Teniposide
"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
| Descriptor ID |
D013713
|
| MeSH Number(s) |
D09.408.348.800
|
| Concept/Terms |
Teniposide- Teniposide
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
Vumon- Vumon
- Bristol-Myers Brand of Teniposide
- Bristol Myers Brand of Teniposide
- Bristol-Myers Squibb Brand of Teniposide
- Bristol Myers Squibb Brand of Teniposide
|
Below are MeSH descriptors whose meaning is more general than "Teniposide".
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This graph shows the total number of publications written about "Teniposide" by people in UAMS Profiles by year, and whether "Teniposide" was a major or minor topic of these publications.
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Below are the most recent publications written about "Teniposide" by people in Profiles over the past ten years.