Disulfiram
"Disulfiram" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
| Descriptor ID |
D004221
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| MeSH Number(s) |
D02.241.081.251.869.220.250 D02.886.520.150.175 D02.886.706.200.200
|
| Concept/Terms |
Disulfiram- Disulfiram
- Tetraethylthiuram Disulfide
- Disulfide, Tetraethylthiuram
- Bis(diethylthiocarbamoyl) Disulfide
- Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
Antabuse- Antabuse
- Odyssey Brand of Disulfiram
- Orphan Brand of Disulfiram
- Allphar Brand of Disulfiram
Esperal- Esperal
- Sanofi Synthelabo Brand of Disulfiram
Refusal- Refusal
- Artu Brand of Disulfiram
Antabus- Antabus
- Bohm Brand of Disulfiram
- Dumex Brand of Disulfiram
- Altana Pharma Brand of Disulfiram
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Below are MeSH descriptors whose meaning is more general than "Disulfiram".
Below are MeSH descriptors whose meaning is more specific than "Disulfiram".
This graph shows the total number of publications written about "Disulfiram" by people in UAMS Profiles by year, and whether "Disulfiram" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2015 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 1993 | 2 | 1 | 3 |
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Below are the most recent publications written about "Disulfiram" by people in Profiles over the past ten years.
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Helton SG, Lohoff FW. Pharmacogenetics of alcohol use disorders and comorbid psychiatric disorders. Psychiatry Res. 2015 Dec 15; 230(2):121-9.
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Salem K, McCormick ML, Wendlandt E, Zhan F, Goel A. Copper-zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma. Redox Biol. 2015; 4:23-33.
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Watts TE, Pandey RA, Vancil TJ. Fatal fulminant hepatic failure related to the use of disulfiram. J Ark Med Soc. 2014 Jun; 110(13):280-3.