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Search Results to Grover Miller

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overview My goals are to assess the biological significance of metabolic activation and clearance of molecules especially related to pharmacological and toxicological effects. In practice, my group leverages powerful analytical and biochemical tools to identify and quantitate small molecules including drugs, pollutants, and food additives during metabolism and correlate findings to biological activity and in vivo outcomes such as liver toxicity. Individual projects aim to (1) determine metabolic mechanisms, efficiencies, and fluxes for activation and elimination of toxic molecules, (2) identify metabolite biomarkers in humans and animal models for correlating in vitro findings to in vivo outcomes and leveraging their diagnostic, theragnostic, and prognostic potential, and (3) develop computational models for drug bioactivation and clearance contributing to adverse drug events to make drugs safer for clinical use. Moreover, I seek translation of novel analytical and diagnostic tools into practical, commercially viable tools. Over time, my research expanded from detailed in vitro metabolic studies to metabolite profiling for translational studies and development of models of metabolism, structure, and reactivity that were made possible through strong, interdisciplinary collaborations.

One or more keywords matched the following items that are connected to Miller, Grover

Item TypeName
Academic Article Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases.
Academic Article Novel multi-mode ultra performance liquid chromatography-tandem mass spectrometry assay for profiling enantiomeric hydroxywarfarins and warfarin in human plasma.
Academic Article Warfarin and UDP-glucuronosyltransferases: writing a new chapter of metabolism.
Academic Article CYP2E1 metabolism of styrene involves allostery.
Academic Article Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin.
Academic Article Global analysis of protein-protein interactions reveals multiple CYP2E1-reductase complexes.
Academic Article Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.
Academic Article Metabolism of R- and S-warfarin by CYP2C19 into four hydroxywarfarins.
Academic Article Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites.
Academic Article Cooperative effects for CYP2E1 differ between styrene and its metabolites.
Academic Article Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding.
Concept Mitochondria, Liver
Concept Liver
Concept Liver Neoplasms
Concept Microsomes, Liver
Academic Article CYP2E1 hydroxylation of aniline involves negative cooperativity.
Academic Article Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity.
Academic Article Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.
Academic Article Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.
Academic Article Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates.
Academic Article 1,3-Butadiene-induced mitochondrial dysfunction is correlated with mitochondrial CYP2E1 activity in Collaborative Cross mice.
Academic Article Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.
Academic Article Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases.
Academic Article Computationally Assessing the Bioactivation of Drugs by N-Dealkylation.
Academic Article Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin.
Grant Effects of Genetic Diversity on Carcinogen Metabolism
Academic Article A Time-Embedding Network Models the Ontogeny of 23 Hepatic Drug Metabolizing Enzymes.
Academic Article Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation.
Academic Article Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam.
Academic Article Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics.
Academic Article Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics.
Academic Article Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam.
Academic Article Impacts of diphenylamine NSAID halogenation on bioactivation risks.
Academic Article Machine learning liver-injuring drug interactions with non-steroidal anti-inflammatory drugs (NSAIDs) from a retrospective electronic health record (EHR) cohort.
Academic Article 4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity.
Academic Article CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs.

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