IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells.
Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol. 2009 May 01; 182(9):5748-56.
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Animals
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Cell Differentiation
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Cell Lineage
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Cells, Cultured
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Encephalomyelitis, Autoimmune, Experimental
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Gene Expression Regulation
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Genetic Predisposition to Disease
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Growth Inhibitors
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Humans
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Interleukin-17
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Interleukins
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nuclear Receptor Subfamily 1, Group F, Member 3
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Protein Subunits
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Receptors, Retinoic Acid
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Receptors, Thyroid Hormone
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T-Lymphocytes, Helper-Inducer