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Connection

William Steinbach to Aspergillus fumigatus

This is a "connection" page, showing publications William Steinbach has written about Aspergillus fumigatus.

 
Connection Strength
  
 
 
19.983
  
  1. Shaheen SK, Juvvadi PR, Allen J, Shwab EK, Cole DC, Asfaw YG, Kapoor M, Shaw KJ, Steinbach WJ. In Vitro Activity of APX2041, a New Gwt1 Inhibitor, and In Vivo Efficacy of the Prodrug APX2104 against Aspergillus fumigatus. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0068221.
    View in: PubMed
    Score: 0.659
  2. Shwab EK, Juvvadi PR, Waitt G, Shaheen S, Allen J, Soderblom EJ, Bobay BG, Asfaw YG, Moseley MA, Steinbach WJ. The Protein Kinase A-Dependent Phosphoproteome of the Human Pathogen Aspergillus fumigatus Reveals Diverse Virulence-Associated Kinase Targets. mBio. 2020 12 15; 11(6).
    View in: PubMed
    Score: 0.632
  3. Roundtree MT, Juvvadi PR, Shwab EK, Cole DC, Steinbach WJ. Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors. Antimicrob Agents Chemother. 2020 09 21; 64(10).
    View in: PubMed
    Score: 0.622
  4. Renshaw H, Juvvadi PR, Cole DC, Steinbach WJ. The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins. Biochem Biophys Res Commun. 2020 06 18; 527(1):232-237.
    View in: PubMed
    Score: 0.605
  5. Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2020 05 21; 526(1):48-54.
    View in: PubMed
    Score: 0.600
  6. Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, Lee SC, Chen YL, Mutz M, Spicer LD, Schumacher MA, Heitman J, Steinbach WJ. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nat Commun. 2019 09 19; 10(1):4275.
    View in: PubMed
    Score: 0.580
  7. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Barrington BC, Asfaw YG, Moseley MA, Steinbach WJ. Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus. Mol Microbiol. 2019 07; 112(1):62-80.
    View in: PubMed
    Score: 0.563
  8. Juvvadi PR, Cole DC, Falloon K, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2018 11 02; 505(3):740-746.
    View in: PubMed
    Score: 0.543
  9. Renshaw H, Vargas-Mu?iz JM, Juvvadi PR, Richards AD, Waitt G, Soderblom EJ, Moseley MA, Steinbach WJ. The tail domain of the Aspergillus fumigatus class V myosin MyoE orchestrates septal localization and hyphal growth. J Cell Sci. 2018 02 07; 131(3).
    View in: PubMed
    Score: 0.519
  10. Juvvadi PR, Moseley MA, Hughes CJ, Soderblom EJ, Lennon S, Perkins SR, Thompson JW, Geromanos SJ, Wildgoose J, Richardson K, Langridge JI, Vissers JPC, Steinbach WJ. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs. J Proteome Res. 2018 02 02; 17(2):780-793.
    View in: PubMed
    Score: 0.515
  11. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ. Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett. 2017 11; 591(22):3730-3744.
    View in: PubMed
    Score: 0.510
  12. Vargas-Mu?iz JM, Renshaw H, Waitt G, Soderblom EJ, Moseley MA, Palmer JM, Juvvadi PR, Keller NP, Steinbach WJ. Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. Biochem Biophys Res Commun. 2017 04 01; 485(2):221-226.
    View in: PubMed
    Score: 0.486
  13. Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ. A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. mBio. 2017 02 07; 8(1).
    View in: PubMed
    Score: 0.484
  14. Renshaw H, Vargas-Mu?iz JM, Richards AD, Asfaw YG, Juvvadi PR, Steinbach WJ. Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. Infect Immun. 2016 05; 84(5):1556-64.
    View in: PubMed
    Score: 0.458
  15. Juvvadi PR, Pemble CW, Ma Y, Steinbach WJ. Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus. FEBS Lett. 2016 Feb; 590(4):501-8.
    View in: PubMed
    Score: 0.452
  16. Falloon K, Juvvadi PR, Richards AD, Vargas-Mu?iz JM, Renshaw H, Steinbach WJ. Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. PLoS One. 2015; 10(9):e0137869.
    View in: PubMed
    Score: 0.439
  17. Juvvadi PR, Mu?oz A, Lamoth F, Soderblom EJ, Moseley MA, Read ND, Steinbach WJ. Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4946-55.
    View in: PubMed
    Score: 0.431
  18. Vargas-Mu?iz JM, Renshaw H, Richards AD, Lamoth F, Soderblom EJ, Moseley MA, Juvvadi PR, Steinbach WJ. The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. Fungal Genet Biol. 2015 Aug; 81:41-51.
    View in: PubMed
    Score: 0.431
  19. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Steinbach WJ. Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2015 Aug; 59(8):4727-33.
    View in: PubMed
    Score: 0.430
  20. Sugui JA, Kwon-Chung KJ, Juvvadi PR, Latg? JP, Steinbach WJ. Aspergillus fumigatus and related species. Cold Spring Harb Perspect Med. 2014 Nov 06; 5(2):a019786.
    View in: PubMed
    Score: 0.414
  21. Lamoth F, Juvvadi PR, Steinbach WJ. Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus. Crit Rev Microbiol. 2016; 42(2):310-21.
    View in: PubMed
    Score: 0.410
  22. Juvvadi PR, Lamoth F, Steinbach WJ. Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia. 2014 Dec; 178(5-6):341-8.
    View in: PubMed
    Score: 0.407
  23. Lamoth F, Juvvadi PR, Soderblom EJ, Moseley MA, Asfaw YG, Steinbach WJ. Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2014; 58(4):1889-96.
    View in: PubMed
    Score: 0.391
  24. Steinbach WJ. Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis. PLoS Pathog. 2013 Oct; 9(10):e1003642.
    View in: PubMed
    Score: 0.385
  25. Lamoth F, Juvvadi PR, Gehrke C, Asfaw YG, Steinbach WJ. Transcriptional activation of heat shock protein 90 mediated via a proximal promoter region as trigger of caspofungin resistance in Aspergillus fumigatus. J Infect Dis. 2014 Feb 01; 209(3):473-81.
    View in: PubMed
    Score: 0.384
  26. Juvvadi PR, Gehrke C, Fortwendel JR, Lamoth F, Soderblom EJ, Cook EC, Hast MA, Asfaw YG, Moseley MA, Creamer TP, Steinbach WJ. Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. PLoS Pathog. 2013; 9(8):e1003564.
    View in: PubMed
    Score: 0.381
  27. Juvvadi PR, Belina D, Soderblom EJ, Moseley MA, Steinbach WJ. Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2013 Feb 15; 431(3):547-53.
    View in: PubMed
    Score: 0.365
  28. Lamoth F, Juvvadi PR, Gehrke C, Steinbach WJ. In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains. Antimicrob Agents Chemother. 2013 Feb; 57(2):1035-9.
    View in: PubMed
    Score: 0.361
  29. Lamoth F, Juvvadi PR, Fortwendel JR, Steinbach WJ. Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot Cell. 2012 Nov; 11(11):1324-32.
    View in: PubMed
    Score: 0.353
  30. Fortwendel JR, Juvvadi PR, Rogg LE, Asfaw YG, Burns KA, Randell SH, Steinbach WJ. Plasma membrane localization is required for RasA-mediated polarized morphogenesis and virulence of Aspergillus fumigatus. Eukaryot Cell. 2012 Aug; 11(8):966-77.
    View in: PubMed
    Score: 0.348
  31. Juvvadi PR, Fortwendel JR, Rogg LE, Burns KA, Randell SH, Steinbach WJ. Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. Mol Microbiol. 2011 Dec; 82(5):1235-59.
    View in: PubMed
    Score: 0.336
  32. Rogg LE, Fortwendel JR, Juvvadi PR, Lilley A, Steinbach WJ. The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus. Biochem Biophys Res Commun. 2011 Aug 05; 411(3):549-54.
    View in: PubMed
    Score: 0.328
  33. Fortwendel JR, Juvvadi PR, Rogg LE, Steinbach WJ. Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus. Eukaryot Cell. 2011 Apr; 10(4):611-5.
    View in: PubMed
    Score: 0.319
  34. Juvvadi PR, Fortwendel JR, Rogg LE, Steinbach WJ. Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):238-43.
    View in: PubMed
    Score: 0.317
  35. Mennink-Kersten MA, Ruegebrink D, Verweij PE, Steinbach WJ. Calcineurin-dependent galactomannan release in Aspergillus fumigatus. Eur J Clin Microbiol Infect Dis. 2011 Apr; 30(4):551-3.
    View in: PubMed
    Score: 0.315
  36. Geunes-Boyer S, Heitman J, Wright JR, Steinbach WJ. Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive. Med Mycol. 2010 Jun; 48(4):580-8.
    View in: PubMed
    Score: 0.304
  37. Fortwendel JR, Juvvadi PR, Perfect BZ, Rogg LE, Perfect JR, Steinbach WJ. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob Agents Chemother. 2010 Apr; 54(4):1555-63.
    View in: PubMed
    Score: 0.298
  38. Pinchai N, Juvvadi PR, Fortwendel JR, Perfect BZ, Rogg LE, Asfaw YG, Steinbach WJ. The Aspergillus fumigatus P-type Golgi apparatus Ca2+/Mn2+ ATPase PmrA is involved in cation homeostasis and cell wall integrity but is not essential for pathogenesis. Eukaryot Cell. 2010 Mar; 9(3):472-6.
    View in: PubMed
    Score: 0.297
  39. Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryot Cell. 2009 Apr; 8(4):511-9.
    View in: PubMed
    Score: 0.279
  40. Fortwendel JR, Juvvadi PR, Pinchai N, Perfect BZ, Alspaugh JA, Perfect JR, Steinbach WJ. Differential effects of inhibiting chitin and 1,3-{beta}-D-glucan synthesis in ras and calcineurin mutants of Aspergillus fumigatus. Antimicrob Agents Chemother. 2009 Feb; 53(2):476-82.
    View in: PubMed
    Score: 0.274
  41. Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryot Cell. 2008 Sep; 7(9):1606-10.
    View in: PubMed
    Score: 0.267
  42. Cramer RA, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryot Cell. 2008 Jul; 7(7):1085-97.
    View in: PubMed
    Score: 0.264
  43. Cowen LE, Steinbach WJ. Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot Cell. 2008 May; 7(5):747-64.
    View in: PubMed
    Score: 0.262
  44. Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrob Agents Chemother. 2007 Aug; 51(8):2979-81.
    View in: PubMed
    Score: 0.246
  45. Steinbach WJ, Cramer RA, Perfect BZ, Asfaw YG, Sauer TC, Najvar LK, Kirkpatrick WR, Patterson TF, Benjamin DK, Heitman J, Perfect JR. Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell. 2006 Jul; 5(7):1091-103.
    View in: PubMed
    Score: 0.232
  46. Cramer RA, Gamcsik MP, Brooking RM, Najvar LK, Kirkpatrick WR, Patterson TF, Balibar CJ, Graybill JR, Perfect JR, Abraham SN, Steinbach WJ. Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. Eukaryot Cell. 2006 Jun; 5(6):972-80.
    View in: PubMed
    Score: 0.231
  47. Steinbach WJ, Singh N, Miller JL, Benjamin DK, Schell WA, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients. Antimicrob Agents Chemother. 2004 Dec; 48(12):4922-5.
    View in: PubMed
    Score: 0.208
  48. Steinbach WJ, Benjamin DK, Trasi SA, Miller JL, Schell WA, Zaas AK, Foster WM, Perfect JR. Value of an inhalational model of invasive aspergillosis. Med Mycol. 2004 Oct; 42(5):417-25.
    View in: PubMed
    Score: 0.206
  49. Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrob Agents Chemother. 2004 May; 48(5):1664-9.
    View in: PubMed
    Score: 0.200
  50. Steinbach WJ, Stevens DA, Denning DW, Moss RB. Advances against aspergillosis. Clin Infect Dis. 2003 Oct 01; 37 Suppl 3:S155-6.
    View in: PubMed
    Score: 0.192
  51. Moreno-Vel?squez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in ?-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 10; 61(10).
    View in: PubMed
    Score: 0.126
  52. Wong SSW, Rasid O, Laskaris P, Fekkar A, Cavaillon JM, Steinbach WJ, Ibrahim-Granet O. Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population. Virulence. 2017 11 17; 8(8):1744-1752.
    View in: PubMed
    Score: 0.124
  53. Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. mBio. 2016 Apr 26; 7(2):e00492-16.
    View in: PubMed
    Score: 0.115
  54. Rebong RA, Santaella RM, Goldhagen BE, Majka CP, Perfect JR, Steinbach WJ, Afshari NA. Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis. Invest Ophthalmol Vis Sci. 2011 Sep 21; 52(10):7309-15.
    View in: PubMed
    Score: 0.083
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.