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Robert Lyle

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Neonatology
AddressG3125 ACH Administration
1900 Maryland Street
Mail Slot # 512-5
Little Rock AR 72202
Phone501-364-1028
ORCID ORCID Icon0009-0005-9397-9864 Additional info
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    Collapse Overview 
    Collapse overview
    Some of the UAMS College of Medicine faculty members provides pediatric patient care at Arkansas Children's Hospital. In addition, a wide range of pediatric services are provided in more than 35 subspecialties around Arkansas in locations such as the Schmieding Developmental Center in Springdale and the James L. Dennis Developmental Center in Little Rock. To make an appointment at Arkansas Children's hospital, please call 501-364-4000.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Jones MJ, Konwar C, Asiimwe R, Dinh L, Razzaghian HR, de Goede O, MacIsaac JL, Morin AM, Kolsun KP, Gervin K, Lyle R, Ng RT, Koestler DC, Felix JF, Lavoie PM, Robinson WP, Mostafavi S, Kobor MS. DNA methylation differences between cord and adult white blood cells reflect postnatal immune cell maturation. Commun Biol. 2025 Feb 14; 8(1):237. PMID: 39953282.
      View in: PubMed
    2. Rostami S, Rounge TB, Pestarino L, Lyle R, Fortner RT, Haaland ?A, Lie RT, Wiklund F, Bj?rge T, Langseth H. Differential levels of circulating RNAs prior to endometrial cancer diagnosis. Int J Cancer. 2024 Sep 01; 155(5):946-956. PMID: 38733362.
      View in: PubMed
    3. Romanowska J, Nustad HE, Page CM, Denault WRP, Lee Y, Magnus MC, Haftorn KL, Gjerdevik M, Novakovic B, Saffery R, Gjessing HK, Lyle R, Magnus P, H?berg SE, Jugessur A. The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? Hum Genomics. 2023 04 21; 17(1):35. PMID: 37085889.
      View in: PubMed
    4. Samara A, Falck M, Spildrejorde M, Leithaug M, Acharya G, Lyle R, Eskeland R. Robust neuronal differentiation of human embryonic stem cells for neurotoxicology. STAR Protoc. 2022 09 16; 3(3):101533. PMID: 36123835.
      View in: PubMed
    5. Kv?rner AS, Birkeland E, Bucher-Johannessen C, Vinberg E, Nordby JI, Kangas H, Bemanian V, Ellonen P, Botteri E, Natvig E, Rognes T, Hovig E, Lyle R, Ambur OH, de Vos WM, Bultman S, Hjart?ker A, Landberg R, Song M, Blix HS, Ursin G, Randel KR, de Lange T, Hoff G, Holme ?, Berstad P, Rounge TB. The CRCbiome study: a large prospective cohort study examining the role of lifestyle and the gut microbiome in colorectal cancer screening participants. BMC Cancer. 2021 Aug 18; 21(1):930. PMID: 34407780.
      View in: PubMed
    6. Lee Y, Haftorn KL, Denault WRP, Nustad HE, Page CM, Lyle R, Lee-?deg?rd S, Moen GH, Prasad RB, Groop LC, Sletner L, Sommer C, Magnus MC, Gjessing HK, Harris JR, Magnus P, H?berg SE, Jugessur A, Bohlin J. Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array. BMC Genomics. 2020 Oct 27; 21(1):747. PMID: 33109080.
      View in: PubMed
    7. Umu SU, Langseth H, Keller A, Meese E, Helland ?, Lyle R, Rounge TB. A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis. Mol Oncol. 2020 02; 14(2):235-247. PMID: 31851411.
      View in: PubMed
    8. Gervin K, Salas LA, Bakulski KM, van Zelm MC, Koestler DC, Wiencke JK, Duijts L, Moll HA, Kelsey KT, Kobor MS, Lyle R, Christensen BC, Felix JF, Jones MJ. Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data. Clin Epigenetics. 2019 08 27; 11(1):125. PMID: 31455416.
      View in: PubMed
    9. Collins RT, Lyle RE, Casey PH. Reply. J Pediatr. 2019 06; 209:257-258. PMID: 30853198.
      View in: PubMed
    10. Collins RT, Lyle RE, Rettiganti M, Gossett JM, Robbins JM, Casey PH. Long-Term Neurodevelopment of Low-Birthweight, Preterm Infants with Patent Ductus Arteriosus. J Pediatr. 2018 12; 203:170-176.e1. PMID: 30268404.
      View in: PubMed
    11. Kuo DZ, Berry JG, Hall M, Lyle RE, Stille CJ. Health-care spending and utilization for children discharged from a neonatal intensive care unit. J Perinatol. 2018 06; 38(6):734-741. PMID: 29449613.
      View in: PubMed
    12. Reppe S, Lien TG, Hsu YH, Gautvik VT, Olstad OK, Yu R, Bakke HG, Lyle R, Kringen MK, Glad IK, Gautvik KM. Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women. Epigenetics. 2017 08; 12(8):674-687. PMID: 28650214.
      View in: PubMed
    13. Kuo DZ, Lyle RE, Casey PH, Stille CJ. Care System Redesign for Preterm Children After Discharge From the NICU. Pediatrics. 2017 Apr; 139(4). PMID: 28250024.
      View in: PubMed
    14. Goode RH, Rettiganti M, Li J, Lyle RE, Whiteside-Mansell L, Barrett KW, Casey PH. Developmental Outcomes of Preterm Infants With Neonatal Hypoglycemia. Pediatrics. 2016 12; 138(6). PMID: 27940690.
      View in: PubMed
    15. Sundaram AY, Hughes T, Biondi S, Bolduc N, Bowman SK, Camilli A, Chew YC, Couture C, Farmer A, Jerome JP, Lazinski DW, McUsic A, Peng X, Shazand K, Xu F, Lyle R, Gilfillan GD. A comparative study of ChIP-seq sequencing library preparation methods. BMC Genomics. 2016 10 21; 17(1):816. PMID: 27769162.
      View in: PubMed
    16. Gervin K, Page CM, Aass HC, Jansen MA, Fjeldstad HE, Andreassen BK, Duijts L, van Meurs JB, van Zelm MC, Jaddoe VW, Nordeng H, Knudsen GP, Magnus P, Nystad W, Staff AC, Felix JF, Lyle R. Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition. Epigenetics. 2016 Sep; 11(9):690-698. PMID: 27494297.
      View in: PubMed
    17. Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Coban Akdemir ZH, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, R?dningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR, Wiszniewski W, Fevang B, Aukrust P, Tj?nnfjord GE, Gedde-Dahl T, Hjorth-Hansen H, Dybedal I, Nord?y I, J?rgensen SF, Abrahamsen TG, ?verland T, Bechensteen AG, Skogen V, Osnes LTN, Kulseth MA, Prescott TE, Rustad CF, Heimdal KR, Belmont JW, Rider NL, Chinen J, Cao TN, Smith EA, Caldirola MS, Bezrodnik L, Lugo Reyes SO, Espinosa Rosales FJ, Guerrero-Cursaru ND, Pedroza LA, Poli CM, Franco JL, Trujillo Vargas CM, Aldave Becerra JC, Wright N, Issekutz TB, Issekutz AC, Abbott J, Caldwell JW, Bayer DK, Chan AY, Aiuti A, Cancrini C, Holmberg E, West C, Burstedt M, Karaca E, Yesil G, Artac H, Bayram Y, Atik MM, Eldomery MK, Ehlayel MS, Jolles S, Flat? B, Bertuch AA, Hanson IC, Zhang VW, Wong LJ, Hu J, Walkiewicz M, Yang Y, Eng CM, Boerwinkle E, Gibbs RA, Shearer WT, Lyle R, Orange JS, Lupski JR. Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders. J Allergy Clin Immunol. 2017 01; 139(1):232-245. PMID: 27577878.
      View in: PubMed
    18. Lekva T, Lyle R, Roland MC, Friis C, Bianchi DW, Jaffe IZ, Norwitz ER, Bollerslev J, Henriksen T, Ueland T. Gene expression in term placentas is regulated more by spinal or epidural anesthesia than by late-onset preeclampsia or gestational diabetes mellitus. Sci Rep. 2016 07 11; 6:29715. PMID: 27405415.
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    19. Kuo DZ, Robbins JM, Lyle RE, Barrett KW, Burns KH, Casey PH. Parent-reported outcomes of comprehensive care for children with medical complexity. Fam Syst Health. 2013 Jun; 31(2):132-41. PMID: 23795625.
      View in: PubMed
    20. Forsberg LA, Rasi C, Razzaghian HR, Pakalapati G, Waite L, Thilbeault KS, Ronowicz A, Wineinger NE, Tiwari HK, Boomsma D, Westerman MP, Harris JR, Lyle R, Essand M, Eriksson F, Assimes TL, Iribarren C, Strachan E, O'Hanlon TP, Rider LG, Miller FW, Giedraitis V, Lannfelt L, Ingelsson M, Piotrowski A, Pedersen NL, Absher D, Dumanski JP. Age-related somatic structural changes in the nuclear genome of human blood cells. Am J Hum Genet. 2012 Feb 10; 90(2):217-28. PMID: 22305530.
      View in: PubMed
    21. Casey PH, Lyle RE, Bird TM, Robbins JM, Kuo DZ, Brown C, Lal A, Tanios A, Burns K. Effect of hospital-based comprehensive care clinic on health costs for Medicaid-insured medically complex children. Arch Pediatr Adolesc Med. 2011 May; 165(5):392-8. PMID: 21300650.
      View in: PubMed
    22. Burns KH, Casey PH, Lyle RE, Bird TM, Fussell JJ, Robbins JM. Increasing prevalence of medically complex children in US hospitals. Pediatrics. 2010 Oct; 126(4):638-46. PMID: 20855383.
      View in: PubMed
    23. Munthe-Kaas MC, Torjussen TM, Gervin K, L?drup Carlsen KC, Carlsen KH, Granum B, Hjorthaug HS, Undlien D, Lyle R. CD14 polymorphisms and serum CD14 levels through childhood: a role for gene methylation? J Allergy Clin Immunol. 2010 Jun; 125(6):1361-8. PMID: 20398919.
      View in: PubMed
    24. Tanios AT, Lyle RE, Casey PH. ACH Medical Home Program for Special Needs Chidren. A New Medical Era. 2009; 105(7):163-5.
    25. Tanios AT, Lyle RE, Casey PH. CH medical home program for special needs children. A new medical era... J Ark Med Soc. 2009 Jan; 105(7):163-5. PMID: 19170334.
      View in: PubMed
    26. Prince AM, May JS, Burton GR, Lyle RE, McGehee RE. Proteasomal degradation of retinoblastoma-related p130 during adipocyte differentiation. Biochem Biophys Res Commun. 2002 Jan 25; 290(3):1066-71. PMID: 11798183.
      View in: PubMed
    27. Prince, A, May, J, Burton, G, Lyle, RE, McGehee, RE, Jr. Specific degradation of the p130tumor suppressor gene by the 26S proteosome during 3T3-L1 Adipocyte differentiation. Biochem Biophys Res Commun. 2002; 290(3):1066-1071.
    28. Lyle, RE, Richon, V, McGehee, RE Jr. TNF-a disrupts mitotic clonal expansion and regulation of retinoblastoma proteins p130 and p107 during 3T3-L1 adipogenesis. Biochem Biophys Res Comm. 1998; 247:373-378.
    29. Lyle, RE, Corley, JD, McGehee, RE Jr. Human milk and infant formula can induce adipocyte differentiation during 3T3-L1 adipogenesis. Ped Res. 1998; 44:798-803.
    30. Richon, VC, Lyle, RE, McGehee, RE Jr. Retinoblastoma proteins p107 and p130 are developmentally regulated during 3T3-L1 adipogenesis. J Biol Chem. 1997; 272:10117-10124.
    31. Lyle, RE, Habener, J, McGehee, RE Jr. Antisense oligonucleotides to differentiation specific element binding protein mRNA inhibit adipocyte differentiation. Biochem Biophys Res Comm. 1996; 228:709-715.
    32. Lyle R, Breaux A, Massey A, Burns K, Robbins J, Curtis T, Bird T, Casey P. Development of a Hospital-Based Medical Home Program for Special Needs Children: Follow-Up of NICU Graduates with Complex Bronchopulmonary Dysplasia.
    33. Lyle, RE, Richon, V, McGehee, RE, Jr. Retinoblastoma proteins p107 and p130 are differentially expressed during 3T3-L1 adipogenesis. Keystone Conference.
    34. Bird T, Tilford M, Robbins J, Casey P, Lyle R. Surfactant Replacement Therapy May Improve Survival for Infants Born with Congenital Diaphragmatic Hernia, an Instrumental Variable Analysis.
    35. Casey P, Lyle R, Bird T, Curtis T, Robbins J. The Impact of a Special Clinical Program Focused on Medically Complex Children on Hospital Contacts and Charges.
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