 Nitric Oxide
"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
| Descriptor ID |
D009569
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| MeSH Number(s) |
D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
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| Concept/Terms |
Nitric Oxide- Nitric Oxide
- Oxide, Nitric
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
- Nitrogen Monoxide
- Monoxide, Nitrogen
- Endogenous Nitrate Vasodilator
- Nitrate Vasodilator, Endogenous
- Vasodilator, Endogenous Nitrate
- Nitric Oxide, Endothelium-Derived
- Endothelium-Derived Nitric Oxide
- Nitric Oxide, Endothelium Derived
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Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".
Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".
This graph shows the total number of publications written about "Nitric Oxide" by people in UAMS Profiles by year, and whether "Nitric Oxide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 1 | 1 | 2 | | 2024 | 1 | 0 | 1 | | 2023 | 1 | 1 | 2 | | 2022 | 1 | 6 | 7 | | 2021 | 1 | 4 | 5 | | 2020 | 2 | 4 | 6 | | 2019 | 1 | 2 | 3 | | 2018 | 0 | 3 | 3 | | 2017 | 3 | 4 | 7 | | 2016 | 3 | 3 | 6 | | 2015 | 4 | 2 | 6 | | 2014 | 3 | 0 | 3 | | 2013 | 6 | 1 | 7 | | 2012 | 5 | 8 | 13 | | 2011 | 3 | 4 | 7 | | 2010 | 6 | 2 | 8 | | 2009 | 5 | 5 | 10 | | 2008 | 2 | 3 | 5 | | 2007 | 2 | 6 | 8 | | 2006 | 8 | 4 | 12 | | 2005 | 3 | 12 | 15 | | 2004 | 5 | 10 | 15 | | 2003 | 5 | 3 | 8 | | 2002 | 5 | 5 | 10 | | 2001 | 2 | 0 | 2 | | 2000 | 2 | 4 | 6 | | 1999 | 1 | 1 | 2 | | 1998 | 1 | 2 | 3 | | 1997 | 3 | 0 | 3 | | 1996 | 3 | 0 | 3 | | 1995 | 0 | 2 | 2 | | 1994 | 0 | 1 | 1 | | 1990 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nitric Oxide" by people in Profiles over the past ten years.
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Turner CG, Stanhewicz AE, Nielsen KE, Otis JS, Feresin RG, Wong BJ. Oral contraceptive pill phase alters mechanisms contributing to cutaneous microvascular function in response to local heating. Am J Physiol Regul Integr Comp Physiol. 2025 Mar 01; 328(3):R374-R385.
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Kurtz JA, Feresin RG, Grazer J, Otis J, Wilson KE, Doyle JA, Zwetsloot KA. Effects of Quercetin and Citrulline on Nitric Oxide Metabolites and Antioxidant Biomarkers in Trained Cyclists. Nutrients. 2025 Jan 09; 17(2).
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Frye RE, Rose S, Voinsky I, Gurwitz D. Nitrosative Stress in Autism: Supportive Evidence and Implications for Mitochondrial Dysfunction. Adv Sci (Weinh). 2024 Apr; 11(16):e2304439.
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Zheng Y, Li Z, Cui X, Yang Z, Bao C, Pan L, Liu X, Chatel-Innocenti G, Vanacker H, Noctor G, Dard A, Reichheld JP, Issakidis-Bourguet E, Zhou DX. S-Nitrosylation of the histone deacetylase HDA19 stimulates its activity to enhance plant stress tolerance in Arabidopsis. Plant J. 2023 05; 114(4):836-854.
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Turner CG, Stanhewicz AE, Nielsen KE, Otis JS, Feresin RG, Wong BJ. Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans. J Appl Physiol (1985). 2023 04 01; 134(4):858-867.
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Liu R, Juncos LA, Lu Y, Wei J, Zhang J, Wang L, Lai EY, Carlstrom M, Persson AEG. The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback. Compr Physiol. 2023 01 30; 13(1):4215-4229.
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Najjar RS, Wong BJ, Feresin RG. Tissue Derivation and Biological Sex Uniquely Mediate Endothelial Cell Protein Expression, Redox Status, and Nitric Oxide Synthesis. Cells. 2022 12 26; 12(1).
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Wierzchowska-McNew RA, Engelen MPKJ, Thaden JJ, Ten Have GAM, Deutz NEP. Obesity- and sex-related metabolism of arginine and nitric oxide in adults. Am J Clin Nutr. 2022 12 19; 116(6):1610-1620.
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Meister ML, Najjar RS, Danh JP, Knapp D, Wanders D, Feresin RG. Berry consumption mitigates the hypertensive effects of a high-fat, high-sucrose diet via attenuation of renal and aortic AT1R expression resulting in improved endothelium-derived NO bioavailability. J Nutr Biochem. 2023 02; 112:109225.
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Shinkawa T. [Emergent Operation for Total Anomalous Pulmonary Venous Return]. Kyobu Geka. 2022 Sep; 75(10):796-801.
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Lin CC, Chang TY, Lu YC, Wu YS, Huang W, Lo WC, Liu GF, Hsu WC, Ohashi PS, Mak TW, Fuh JL, Chen HC, Tarng DC, Chen NJ. TREM-2 mediates dendritic cell-induced NO to suppress Th17 activation and ameliorate chronic kidney diseases. J Mol Med (Berl). 2022 06; 100(6):917-931.
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Yates AR, Berger JT, Reeder RW, Banks R, Mourani PM, Berg RA, Carcillo JA, Carpenter T, Hall MW, Meert KL, McQuillen PS, Pollack MM, Sapru A, Notterman DA, Holubkov R, Dean JM, Wessel DL. Characterization of Inhaled Nitric Oxide Use for Cardiac Indications in Pediatric Patients. Pediatr Crit Care Med. 2022 04 01; 23(4):245-254.
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Sharma M, Callan E, Konduri GG. Pulmonary Vasodilator Therapy in Persistent Pulmonary Hypertension of the Newborn. Clin Perinatol. 2022 03; 49(1):103-125.
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Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2022 01; 42(1):14-18.
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Maddux AB, Mourani PM, Banks R, Reeder RW, Pollack MM, Berg RA, Meert KL, McQuillen PS, Yates AR, Notterman DA, Berger JT. Inhaled Nitric Oxide Use and Outcomes in Critically Ill Children With a History of Prematurity. Respir Care. 2021 Oct; 66(10):1549-1559.
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Bath PM, Coleman CM, Gordon AL, Lim WS, Webb AJ. Nitric oxide for the prevention and treatment of?viral, bacterial,?protozoal?and?fungal?infections. F1000Res. 2021; 10:536.
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Blackburn ML, Wankhade UD, Ono-Moore KD, Chintapalli SV, Fox R, Rutkowsky JM, Willis BJ, Tolentino T, Lloyd KCK, Adams SH. On the potential role of globins in brown adipose tissue: a novel conceptual model and studies in myoglobin knockout mice. Am J Physiol Endocrinol Metab. 2021 07 01; 321(1):E47-E62.
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Coleman RD, Chartan CA, Mourani PM. Intensive care management of right ventricular failure and pulmonary hypertension crises. Pediatr Pulmonol. 2021 03; 56(3):636-648.
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Najjar RS, Akhavan NS, Pourafshar S, Arjmandi BH, Feresin RG. Cornus officinalis var. koreana Kitam polyphenol extract decreases pro-inflammatory markers in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages by reducing Akt phosphorylation. J Ethnopharmacol. 2021 Apr 24; 270:113734.
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Chen JZ, Joshipura KJ, Habash F, Lopez-Candales A. Dentists and physicians' practices meet once again: Potential unfavorable clinical effects of frequent mouthwash use. Postgrad Med. 2021 Mar; 133(2):123-124.
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Berger JT, Maddux AB, Reeder RW, Banks R, Mourani PM, Berg RA, Carcillo JA, Carpenter T, Hall MW, Meert KL, McQuillen PS, Pollack MM, Sapru A, Yates AR, Notterman DA, Holubkov R, Dean JM, Wessel DL. Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure. Pediatr Crit Care Med. 2020 08; 21(8):708-719.
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Granados JZ, Ten Have GAM, Letsinger AC, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Activated whole-body arginine pathway in high-active mice. PLoS One. 2020; 15(6):e0235095.
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Ranallo CD, Thurman TL, Holt SJ, Frank-Pearce SG, Anderson MP, Heulitt MJ. Effect of Nitric Oxide Delivery Device on Tidal Volume Accuracy During Mechanical Ventilation at Small Tidal Volumes. Respir Care. 2020 Nov; 65(11):1641-1647.
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Liu D, Zeng X, Li X, Cui C, Hou R, Guo Z, Mehta JL, Wang X. Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators. Biochem Pharmacol. 2020 05; 175:113863.
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Joshipura K, Mu?oz-Torres F, Fern?ndez-Santiago J, Patel RP, Lopez-Candales A. Over-the-counter mouthwash use, nitric oxide and hypertension risk. Blood Press. 2020 04; 29(2):103-112.
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Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2020 06; 39(6):1764-1773.
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Bavineni M, Wassenaar TM, Agnihotri K, Ussery DW, L?scher TF, Mehta JL. Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood. Eur Heart J. 2019 04 07; 40(14):1107-1112.
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Dibo P, Mara??n RO, Chandrashekar K, Mazzuferi F, Silva GB, Juncos LA, Juncos LI. Angiotensin-(1-7) inhibits sodium transport via Mas receptor by increasing nitric oxide production in thick ascending limb. Physiol Rep. 2019 03; 7(5):e14015.
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Fouda AY, Xu Z, Shosha E, Lemtalsi T, Chen J, Toque HA, Tritz R, Cui X, Stansfield BK, Huo Y, Rodriguez PC, Smith SB, Caldwell RW, Narayanan SP, Caldwell RB. Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses. Cell Death Dis. 2018 09 25; 9(10):1001.
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Choubey M, Ranjan A, Bora PS, Baltazar F, Krishna A. Direct actions of adiponectin on changes in reproductive, metabolic, and anti-oxidative enzymes status in the testis of adult mice. Gen Comp Endocrinol. 2019 08 01; 279:1-11.
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Hejazi II, Khanam R, Mehdi SH, Bhat AR, Rizvi MMA, Thakur SC, Athar F. Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies. Food Chem Toxicol. 2018 May; 115:244-259.
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Halterman JS, Fagnano M, Tajon RS, Tremblay P, Wang H, Butz A, Perry TT, McConnochie KM. Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial. JAMA Pediatr. 2018 03 05; 172(3):e174938.
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Dunn SM, Hilgers R, Das KC. Decreased EDHF-mediated relaxation is a major mechanism in endothelial dysfunction in resistance arteries in aged mice on prolonged high-fat sucrose diet. Physiol Rep. 2017 12; 5(23).
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Bhatta A, Yao L, Xu Z, Toque HA, Chen J, Atawia RT, Fouda AY, Bagi Z, Lucas R, Caldwell RB, Caldwell RW. Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1. Cardiovasc Res. 2017 Nov 01; 113(13):1664-1676.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Gupta P, Rettiganti M, Wilcox A, Eble BK, Schmitz ML, Zakaria D. Spectrum of Off-Label Nitric Oxide Utilization After Pediatric Cardiac Surgery Among Centers of Varying Surgical Volume. J Intensive Care Med. 2019 Nov-Dec; 34(11-12):917-923.
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Engelen MPKJ, Klimberg VS, Allasia A, Deutz NEP. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer. Clin Nutr. 2018 10; 37(5):1645-1653.
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Manicam C, Ginter N, Li H, Xia N, Goloborodko E, Zadeh JK, Musayeva A, Pfeiffer N, Gericke A. Compensatory Vasodilator Mechanisms in the Ophthalmic Artery of Endothelial Nitric Oxide Synthase Gene Knockout Mice. Sci Rep. 2017 08 02; 7(1):7111.
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Liu Z, Nemec-Bakk A, Khaper N, Chen A. Sensitive Electrochemical Detection of Nitric Oxide Release from Cardiac and Cancer Cells via a Hierarchical Nanoporous Gold Microelectrode. Anal Chem. 2017 08 01; 89(15):8036-8043.
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Song J, Wang L, Fan F, Wei J, Zhang J, Lu Y, Fu Y, Wang S, Juncos LA, Liu R. Role of the Primary Cilia on the Macula Densa and Thick Ascending Limbs in Regulation of Sodium Excretion and Hemodynamics. Hypertension. 2017 08; 70(2):324-333.
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Chang JYH, Chow LW, Dismuke WM, Ethier CR, Stevens MM, Stamer WD, Overby DR. Peptide-Functionalized Fluorescent Particles for In Situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration. Adv Healthc Mater. 2017 Aug; 6(16).
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Chandrawati R, Chang JYH, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, Zelikin AN, Overby DR, Stevens MM. Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma. Adv Mater. 2017 Apr; 29(16).
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Akolkar G, Bagchi AK, Ayyappan P, Jassal DS, Singal PK. Doxorubicin-induced nitrosative stress is mitigated by vitamin C via the modulation of nitric oxide synthases. Am J Physiol Cell Physiol. 2017 Apr 01; 312(4):C418-C427.
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Keller RL, Eichenwald EC, Hibbs AM, Rogers EE, Wai KC, Black DM, Ballard PL, Asselin JM, Truog WE, Merrill JD, Mammel MC, Steinhorn RH, Ryan RM, Durand DJ, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, Helderman J, Porta NF, Wadhawan R, Palermo L, Ballard RA. The Randomized, Controlled Trial of Late Surfactant: Effects on Respiratory Outcomes at 1-Year Corrected Age. J Pediatr. 2017 04; 183:19-25.e2.
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Tadphale SD, Rettiganti M, Gossett JM, Beam BW, Padiyath A, Schmitz ML, Gupta P. Is Administration of Nitric Oxide During Extracorporeal Membrane Oxygenation Associated With Improved Patient Survival? Pediatr Crit Care Med. 2016 11; 17(11):1080-1087.
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Gupta P, Richardson T, Hall M, Bertoch D, Hebbar KB, Fortenberry JD, Wetzel RC. Effect of Inhaled Nitric Oxide on Outcomes in Children With Acute Lung Injury: Propensity Matched Analysis From a Linked Database. Crit Care Med. 2016 Oct; 44(10):1901-9.
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Rosas-Hernandez H, Cuevas E, Lantz SM, Rice KC, Gannon BM, Fantegrossi WE, Gonzalez C, Paule MG, Ali SF. Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. Neurosci Lett. 2016 08 26; 629:125-130.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Alterations in whole-body arginine metabolism in chronic obstructive pulmonary disease. Am J Clin Nutr. 2016 06; 103(6):1458-64.
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Engelen MP, Safar AM, Bartter T, Koeman F, Deutz NE. Reduced arginine availability and nitric oxide synthesis?in cancer?is related to impaired endogenous arginine synthesis. Clin Sci (Lond). 2016 07 01; 130(14):1185-95.
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Glenn JM, Gray M, Jensen A, Stone MS, Vincenzo JL. Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players. Eur J Sport Sci. 2016 Nov; 16(8):1095-103.
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Imig JD. Renal blood flow autoregulation: what are the contributions for nitric oxide or superoxide to modulate the myogenic response? Am J Physiol Renal Physiol. 2016 05 15; 310(10):F1013-5.
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Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tasc?n GA, Hernandez G, Murray P, De Backer D. THE ENDOTHELIUM IN SEPSIS. Shock. 2016 Mar; 45(3):259-70.
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Morshedi RG, Ricca AM, Wirostko BM. Ocular Hypertension Following Intravitreal Antivascular Endothelial Growth Factor Therapy: Review of the Literature and Possible Role of Nitric Oxide. J Glaucoma. 2016 Mar; 25(3):291-300.
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Ballard RA, Keller RL, Black DM, Ballard PL, Merrill JD, Eichenwald EC, Truog WE, Mammel MC, Steinhorn RH, Rogers EE, Ryan RM, Durand DJ, Asselin JM, Bendel CM, Bendel-Stenzel EM, Courtney SE, Dhanireddy R, Hudak ML, Koch FR, Mayock DE, McKay VJ, O'Shea TM, Porta NF, Wadhawan R, Palermo L. Randomized Trial of Late Surfactant Treatment in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide. J Pediatr. 2016 Jan; 168:23-29.e4.
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Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, Deutz NE, Wolfe RR. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015 Dec 01; 309(11):E915-24.
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Mourani PM, Abman SH. Pulmonary Hypertension and Vascular Abnormalities in Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec; 42(4):839-55.
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Wang L, Shen C, Liu H, Wang S, Chen X, Roman RJ, Juncos LA, Lu Y, Wei J, Zhang J, Yip KP, Liu R. Shear stress blunts tubuloglomerular feedback partially mediated by primary cilia and nitric oxide at the macula densa. Am J Physiol Regul Integr Comp Physiol. 2015 Oct; 309(7):R757-66.
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