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Philip Palade

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPharmacology & Toxicology, College of Medicine
DivisionPharmacology Research
AddressB341-2 Biomedical Research II
200 South Cedar
Mail Slot # 611
Little Rock AR 72202
Phone501-526-4757
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    Collapse Research 
    Collapse research activities and funding
    R01HL095846     (PALADE, PHILIP T.)Jan 22, 2010 - Nov 30, 2014
    NIH
    MicroRNA to decrease vascular CaV1.2 in hypertension
    Role: Principal Investigator
    09GRNT2110149     (PALADE, PHILIP T)Jul 1, 2009 - Jun 30, 2011
    American Heart Association (South Central Affiliate)
    RNA interference to decrease vascular CaV1.2 in hypertension
    Role: Principal Investigator
    R01HL073097     (PALADE, PHILIP T.)Dec 20, 2003 - Nov 30, 2008
    NIH
    Cav1.2 Transcript Regulation in Heart and Smooth Muscle
    Role: Principal Investigator
    R01HL063903     (PALADE, PHILIP T.)Sep 27, 2000 - Jul 31, 2007
    NIH
    THE ALPHA-1C CALCIUM CHANNEL IN MUSCLE
    Role: Principal Investigator
    R01AR041526     (PALADE, PHILIP T.)Sep 30, 1996 - Aug 31, 2002
    NIH
    CA INDUCED CA RELEASE FROM STRIATED MUSCLE
    Role: Principal Investigator
    R01AR043200     (PALADE, PHILIP T.)Jul 10, 1995 - Jun 30, 2000
    NIH
    PHARMACOLOGY OF QUANTAL INTRACELLULAR CALCIUM RELEASE
    Role: Principal Investigator
    R01HL042527     (PALADE, PHILIP T.)May 1, 1989 - Apr 30, 1994
    NIH
    PHARMACOLOGY OF MUSCLE EXCITATION-CONTRACTION COUPLING
    Role: Principal Investigator
    R01AR034377     (PALADE, PHILIP T.)Aug 1, 1984 - Sep 30, 1992
    NIH
    CA RELEASE FROM SARCOPLASMIC RETICULUM: THE FROG PACKAGE
    Role: Principal Investigator
    K04AM001347     (PALADE, PHILIP T.)Aug 1, 1984 - Jul 31, 1989
    NIH
    CALCIUM RELEASE PROCESS OF SARCOPLASMIC RETICULUM
    Role: Principal Investigator
    K04AR001347     (PALADE, PHILIP T.)Aug 1, 1984 - Jul 31, 1989
    NIH
    CALCIUM RELEASE PROCESS OF SARCOPLASMIC RETICULUM
    Role: Principal Investigator
    R01AM034377     (PALADE, PHILIP T.)Aug 1, 1984 - Jul 31, 1987
    NIH
    CALCIUM RELEASE FROM ISOLATED SARCOPLASMIC RETICULUM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Wang X, Liu L, Zhai L, Palade P, Wang X, Mehta JL. Direct Impact of PCSK9 on SMC Senescence and Apoptosis: A New Focus in Cardiovascular Diseases. Arterioscler Thromb Vasc Biol. 2024 Jul; 44(7):1491-1496. PMID: 38924434.
      View in: PubMed
    2. Hindle A, Bose C, Lee J, Palade PT, Peterson CJ, Reddy PH, Awasthi S, Singh SP. Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels. Cancers (Basel). 2022 Jan 21; 14(3). PMID: 35158795.
      View in: PubMed
    3. Bose C, Hindle A, Lee J, Kopel J, Tonk S, Palade PT, Singhal SS, Awasthi S, Singh SP. Anticancer Activity of O-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells. Cancers (Basel). 2021 Dec 20; 13(24). PMID: 34944997.
      View in: PubMed
    4. Awasthi S, Hindle A, Sawant NA, George M, Vijayan M, Kshirsagar S, Morton H, Bunquin LE, Palade PT, Lawrence JJ, Khan H, Bose C, Reddy PH, Singh SP. RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease. Cells. 2021 11 10; 10(11). PMID: 34831336.
      View in: PubMed
    5. Petkovic M, Leal EC, Alves I, Bose C, Palade PT, Singh P, Awasthi S, B?rsheim E, Dalgaard LT, Singh SP, Carvalho E. Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway. J Nutr Biochem. 2021 12; 98:108817. PMID: 34271100.
      View in: PubMed
    6. Singh SP, Lee J, Bose C, Li H, Yuan YC, Hindle A, Singhal SS, Kopel J, Palade PT, Jones C, Rahman RL, Awasthi S. Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis. Cancers (Basel). 2021 Jul 02; 13(13). PMID: 34283045.
      View in: PubMed
    7. Garner BR, Stolarz AJ, Stuckey D, Sarimollaoglu M, Liu Y, Palade PT, Rusch NJ, Mu S. KATP Channel Openers Inhibit Lymphatic Contractions and Lymph Flow as a Possible Mechanism of Peripheral Edema. J Pharmacol Exp Ther. 2021 01; 376(1):40-50. PMID: 33100270.
      View in: PubMed
    8. Bose C, Alves I, Singh P, Palade PT, Carvalho E, B?rsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP. Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell. 2020 11; 19(11):e13261. PMID: 33067900.
      View in: PubMed
    9. Jun SR, Cheema A, Bose C, Boerma M, Palade PT, Carvalho E, Awasthi S, Singh SP. Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. Microorganisms. 2020 Sep 29; 8(10). PMID: 33003447.
      View in: PubMed
    10. Bose C, Yadav S, Singhal SS, Singhal J, Hindle A, Lee J, Cheedella NKS, Rehman S, Rahman RL, Jones C, Darden M, Palade PT, Berz D, Singh SP, Awasthi S. Rlip Depletion Suppresses Growth of Breast Cancer. Cancers (Basel). 2020 Jun 02; 12(6). PMID: 32498332.
      View in: PubMed
    11. Bose C, Singh SP, Igid H, Green WC, Singhal SS, Lee J, Palade PT, Rajan A, Ball S, Tonk V, Hindle A, Tarbox M, Awasthi S. Topical 2'-Hydroxyflavanone for Cutaneous Melanoma. Cancers (Basel). 2019 Oct 14; 11(10). PMID: 31615091.
      View in: PubMed
    12. Dai Y, Palade P, Wang X, Mercanti F, Ding Z, Dai D, Mehta JL. High fat diet causes renal fibrosis in LDLr-null mice through MAPK-NF-?B pathway mediated by Ox-LDL. J Cardiovasc Pharmacol. 2014 Feb; 63(2):158-66. PMID: 24220312.
      View in: PubMed
    13. Krishna A, Valderr?bano M, Palade PT, Clark JW. Rate-dependent Ca2+ signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study. Theor Biol Med Model. 2013 Sep 10; 10:54. PMID: 24020888.
      View in: PubMed
    14. Dai Y, Khaidakov M, Wang X, Ding Z, Su W, Price E, Palade P, Chen M, Mehta JL. MicroRNAs involved in the regulation of postischemic cardiac fibrosis. Hypertension. 2013 Apr; 61(4):751-6. PMID: 23381794.
      View in: PubMed
    15. Krishna A, Valderr?bano M, Palade PT, Clark WJ. Multiphysics model of a rat ventricular myocyte: a voltage-clamp study. Theor Biol Med Model. 2012 Nov 21; 9:48. PMID: 23171697.
      View in: PubMed
    16. Krishna A, Sun L, Valderr?bano M, Palade PT, Clark JW. Modeling CICR in rat ventricular myocytes: voltage clamp studies. Theor Biol Med Model. 2010 Nov 10; 7:43. PMID: 21062495.
      View in: PubMed
    17. Wang W, Pang L, Palade P. Angiotensin II upregulates Ca(V)1.2 protein expression in cultured arteries via endothelial H(2)O(2) production. J Vasc Res. 2011; 48(1):67-78. PMID: 20639649.
      View in: PubMed
    18. Wang W, Rhee SW, Mehta JL, Palade P. Vascular CaV1.2 expression is increased in atherosclerosis. 2010; 3621-Pos/B345.
    19. Wang W, Rhee SW, Chen C, Palade P, Mehta JL. Upregulation of the CaV1.2 expression in atherosclerosis. 2010; Peer Reviewed Abstract.
    20. Kang BY, Wang W, Palade P, Sharma SG, Mehta JL. Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. J Cardiovasc Pharmacol. 2009 Oct; 54(4):327-34. PMID: 19687748.
      View in: PubMed
    21. Pang, L., Sonkusare, S., Thakali, K., Melchert, R., Roberto, K., Palade, P. AAV-mediated vascular smooth muscle-specific knockdown of Cav1.2 as a long-term anti-hypertensive therapy. FASEB J. 23. 2009; 932.4.
    22. Wang WZ, Pang L, Palade P. Angiotensin II causes endothelial-dependent increase in expression of Ca(V)1.2 protein in cultured arteries. Eur J Pharmacol. 2008 Dec 03; 599(1-3):117-20. PMID: 18848828.
      View in: PubMed
    23. Germinario E, Esposito A, Midrio M, Peron S, Palade PT, Betto R, Danieli-Betto D. High-frequency fatigue of skeletal muscle: role of extracellular Ca(2+). Eur J Appl Physiol. 2008 Oct; 104(3):445-53. PMID: 18560877.
      View in: PubMed
    24. Wang, W. Effects of Angiotensin II on CaV1.2 Expression in Mesenteric Artery. FASEB J. 2008; 22: 912.29.
    25. Pang, L.; Stimers, J.; Rhee, S. Smooth muscle specific knockdown of L-type calcium channel by exogenous microRNA (miRNA). FASEB J. 2008; 22: 912.32.
    26. Esposito A, Germinario E, Zanin M, Palade PT, Betto R, Danieli-Betto D. Isoform switching in myofibrillar and excitation-contraction coupling proteins contributes to diminished contractile function in regenerating rat soleus muscle. J Appl Physiol (1985). 2007 Apr; 102(4):1640-8. PMID: 17234797.
      View in: PubMed
    27. Wang W, Machaca K, Marsh J, Palade P. Angiotensin II upregulates the expression of L-type calcium channels, inositol trisphosphate receptors and ryanodine receptors in rat mesenteric vascular bed. 2007; 21: A1156 (873.2).
    28. Palade P. The hunt for an alternate way to generate NAADP. Focus on "NAADP as a second messenger: neither CD38 nor base-exchange reaction are necessary for in vivo generation of NAADP in myometrial cells". Am J Physiol Cell Physiol. 2007 Jan; 292(1):C4-7. PMID: 16899546.
      View in: PubMed
    29. Wang WZ, Saada N, Dai B, Pang L, Palade P. Vascular-specific increase in exon 1B-encoded CAV1.2 channels in spontaneously hypertensive rats. Am J Hypertens. 2006 Aug; 19(8):823-31. PMID: 16876682.
      View in: PubMed
    30. Sonkusare S, Palade PT, Marsh JD, Telemaque S, Pesic A, Rusch NJ. Vascular calcium channels and high blood pressure: pathophysiology and therapeutic implications. Vascul Pharmacol. 2006 Mar; 44(3):131-42. PMID: 16427812.
      View in: PubMed
    31. Shi XZ, Pazdrak K, Saada N, Dai B, Palade P, Sarna SK. Negative transcriptional regulation of human colonic smooth muscle Cav1.2 channels by p50 and p65 subunits of nuclear factor-kappaB. Gastroenterology. 2005 Nov; 129(5):1518-32. PMID: 16285952.
      View in: PubMed
    32. Germinario E, Esposito A, Zanin M, Palade PT, Betto R, Danieli-Betto D. Physiological characterization of 2-week regenerated soleus muscle fibers. 2005; Basic & Appl Myol 15:156.
    33. Saada NI, Carrillo ED, Dai B, Wang WZ, Dettbarn C, Sanchez J, Palade P. Expression of multiple CaV1.2 transcripts in rat tissues mediated by different promoters. Cell Calcium. 2005 Apr; 37(4):301-9. PMID: 15755491.
      View in: PubMed
    34. Wang, W.-Z. Hypertensive SHR rat blood vessels express more exon 1b-encoded CaV1.2 channels than their WKY counterparts. Biophys. J. 2005; 88: 276a-277a.
    35. Winston J, Wang W, Yin H, Choksi D, Medley D, Palade P, Pasricha PJ. NGF induces sensitization of the vanilloid receptor (TRPV1) response in sensory neurons in acute pancreatitis by recruiting silent nociceptors. Gastroenterology. 2005; 128 (Supp 2): A-86.
    36. Saada N, Dai B, Echetebu C, Sarna SK, Palade P. Smooth muscle uses another promoter to express primarily a form of human Cav1.2 L-type calcium channel different from the principal heart form. Biochem Biophys Res Commun. 2003 Feb 28; 302(1):23-8. PMID: 12593842.
      View in: PubMed
    37. Cavalli AL, O'Brien NW, Barlow SB, Betto R, Glembotski CC, Palade PT, Sabbadini RA. Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes. Am J Physiol Cell Physiol. 2003 Mar; 284(3):C780-90. PMID: 12421694.
      View in: PubMed
    38. Dai B, Saada N, Echetebu C, Dettbarn C, Palade P. A new promoter for alpha1C subunit of human L-type cardiac calcium channel Ca(V)1.2. Biochem Biophys Res Commun. 2002 Aug 16; 296(2):429-33. PMID: 12163037.
      View in: PubMed
    39. Fan JS, Palade P. Preferential loss of EC coupling gradation at positive membrane potentials in rat ventricular myocytes. Pflugers Arch. 2002 Aug; 444(5):654-62. PMID: 12194019.
      View in: PubMed
    40. Fan JS, Palade P. Effects of FPL 64176 on Ca transients in voltage-clamped rat ventricular myocytes. Br J Pharmacol. 2002 Mar; 135(6):1495-504. PMID: 11906963.
      View in: PubMed
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