Item Type | Name |
Concept
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Animals
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Concept
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Animals, Genetically Modified
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Concept
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Disease Models, Animal
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Academic Article
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Cardiovascular therapeutic aspects of soluble epoxide hydrolase inhibitors.
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Academic Article
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Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.
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Academic Article
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Telmisartan provides better renal protection than valsartan in a rat model of metabolic syndrome.
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Academic Article
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Inactivation of p66Shc Decreases Afferent Arteriolar KATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats.
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Academic Article
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Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells.
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Academic Article
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Synergistic actions of enalapril and tempol during chronic angiotensin II-induced hypertension.
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Academic Article
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Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases.
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Academic Article
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Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance.
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Academic Article
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Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath.
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Academic Article
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Inhibition of soluble epoxide hydrolase improves the impaired pressure-natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats.
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Academic Article
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Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.
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Academic Article
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Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats.
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Academic Article
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ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin.
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Academic Article
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Soluble epoxide hydrolase contamination of specific catalase preparations inhibits epoxyeicosatrienoic acid vasodilation of rat renal arterioles.
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Academic Article
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Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes.
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Academic Article
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Novel nitric oxide synthase--dependent mechanism of vasorelaxation in small arteries from hypertensive rats.
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Academic Article
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Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
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Academic Article
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Role of the cytochrome P-450/ epoxyeicosatrienoic acids pathway in the pathogenesis of renal dysfunction in cirrhosis.
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Academic Article
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Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.
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Academic Article
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Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.
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Academic Article
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Tumor necrosis factor alpha blockade increases renal Cyp2c23 expression and slows the progression of renal damage in salt-sensitive hypertension.
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Academic Article
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Reply to "Letter to the editor: 'Concern regarding quantification of urinary nephrin by commercially available ELISA'".
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Academic Article
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Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease.
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Academic Article
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Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats.
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Academic Article
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Increased RhoA/Rho-kinase signaling mediates spontaneous tone in aorta from angiotensin II-induced hypertensive rats.
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Academic Article
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Tim-1 Deficiency Aggravates High-Fat Diet-Induced Steatohepatitis in Mice.
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Academic Article
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Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting.
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Academic Article
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Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension.
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Academic Article
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Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes.
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Academic Article
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The roles of intrarenal 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of renal function in hypertensive Ren-2 transgenic rats.
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Academic Article
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Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels.
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Academic Article
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Renal AT1 receptor protein expression during the early stage of diabetes mellitus.
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Academic Article
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Normalization of the ovarian cancer microenvironment by SPARC.
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Academic Article
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Epoxides and soluble epoxide hydrolase in cardiovascular physiology.
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Academic Article
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Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.
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Academic Article
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11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries.
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Academic Article
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Inhibition of soluble epoxide hydrolase by cis-4-[4-(3-adamantan-1-ylureido)cyclohexyl-oxy]benzoic acid exhibits antihypertensive and cardioprotective actions in transgenic rats with angiotensin II-dependent hypertension.
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Academic Article
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TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats.
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Academic Article
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Epoxylipids and soluble epoxide hydrolase in heart diseases.
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Academic Article
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Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib.
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Academic Article
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Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice.
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Academic Article
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Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.
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Academic Article
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Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal renin-angiotensin system.
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Academic Article
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Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats.
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Academic Article
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20-Hydroxyeicosatetraenoic acid antagonist attenuates the development of malignant hypertension and reverses it once established: a study in Cyp1a1-Ren-2 transgenic rats.
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Academic Article
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Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1a via downregulation of prolyl hydroxylase 3.
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Academic Article
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A dual farnesoid X receptor/soluble epoxide hydrolase modulator treats non-alcoholic steatohepatitis in mice.
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Academic Article
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Radiation-induced afferent arteriolar endothelial-dependent dysfunction involves decreased epoxygenase metabolites.
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Academic Article
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Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
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Academic Article
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Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids.
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Academic Article
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Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis.
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Academic Article
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Decreased renal cytochrome P450 2C enzymes and impaired vasodilation are associated with angiotensin salt-sensitive hypertension.
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Academic Article
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Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension.
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Academic Article
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Epoxyeicosatrienoic acids, hypertension, and kidney injury.
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Academic Article
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p66Shc regulates renal vascular tone in hypertension-induced nephropathy.
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Academic Article
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Increased blood pressure in mice lacking cytochrome P450 2J5.
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Academic Article
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Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.
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Academic Article
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A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat.
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Academic Article
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Regulation of Cardiac Mast Cell Maturation and Function by the Neurokinin-1 Receptor in the Fibrotic Heart.
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Academic Article
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Orally active epoxyeicosatrienoic acid analogs in hypertension and renal injury.
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Academic Article
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Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure.
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Academic Article
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Chemokine receptor 2b inhibition provides renal protection in angiotensin II - salt hypertension.
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Academic Article
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Adaptations of the renal microcirculation to hypertension.
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Academic Article
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Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor ? agonist improve vascular function and decrease renal injury in hypertensive obese rats.
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Academic Article
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Endothelial dysfunction and the development of renal injury in spontaneously hypertensive rats fed a high-fat diet.
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Academic Article
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Eicosanoids and renal damage in cardiometabolic syndrome.
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Academic Article
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Afferent arteriolar dilation to 11, 12-EET analogs involves PP2A activity and Ca2+-activated K+ Channels.
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Academic Article
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Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.
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Academic Article
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Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats.
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Academic Article
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Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension.
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Academic Article
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Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats.
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Academic Article
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Anti-inflammatory effects of ?-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension.
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Academic Article
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Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.
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Academic Article
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Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats.
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Academic Article
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Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors.
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Academic Article
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Downregulation of renal CYP-derived eicosanoid synthesis in rats with diet-induced hypertension.
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Academic Article
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12-Hydroxyeicosatetraenoic acid participates in angiotensin II afferent arteriolar vasoconstriction by activating L-type calcium channels.
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Academic Article
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Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.
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Academic Article
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Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension.
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Academic Article
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Orally active epoxyeicosatrienoic acid analog attenuates kidney injury in hypertensive Dahl salt-sensitive rat.
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Academic Article
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Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.
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Academic Article
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Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats.
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Academic Article
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The Bradykinin B2 receptor is required for full expression of renal COX-2 and renin.
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Academic Article
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Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans.
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Academic Article
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The epoxyeicosatrienoic acid analog PVPA ameliorates cyclosporine-induced hypertension and renal injury in rats.
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Academic Article
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Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet.
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Academic Article
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ACE Inhibition and Bradykinin-Mediated Renal Vascular Responses: EDHF Involvement.
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Academic Article
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Combined treatment with epoxyeicosatrienoic acid analog and 20-hydroxyeicosatetraenoic acid antagonist provides substantial hypotensive effect in spontaneously hypertensive rats.
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Academic Article
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Salt-sensitive hypertension after exposure to angiotensin is associated with inability to upregulate renal epoxygenases.
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Academic Article
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Obesity induced renal oxidative stress contributes to renal injury in salt-sensitive hypertension.
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Academic Article
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Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.
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Academic Article
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Cytochrome P450 and Lipoxygenase Metabolites on Renal Function.
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Academic Article
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Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries.
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Academic Article
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The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt.
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Academic Article
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Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
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Academic Article
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Epoxyeicosatrienoic acid analogue mitigates kidney injury in a rat model of radiation nephropathy.
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Academic Article
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Fructose stimulates Na/H exchange activity and sensitizes the proximal tubule to angiotensin II.
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Academic Article
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Elevated arterial pressure impairs autoregulation independently of AT(1) receptor activation.
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Academic Article
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Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.
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Academic Article
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Dual soluble epoxide hydrolase inhibitor/PPAR-? agonist attenuates renal fibrosis.
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Academic Article
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Rofecoxib decreases renal injury in obese Zucker rats.
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Academic Article
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P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid.
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Academic Article
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Ang II accumulation in rat renal endosomes during Ang II-induced hypertension: role of AT(1) receptor.
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Academic Article
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20-hydroxyeicosatetraenoic acid and angiotensin: a positive feedback system to cause hypertension.
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Academic Article
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Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.
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Academic Article
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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases.
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Academic Article
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Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity.
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Academic Article
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Orally Active Epoxyeicosatrienoic Acid Analogs.
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Academic Article
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Adenosine2A receptors and epoxyeicosatrienoic acids: a recipe for salt and blood pressure regulation.
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Academic Article
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Azilsartan decreases renal and cardiovascular injury in the spontaneously hypertensive obese rat.
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Academic Article
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Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
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Academic Article
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Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.
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Academic Article
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Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy.
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Academic Article
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Eicosanoid blood vessel regulation in physiological and pathological states.
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Academic Article
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Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade.
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Academic Article
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14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.
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Academic Article
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Impaired Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension.
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Academic Article
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Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior.
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Academic Article
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Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
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Academic Article
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An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension.
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Academic Article
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Targeting epoxides for organ damage in hypertension.
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Academic Article
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Angiotensin II hypertension is attenuated in interleukin-6 knockout mice.
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Academic Article
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Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.
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Academic Article
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An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats.
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Academic Article
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Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.
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Academic Article
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Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores.
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Academic Article
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Age-related alterations in NOS and oxidative stress in mesenteric arteries from male and female rats.
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Academic Article
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20-HETE or EETs: which arachidonic acid metabolite regulates proximal tubule transporters and contributes to pressure natriuresis?
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Academic Article
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Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension.
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Academic Article
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PPAR-alpha activator fenofibrate increases renal CYP-derived eicosanoid synthesis and improves endothelial dilator function in obese Zucker rats.
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Academic Article
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Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity.
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Academic Article
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Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria.
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Academic Article
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Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats.
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Academic Article
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Immune and inflammatory role in renal disease.
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Academic Article
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L-type calcium channels in the renal microcirculatory response to endothelin.
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Academic Article
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Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.
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Academic Article
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Prospective for cytochrome P450 epoxygenase cardiovascular and renal therapeutics.
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Academic Article
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Glomerular expression of kidney injury molecule-1 and podocytopenia in diabetic glomerulopathy.
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Academic Article
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Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.
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Academic Article
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A novel dual PPAR-? agonist/sEH inhibitor treats diabetic complications in a rat model of type 2 diabetes.
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Academic Article
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Salt-sensitive hypertension after reversal of unilateral ureteral obstruction.
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Grant
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Eicosanoid-based Therapy for Diabetes
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Grant
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Epoxyeicosanoids and Renal Vascular Function in Obesity &Hypertension
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Grant
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Novel epoxide hydrolase inhibitor for stroke prevention
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Academic Article
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Dual soluble epoxide hydrolase inhibitor - farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis.
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Academic Article
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Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences.
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