An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Descriptor ID	D002772
MeSH Number(s)	D08.811.913.400.725.115.180 D23.946.123.194 D23.946.330.150
Concept/Terms	Cholera Toxin Cholera Toxin Toxin, Cholera Cholera Exotoxin Exotoxin, Cholera Choleragen Cholera Enterotoxin CT CT, Cholera Enterotoxin Enterotoxin CT, Cholera Procholeragenoid Procholeragenoid Cholera Toxin Protomer A Cholera Toxin Protomer A Cholera Toxin A Subunit Choleragenoid Choleragenoid Cholera Toxin Protomer B Cholera Toxin B Subunit

Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".

Below are MeSH descriptors whose meaning is related to "Cholera Toxin".

Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".