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Search Results to Alan Tackett

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article Proteomic and genomic characterization of chromatin complexes at a boundary.
Academic Article Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Academic Article I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions.
Academic Article MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Academic Article Saccharomyces cerevisiae Yta7 regulates histone gene expression.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.
Academic Article Rapid isolation and identification of bacteriophage T4-encoded modifications of Escherichia coli RNA polymerase: a generic method to study bacteriophage/host interactions.
Academic Article ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis.
Academic Article Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.
Academic Article A quantitative proteomic analysis of FFPE melanoma.
Academic Article Application of MassSQUIRM for quantitative measurements of lysine demethylase activity.
Academic Article Purification of a specific native genomic locus for proteomic analysis.
Concept Spectrometry, Fluorescence
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Tandem Mass Spectrometry
Concept Mass Spectrometry
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article Purification of specific chromatin loci for proteomic analysis.
Academic Article Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection.
Academic Article Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Academic Article Oxidation resistance 1 is a novel senolytic target.
Academic Article Proteomic Changes in Mouse Spleen after Radiation-Induced Injury and its Modulation by Gamma-Tocotrienol.
Academic Article Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Analysis of Proteins Involed in Genome Duplication
Grant Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Role of the Leprecan Genes in Skeletal Formation
Grant Biochemistry of recombination in meiosis
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Lipid Stress and MC4R
Grant Identification of Druggable Targets to Complement Melanoma Therapy
Academic Article Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes.

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