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Search Results to Laura James

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overview Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.

One or more keywords matched the following items that are connected to James, Laura

Item TypeName
Academic Article Correlation of MCP1 with toxicity in acetaminophen overdose.
Academic Article Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse.
Academic Article Acetaminophen-induced hepatotoxicity.
Academic Article Cytokines and toxicity in acetaminophen overdose.
Academic Article Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause.
Academic Article Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition.
Academic Article Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation.
Academic Article Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
Academic Article Induction of the nuclear factor HIF-1alpha in acetaminophen toxicity: evidence for oxidative stress.
Academic Article Vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity.
Academic Article Acetaminophen-associated hepatic injury: evaluation of acetaminophen protein adducts in children and adolescents with acetaminophen overdose.
Academic Article Mechanisms of acetaminophen-induced liver necrosis.
Academic Article Tumour necrosis factor receptor 1 and hepatocyte regeneration in acetaminophen toxicity: a kinetic study of proliferating cell nuclear antigen and cytokine expression.
Academic Article Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice.
Academic Article Acute and chronic acetaminophen use and renal disease: a case-control study using pharmacy and medical claims.
Academic Article Acetaminophen hepatotoxicity and HIF-1a induction in acetaminophen toxicity in mice occurs without hypoxia.
Academic Article Acute liver failure after recommended doses of acetaminophen in patients with myopathies.
Academic Article Measurement of serum acetaminophen-protein adducts in patients with acute liver failure.
Academic Article Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure.
Academic Article Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.
Academic Article Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase.
Academic Article Prescription-acquired acetaminophen use and the risk of asthma in adults: a case-control study.
Academic Article Elevation of serum interleukin 8 levels in acetaminophen overdose in children and adolescents.
Academic Article Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice.
Academic Article Effect of trifluoperazine on toxicity, HIF-1a induction and hepatocyte regeneration in acetaminophen toxicity in mice.
Academic Article The proper use of acetaminophen.
Academic Article Indocyanine green clearance varies as a function of N-acetylcysteine treatment in a murine model of acetaminophen toxicity.
Academic Article Correlation of MRI findings to histology of acetaminophen toxicity in the mouse.
Academic Article Acetaminophen-cysteine adducts during therapeutic dosing and following overdose.
Academic Article Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations.
Academic Article Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure.
Academic Article Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection.
Academic Article Predictors of outcome after acetaminophen poisoning in children and adolescents.
Academic Article Predicting risk in patients with acetaminophen overdose.
Concept Acetaminophen
Academic Article Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children.
Academic Article CYP1A2*1F allele predicts risk of liver toxicity in children prescribed acetaminophen following surgery
Academic Article Elevation of Cytokines in acetaminophen overdose
Academic Article Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen
Academic Article Effects of trifluoperazine on toxicity, HIF-1 induction and hepatocyte regeneration in acetaminophen toxicity in mice
Academic Article Elevated acetaminophen concentration measured after nasal insufflation of Percocet
Academic Article Acetaminophen-cystiene adducts during therapeutic dosing and following overdose
Academic Article Susceptibility to acetaminophen (APAP) toxicity unexpectedly is decreased during acute viral hepatitis in mice
Academic Article Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity
Academic Article Adverse Drug Reactions, Handbook of Experimental Pharmacology
Academic Article Acetaminophen hepatotoxicity and HIF-1alpha induction in mice occurs without hypoxia
Academic Article Induction of the neclear factor HIF-1alpha in livers of acetaminophen treated mice and freshly isolated hepatocytes: evidence for oxidative stress
Academic Article A proper use of acetaminophen
Academic Article Tumor Necrosis Factor Receptor 1 and Hepatocyte Regeneration in Acetaminophen Toxicity: A Kinetic Study of Proliferating Cell Nuclear Antigen and Cytoline Expression
Academic Article Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration
Academic Article Predictions of outcome following acetaminophen poisoning in children and adolscents
Academic Article Indocyanin green clearance varies as a function of n-acetylcysteine treatment in a murine model of acetaminophen toxicity
Academic Article Protein tyrosine phosphatase 1B modulates GSK3ß/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity
Academic Article Examination of exogenous hrVEGF in a mouse model of acetaminophen toxicity
Academic Article Detection of Acetaminophen Protein Adducts in Children with Acute Liver Failure of Indeterminate Etiology
Academic Article SELDI based proteomic determination of hepatic biomarkers in mourse serum following acetaminophen administration
Academic Article Elevation of serum interleukin-8 in acetaminophen overdose in children and adolescents
Academic Article Acylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration.
Academic Article Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.
Academic Article The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity.
Academic Article Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children.
Academic Article Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.
Academic Article A Cytochrome P450-Independent Mechanism of Acetaminophen-Induced Injury in Cultured Mouse Hepatocytes.
Academic Article Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity.
Academic Article Translational biomarkers of acetaminophen-induced acute liver injury.
Academic Article Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.
Academic Article Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.
Academic Article The neuronal nitric oxide synthase inhibitor NANT blocks acetaminophen toxicity and protein nitration in freshly isolated hepatocytes.
Academic Article An Immunoassay to Rapidly Measure Acetaminophen Protein?Adducts Accurately Identifies Patients With Acute Liver?Injury or Failure.
Academic Article Trifluoperazine inhibits acetaminophen-induced hepatotoxicity and hepatic reactive nitrogen formation in mice and in freshly isolated hepatocytes.
Academic Article Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers.
Academic Article Metabolomics Analysis of Urine Samples from Children after Acetaminophen Overdose.
Academic Article MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.
Academic Article Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose.
Academic Article SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.
Academic Article Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Academic Article Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways.
Academic Article The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3? and Wnt/?-catenin signaling.
Grant AcetaSTAT Rapid Assay for Acetaminophen Liver Injury
Grant NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY
Grant Identification of new mechanistic biomarkers of adverse responses to acetaminophe
Grant Dipstick Assay for Detection of Acetaminophen Protein Adducts
Grant Evaluation of a Biomarker for Acetaminophen Toxicity
Grant HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair
Grant Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
Academic Article Acute Liver Failure of Indeterminate Etiology: A Comprehensive Systematic Approach by An Expert Committee to Establish Causality.
Academic Article Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen.
Academic Article Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration.
Academic Article Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children.
Academic Article Early acetaminophen-protein adducts predict hepatotoxicity following overdose (ATOM-5).
Academic Article Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children.
Academic Article Advances in biomarker development in acetaminophen toxicity.
Academic Article Pre-treatment twice with liposomal clodronate protects against acetaminophen hepatotoxicity through a pre-conditioning effect.
Academic Article Acute Liver Failure of unclear cause? Acetaminophen-protein adducts make the diagnosis.
Academic Article Short-Term Safety of Repeated Acetaminophen Use in Patients With Compensated Cirrhosis.
Academic Article Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk.
Academic Article Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult.

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  • Acetaminophen