylococcus aureus bacterial biofilm in the sheep model of rhinosinusitis. Am J Rhinol Allergy. 2011 Sep-Oct; 25(5):323-6.
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Lei MG, Cue D, Roux CM, Dunman PM, Lee CY. Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2. J Bacteriol. 2011 Oct; 193(19):5231-41.
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Singhal D, Foreman A, Jervis-Bardy J, Bardy JJ, Wormald PJ. Staphylococcus aureus biofilms: Nemesis of endoscopic sinus surgery. Laryngoscope. 2011 Jul; 121(7):1578-83.
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Foreman A, Jervis-Bardy J, Wormald PJ. Do biofilms contribute to the initiation and recalcitrance of chronic rhinosinusitis? Laryngoscope. 2011 May; 121(5):1085-91.
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Jervis-Bardy J, Foreman A, Bray S, Tan L, Wormald PJ. Methylglyoxal-infused honey mimics the anti-Staphylococcus aureus biofilm activity of manuka honey: potential implication in chronic rhinosinusitis. Laryngoscope. 2011 May; 121(5):1104-7.
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Jervis-Bardy J, Foreman A, Boase S, Valentine R, Wormald PJ. What is the origin of Staphylococcus aureus in the early postoperative sinonasal cavity? Int Forum Allergy Rhinol. 2011 Jul-Aug; 1(4):308-12.
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Gurjala AN, Geringer MR, Seth AK, Hong SJ, Smeltzer MS, Galiano RD, Leung KP, Mustoe TA. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen. 2011 May-Jun; 19(3):400-10.
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