 Cilastatin
"Cilastatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
| Descriptor ID |
D015377
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| MeSH Number(s) |
D02.455.426.392.368.533.200 D10.251.355.325.200
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| Concept/Terms |
Cilastatin Sodium- Cilastatin Sodium
- Sodium, Cilastatin
- Cilastatin Monosodium Salt
- Monosodium Salt, Cilastatin
- Salt, Cilastatin Monosodium
MK 0791- MK 0791
- 0791, MK
- MK0791
- MK-791
- MK 791
- MK791
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Below are MeSH descriptors whose meaning is more general than "Cilastatin".
Below are MeSH descriptors whose meaning is more specific than "Cilastatin".
This graph shows the total number of publications written about "Cilastatin" by people in UAMS Profiles by year, and whether "Cilastatin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2000 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cilastatin" by people in Profiles over the past ten years.
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Bradley JS, Makieieva N, T?ndel C, Roilides E, Kelly MS, Patel M, Vaddady P, Maniar A, Zhang Y, Paschke A, Chen LF. Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase?1b, Open-Label, Single-Dose Clinical Trial. J Clin Pharmacol. 2023 12; 63(12):1387-1397.
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