 Polypyrimidine Tract-Binding Protein
"Polypyrimidine Tract-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
| Descriptor ID |
D038941
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| MeSH Number(s) |
D12.776.157.725.468 D12.776.664.962.468
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| Concept/Terms |
Polypyrimidine Tract-Binding Protein- Polypyrimidine Tract-Binding Protein
- Polypyrimidine Tract Binding Protein
- Tract-Binding Protein, Polypyrimidine
- PTB Splicing Factor
- Splicing Factor, PTB
- PTB Protein
- p57 Cytoplasmic RNA-Binding Protein
- p57 Cytoplasmic RNA Binding Protein
- pPTB
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Below are MeSH descriptors whose meaning is more general than "Polypyrimidine Tract-Binding Protein".
Below are MeSH descriptors whose meaning is more specific than "Polypyrimidine Tract-Binding Protein".
This graph shows the total number of publications written about "Polypyrimidine Tract-Binding Protein" by people in UAMS Profiles by year, and whether "Polypyrimidine Tract-Binding Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polypyrimidine Tract-Binding Protein" by people in Profiles over the past ten years.
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Ohno K, Rahman MA, Nazim M, Nasrin F, Lin Y, Takeda JI, Masuda A. Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction. J Neurochem. 2017 08; 142 Suppl 2:64-72.
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Mickleburgh I, Kafasla P, Cherny D, Llorian M, Curry S, Jackson RJ, Smith CW. The organization of RNA contacts by PTB for regulation of FAS splicing. Nucleic Acids Res. 2014 Jul; 42(13):8605-20.
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Rahman MA, Masuda A, Ohe K, Ito M, Hutchinson DO, Mayeda A, Engel AG, Ohno K. HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA. Sci Rep. 2013 Oct 14; 3:2931.
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