 Osteoarthritis, Knee
"Osteoarthritis, Knee" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Descriptor ID |
D020370
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| MeSH Number(s) |
C05.550.114.606.500 C05.799.613.500
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| Concept/Terms |
Osteoarthritis, Knee- Osteoarthritis, Knee
- Knee Osteoarthritides
- Knee Osteoarthritis
- Osteoarthritides, Knee
- Osteoarthritis Of Knee
- Knee, Osteoarthritis Of
- Knees, Osteoarthritis Of
- Osteoarthritis Of Knees
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Below are MeSH descriptors whose meaning is more general than "Osteoarthritis, Knee".
Below are MeSH descriptors whose meaning is more specific than "Osteoarthritis, Knee".
This graph shows the total number of publications written about "Osteoarthritis, Knee" by people in UAMS Profiles by year, and whether "Osteoarthritis, Knee" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 3 | 0 | 3 | | 2024 | 2 | 0 | 2 | | 2023 | 8 | 0 | 8 | | 2022 | 4 | 0 | 4 | | 2021 | 4 | 0 | 4 | | 2020 | 4 | 0 | 4 | | 2019 | 1 | 2 | 3 | | 2018 | 1 | 0 | 1 | | 2017 | 4 | 0 | 4 | | 2016 | 3 | 0 | 3 | | 2015 | 3 | 1 | 4 | | 2013 | 2 | 0 | 2 | | 2012 | 2 | 0 | 2 | | 2011 | 5 | 0 | 5 | | 2010 | 2 | 0 | 2 | | 2009 | 1 | 3 | 4 | | 2008 | 6 | 0 | 6 | | 2006 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 1998 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Osteoarthritis, Knee" by people in Profiles over the past ten years.
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Tambiah J, Kennedy S, Swearingen C, McAlindon T, Yazici Y. Impact of structural severity on outcomes in knee osteoarthritis: an analysis of data from phase 2 and phase 3 lorecivivint clinical trials. Rheumatology (Oxford). 2025 May 01; 64(5):2583-2590.
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Yazici Y, Tambiah JRS, Swearingen CJ, Britt J, Kennedy S, Fineman MS, Simsek I, Solomon E, McAlindon TE. A Phase 3, 56-week, randomised, double-blind, placebo-controlled study (OA-11) utilising patient-reported and radiographic outcomes evaluating the efficacy and safety of a lorecivivint injection in patients with moderate to severe knee osteoarthritis. Clin Exp Rheumatol. 2025 May; 43(5):854-860.
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Yazici Y, Tambiah JRS, Swearingen CJ, Lopez VA, Kennedy S, Fineman MS, Simsek I, Solomon E, Mcalindon TE. A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients. Clin Exp Rheumatol. 2025 May; 43(5):847-853.
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Kirchner GJ, Stambough JB, Jimenez E, Mullen K, Nikkel LE. Robotic Assistance Is Not Associated With Decreased Early Revisions in Cementless TKA: An Analysis of the American Joint Replacement Registry. Clin Orthop Relat Res. 2025 Mar 01; 483(3):431-438.
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Inclan PM, Brophy RH, Saccone NL, Ma Y, Pham V, Yanik EL. Environmental and genetic risk factors associated with total knee arthroplasty following cruciate ligament surgery. Bone Joint J. 2024 Mar 01; 106-B(3):249-255.
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Hamilton LD, Shelburne KB, Rullkoetter PJ, Barnes CL, Mannen EM. Kinematic Performance of Medial Pivot Total Knee Arthroplasty. J Arthroplasty. 2024 Jun; 39(6):1595-1601.e7.
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Kviatkovsky SA, Hickner RC, Cabre HE, Small SD, Ormsbee MJ. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults. J Int Soc Sports Nutr. 2023 Dec; 20(1):2243252.
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Brown NM, Lingampalli N, Hellman MD. Intraoperative Challenges of the Kinematic Knee. Orthop Clin North Am. 2024 Jan; 55(1):27-32.
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Hodgeson SM, Soeno T, Mears SC, Stambough JB, Barnes CL, Stronach BM. The Medial Pivot Design in Total Knee Arthroplasty. Orthop Clin North Am. 2024 Jan; 55(1):49-59.
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Nieuwenhuijse MJ, Randsborg PH, Hyde JH, Xi W, Franklin P, Sun L, Zheng X, Banerjee S, Mao J, Aryal S, Chan P, Chen A, Liebeskind A, Bonangelino P, Voorhorst P, Gressler LE, Devlin V, Peat R, Marinac-Dabic D, Paxton E, Sedrakyan A. Evidence-based objective performance criteria for the evaluation of hip and knee replacement devices and technologies. Int J Surg. 2023 May 01; 109(5):1125-1135.
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Stambough JB. In Patients with Knee OA and Severe Obesity, Bariatric Surgery and Weight Loss Before TKA Reduced Complications Versus TKA Alone. J Bone Joint Surg Am. 2023 05 17; 105(10):805.
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Park D, Park YM, Ko SH, Hyun KS, Choi YH, Min DU, Han K, Koh HS. Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study. Sci Rep. 2023 03 07; 13(1):3796.
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Park D, Park YM, Ko SH, Choi YH, Min DU, Ahn JH, Kim B, Koh HS, Han K. Association between knee osteoarthritis and the risk of cardiovascular disease and the synergistic adverse effects of lack of exercise. Sci Rep. 2023 02 16; 13(1):2777.
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Colloca L, Dworkin RH, Farrar JT, Tive L, Yang J, Viktrup L, Dasic G, West CR, Whalen E, Brown MT, Gilbert SA, Verburg KM. Predicting Treatment Responses in Patients With Osteoarthritis: Results From Two Phase III Tanezumab Randomized Clinical Trials. Clin Pharmacol Ther. 2023 04; 113(4):878-886.
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Katsumi R, Mannen EM, Bajaj G, Smith JR, Mears SC, Stambough JB, Barnes CL. The Influence of Knee Osteoarthritis on Spinopelvic Alignment and Global Sagittal Balance. J Knee Surg. 2023 Jul; 36(9):917-924.
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Chen Z, Bonutti PM, Barsoum WK, Mont MA, Bains SS, Jacofsky DJ. Technology Review: CT Scan-Guided, 3-Dimensional, Robotic-Arm Assisted Lower Extremity Arthroplasty. Surg Technol Int. 2022 May 19; 40:297-308.
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Drummer DJ, McAdam JS, Seay R, Aban I, Lavin KM, Wiggins D, Touliatos G, Yang S, Kelley C, Tuggle SC, Peoples B, Siegel H, Ghanem E, Singh JA, Schutzler S, Barnes CL, Ferrando AA, Bridges SL, Bamman MM. Perioperative assessment of muscle inflammation susceptibility in patients with end-stage osteoarthritis. J Appl Physiol (1985). 2022 04 01; 132(4):984-994.
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Anz AW, Plummer HA, Cohen A, Everts PA, Andrews JR, Hackel JG. Bone Marrow Aspirate Concentrate Is Equivalent to Platelet-Rich Plasma for the Treatment of Knee Osteoarthritis at 2 Years: A Prospective Randomized Trial. Am J Sports Med. 2022 03; 50(3):618-629.
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Tambiah JRS, Simsek I, Swearingen CJ, Kennedy S, Cole BJ, McAlindon TE, Yazici Y. Comparing Patient-Reported Outcomes From Sham and Saline-Based Placebo Injections for Knee Osteoarthritis: Data From a Randomized Clinical Trial of Lorecivivint. Am J Sports Med. 2022 Mar; 50(3):630-636.
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Howie CM, Mears SC, Barnes CL, Mannen EM, Stambough JB. Radiographic Findings in Flexion Instability after Total Knee Arthroplasty. J Knee Surg. 2023 Mar; 36(4):411-416.
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Wang J, Severin AC, Mears SC, Stambough JB, Barnes CL, Mannen EM. Changes in Mediolateral Postural Control Mechanisms During Gait After Total Knee Arthroplasty. J Arthroplasty. 2021 Sep; 36(9):3326-3332.
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Parekh SM, Fernandes GS, Moses JP, Fuller CW, Scammell BE, Batt ME, Zhang W, Doherty M. Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study. Clin J Sport Med. 2021 May 01; 31(3):281-288.
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Yazici Y, McAlindon TE, Gibofsky A, Lane NE, Lattermann C, Skrepnik N, Swearingen CJ, Simsek I, Ghandehari H, DiFrancesco A, Gibbs J, Tambiah JRS, Hochberg MC. A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis. Osteoarthritis Cartilage. 2021 05; 29(5):654-666.
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Varady NH, Cate G, Barghi A, Jobe N, Yakin D, Ylanan RC, Arnold CA. Positive early clinical outcomes of bone marrow aspirate concentrate for osteoarthritis using a novel fenestrated trocar. Knee. 2020 Oct; 27(5):1627-1634.
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Yazici Y, McAlindon TE, Gibofsky A, Lane NE, Clauw D, Jones M, Bergfeld J, Swearingen CJ, DiFrancesco A, Simsek I, Tambiah J, Hochberg MC. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial. Arthritis Rheumatol. 2020 10; 72(10):1694-1706.
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Fernandes GS, Parekh SM, Moses JP, Fuller CW, Scammell BE, Batt ME, Zhang W, Doherty M. Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis. Sports Med. 2020 May; 50(5):1039-1046.
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Davis HC, Blue MNM, Hirsch KR, Luc-Harkey BA, Anderson KC, Smith-Ryan AE, Pietrosimone B. Body Composition Is Associated With Physical Performance in Individuals With Knee Osteoarthritis. J Clin Rheumatol. 2020 Apr; 26(3):109-114.
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Wang J, Siddicky SF, Oliver TE, Dohm MP, Barnes CL, Mannen EM. Biomechanical Changes Following Knee Arthroplasty During Sit-To-Stand Transfers: Systematic Review. J Arthroplasty. 2019 Oct; 34(10):2494-2501.
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Teeter MG, Marsh JD, Howard JL, Yuan X, Vasarhelyi EM, McCalden RW, Naudie DDR. A randomized controlled trial investigating the value of patient-specific instrumentation for total knee arthroplasty in the Canadian healthcare system. Bone Joint J. 2019 May; 101-B(5):565-572.
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Quinlan ND, Chen DQ, Werner BC, Barnes CL, Browne JA. Patients With Multiple Sclerosis are at Increased Risk for Postoperative Complications Following Total Hip and Knee Arthroplasty. J Arthroplasty. 2019 Aug; 34(8):1606-1610.
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Lombardi AV, Berend KR, Tria AJ, Peters CL, Kagan R, Callaghan JJ, Iorio R, Lieberman JR, Della Valle CJ, Calkins TE, Barrack RL, Edelstein AI, Barnes CL, Mears SC. Choices, Compromises, and Controversies in Total Knee Arthroplasty. Instr Course Lect. 2019; 68:187-216.
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Hereford TE, Cryar KA, Edwards PK, Siegel ER, Barnes CL, Mears SC. Patients With Hip or Knee Arthritis Underreport Narcotic Usage. J Arthroplasty. 2018 10; 33(10):3113-3117.
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Fernandes GS, Parekh SM, Moses J, Fuller C, Scammell B, Batt ME, Zhang W, Doherty M. Prevalence of knee pain, radiographic osteoarthritis and arthroplasty in retired professional footballers compared with men in the general population: a cross-sectional study. Br J Sports Med. 2018 May; 52(10):678-683.
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Shewale AR, Barnes CL, Fischbach LA, Ounpraseuth ST, Painter JT, Martin BC. Comparative Effectiveness of Intra-Articular Hyaluronic Acid and Corticosteroid Injections on the Time to Surgical Knee Procedures. J Arthroplasty. 2017 12; 32(12):3591-3597.e24.
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Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ, Skrepnik N, Armas E, Swearingen CJ, DiFrancesco A, Tambiah JRS, Hood J, Hochberg MC. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthritis Cartilage. 2017 10; 25(10):1598-1606.
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Shewale AR, Barnes CL, Fischbach LA, Ounpraseuth ST, Painter JT, Martin BC. Comparison of Low-, Moderate-, and High-Molecular-Weight Hyaluronic Acid Injections in Delaying Time to Knee Surgery. J Arthroplasty. 2017 10; 32(10):2952-2957.e21.
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Shewale AR, Fischbach LA, Hammond DA, Martin BC. Letter to the Editor on 'Hyaluronic Acid Injections in Medicare Knee Osteoarthritis Patients Are Associated With Longer Time to Knee Arthroplasty'. J Arthroplasty. 2017 02; 32(2):696-697.
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Smith SM, Amtmann D, Askew RL, Gewandter JS, Hunsinger M, Jensen MP, McDermott MP, Patel KV, Williams M, Bacci ED, Burke LB, Chambers CT, Cooper SA, Cowan P, Desjardins P, Etropolski M, Farrar JT, Gilron I, Huang IZ, Katz M, Kerns RD, Kopecky EA, Rappaport BA, Resnick M, Strand V, Vanhove GF, Veasley C, Versavel M, Wasan AD, Turk DC, Dworkin RH. Pain intensity rating training: results from an exploratory study of the ACTTION PROTECCT system. Pain. 2016 May; 157(5):1056-1064.
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O'Neal RM, Cryer KA, Edwards PK, Barnes CL, Mears SC. Narcotic Use: A Modifiable Risk Factor for Hip and Knee Arthroplasty. J Surg Orthop Adv. 2016 Winter; 25(4):227-233.
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