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Ruofei Du

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiostatistics, College of Public Health
Address3218 ED III
4301 W. Markham
Mail Slot # 781
Little Rock AR 72205
Phone501-686-5353
Fax501-526-6729
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    Other Positions
    TitleAssistant Professor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentBiostatistics, College of Medicine
    DivisionBiostatistics Faculty


    Collapse Research 
    Collapse research activities and funding
    SUB-OTA No. 6922-03-COVID-S016     (HENRY-TILLMAN, RONDA S)Jul 16, 2023 - Mar 31, 2024
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    Community Engagement Research Alliance (CEAL) 2023-2024 Renewal
    Role: Principal Investigator
    SUB-OTANo.6922     (HENRY-TILLMAN, RONDA S)Jul 16, 2023 - Mar 31, 2024
    NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat
    Community Engagement Research Alliance (CEAL) 2023-2024 Renewal
    Role: Principal Investigator
    2P42ES025589     (DU, RUOFEI)Sep 20, 2022 - Jun 30, 2027
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of New Mexico
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Principal Investigator
    2P42ES025589-06     (DU, RUOFEI)Sep 20, 2022 - Jun 30, 2027
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of New Mexico
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Principal Investigator
    P42ES025589     (DU, RUOFEI)Sep 20, 2022 - Jun 30, 2027
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of New Mexico
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Principal Investigator
    U01AI170039     (CANNON, MARTIN)Jul 25, 2022 - May 31, 2027
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Platelets in radiation-induced immune dysregulation
    Role: Principal Investigator
    2SB1DK079387     (JAMES, LAURA P)Apr 15, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Acetaminophen Toxicity Diagnostics, LLC
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    2SB1DK079387-09A1     (JAMES, LAURA P)Apr 15, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Acetaminophen Toxicity Diagnostics, LLC
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    2SB1DK079387-10     (JAMES, LAURA P)Apr 15, 2022 - Mar 31, 2026
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Acetaminophen Toxicity Diagnostics, LLC
    AcetaSTAT Validation and Commercialization
    Role: Principal Investigator
    80NSSC21M0323     (CANNON, MARTIN)Aug 15, 2021 - Aug 14, 2024
    National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium
    Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request
    Role: Principal Investigator
    P50MD015706     (DU, RUOFEI)Apr 1, 2021 - Mar 31, 2025
    NIH/National Center on Minority Health and Health Disparities - Pass Through: University of New Mexico
    Center for Native American Environmental Health Equity Research
    Role: Principal Investigator
    5P42ES025589     (DU, RUOFEI)Apr 1, 2021 - Mar 31, 2022
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of New Mexico
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Principal Investigator
    5P42ES025589-05     (DU, RUOFEI)Apr 1, 2021 - Mar 31, 2022
    NIH/Nat. Inst. of Environmental Health Sciences - Pass Through: University of New Mexico
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Principal Investigator
    U01CA260526     (NEMBHARD, WENDY N)Sep 30, 2020 - Feb 28, 2025
    NIH
    DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas
    Role: Co-Investigator
    UH3OD023344     (DU, RUOFEI)Sep 1, 2020 - Aug 31, 2023
    NIH/Office of the Director - Pass Through: University of New Mexico
    Understanding Risk Gradients from Environment on Native American Child Health Trajectories: Toxicants, Immunomodulation, Metabolic syndromes, & Metals Exposure
    Role: Principal Investigator
    COVID-19 Testing for Arkansas     (JAMES, LAURA P)Jun 23, 2020 - May 31, 2022
    State of Arkansas
    Arkansas CASS: Arkansas Coronavirus Antibodies Seroprevalence Survey
    Role: Faculty
    P42ES025589     (LEWIS, JOHNNYE L)Aug 15, 2017 - Mar 31, 2022
    NIH/NIEHS
    UNM Metal Exposure Toxicity Assessment on Tribal Lands in the Southwest (METALS) Superfund Research Program
    Role: Other Professional
    P50ES026102     (LEWIS, JOHNNYE L)Aug 1, 2015 - Jul 15, 2020
    NIH, EPA
    Center for Native American Environmental Health Equity Research
    Role: Other Professional
    ADH7356209     (ESWARAN, HARI)Jul 1, 2006 - Jun 30, 2021
    Arkansas Department of Health and Human Services
    Evaluation of the ANGELS High Risk Pregnancy Program
    Role: Faculty

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Du R, Ali MM, Sung YS, Pandit AA, Payakachat N, Ounpraseuth ST, Magann EF, Eswaran H. Maternal comorbidity index and severe maternal morbidity among medicaid covered pregnant women in a US Southern rural state. J Matern Fetal Neonatal Med. 2023 Dec; 36(1):2167073. PMID: 36683016.
      View in: PubMed
    2. Wheeler CM, Torrez-Martinez NE, Torres-Chavolla E, Parvu V, Andrews JC, Du R, Robertson M, Joste NE, Cuzick J. Comparing the performance of 2 human papillomavirus assays for a new use indication: a real-world evidence-based evaluation in the United States. Am J Obstet Gynecol. 2024 Feb; 230(2):243.e1-243.e11. PMID: 37806613.
      View in: PubMed
    3. Yang X, Tang Y, Du R, Yu Y, Xu J, Zhang J, Liu H, Zou X, Ren L, Yuan S, Shang Y. Long-term sedation with remimazolam besylate versus propofol in critically ill patients during invasive mechanical ventilation: a study protocol for a multicenter randomized non-inferior trial. Front Pharmacol. 2023; 14:1139872. PMID: 37576823.
      View in: PubMed
    4. Cuzick J, Adcock R, Kinney W, Castle PE, Robertson M, McDonald RM, Stoler MH, Du R, Wheeler CM. Impact of HPV testing in opportunistic cervical screening: Support for primary HPV screening in the United States. Int J Cancer. 2023 07 01; 153(1):83-93. PMID: 36946690.
      View in: PubMed
    5. Bhandari SK, Wiest N, Sallmyr A, Du R, Ferry L, Defossez PA, Tomkinson AE. Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. Sci Rep. 2023 03 16; 13(1):4363. PMID: 36928068.
      View in: PubMed
    6. Lauer RC, Barry M, Smith TL, Thomas AM, Wu J, Du R, Lee JH, Rao A, Dobroff AS, Arap MA, Nunes DN, Silva IT, Dias-Neto E, Chen I, McCance DJ, Cavenee WK, Pasqualini R, Arap W. Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts. Elife. 2023 01 16; 12. PMID: 36645410.
      View in: PubMed
    7. Allen JL, Du R, Powell T, Hobbs KL, Amick BC. Characterizing Cancer and Work Disparities Using Electronic Health Records. Int J Environ Res Public Health. 2022 Nov 29; 19(23). PMID: 36497959.
      View in: PubMed
    8. Du R, Yang H, Zhou H, Ma L, Getu MA, Chen C, Wang T. Home-based multidisciplinary interventions on skin adverse reactions in EGFR-TKI-treated patients with lung cancer: a protocol for a randomised controlled trial. BMJ Open. 2022 11 28; 12(11):e063921. PMID: 36442902.
      View in: PubMed
    9. Nozadi SS, Aguiar A, Du R, Enright EA, Schantz SL, Miller C, Rennie B, Quetawki M, MacKenzie D, Lewis JL. Cross-cultural applicability of eye-tracking in assessing attention to emotional faces in preschool-aged children. Emotion. 2023 Aug; 23(5):1385-1399. PMID: 36107657.
      View in: PubMed
    10. Wang J, Zeng J, Liu Z, Zhou Q, Wang X, Zhao F, Zhang Y, Wang J, Liu M, Du R. Promising Strategies for Transdermal Delivery of Arthritis Drugs: Microneedle Systems. Pharmaceutics. 2022 Aug 19; 14(8). PMID: 36015362.
      View in: PubMed
    11. Boehme KW, Kennedy JL, Snowden J, Owens SM, Kouassi M, Mann RL, Paredes A, Putt C, James L, Jin J, Du R, Kirkpatrick C, Modi Z, Caid K, Young S, Zohoori N, Kothari A, Boyanton BL, Craig Forrest J. Pediatric SARS-CoV-2 Seroprevalence in Arkansas Over the First Year of the COVID-19 Pandemic. J Pediatric Infect Dis Soc. 2022 Jun 22; 11(6):248-256. PMID: 35294550.
      View in: PubMed
    12. Figueiredo JC, Hirsch FR, Kushi LH, Nembhard WN, Crawford JM, Mantis N, Finster L, Merin NM, Merchant A, Reckamp KL, Melmed GY, Braun J, McGovern D, Parekh S, Corley DA, Zohoori N, Amick BC, Du R, Gregersen PK, Diamond B, Taioli E, Sariol C, Espino A, Weiskopf D, Gifoni A, Brien J, Hanege W, Lipsitch M, Zidar DA, Scheck McAlearney A, Wajnberg A, LaBaer J, Yvonne Lewis E, Binder RA, Moormann AM, Forconi C, Forrester S, Batista J, Schieffelin J, Kim D, Biancon G, VanOudenhove J, Halene S, Fan R, Barouch DH, Alter G, Pinninti S, Boppana SB, Pati SK, Latting M, Karaba AH, Roback J, Sekaly R, Neish A, Brincks AM, Granger DA, Karger AB, Thyagarajan B, Thomas SN, Klein SL, Cox AL, Lucas T, Furr-Holden D, Key K, Jones N, Wrammerr J, Suthar M, Yu Wong S, Bowman NM, Simon V, Richardson LD, McBride R, Krammer F, Rana M, Kennedy J, Boehme K, Forrest C, Granger SW, Heaney CD, Knight Lapinski M, Wallet S, Baric RS, Schifanella L, Lopez M, Fern?ndez S, Kenah E, Panchal AR, Britt WJ, Sanz I, Dhodapkar M, Ahmed R, Bartelt LA, Markmann AJ, Lin JT, Hagan RS, Wolfgang MC, Skarbinski J. Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies. Open Forum Infect Dis. 2022 Jun; 9(6):ofac171. PMID: 35765315.
      View in: PubMed
    13. Cardenas VM, Kennedy JL, Williams M, Nembhard WN, Zohoori N, Du R, Jin J, Boothe D, Fischbach LA, Kirkpatrick C, Modi Z, Caid K, Owens S, Forrest JC, James L, Boehme KW, Olgaard E, Gardner SF, Amick BC. State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020. PLoS One. 2022; 17(4):e0267322. PMID: 35476717.
      View in: PubMed
    14. Kennedy JL, Forrest JC, Young SG, Amick B, Williams M, James L, Snowden J, Cardenas VM, Boothe D, Kirkpatrick C, Modi Z, Caid K, Owens S, Kouassi M, Mann R, Putt C, Irish-Clardy K, Macechko M, Brimberry RK, Nembhard WN, McElfish PA, Du R, Jin J, Zohoori N, Kothari A, Hagrass H, Olgaard E, Boehme KW. Temporal Variations in Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Infections by Race and Ethnicity in Arkansas. Open Forum Infect Dis. 2022 May; 9(5):ofac154. PMID: 35493126.
      View in: PubMed
    15. Du R, Luo L, Hudson LG, Nozadi S, Lewis J. An adjusted partial least squares regression framework to utilize additional exposure information in environmental mixture data analysis. J Appl Stat. 2023; 50(8):1790-1811. PMID: 37260474.
      View in: PubMed
    16. Du R, Choi YJ, Lee JH, Songthip O, Hu Z. A weighted Jackknife approach utilizing linear model based-estimators for clustered data. Commun Stat Simul Comput. 2024; 53(2):1048-1067. PMID: 38523866.
      View in: PubMed
    17. Nozadi SS, Li L, Luo L, MacKenzie D, Erdei E, Du R, Roman CW, Hoover J, O'Donald E, Burnette C, Lewis J. Prenatal Metal Exposures and Infants' Developmental Outcomes in a Navajo Population. Int J Environ Res Public Health. 2021 12 31; 19(1). PMID: 35010683.
      View in: PubMed
    18. Corken A, Ghosh SP, Du R, Boerma M, Ware J, Pathak R. Platelet glycoprotein Iba provides radiation protection. Radiother Oncol. 2022 02; 167:143-148. PMID: 34971661.
      View in: PubMed
    19. Cuzick J, Du R, Adcock R, Kinney W, Joste N, McDonald RM, English K, Torres SM, Saslow D, Wheeler CM. Uptake of co-testing with HPV and cytology for cervical screening: a population-based evaluation in the United States. Gynecologic Oncology. 2021; 162(3):555-559.
      View Publication
    20. Cuzick J, Du R, Adcock R, Kinney W, Joste N, McDonald RM, English K, Torres SM, Saslow D, Wheeler CM. Uptake of co-testing with HPV and cytology for cervical screening: A population-based evaluation in the United States. Gynecol Oncol. 2021 09; 162(3):555-559. PMID: 34253387.
      View in: PubMed
    21. Harris M, Mendiratta P, Azhar G, Du R, Jin J. . The PBAR Protocol: Antipsychotic Medication Reduction in the Nursing Home. OBM Geriatrics. 2021; 2(5).
    22. Blair CK, Harding E, Wiggins C, Kang H, Schwartz M, Tarnower A, Du R, Kinney AY. A Home-Based Mobile Health Intervention to Replace Sedentary Time With Light Physical Activity in Older Cancer Survivors: Randomized Controlled Pilot Trial. JMIR Cancer. 2021 Apr 13; 7(2):e18819. PMID: 33847588.
      View in: PubMed
    23. Manda-Mapalo MT, Fine SG, Safadi S, Lee JH, Du R, Sussman AL, Mishra S, Selwyn RG, Saline JL, Hine WL, Brown-Glaberman UA. Breast Cancer Screening Among Medically Underserved Women in New Mexico: Potential for Lower Recall Rates with Digital Breast Tomosynthesis. J Womens Health (Larchmt). 2020 12; 29(12):1596-1601. PMID: 32991242.
      View in: PubMed
    24. De La Rosa VY, Hoover J, Du R, Jimenez EY, MacKenzie D, Lewis J. Diet quality among pregnant women in the Navajo Birth Cohort Study. Matern Child Nutr. 2020 07; 16(3):e12961. PMID: 32026554.
      View in: PubMed
    25. Zhang Y, Xia H, Wang Y, Chen L, Li S, Hussein IA, Wu Y, Shang Y, Yao S, Du R. The rate of missed diagnosis of lower-limb DVT by ultrasound amounts to 50% or so in patients without symptoms of DVT: A meta-analysis. Medicine. 2019; 37(98):e17103.
    26. Nozadi SS, Li L, Clifford J, Du R, Murphy K, Chen L, Seanez P, Burnette C, MacKenzie D, Lewis JL. Use of Ages and Stages Questionnaires? (ASQ) in a Navajo population: Comparison with the U.S. normative dataset. Child Care Health Dev. 2019 09; 45(5):709-718. PMID: 31276599.
      View in: PubMed
    27. Du, R, Lee JH. A weighted Jackknife method for clustered data. Communications in Statistics-Theory and Methods. 2019; 8(48):1963-1980.
    28. Du R, An L, Fang Z. Performance evaluation of normalization approaches for metagenomic compositional data on differential abundance analysis. New Frontiers of Biostatistics and Bioinformatics. 2018; 329-344.
    29. Chen Y, Hou Y, Yang J, Du R, Chen C, Chen F, Wang H, Ge R, Chen J. P75 Involved in the Ubiquitination of a-synuclein in Rotenone-based Parkinson's Disease Models. Neuroscience. 2018 09 15; 388:367-373. PMID: 30081046.
      View in: PubMed
    30. Dashner-Titus EJ, Hoover J, Li L, Lee JH, Du R, Liu KJ, Traber MG, Ho E, Lewis J, Hudson LG. Metal exposure and oxidative stress markers in pregnant Navajo Birth Cohort Study participants. Free Radic Biol Med. 2018 08 20; 124:484-492. PMID: 29723666.
      View in: PubMed
    31. Jiang X, Xing H, Wu J, Du R, Liu H, Chen J, Wang J, Wang C, Wu Y. Author Correction: Prognostic value of thyroid hormones in acute ischemic stroke - a meta analysis. Sci Rep. 2018 Apr 24; 8(1):6651. PMID: 29691475.
      View in: PubMed
    32. Du R, Fang Z. Statistical correction for functional metagenomic profiling of a microbial community with short NGS reads. J Appl Stat. 2018; 45(14):2521-2535. PMID: 30505061.
      View in: PubMed
    33. Jiang X, Xing H, Wu J, Du R, Liu H, Chen J, Wang J, Wang C, Wu Y. Prognostic value of thyroid hormones in acute ischemic stroke - a meta analysis. Sci Rep. 2017 11 24; 7(1):16256. PMID: 29176727.
      View in: PubMed
    34. Floruta CM, Du R, Kang H, Stein JL, Weick JP. Default Patterning Produces Pan-cortical Glutamatergic and CGE/LGE-like GABAergic Neurons from Human Pluripotent Stem Cells. Stem Cell Reports. 2017 11 14; 9(5):1463-1476. PMID: 29107596.
      View in: PubMed
    35. Steffen LE, Du R, Gammon A, Mandelblatt JS, Kohlmann WK, Lee JH, Buys SS, Stroup AM, Campo RA, Flores KG, Vicu?a B, Schwartz MD, Kinney AY. Genetic Testing in a Population-Based Sample of Breast and Ovarian Cancer Survivors from the REACH Randomized Trial: Cost Barriers and Moderators of Counseling Mode. Cancer Epidemiol Biomarkers Prev. 2017 12; 26(12):1772-1780. PMID: 28971986.
      View in: PubMed
    36. Patt YZ, Murad W, Fekrazad MH, Baron AD, Bansal P, Boumber Y, Steinberg K, Lee SJ, Bedrick E, Du R, Lee FC. INST OX-05-024: first line gemcitabine, oxaliplatin, and erlotinib for primary hepatocellular carcinoma and bile duct cancers: a multicenter Phase II trial. Cancer Med. 2017 Sep; 6(9):2042-2051. PMID: 28801995.
      View in: PubMed
    37. Benard VB, Castle PE, Jenison SA, Hunt WC, Kim JJ, Cuzick J, Lee JH, Du R, Robertson M, Norville S, Wheeler CM. Population-Based Incidence Rates of Cervical Intraepithelial Neoplasia in the Human Papillomavirus Vaccine Era. JAMA Oncol. 2017 Jun 01; 3(6):833-837. PMID: 27685805.
      View in: PubMed
    38. Kinney AY, Steffen LE, Brumbach BH, Kohlmann W, Du R, Lee JH, Gammon A, Butler K, Buys SS, Stroup AM, Campo RA, Flores KG, Mandelblatt JS, Schwartz MD. Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up. J Clin Oncol. 2016 08 20; 34(24):2914-24. PMID: 27325848.
      View in: PubMed
    39. Sohn MB, Du R, An L. A robust approach for identifying differentially abundant features in metagenomic samples. Bioinformatics. 2015 Jul 15; 31(14):2269-75. PMID: 25792553.
      View in: PubMed
    40. Du R, Mercante D, An L, Fang Z. A Statistical Approach to Correcting Cross-Annotations in a Metagenomic Functional Profile Generated by Short Reads. J Biom Biostat. 2014; 5(4). PMID: 29710879.
      View in: PubMed
    41. Pookhao N, Sohn MB, Li Q, Jenkins I, Du R, Jiang H, An L. A two-stage statistical procedure for feature selection and comparison in functional analysis of metagenomes. Bioinformatics. 2015 Jan 15; 31(2):158-65. PMID: 25256572.
      View in: PubMed
    42. Du R, Fang Z. Analysis of Metagenomic Data. Statistical Analysis of Next Generation Sequencing Data. 2014; 335-353.
    43. Du R, Mercante D, Fang Z. An artificial functional family filter in homolog searching in next-generation sequencing metagenomics. PLoS One. 2013; 8(3):e58669. PMID: 23516532.
      View in: PubMed
    44. Fang Z, Du R, Edwards A, Flemington EK, Zhang K. The sequence structures of human microRNA molecules and their implications. PLoS One. 2013; 8(1):e54215. PMID: 23349828.
      View in: PubMed
    45. Fang Z, Du R, Cui X. Uniform approximation is more appropriate for Wilcoxon Rank-Sum Test in gene set analysis. PLoS One. 2012; 7(2):e31505. PMID: 22347488.
      View in: PubMed
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