 Nitric Oxide
"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
| Descriptor ID |
D009569
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| MeSH Number(s) |
D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
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| Concept/Terms |
Nitric Oxide- Nitric Oxide
- Oxide, Nitric
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
- Nitrogen Monoxide
- Monoxide, Nitrogen
- Endogenous Nitrate Vasodilator
- Nitrate Vasodilator, Endogenous
- Vasodilator, Endogenous Nitrate
- Nitric Oxide, Endothelium-Derived
- Endothelium-Derived Nitric Oxide
- Nitric Oxide, Endothelium Derived
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Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".
Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".
This graph shows the total number of publications written about "Nitric Oxide" by people in UAMS Profiles by year, and whether "Nitric Oxide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2022 | 0 | 3 | 3 | | 2021 | 0 | 5 | 5 | | 2020 | 2 | 4 | 6 | | 2019 | 2 | 2 | 4 | | 2018 | 0 | 4 | 4 | | 2017 | 7 | 4 | 11 | | 2016 | 5 | 4 | 9 | | 2015 | 7 | 2 | 9 | | 2014 | 3 | 0 | 3 | | 2013 | 7 | 1 | 8 | | 2012 | 4 | 11 | 15 | | 2011 | 3 | 7 | 10 | | 2010 | 6 | 4 | 10 | | 2009 | 5 | 5 | 10 | | 2008 | 2 | 3 | 5 | | 2007 | 2 | 5 | 7 | | 2006 | 8 | 3 | 11 | | 2005 | 4 | 12 | 16 | | 2004 | 5 | 9 | 14 | | 2003 | 6 | 5 | 11 | | 2002 | 5 | 6 | 11 | | 2001 | 1 | 2 | 3 | | 2000 | 3 | 4 | 7 | | 1999 | 2 | 1 | 3 | | 1998 | 2 | 1 | 3 | | 1997 | 4 | 0 | 4 | | 1996 | 4 | 0 | 4 | | 1995 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1990 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nitric Oxide" by people in Profiles over the past ten years.
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Lin CC, Chang TY, Lu YC, Wu YS, Huang W, Lo WC, Liu GF, Hsu WC, Ohashi PS, Mak TW, Fuh JL, Chen HC, Tarng DC, Chen NJ. TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases. J Mol Med (Berl). 2022 06; 100(6):917-931.
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Yates AR, Berger JT, Reeder RW, Banks R, Mourani PM, Berg RA, Carcillo JA, Carpenter T, Hall MW, Meert KL, McQuillen PS, Pollack MM, Sapru A, Notterman DA, Holubkov R, Dean JM, Wessel DL. Characterization of Inhaled Nitric Oxide Use for Cardiac Indications in Pediatric Patients. Pediatr Crit Care Med. 2022 04 01; 23(4):245-254.
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Sharma M, Callan E, Konduri GG. Pulmonary Vasodilator Therapy in Persistent Pulmonary Hypertension of the Newborn. Clin Perinatol. 2022 03; 49(1):103-125.
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Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2022 01; 42(1):14-18.
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Maddux AB, Mourani PM, Banks R, Reeder RW, Pollack MM, Berg RA, Meert KL, McQuillen PS, Yates AR, Notterman DA, Berger JT. Inhaled Nitric Oxide Use and Outcomes in Critically Ill Children With a History of Prematurity. Respir Care. 2021 Oct; 66(10):1549-1559.
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Bath PM, Coleman CM, Gordon AL, Lim WS, Webb AJ. Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections. F1000Res. 2021; 10:536.
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Blackburn ML, Wankhade UD, Ono-Moore KD, Chintapalli SV, Fox R, Rutkowsky JM, Willis BJ, Tolentino T, Lloyd KCK, Adams SH. On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E47-E62.
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Coleman RD, Chartan CA, Mourani PM. Intensive care management of right ventricular failure and pulmonary hypertension crises. Pediatr Pulmonol. 2021 03; 56(3):636-648.
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Najjar RS, Akhavan NS, Pourafshar S, Arjmandi BH, Feresin RG. Cornus officinalis var. koreana Kitam polyphenol extract decreases pro-inflammatory markers in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by reducing Akt phosphorylation. J Ethnopharmacol. 2021 Apr 24; 270:113734.
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Chen JZ, Joshipura KJ, Habash F, Lopez-Candales A. Dentists and physicians' practices meet once again: Potential unfavorable clinical effects of frequent mouthwash use. Postgrad Med. 2021 Mar; 133(2):123-124.
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Berger JT, Maddux AB, Reeder RW, Banks R, Mourani PM, Berg RA, Carcillo JA, Carpenter T, Hall MW, Meert KL, McQuillen PS, Pollack MM, Sapru A, Yates AR, Notterman DA, Holubkov R, Dean JM, Wessel DL. Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure. Pediatr Crit Care Med. 2020 08; 21(8):708-719.
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Granados JZ, Ten Have GAM, Letsinger AC, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Activated whole-body arginine pathway in high-active mice. PLoS One. 2020; 15(6):e0235095.
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Ranallo CD, Thurman TL, Holt SJ, Frank-Pearce SG, Anderson MP, Heulitt MJ. Effect of Nitric Oxide Delivery Device on Tidal Volume Accuracy During Mechanical Ventilation at Small Tidal Volumes. Respir Care. 2020 Nov; 65(11):1641-1647.
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Liu D, Zeng X, Li X, Cui C, Hou R, Guo Z, Mehta JL, Wang X. Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators. Biochem Pharmacol. 2020 05; 175:113863.
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Joshipura K, Muñoz-Torres F, Fernández-Santiago J, Patel RP, Lopez-Candales A. Over-the-counter mouthwash use, nitric oxide and hypertension risk. Blood Press. 2020 04; 29(2):103-112.
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Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2020 06; 39(6):1764-1773.
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Bavineni M, Wassenaar TM, Agnihotri K, Ussery DW, Lüscher TF, Mehta JL. Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood. Eur Heart J. 2019 04 07; 40(14):1107-1112.
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Dibo P, Marañón RO, Chandrashekar K, Mazzuferi F, Silva GB, Juncos LA, Juncos LI. Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb. Physiol Rep. 2019 03; 7(5):e14015.
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Fouda AY, Xu Z, Shosha E, Lemtalsi T, Chen J, Toque HA, Tritz R, Cui X, Stansfield BK, Huo Y, Rodriguez PC, Smith SB, Caldwell RW, Narayanan SP, Caldwell RB. Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses. Cell Death Dis. 2018 09 25; 9(10):1001.
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Choubey M, Ranjan A, Bora PS, Baltazar F, Krishna A. Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. Gen Comp Endocrinol. 2019 08 01; 279:1-11.
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Hejazi II, Khanam R, Mehdi SH, Bhat AR, Rizvi MMA, Thakur SC, Athar F. Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies. Food Chem Toxicol. 2018 May; 115:244-259.
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Halterman JS, Fagnano M, Tajon RS, Tremblay P, Wang H, Butz A, Perry TT, McConnochie KM. Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial. JAMA Pediatr. 2018 03 05; 172(3):e174938.
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Dunn SM, Hilgers R, Das KC. Decreased EDHF-mediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged high-fat sucrose diet. Physiol Rep. 2017 12; 5(23).
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Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW. Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. Cardiovasc Res. 2017 Nov 01; 113(13):1664-1676.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Gupta P, Rettiganti M, Wilcox A, Eble BK, Schmitz ML, Zakaria D. Spectrum of Off-Label Nitric Oxide Utilization After Pediatric Cardiac Surgery Among Centers of Varying Surgical Volume. J Intensive Care Med. 2019 Nov-Dec; 34(11-12):917-923.
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Engelen MPKJ, Klimberg VS, Allasia A, Deutz NEP. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr. 2018 10; 37(5):1645-1653.
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Liu Z, Nemec-Bakk A, Khaper N, Chen A. Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode. Anal Chem. 2017 08 01; 89(15):8036-8043.
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Song J, Wang L, Fan F, Wei J, Zhang J, Lu Y, Fu Y, Wang S, Juncos LA, Liu R. Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics. Hypertension. 2017 08; 70(2):324-333.
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Chang JYH, Chow LW, Dismuke WM, Ethier CR, Stevens MM, Stamer WD, Overby DR. Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration. Adv Healthc Mater. 2017 Aug; 6(16).
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Chandrawati R, Chang JYH, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, Zelikin AN, Overby DR, Stevens MM. Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. Adv Mater. 2017 Apr; 29(16).
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Akolkar G, Bagchi AK, Ayyappan P, Jassal DS, Singal PK. Doxorubicin-induced nitrosative stress is mitigated by vitamin C via the modulation of nitric oxide synthases. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C418-C427.
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Keller RL, Eichenwald EC, Hibbs AM, Rogers EE, Wai KC, Black DM, Ballard PL, Asselin JM, Truog WE, Merrill JD, Mammel MC, Steinhorn RH, Ryan RM, Durand DJ, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, Helderman J, Porta NF, Wadhawan R, Palermo L, Ballard RA. The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age. J Pediatr. 2017 04; 183:19-25.e2.
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Tadphale SD, Rettiganti M, Gossett JM, Beam BW, Padiyath A, Schmitz ML, Gupta P. Is Administration of Nitric Oxide During Extracorporeal Membrane Oxygenation Associated With Improved Patient Survival? Pediatr Crit Care Med. 2016 11; 17(11):1080-1087.
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Gupta P, Richardson T, Hall M, Bertoch D, Hebbar KB, Fortenberry JD, Wetzel RC. Effect of Inhaled Nitric Oxide on Outcomes in Children With Acute Lung Injury: Propensity Matched Analysis From a Linked Database. Crit Care Med. 2016 Oct; 44(10):1901-9.
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Rosas-Hernandez H, Cuevas E, Lantz SM, Rice KC, Gannon BM, Fantegrossi WE, Gonzalez C, Paule MG, Ali SF. Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. Neurosci Lett. 2016 08 26; 629:125-130.
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Seawright JW, Luttrell M, Trache A, Woodman CR. Short-term increases in pressure and shear stress attenuate age-related declines in endothelial function in skeletal muscle feed arteries. Eur J Appl Physiol. 2016 Jul; 116(7):1305-11.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016 06; 103(6):1458-64.
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Thomas B, Chay OM, Allen JC, Chiang AS, Pugalenthi A, Goh A, Wong P, Teo AH, Tan SG, Teoh OH. Concordance between bronchial hyperresponsiveness, fractional exhaled nitric oxide, and asthma control in children. Pediatr Pulmonol. 2016 10; 51(10):1004-1009.
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Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis in cancer is related to impaired endogenous arginine synthesis. Clin Sci (Lond). 2016 07 01; 130(14):1185-95.
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Glenn JM, Gray M, Jensen A, Stone MS, Vincenzo JL. Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players. Eur J Sport Sci. 2016 Nov; 16(8):1095-103.
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Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tascón GA, Hernandez G, Murray P, De Backer D. THE ENDOTHELIUM IN SEPSIS. Shock. 2016 Mar; 45(3):259-70.
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Morshedi RG, Ricca AM, Wirostko BM. Ocular Hypertension Following Intravitreal Antivascular Endothelial Growth Factor Therapy: Review of the Literature and Possible Role of Nitric Oxide. J Glaucoma. 2016 Mar; 25(3):291-300.
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Ballard RA, Keller RL, Black DM, Ballard PL, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn RH, Rogers EE, Ryan RM, Durand DJ, Asselin JM, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, O'Shea TM, Porta NF, Wadhawan R, Palermo L. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr. 2016 Jan; 168:23-29.e4.
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Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015 Dec 01; 309(11):E915-24.
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Mourani PM, Abman SH. Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec; 42(4):839-55.
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Wang L, Shen C, Liu H, Wang S, Chen X, Roman RJ, Juncos LA, Lu Y, Wei J, Zhang J, Yip KP, Liu R. Shear stress blunts tubuloglomerular feedback partially mediated by primary cilia and nitric oxide at the macula densa. Am J Physiol Regul Integr Comp Physiol. 2015 Oct; 309(7):R757-66.
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Chang JY, Stamer WD, Bertrand J, Read AT, Marando CM, Ethier CR, Overby DR. Role of nitric oxide in murine conventional outflow physiology. Am J Physiol Cell Physiol. 2015 Aug 15; 309(4):C205-14.
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Todd Tzanetos DR, Housley JJ, Barr FE, May WL, Landers CD. Implementation of an inhaled nitric oxide protocol decreases direct cost associated with its use. Respir Care. 2015 May; 60(5):644-50.
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Ricca AM, Morshedi RG, Wirostko BM. High intraocular pressure following anti-vascular endothelial growth factor therapy: proposed pathophysiology due to altered nitric oxide metabolism. J Ocul Pharmacol Ther. 2015 Feb; 31(1):2-10.
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Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, Feresin RG, Elam ML, Hooshmand S, Payton ME, Arjmandi BH. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: a randomized, double-blind, placebo-controlled clinical trial. J Acad Nutr Diet. 2015 Mar; 115(3):369-377.
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Luiking YC, Poeze M, Deutz NE. Arginine infusion in patients with septic shock increases nitric oxide production without haemodynamic instability. Clin Sci (Lond). 2015 Jan; 128(1):57-67.
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Hilgers RH, Das KC. Role of in vivo vascular redox in resistance arteries. Hypertension. 2015 Jan; 65(1):130-9.
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Huang L, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophil-derived IL-10 supports chronic nematode infection. J Immunol. 2014 Oct 15; 193(8):4178-87.
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De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM. Role of peroxisome proliferator-activated receptor-? in vascular muscle in the cerebral circulation. Hypertension. 2014 Nov; 64(5):1088-93.
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Seawright JW, Luttrell MJ, Woodman CR. Acute increases in intraluminal pressure improve vasodilator responses in aged soleus muscle feed arteries. Eur J Appl Physiol. 2014 Oct; 114(10):2213-21.
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Ballard PL, Keller RL, Black DM, Durand DJ, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn R, Ryan RM, Courtney SE, Horneman H, Ballard RA. Inhaled nitric oxide increases urinary nitric oxide metabolites and cyclic guanosine monophosphate in premature infants: relationship to pulmonary outcome. Am J Perinatol. 2015 Feb; 32(3):225-32.
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Delgado-Calle J, Riancho JA, Klein-Nulend J. Nitric oxide is involved in the down-regulation of SOST expression induced by mechanical loading. Calcif Tissue Int. 2014 Apr; 94(4):414-22.
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Raber PL, Thevenot P, Sierra R, Wyczechowska D, Halle D, Ramirez ME, Ochoa AC, Fletcher M, Velasco C, Wilk A, Reiss K, Rodriguez PC. Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways. Int J Cancer. 2014 Jun 15; 134(12):2853-64.
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Peter EA, Shen X, Shah SH, Pardue S, Glawe JD, Zhang WW, Reddy P, Akkus NI, Varma J, Kevil CG. Plasma free H2S levels are elevated in patients with cardiovascular disease. J Am Heart Assoc. 2013 Oct 23; 2(5):e000387.
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de Betue CT, Deutz NE. Changes in arginine metabolism during sepsis and critical illness in children. Nestle Nutr Inst Workshop Ser. 2013; 77:17-28.
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de Betue CT, Joosten KF, Deutz NE, Vreugdenhil AC, van Waardenburg DA. Arginine appearance and nitric oxide synthesis in critically ill infants can be increased with a protein-energy-enriched enteral formula. Am J Clin Nutr. 2013 Oct; 98(4):907-16.
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Marañon RO, Juncos LA, Joo Turoni C, Karbiner S, Romero D, Peral de Bruno M. Tempol blunts afferent arteriolar remodeling in chronic nitric oxide-deficient hypertension without normalizing blood pressure. Clin Exp Hypertens. 2014; 36(3):132-9.
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Rogers SC, Zhang X, Azhar G, Luo S, Wei JY. Exposure to high or low glucose levels accelerates the appearance of markers of endothelial cell senescence and induces dysregulation of nitric oxide synthase. J Gerontol A Biol Sci Med Sci. 2013 Dec; 68(12):1469-81.
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Trott DW, Luttrell MJ, Seawright JW, Woodman CR. Aging impairs PI3K/Akt signaling and NO-mediated dilation in soleus muscle feed arteries. Eur J Appl Physiol. 2013 Aug; 113(8):2039-46.
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Engelen MP, Com G, Luiking YC, Deutz NE. Stimulated nitric oxide production and arginine deficiency in children with cystic fibrosis with nutritional failure. J Pediatr. 2013 Aug; 163(2):369-75.
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Sawant A, Deshane J, Jules J, Lee CM, Harris BA, Feng X, Ponnazhagan S. Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res. 2013 Jan 15; 73(2):672-82.
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Patil NK, Saba H, MacMillan-Crow LA. Effect of S-nitrosoglutathione on renal mitochondrial function: a new mechanism for reversible regulation of manganese superoxide dismutase activity? Free Radic Biol Med. 2013 Mar; 56:54-63.
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Isaac J, Tarapore P, Zhang X, Lam YW, Ho SM. Site-specific S-nitrosylation of integrin a6 increases the extent of prostate cancer cell migration by enhancing integrin ß1 association and weakening adherence to laminin-1. Biochemistry. 2012 Dec 04; 51(48):9689-97.
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