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overview The Porter lab focuses on developing strategies to prevent articular cartilage degeneration or stimulate cartilage repair. Currently, his group is pursuing two areas of research: one focused on improving the intra-articular delivery of therapeutics within synovial joints to prevent or treat osteoarthritis; the other on overcoming key bottlenecks to stimulating chondrogenesis within skeletal defects. These projects use mouse, rat, and rabbit models of bone and joint injury to help answer specific research questions. This work has been supported by grants from the National Institutes of Health, the Klarman Family Foundation, the UAMS Bone and Joint Initiative, and the Arkansas Biosciences Institute.

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Concept Rats, Inbred Lew
Concept Rats, Inbred F344
Concept Rats, Sprague-Dawley
Concept Rats, Wistar
Concept Rats
Concept Rats, Transgenic
Academic Article Effect of dexamethasone withdrawal on osteoblastic differentiation of bone marrow stromal cells.
Academic Article Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.
Academic Article Improvement of tendon repair using muscle grafts transduced with TGF-?1 cDNA.
Academic Article Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle.
Academic Article Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair.
Academic Article Contribution of Implanted, Genetically Modified Muscle Progenitor Cells Expressing BMP-2 to New Bone Formation in a Rat Osseous Defect.
Academic Article Interaction between living bone particles and rhBMP-2 in large segmental defect healing in the rat femur.
Academic Article Electrostatic interactions enable rapid penetration, enhanced uptake and retention of intra-articular injected avidin in rat knee joints.
Academic Article A simple, lanthanide-based method to enhance the transduction efficiency of adenovirus vectors.
Academic Article Ex vivo adenoviral transfer of bone morphogenetic protein 12 (BMP-12) cDNA improves Achilles tendon healing in a rat model.
Academic Article Specific, Sensitive, and Stable Reporting of Human Mesenchymal Stromal Cell Chondrogenesis.
Grant A Transgenic Rat for Noninvasive Assessment of Chondrogenic Activity in vivo
Grant Harnessing Extracellular Vesicles to Direct the Repair of Osseous Defects
Academic Article A Transgenic Rat for Noninvasive Assessment of Chondrogenesis in Vivo.
Academic Article Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery.
Academic Article IL-1Ra gene transfer potentiates BMP2-mediated bone healing by redirecting osteogenesis toward endochondral ossification.

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  • Rats