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research overview Our research focus on the interplay between chemical exposure and nutritional or lifestyle habits, such as diet selection and physical activity. To achieve this we utilize DNA and protein adducts to study carcinogen metabolism, how it is modified by nutritional components and the underlying mechanisms regulating corresponding enzyme activities. In addition, studies investigate exposures related changes in common metabolic pathways, using targeted and un-targeted mass spectrometry based metabolomic approaches. A second line of research applies systems biology approaches such as metabolomics to improve diagnosis of lung cancer patients and to elucidate mechanism that can be targeted with common or novel drugs.

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  • Metabolic Networks and Pathways