 Nicotine
"Nicotine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
| Descriptor ID |
D009538
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| MeSH Number(s) |
D03.132.760.570 D03.383.725.518
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Nicotine".
Below are MeSH descriptors whose meaning is more specific than "Nicotine".
This graph shows the total number of publications written about "Nicotine" by people in UAMS Profiles by year, and whether "Nicotine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 1 | 2 | 3 | | 2021 | 0 | 1 | 1 | | 2020 | 3 | 3 | 6 | | 2019 | 5 | 2 | 7 | | 2018 | 5 | 5 | 10 | | 2017 | 6 | 0 | 6 | | 2016 | 2 | 3 | 5 | | 2015 | 8 | 2 | 10 | | 2014 | 1 | 0 | 1 | | 2013 | 3 | 0 | 3 | | 2012 | 3 | 0 | 3 | | 2011 | 5 | 1 | 6 | | 2010 | 4 | 4 | 8 | | 2009 | 4 | 4 | 8 | | 2008 | 8 | 2 | 10 | | 2007 | 7 | 1 | 8 | | 2006 | 7 | 3 | 10 | | 2005 | 15 | 2 | 17 | | 2004 | 4 | 3 | 7 | | 2003 | 4 | 2 | 6 | | 2002 | 6 | 0 | 6 | | 2001 | 5 | 0 | 5 | | 2000 | 3 | 0 | 3 | | 1999 | 7 | 1 | 8 | | 1998 | 2 | 1 | 3 | | 1997 | 7 | 0 | 7 | | 1995 | 3 | 1 | 4 | | 1994 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 | | 1992 | 4 | 1 | 5 | | 1991 | 1 | 0 | 1 | | 1990 | 1 | 1 | 2 | | 1989 | 4 | 0 | 4 | | 1988 | 10 | 2 | 12 |
To return to the timeline, click here.
Below are the most recent publications written about "Nicotine" by people in Profiles over the past ten years.
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Merii MH, Fardoun MM, El Asmar K, Khalil MI, Eid AH, Dhaini HR. Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain. Neurotoxicol Teratol. 2022 Jul-Aug; 92:107095.
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al'Absi M, DeAngelis B, Fiecas M, Budney A, Allen S. Effects of regular cannabis and nicotine use on acute stress responses: chronic nicotine, but not cannabis use, is associated with blunted adrenocortical and cardiovascular responses to stress. Psychopharmacology (Berl). 2022 May; 239(5):1551-1561.
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Derefinko KJ, Bursac Z, Hand SB, Ebbert JO, Womack C, Klesges RC. Planning a Change Easily (PACE) for smokers who are not ready to quit: a telephone-based, randomized controlled trial. Addiction. 2022 Jun; 117(6):1748-1757.
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Jones DM, Guy MC, Soule E, Sakuma KK, Pokhrel P, Orloff M, Trinidad D, Smith D, Browley S, Walker AP, Bullock S, Eissenberg T, Fagan P. Characterization of Electronic Cigarette Warning Statements Portrayed in YouTube Videos. Nicotine Tob Res. 2021 08 04; 23(8):1358-1366.
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Knapp AA, Allan NP, Cloutier R, Blumenthal H, Moradi S, Budney AJ, Lord SE. Effects of anxiety sensitivity on cannabis, alcohol, and nicotine use among adolescents: evaluating pathways through anxiety, withdrawal symptoms, and coping motives. J Behav Med. 2021 04; 44(2):187-201.
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Cardenas VM, Ali MM, Fischbach LA, Nembhard WN. Dual use of cigarettes and electronic nicotine delivery systems during pregnancy and the risk of small for gestational age neonates. Ann Epidemiol. 2020 12; 52:86-92.e2.
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Clawson AH, Ruppe NM, Nwankwo CN, Blair AL. Profiles of Nicotine and Cannabis Exposure among Young Adults with Asthma. Behav Med. 2022 Jan-Mar; 48(1):18-30.
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Streck JM, Davis DR, Pang RD, Sigmon SC, Bunn JY, Bergeria CL, Tidey JW, Heil SH, Gaalema DE, Hughes JR, Stitzer ML, Reed E, Higgins ST. Potential Moderating Effects of Sex/Gender on the Acute Relative Reinforcing and Subjective Effects of Reduced Nicotine Content Cigarettes in Vulnerable Populations. Nicotine Tob Res. 2020 05 26; 22(6):878-884.
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Streck JM, Sigmon SC, Priest J, Bergeria CL, Davis DR, Hughes JR, Villanti AC, Tidey JW, Heil SH, Gaalema DE, Stitzer ML, Higgins ST. Investigating tobacco withdrawal in response to reduced nicotine cigarettes among smokers with opioid use disorder and other vulnerabilities. Exp Clin Psychopharmacol. 2020 Dec; 28(6):714-723.
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Davis DR, Hickman NJ, Choi K, Robinson CD, Patten CA, Fagan P, Okuyemi KS, Nahvi S. Impact of the Society for Research on Nicotine and Tobacco Health Disparities Network's Scholarship on Professional Development of Its Recipients. Nicotine Tob Res. 2020 01 27; 22(1):141-143.
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Gaalema DE, Tidey JW, Davis DR, Sigmon SC, Heil SH, Stitzer ML, Desarno MJ, Diaz V, Hughes JR, Higgins ST. Potential Moderating Effects of Psychiatric Diagnosis and Symptom Severity on Subjective and Behavioral Responses to Reduced Nicotine Content Cigarettes. Nicotine Tob Res. 2019 12 23; 21(Suppl 1):S29-S37.
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Davis DR, DeSarno MJ, Bergeria CL, Streck JM, Tidey JW, Sigmon SC, Heil SH, Gaalema DE, Stitzer ML, Higgins ST. Examining effects of unit price on preference for reduced nicotine content cigarettes and smoking rate. Prev Med. 2019 11; 128:105823.
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Maziak W, Ben Taleb Z, Ebrahimi Kalan M, Ward-Peterson M, Bursac Z, Osibogun O, Eissenberg T. Effect of flavour manipulation on low and high-frequency waterpipe users' puff topography, toxicant exposures and subjective experiences. Tob Control. 2020 02; 29(Suppl 2):s95-s101.
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Addicott MA, Sweitzer MM, McClernon FJ. The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity. Nicotine Tob Res. 2019 05 21; 21(6):764-771.
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Stancil SL, Pearce RE, Tyndale RF, Kearns GL, Vyhlidal CA, Leeder JS, Abdel-Rahman S. Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults. Br J Clin Pharmacol. 2019 05; 85(5):960-969.
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Elton A, Chanon VW, Boettiger CA. Multivariate pattern analysis of the neural correlates of smoking cue attentional bias. Pharmacol Biochem Behav. 2019 05; 180:1-10.
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Bergeria CL, Heil SH, Davis DR, Streck JM, Sigmon SC, Bunn JY, Tidey JW, Arger CA, Reed DD, Gallagher T, Hughes JR, Gaalema DE, Stitzer ML, Higgins ST. Evaluating the utility of the modified cigarette evaluation questionnaire and cigarette purchase task for predicting acute relative reinforcing efficacy of cigarettes varying in nicotine content. Drug Alcohol Depend. 2019 04 01; 197:56-64.
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Maggio SE, Saunders MA, Nixon K, Prendergast MA, Zheng G, Crooks PA, Dwoskin LP, Bell RL, Bardo MT. An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic a6ß2* antagonist r-bPiDI. Drug Alcohol Depend. 2018 12 01; 193:154-161.
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Pack QR, Priya A, Lagu TC, Pekow PS, Atreya A, Rigotti NA, Lindenauer PK. Short-Term Safety of Nicotine Replacement in Smokers Hospitalized With Coronary Heart Disease. J Am Heart Assoc. 2018 09 18; 7(18):e009424.
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Badanavalu MP, Srivatsan M. Nicotine is neuroprotective to neonatal neurons of sympathetic ganglion in rat. Auton Neurosci. 2019 01; 216:25-32.
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Whittington JR, Simmons PM, Phillips AM, Gammill SK, Cen R, Magann EF, Cardenas VM. The Use of Electronic Cigarettes in Pregnancy: A Review of the Literature. Obstet Gynecol Surv. 2018 Sep; 73(9):544-549.
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Fagan P, Pokhrel P, Herzog TA, Moolchan ET, Cassel KD, Franke AA, Li X, Pagano I, Trinidad DR, Sakuma KK, Sterling K, Jorgensen D, Lynch T, Kawamoto C, Guy MC, Lagua I, Hanes S, Alexander LA, Clanton MS, Graham-Tutt C, Eissenberg T. Sugar and Aldehyde Content in Flavored Electronic Cigarette Liquids. Nicotine Tob Res. 2018 07 09; 20(8):985-992.
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Fagan P, Pokhrel P, Herzog TA, Guy MC, Sakuma KK, Trinidad DR, Cassel KD, Jorgensen D, Lynch T, Felicitas-Perkins JQ, Palafox S, Hamamura FD, Maloney S, Degree K, Sterling K, Moolchan ET, Clanton MS, Eissenberg TE. Warning Statements and Safety Practices Among Manufacturers and Distributors of Electronic Cigarette Liquids in the United States. Nicotine Tob Res. 2018 07 09; 20(8):970-976.
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Higgins ST, Bergeria CL, Davis DR, Streck JM, Villanti AC, Hughes JR, Sigmon SC, Tidey JW, Heil SH, Gaalema DE, Stitzer ML, Priest JS, Skelly JM, Reed DD, Bunn JY, Tromblee MA, Arger CA, Miller ME. Response to reduced nicotine content cigarettes among smokers differing in tobacco dependence severity. Prev Med. 2018 12; 117:15-23.
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Bhandari NR, Day KD, Payakachat N, Franks AM, McCain KR, Ragland D. Use and Risk Perception of Electronic Nicotine Delivery Systems and Tobacco in Pregnancy. Womens Health Issues. 2018 May - Jun; 28(3):251-257.
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Maggio SE, Saunders MA, Baxter TA, Nixon K, Prendergast MA, Zheng G, Crooks P, Dwoskin LP, Slack RD, Newman AH, Bell RL, Bardo MT. Effects of the nicotinic agonist varenicline, nicotinic antagonist r-bPiDI, and DAT inhibitor (R)-modafinil on co-use of ethanol and nicotine in female P rats. Psychopharmacology (Berl). 2018 05; 235(5):1439-1453.
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Kulik MC, Lisha NE, Glantz SA. E-cigarettes Associated With Depressed Smoking Cessation: A Cross-sectional Study of 28 European Union Countries. Am J Prev Med. 2018 04; 54(4):603-609.
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Arger CA, Heil SH, Sigmon SC, Tidey JW, Stitzer ML, Gaalema DE, Durand HJ, Bunn JY, Ruggieri EK, Higgins ST. Preliminary validity of the modified Cigarette Evaluation Questionnaire in predicting the reinforcing effects of cigarettes that vary in nicotine content. Exp Clin Psychopharmacol. 2017 12; 25(6):473-478.
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Higgins ST, Heil SH, Sigmon SC, Tidey JW, Gaalema DE, Hughes JR, Stitzer ML, Durand H, Bunn JY, Priest JS, Arger CA, Miller ME, Bergeria CL, Davis DR, Streck JM, Reed DD, Skelly JM, Tursi L. Addiction Potential of Cigarettes With Reduced Nicotine Content in Populations With Psychiatric Disorders and Other Vulnerabilities to Tobacco Addiction. JAMA Psychiatry. 2017 10 01; 74(10):1056-1064.
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Naylor JE, Hiranita T, Matazel KS, Zhang X, Paule MG, Goodwin AK. Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [18F]Fallypride. Drug Alcohol Depend. 2017 10 01; 179:254-259.
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Oliver JA, Evans DE, Addicott MA, Potts GF, Brandon TH, Drobes DJ. Nicotine Withdrawal Induces Neural Deficits in Reward Processing. Nicotine Tob Res. 2017 Jun 01; 19(6):686-693.
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Addicott MA, Oliver JA, Joseph McClernon F. Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers. Psychopharmacology (Berl). 2017 Apr; 234(7):1145-1154.
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Ekanem US, Cardenas VM, Cen R, Simon W, Chedjieu IP, Woodward M, Delongchamp RR, Wheeler JG. Electronic Nicotine Delivery Systems and Smoking Cessation in Arkansas, 2014. Public Health Rep. 2017 Mar/Apr; 132(2):210-219.
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Spears CA, Jones DM, Weaver SR, Pechacek TF, Eriksen MP. Use of Electronic Nicotine Delivery Systems among Adults with Mental Health Conditions, 2015. Int J Environ Res Public Health. 2016 12 23; 14(1).
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Higgins ST, Heil SH, Sigmon SC, Tidey JW, Gaalema DE, Stitzer ML, Durand H, Bunn JY, Priest JS, Arger CA, Miller ME, Bergeria CL, Davis DR, Streck JM, Zvorsky I, Redner R, Vandrey R, Pacek LR. Response to varying the nicotine content of cigarettes in vulnerable populations: an initial experimental examination of acute effects. Psychopharmacology (Berl). 2017 Jan; 234(1):89-98.
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Hsu PC, Lan RS, Brasky TM, Marian C, Cheema AK, Ressom HW, Loffredo CA, Pickworth WB, Shields PG. Menthol Smokers: Metabolomic Profiling and Smoking Behavior. Cancer Epidemiol Biomarkers Prev. 2017 01; 26(1):51-60.
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Sun J, Jin J, Beger RD, Cerniglia CE, Yang M, Chen H. Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena. Toxicol In Vitro. 2016 Oct; 36:133-141.
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Cardenas VM, Evans VL, Balamurugan A, Faramawi MF, Delongchamp RR, Wheeler JG. Use of electronic nicotine delivery systems and recent initiation of smoking among US youth. Int J Public Health. 2016 Mar; 61(2):237-41.
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Prueitt RL, Wallace TA, Glynn SA, Yi M, Tang W, Luo J, Dorsey TH, Stagliano KE, Gillespie JW, Hudson RS, Terunuma A, Shoe JL, Haines DC, Yfantis HG, Han M, Martin DN, Jordan SV, Borin JF, Naslund MJ, Alexander RB, Stephens RM, Loffredo CA, Lee DH, Putluri N, Sreekumar A, Hurwitz AA, Ambs S. An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers. Cancer Res. 2016 Mar 01; 76(5):1055-1065.
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Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. N Engl J Med. 2015 Oct; 373(14):1340-9.
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Sisterhen L. Liquid Nicotine and Children. J Ark Med Soc. 2015 Sep; 112(5):53.
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Beckmann JS, Meyer AC, Pivavarchyk M, Horton DB, Zheng G, Smith AM, Wooters TE, McIntosh JM, Crooks PA, Bardo MT, Dwoskin LP. r-bPiDI, an a6ß2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement. Neurochem Res. 2015 Oct; 40(10):2121-30.
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Fagan P, Pokhrel P, Herzog TA, Pagano IS, Franke AA, Clanton MS, Alexander LA, Trinidad DR, Sakuma KL, Johnson CA, Moolchan ET. Nicotine Metabolism in Young Adult Daily Menthol and Nonmenthol Smokers. Nicotine Tob Res. 2016 Apr; 18(4):437-46.
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Sakamoto M, Itoh T, Tukey RH, Fujiwara R. Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain. Drug Metab Pharmacokinet. 2015 Aug; 30(4):269-75.
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McClernon FJ, Froeliger B, Rose JE, Kozink RV, Addicott MA, Sweitzer MM, Westman EC, Van Wert DM. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addict Biol. 2016 07; 21(4):954-61.
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Fagan P, Moolchan ET, Pokhrel P, Herzog T, Cassel KD, Pagano I, Franke AA, Kaholokula JK, Sy A, Alexander LA, Trinidad DR, Sakuma KL, Johnson CA, Antonio A, Jorgensen D, Lynch T, Kawamoto C, Clanton MS. Biomarkers of tobacco smoke exposure in racial/ethnic groups at high risk for lung cancer. Am J Public Health. 2015 Jun; 105(6):1237-45.
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Goodwin AK, Hiranita T, Paule MG. The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research. Nicotine Tob Res. 2015 Nov; 17(11):1297-310.
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McClernon FJ, Addicott MA, Sweitzer MM. Smoking abstinence and neurocognition: implications for cessation and relapse. Curr Top Behav Neurosci. 2015; 23:193-227.
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Addicott MA, Froeliger B, Kozink RV, Van Wert DM, Westman EC, Rose JE, McClernon FJ. Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. 2014 Nov; 39(12):2750-9.
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Halder S, Lynch JM, Pearce AR. The multiple bottle effect is overridden in male and female rats by simultaneous presentation of two oral nicotine solutions. Am J Drug Alcohol Abuse. 2013 May; 39(3):161-7.
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