Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.

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Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.

Thakkar S, Nanaware-Kharade N, Celikel R, Peterson EC, Varughese KI. Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering. Sci Rep. 2014 Jan 14; 4:3673.

View in: PubMed

subject areas

Amino Acid Sequence
Amphetamine
Antibodies, Monoclonal
Antibody Affinity
Binding Sites
Hydrophobic and Hydrophilic Interactions
Methamphetamine
Models, Molecular
Molecular Conformation
Molecular Sequence Data
Mutation
Protein Binding
Protein Engineering
Single-Chain Antibodies
Structure-Activity Relationship

authors with profiles

Eric Peterson