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Search Results to Alan Tackett

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One or more keywords matched the following properties of Tackett, Alan

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Academic Article Proteomic and genomic characterization of chromatin complexes at a boundary.
Academic Article A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Academic Article Saccharomyces cerevisiae Yta7 regulates histone gene expression.
Academic Article Misregulation of Rad50 expression in melanoma cells.
Academic Article A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.
Academic Article Myogenin recruits the histone chaperone facilitates chromatin transcription (FACT) to promote nucleosome disassembly at muscle-specific genes.
Academic Article A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article Mapping the local protein interactome of the NuA3 histone acetyltransferase.
Academic Article ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.
Academic Article sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates.
Concept Amino Acid Sequence
Concept Base Sequence
Concept Epistasis, Genetic
Concept Genes, Fungal
Concept Operon
Concept Gene Expression Regulation, Leukemic
Concept Gene Expression Regulation, Fungal
Concept Molecular Sequence Data
Concept Gene Expression
Concept Gene Expression Regulation, Enzymologic
Concept Histone Code
Concept Proto-Oncogenes
Concept Transcriptome
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Gene Silencing
Concept Catalytic Domain
Concept Major Histocompatibility Complex
Concept Genome, Human
Concept Gene Deletion
Concept Gene Expression Profiling
Concept Sequence Homology, Amino Acid
Concept Open Reading Frames
Concept Genome, Fungal
Concept Gene Knockdown Techniques
Concept Genome
Concept Gene Expression Regulation, Bacterial
Concept Gene Expression Regulation, Neoplastic
Concept Genetic Loci
Academic Article TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Academic Article DNA methylation on N(6)-adenine in mammalian embryonic stem cells.
Academic Article ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Academic Article Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus.
Academic Article Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.
Academic Article Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation.
Academic Article Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology.
Academic Article 16S rRNA Gene-Based Metagenomic Analysis of Ozark Cave Bacteria.
Academic Article Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.
Academic Article An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
Academic Article Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma.
Grant Sirt3: A Key Player Against PCB-Induced Mitochondrial Injury
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Role of the Leprecan Genes in Skeletal Formation
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Grant Transgenic analysis of platelet receptor expression
Academic Article Proteomic characterization of the arsenic response locus in S. cerevisiae.
Academic Article Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis.
Academic Article Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes.
Academic Article SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1.
Academic Article ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
Academic Article TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

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