Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.
Glazko GV, Babenko VN, Koonin EV, Rogozin IB. Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection. Biol Direct. 2006 Jan 31; 1:4.