Design and synthesis of non-hydrolyzable homoisoprenoid a-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases.

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Design and synthesis of non-hydrolyzable homoisoprenoid a-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases.

Subramanian T, Ren H, Subramanian KL, Sunkara M, Onono FO, Morris AJ, Spielmann HP. Design and synthesis of non-hydrolyzable homoisoprenoid a-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases. Bioorg Med Chem Lett. 2014 Sep 15; 24(18):4414-4417.

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subject areas

Dose-Response Relationship, Drug
Drug Design
Enzyme Inhibitors
Molecular Structure
Phosphoric Monoester Hydrolases
Polyisoprenyl Phosphates
Structure-Activity Relationship

authors with profiles

Andrew Morris