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Antineoplastic Agents, Alkylating

"Antineoplastic Agents, Alkylating" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)


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This graph shows the total number of publications written about "Antineoplastic Agents, Alkylating" by people in UAMS Profiles by year, and whether "Antineoplastic Agents, Alkylating" was a major or minor topic of these publications.
Bar chart showing 43 publications over 17 distinct years, with a maximum of 5 publications in 2003 and 2007
To see the data from this visualization as text, click here.