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Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis.
Kiaei M, Kipiani K, Petri S, Chen J, Calingasan NY, Beal MF. Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis. Neurodegener Dis. 2005; 2(5):246-54.
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PubMed
subject areas
Amyotrophic Lateral Sclerosis
Animals
Astrocytes
Cell Count
Cell Death
Female
Fluorescent Antibody Technique, Indirect
Glial Fibrillary Acidic Protein
HSP70 Heat-Shock Proteins
Longevity
Mice
Mice, Transgenic
Motor Neurons
Neuroglia
Neurons
Neuroprotective Agents
Pentacyclic Triterpenes
Postural Balance
Psychomotor Performance
Superoxide Dismutase
Survival Analysis
Triterpenes
Tumor Necrosis Factor-alpha
Up-Regulation