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Search Results to Vladimir Lupashin

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One or more keywords matched the following properties of Lupashin, Vladimir

overview Our laboratory is interested in understanding the molecular mechanisms responsible for the generation and maintenance of intra-cellular membrane-bounded compartments. In all eukaryotic cells intracellular membrane trafficking is critical for a range of important cellular functions including protein secretion, post-translational modifications, cell signalling, cell polarization, and cell maintenance. Defects in membrane trafficking can underline, or even exacerbate, a number of human diseases including cancer, diabetes mellitus, Alzheimer’s, cystic fibrosis, Hermansky-Pudlak syndrome and Congenital Disorders of Glycosylation. Our research directed towards the understanding of the basic mechanisms of intracellular vesicular trafficking using both yeast and mammalian tissue culture cell model systems. Our lab played a principal role in the discovery of a novel vesicle tethering factors, published more than 60 original papers in high-profile journals, including Journal of Cell Biology, PNAS, Science, Journal of Neuroscience, Molecular Biology of Cell and Nature Communications. My current research has been continuously supported by grants from both NSF and NIH. We have pioneered the functional analysis of the Conserved Oligomeric Golgi (COG), an evolutionarily conserved complex of eight gene products, each of which is critical for the membrane trafficking and protein modifications in the Golgi apparatus. The COG complex interacts with core fusion machinery components including SNAREs, SM proteins, Rabs, coiled-coil tethers and COPI coat to organize specific docking and fusion of transport intermediates with their acceptor membrane. By using state of the art biochemical, genetic and microscopy approaches (including mass-spectrometry, electron and super-resolution microscopy, CRISPR directed gene editing techniques) we would like to determine how the key components of intracellular membrane trafficking machinery work together to direct efficient protein trafficking in human cells in health and disease.

One or more keywords matched the following items that are connected to Lupashin, Vladimir

Item TypeName
Academic Article Cog1p plays a central role in the organization of the yeast conserved oligomeric Golgi complex.
Academic Article Role of tethering factors in secretory membrane traffic.
Academic Article Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter.
Academic Article Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation.
Academic Article Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells.
Academic Article Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.
Academic Article The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin.
Academic Article Oxysterol-binding protein (OSBP) is required for the perinuclear localization of intra-Golgi v-SNAREs.
Academic Article COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Academic Article COG complexes form spatial landmarks for distinct SNARE complexes.
Academic Article Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene.
Academic Article Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.
Academic Article COG6 interacts with a subset of the Golgi SNAREs and is important for the Golgi complex integrity.
Academic Article Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Academic Article Molecular insights into vesicle tethering at the Golgi by the conserved oligomeric Golgi (COG) complex and the golgin TATA element modulatory factor (TMF).
Academic Article The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.
Concept Protein Subunits
Concept Protein Conformation
Concept Protein Processing, Post-Translational
Concept Protein Structure, Quaternary
Concept Protein Binding
Concept Protein Transport
Concept Protein Interaction Maps
Concept Protein Multimerization
Concept Protein Stability
Concept Protein Structure, Secondary
Concept Coat Protein Complex I
Concept Protein Structure, Tertiary
Concept Structural Homology, Protein
Academic Article Mini-Review: Role of the Conserved Oligomeric Golgi (COG) complex in protein glycosylation
Academic Article The COG Complex-mediated Docking of intra-Golgi Vesicles is Essential for Normal Protein Glycosylation
Academic Article The COG complex interacts with the t-SNARE Syntaxin5 to direct trafficking of recyling intra-Golgi vesicles that is essential for normal protein glycosylation
Academic Article Serotonin Regulates the Plasma Membrane Expression of Serotonin Transporter Protein Via its Interactions with Rab4
Academic Article The COG Complex-mediated Recyling of Golgi Enzymes is Essential for Normal Protein Glycosylation
Academic Article Macromolecules in functioning cell
Academic Article Protein Trafficking: Mechanisms and Regulations
Academic Article The role of glycosylation in protein secretion
Academic Article Optimal conditions for homologic and heterologic protein export by S. cerevisiae
Academic Article Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.
Academic Article Expression of functional Myc-tagged conserved oligomeric Golgi (COG) subcomplexes in mammalian cells.
Academic Article COG lobe B sub-complex engages v-SNARE GS15 and functions via regulated interaction with lobe A sub-complex.
Academic Article Creating Knockouts of Conserved Oligomeric Golgi Complex Subunits Using CRISPR-Mediated Gene Editing Paired with a Selection Strategy Based on Glycosylation Defects Associated with Impaired COG Complex Function.
Academic Article A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Academic Article Conserved Oligomeric Golgi and Neuronal Vesicular Trafficking.
Academic Article The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors.
Academic Article Membrane detachment is not essential for COG complex function.
Academic Article More than just sugars: Conserved oligomeric Golgi complex deficiency causes glycosylation-independent cellular defects.
Academic Article Detailed Analysis of the Interaction of Yeast COG Complex.
Grant Super-Resolution Light Microscope at University of Arkansas for Medical Sciences
Grant Characterization of mammalian COG complex-interacting Golgi trafficking machinery
Grant Structural and functional analysis of SEC 34 Protein complex
Academic Article Golgi inCOGnito: From vesicle tethering to human disease.
Academic Article Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma.
Academic Article The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery.

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