An autosomal recessive neurodegenerative disorder characterized by an accumulation of G(M2) GANGLIOSIDE in neurons and other tissues. It is caused by mutation in the common beta subunit of HEXOSAMINIDASE A and HEXOSAMINIDASE B. Thus this disease is also known as the O variant since both hexosaminidase A and B are missing. Clinically, it is indistinguishable from TAY-SACHS DISEASE.

Descriptor ID	D012497
MeSH Number(s)	C10.228.140.163.100.435.825.300.300.249 C10.228.140.163.100.435.825.300.700 C16.320.565.189.435.825.300.300.249 C16.320.565.189.435.825.300.700 C16.320.565.398.641.803.350.300.700 C16.320.565.595.554.825.300.300.800 C18.452.132.100.435.825.300.300.249 C18.452.132.100.435.825.300.700 C18.452.584.687.803.350.300.700 C18.452.648.189.435.825.300.300.249 C18.452.648.189.435.825.300.700 C18.452.648.398.641.803.350.300.700 C18.452.648.595.554.825.300.300.800
Concept/Terms	Sandhoff Disease Sandhoff Disease Deficiency Disease, Hexosaminidase A and B Gangliosidosis G(M2), Type II Gangliosidosis GM2, Type II GM2-Gangliosidosis, Type II GM2-Gangliosidoses, Type II Type II GM2-Gangliosidoses Type II GM2-Gangliosidosis GM2 Gangliosidosis, Type II Hexosaminidase A and B Deficiency Disease Hexosaminidases A And B Deficiency Sandhoff's Disease Sandhoffs Disease Sandhoff-Jatzkewitz-Pilz Disease Disease, Sandhoff-Jatzkewitz-Pilz Sandhoff Jatzkewitz Pilz Disease G(M2) Gangliosidosis, Type II GM2 Gangliosidosis, Type 2 Total Hexosaminidase Deficiency Total Hexosaminidase Deficiency Deficiencies, Total Hexosaminidase Deficiency, Total Hexosaminidase Hexosaminidase Deficiencies, Total Hexosaminidase Deficiency, Total Total Hexosaminidase Deficiencies beta-Hexosaminidase-beta-Subunit Deficiency Deficiencies, beta-Hexosaminidase-beta-Subunit Deficiency, beta-Hexosaminidase-beta-Subunit beta Hexosaminidase beta Subunit Deficiency beta-Hexosaminidase-beta-Subunit Deficiencies Juvenile Sandhoff Disease Juvenile Sandhoff Disease Sandhoff Disease, Juvenile Adult Sandhoff Disease Adult Sandhoff Disease Sandhoff Disease, Adult Infantile Sandhoff Disease Infantile Sandhoff Disease Sandhoff Disease, Infantile

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Below are MeSH descriptors whose meaning is more specific than "Sandhoff Disease".