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Mourani, Peter

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research overview

My overall research focus has been the identification of mechanisms and biomarkers of acute lung disease in critically ill neonates, infants, and children. Specifically, I have had two research foci: 1) Developmental lung and lung vascular disease in infants who are born extremely premature; and 2) Lower respiratory tract infections, including ventilator-associated-pneumonia in critically ill children requiring mechanical ventilator support. While seemingly disparate topics, these two foci have capitalized on the breadth of my training as both a pulmonologist and critical care physician and collaboration with multi-disciplinary scientific teams to obtain a consistent level of funded projects (including NIH R and U mechanisms) and produce impactful results. In addition to serving as principal investigator (PI) for funded projects in these focused areas, I serve as the site PI and Steering Committee member for the prestigious NICHD supported Collaborative Pediatric Critical Care Research Network (CPCCRN), which performs meaningful clinical research in the field of pediatric critical illness and injury. I am a key member of the team that designed the Personalized Immunomodulation in Pediatric Sepsis-induced MODS (PRECISE) for the upcoming cycle of CPCCRN, which will be among the first personalized medicine trials in pediatric critical care.

One or more keywords matched the following items that are connected to Mourani, Peter

Item Type	Name
Concept	Lung
Concept	Lung Diseases
Grant	Genetic Basis for Impaired Angiogenic Signaling in BPD
Grant	The Microbiome, Virome and Host Responses Preceding Ventilator-Associated Pneumon
Grant	Pathogenetic Mechanisms of Brochopulmonary Dysplasia
Grant	Physiological Phenotyping of Respiratory Outcomes in Infants Born Premature
Academic Article	Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm.
Academic Article	Early pulmonary vascular disease in preterm infants at risk for bronchopulmonary dysplasia.
Academic Article	Prenatal complications are associated with the postnatal airway host response and microbiota in intubated preterm infants.
Academic Article	Clinical utility of echocardiography for the diagnosis and management of pulmonary vascular disease in young children with chronic lung disease.
Academic Article	Early angiogenic proteins associated with high risk for bronchopulmonary dysplasia and pulmonary hypertension in preterm infants.
Academic Article	Effects of long-term sildenafil treatment for pulmonary hypertension in infants with chronic lung disease.
Academic Article	Airway Microbial Community Turnover Differs by BPD Severity in Ventilated Preterm Infants.
Academic Article	Exuberant fibroblast activity compromises lung function via ADAMTS4.
Academic Article	Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4.
Academic Article	Scope and impact of early and late preterm infants admitted to the PICU with respiratory illness.
Academic Article	Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children.
Academic Article	The antibiotic resistance reservoir of the lung microbiome expands with age.
Academic Article	The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.

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Lung