 Monoamine Oxidase
"Monoamine Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.
| Descriptor ID |
D008995
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| MeSH Number(s) |
D08.811.682.664.750
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| Concept/Terms |
Monoamine Oxidase- Monoamine Oxidase
- Oxidase, Monoamine
- Amine Oxidase (Flavin-Containing)
- MAO
- Tyramine Oxidase
- Oxidase, Tyramine
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Below are MeSH descriptors whose meaning is more general than "Monoamine Oxidase".
Below are MeSH descriptors whose meaning is more specific than "Monoamine Oxidase".
This graph shows the total number of publications written about "Monoamine Oxidase" by people in UAMS Profiles by year, and whether "Monoamine Oxidase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 1 | 1 | 2 | | 2021 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2014 | 2 | 1 | 3 | | 2005 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 1993 | 1 | 2 | 3 |
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Below are the most recent publications written about "Monoamine Oxidase" by people in Profiles over the past ten years.
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Safdar B, Wang M, Guo X, Cha C, Chun HJ, Deng Y, Dziura J, El-Khoury JM, Gorelick F, Ko AI, Lee AI, Safirstein R, Simonov M, Zhou B, Desir GV. Association of renalase with clinical outcomes in hospitalized patients with COVID-19. PLoS One. 2022; 17(3):e0264178.
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Guo X, Jessel S, Qu R, Kluger Y, Chen TM, Hollander L, Safirstein R, Nelson B, Cha C, Bosenberg M, Jilaveanu LB, Rimm D, Rothlin CV, Kluger HM, Desir GV. Inhibition of renalase drives tumour rejection by promoting T cell activation. Eur J Cancer. 2022 04; 165:81-96.
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Guo X, Xu L, Velazquez H, Chen TM, Williams RM, Heller DA, Burtness B, Safirstein R, Desir GV. Kidney-Targeted Renalase Agonist Prevents Cisplatin-Induced Chronic Kidney Disease by Inhibiting Regulated Necrosis and Inflammation. J Am Soc Nephrol. 2022 02; 33(2):342-356.
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Wang Y, Safirstein R, Velazquez H, Guo XJ, Hollander L, Chang J, Chen TM, Mu JJ, Desir GV. Extracellular renalase protects cells and organs by outside-in signalling. J Cell Mol Med. 2017 07; 21(7):1260-1265.
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Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV. Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism. Cancer Res. 2016 07 01; 76(13):3884-94.
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Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV. Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer. Sci Rep. 2016 Mar 14; 6:22996.
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Wang L, Velazquez H, Chang J, Safirstein R, Desir GV. Identification of a receptor for extracellular renalase. PLoS One. 2015; 10(4):e0122932.
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